{"id":"https://openalex.org/W2800986973","doi":"https://doi.org/10.3389/fimmu.2018.00985","title":"Human \u03b3\u03b4 T-Cell Control of Mucosal Immunity and Inflammation","display_name":"Human \u03b3\u03b4 T-Cell Control of Mucosal Immunity and Inflammation","publication_year":2018,"publication_date":"2018-05-07","ids":{"openalex":"https://openalex.org/W2800986973","doi":"https://doi.org/10.3389/fimmu.2018.00985","mag":"2800986973","pmid":"https://pubmed.ncbi.nlm.nih.gov/29867962","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5949325"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2018.00985","doi":"https://doi.org/10.3389/fimmu.2018.00985","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.00985","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00985/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00985/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061019212","display_name":"Neil E. McCarthy","orcid":"https://orcid.org/0000-0002-4330-4747","observed_orcids":["https://orcid.org/0000-0002-4330-4747"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neil E. McCarthy","raw_affiliation_strings":["Centre for Immunobiology, Bart's and The London School of Medicine and Dentistry, The Blizard Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunobiology, Bart's and The London School of Medicine and Dentistry, The Blizard Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006981120","display_name":"Matthias Eberl","orcid":"https://orcid.org/0000-0002-9390-5348","observed_orcids":["https://orcid.org/0000-0002-9390-5348"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthias Eberl","raw_affiliation_strings":["Division of Infection and Immunity, School of Medicine, Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Immunity, School of Medicine, Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061019212"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":1775,"currency":"EUR","value_usd":1914},"fwci":0.9231,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.67710165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"985","last_page":"985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vdelta1-t-cells","display_name":"V\u03b41 T cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/vdelta2-t-cells","display_name":"V\u03b42 T cells","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/vedolizumab","display_name":"vedolizumab","score":0.8309999704360962},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5945765376091003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5862110257148743},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5106177926063538},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4864920973777771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4758013188838959},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.47149723768234253},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47116097807884216},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4548940062522888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3538731336593628}],"mesh":[{"descriptor_ui":"D000075942","descriptor_name":"Intraepithelial Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.3389/fimmu.2018.00985","doi":"https://doi.org/10.3389/fimmu.2018.00985","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.00985","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00985/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4937315","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5949325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5949325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5949325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:29867962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29867962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:111314","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/111314/1/fimmu-09-00985.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/111314/1/fimmu-09-00985.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:5ac34a84aff44584bec3ff33b96ec581","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ac34a84aff44584bec3ff33b96ec581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 9 (2018)","raw_type":"article"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/41663","doi":null,"is_oa":true,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/41663","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2018.00985","doi":"https://doi.org/10.3389/fimmu.2018.00985","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.00985","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00985/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1611667604","display_name":"Innate pathogen sensing by local unconventional T cells during microbial infections","funder_award_id":"MR/N023145/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5093158474","display_name":null,"funder_award_id":"M13-5","funder_id":"https://openalex.org/F4320321982","funder_display_name":"Crohn's and Colitis UK"},{"id":"https://openalex.org/G5781017958","display_name":"UoCardiff Confidence in Concept 2013","funder_award_id":"MC_PC_13060","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7269569562","display_name":"Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammation","funder_award_id":"MR/R008302/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8762938552","display_name":null,"funder_award_id":"AC1120IF06","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312939","display_name":"Crohn's in Childhood Research Association","ror":"https://ror.org/0537aj111"},{"id":"https://openalex.org/F4320321982","display_name":"Crohn's and Colitis UK","ror":"https://ror.org/058c0xb46"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2800986973.pdf","grobid_xml":"https://content.openalex.org/works/W2800986973.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W113049030","https://openalex.org/W1107917109","https://openalex.org/W1512725729","https://openalex.org/W1524690007","https://openalex.org/W1555118964","https://openalex.org/W1571096646","https://openalex.org/W1605391507","https://openalex.org/W1658971169","https://openalex.org/W1679878748","https://openalex.org/W1764179577","https://openalex.org/W1851838095","https://openalex.org/W1869494113","https://openalex.org/W1910445189","https://openalex.org/W1922746363","https://openalex.org/W1944454646","https://openalex.org/W1950074061","https://openalex.org/W1954884893","https://openalex.org/W1967679528","https://openalex.org/W1968797543","https://openalex.org/W1981756981","https://openalex.org/W1982611882","https://openalex.org/W1984282453","https://openalex.org/W1984849109","https://openalex.org/W1987917362","https://openalex.org/W1991473719","https://openalex.org/W1992697645","https://openalex.org/W1992979350","https://openalex.org/W1993786192","https://openalex.org/W1994505708","https://openalex.org/W1994956078","https://openalex.org/W1999341606","https://openalex.org/W2012636177","https://openalex.org/W2017938541","https://openalex.org/W2018540827","https://openalex.org/W2022323103","https://openalex.org/W2022497001","https://openalex.org/W2042550965","https://openalex.org/W2047944199","https://openalex.org/W2050316762","https://openalex.org/W2051579898","https://openalex.org/W2052275203","https://openalex.org/W2056204715","https://openalex.org/W2061699947","https://openalex.org/W2067194679","https://openalex.org/W2076988166","https://openalex.org/W2078710292","https://openalex.org/W2112517102","https://openalex.org/W2117084942","https://openalex.org/W2118802947","https://openalex.org/W2126078533","https://openalex.org/W2126199370","https://openalex.org/W2127367385","https://openalex.org/W2129799990","https://openalex.org/W2130272079","https://openalex.org/W2130454671","https://openalex.org/W2131204388","https://openalex.org/W2132784721","https://openalex.org/W2134235768","https://openalex.org/W2137114871","https://openalex.org/W2138986864","https://openalex.org/W2142450028","https://openalex.org/W2144247138","https://openalex.org/W2146430516","https://openalex.org/W2151272317","https://openalex.org/W2151412551","https://openalex.org/W2154645461","https://openalex.org/W2155841056","https://openalex.org/W2162298266","https://openalex.org/W2164035788","https://openalex.org/W2165547934","https://openalex.org/W2165979849","https://openalex.org/W2170069789","https://openalex.org/W2170995642","https://openalex.org/W2179234980","https://openalex.org/W2320179153","https://openalex.org/W2494177319","https://openalex.org/W2520176593","https://openalex.org/W2559040611","https://openalex.org/W2559909402","https://openalex.org/W2576836661","https://openalex.org/W2591742226","https://openalex.org/W2593164559","https://openalex.org/W2598302258","https://openalex.org/W2624491356","https://openalex.org/W2691941774","https://openalex.org/W2728540238","https://openalex.org/W2734735597","https://openalex.org/W2736162768","https://openalex.org/W2736193208","https://openalex.org/W2746726011","https://openalex.org/W2766131970","https://openalex.org/W2772067453","https://openalex.org/W2788682499","https://openalex.org/W4313343448"],"related_works":["https://openalex.org/W2981394706","https://openalex.org/W7005621792","https://openalex.org/W4396871541","https://openalex.org/W2126694219","https://openalex.org/W7202032083","https://openalex.org/W2118828549","https://openalex.org/W3044843687","https://openalex.org/W2043577628","https://openalex.org/W7204805944","https://openalex.org/W4386606700"],"abstract_inverted_index":{"Human":[0,207],"\u03b3\u03b4":[1,33,68,113,136,176,208,247],"T-cells":[2,53,69],"include":[3,171],"some":[4],"of":[5,86,92,102,112,135,142,174,211,222,228,245],"the":[6,32,195,232,243],"most":[7],"common":[8],"\u2018antigen-specific\u2019":[9],"cell":[10],"types":[11],"in":[12,82,109,119,131,151,194],"peripheral":[13,199],"blood":[14,205],"and":[15,27,54,80,100,125,154,225],"are":[16,47],"enriched":[17],"yet":[18],"further":[19],"at":[20],"mucosal":[21,45,94,212],"barrier":[22],"sites":[23],"where":[24],"microbial":[25],"infection":[26],"tumors":[28],"often":[29],"originate.":[30],"While":[31],"T-cell":[34,137,177,209],"compartment":[35],"includes":[36],"multiple":[37,218],"subsets":[38],"with":[39],"highly":[40],"flexible":[41],"effector":[42],"functions,":[43],"human":[44,152],"tissues":[46,181],"dominated":[48],"by":[49],"host":[50,184],"stress-responsive":[51],"V\u03b41+":[52],"microbe-responsive":[55],"V\u03b42+":[56,143],"T-cells.":[57,114],"Widely":[58],"recognized":[59],"for":[60],"their":[61,129],"potent":[62],"cytotoxicity,":[63],"emerging":[64],"data":[65],"suggest":[66],"that":[67,235],"also":[70],"exert":[71],"strong":[72],"influences":[73],"on":[74],"downstream":[75],"adaptive":[76],"immunity":[77,213],"to":[78,133,158,165,179,182,197,204,242],"pathogens":[79],"tumors,":[81],"particular":[83],"via":[84,217],"activation":[85,221],"antigen-presenting":[87,223],"cells":[88,193,224],"and/or":[89,201],"direct":[90,226],"stimulation":[91,227],"other":[93],"leukocytes.":[95,230],"These":[96],"unique":[97],"functional":[98],"attributes":[99],"lack":[101],"MHC":[103],"restriction":[104],"have":[105],"prompted":[106],"considerable":[107],"interest":[108],"therapeutic":[110],"targeting":[111],"Indeed,":[115],"several":[116],"drugs":[117,163],"already":[118],"clinical":[120,140],"use":[121],"including":[122,220],"vedolizumab,":[123],"infliximab,":[124],"azathioprine":[126],"likely":[127,215],"owe":[128],"efficacy":[130,155],"part":[132],"modulation":[134],"function.":[138],"Recent":[139],"trials":[141],"T-cell-selective":[144],"treatments":[145],"indicate":[146],"a":[147],"good":[148],"safety":[149],"profile":[150],"patients,":[153],"is":[156,214],"set":[157],"increase":[159],"as":[160],"more":[161],"potent/targeted":[162],"continue":[164],"be":[166,240],"developed.":[167],"Key":[168],"advances":[169],"will":[170,239],"identifying":[172],"methods":[173],"directing":[175],"recruitment":[178],"specific":[180],"enhance":[183],"protection":[185],"against":[186],"invading":[187],"pathogens,":[188],"or":[189],"alternatively,":[190],"retaining":[191],"these":[192,237],"circulation":[196],"limit":[198],"inflammation":[200],"improve":[202],"responses":[203],"malignancies.":[206],"control":[210],"exerted":[216],"mechanisms":[219],"tissue-resident":[229],"Understanding":[231],"microenvironmental":[233],"signals":[234],"regulate":[236],"functions":[238],"critical":[241],"development":[244],"new":[246],"T-cell-based":[248],"therapies.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-05-17T00:00:00"}
