{"id":"https://openalex.org/W2800733010","doi":"https://doi.org/10.1038/s41416-018-0081-2","title":"Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division","display_name":"Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division","publication_year":2018,"publication_date":"2018-05-04","ids":{"openalex":"https://openalex.org/W2800733010","doi":"https://doi.org/10.1038/s41416-018-0081-2","mag":"2800733010","pmid":"https://pubmed.ncbi.nlm.nih.gov/29736010","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008333"},"language":"en","primary_location":{"id":"doi:10.1038/s41416-018-0081-2","doi":"https://doi.org/10.1038/s41416-018-0081-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-018-0081-2","pdf_url":"https://www.nature.com/articles/s41416-018-0081-2.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41416-018-0081-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101888622","display_name":"Ana Rita R. Maia","orcid":"https://orcid.org/0000-0003-1261-7211","observed_orcids":["https://orcid.org/0000-0003-1261-7211"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ana Rita R. Maia","raw_affiliation_strings":["Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061546693","display_name":"Simon Linder","orcid":"https://orcid.org/0000-0002-3315-305X","observed_orcids":["https://orcid.org/0000-0002-3315-305X"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Simon Linder","raw_affiliation_strings":["Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","Division of Oncogenomics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Oncogenomics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052244370","display_name":"Ji\u2010Ying Song","orcid":"https://orcid.org/0000-0002-6296-1996","observed_orcids":["https://orcid.org/0000-0002-6296-1996"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ji-Ying Song","raw_affiliation_strings":["Division of Experimental Animal Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Animal Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055879942","display_name":"Chantal Vaarting","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chantal Vaarting","raw_affiliation_strings":["Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053416545","display_name":"Ute Boon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ute Boon","raw_affiliation_strings":["Division of Molecular Pathology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044428638","display_name":"Colin E.J. Pritchard","orcid":"https://orcid.org/0000-0001-7848-9377","observed_orcids":["https://orcid.org/0000-0001-7848-9377"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Colin E. J. Pritchard","raw_affiliation_strings":["Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061855274","display_name":"Arno Velds","orcid":"https://orcid.org/0000-0003-4333-8872","observed_orcids":["https://orcid.org/0000-0003-4333-8872"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arno Velds","raw_affiliation_strings":["Genomics Core Facility, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Core Facility, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029568628","display_name":"Ivo Johan Huijbers","orcid":"https://orcid.org/0000-0002-7954-8604","observed_orcids":["https://orcid.org/0000-0002-7954-8604","https://orcid.org/0009-0001-2028-2573"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ivo J. Huijbers","raw_affiliation_strings":["Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034151807","display_name":"Olaf van Tellingen","orcid":"https://orcid.org/0000-0002-1037-6269","observed_orcids":["https://orcid.org/0000-0002-1037-6269"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Olaf van Tellingen","raw_affiliation_strings":["Laboratory of Clinical Chemistry and Hematology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Chemistry and Hematology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061340130","display_name":"Jos Jonkers","orcid":"https://orcid.org/0000-0002-9264-9792","observed_orcids":["https://orcid.org/0000-0002-9264-9792"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos Jonkers","raw_affiliation_strings":["Division of Molecular Pathology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074565662","display_name":"Ren\u00e9 H. Medema","orcid":"https://orcid.org/0000-0002-6754-0381","observed_orcids":["https://orcid.org/0000-0002-6754-0381","https://orcid.org/0009-0004-3701-7751"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Ren\u00e9 H. Medema","raw_affiliation_strings":["Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands. r.medema@nki.nl","Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands. r.medema@nki.nl","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Cell Biology and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074565662"],"corresponding_institution_ids":["https://openalex.org/I2898336195"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.8547,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.8336387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"118","issue":"12","first_page":"1586","last_page":"1595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chromosome-segregation-errors","display_name":"chromosome segregation errors","score":0.781000018119812},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.41600000858306885},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.800000011920929},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/spindle-poisons","display_name":"spindle poisons","score":0.5519999861717224},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9130598306655884},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6526715159416199},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5967923402786255},{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.5391583442687988},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5292177796363831},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5277206301689148},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.425453245639801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42405977845191956},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4034397006034851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39915597438812256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37051230669021606},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3280419707298279},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32141944766044617},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20269662141799927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14239436388015747}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41416-018-0081-2","doi":"https://doi.org/10.1038/s41416-018-0081-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-018-0081-2","pdf_url":"https://www.nature.com/articles/s41416-018-0081-2.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5039443","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6008333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6008333","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:29736010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29736010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41416-018-0081-2","doi":"https://doi.org/10.1038/s41416-018-0081-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-018-0081-2","pdf_url":"https://www.nature.com/articles/s41416-018-0081-2.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2800733010.pdf","grobid_xml":"https://content.openalex.org/works/W2800733010.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1962572582","https://openalex.org/W1973508729","https://openalex.org/W1974062341","https://openalex.org/W1978308161","https://openalex.org/W1990899207","https://openalex.org/W1992661182","https://openalex.org/W1994378895","https://openalex.org/W2006620593","https://openalex.org/W2007472864","https://openalex.org/W2009134815","https://openalex.org/W2015360671","https://openalex.org/W2021406428","https://openalex.org/W2036292773","https://openalex.org/W2039661168","https://openalex.org/W2041594739","https://openalex.org/W2045897698","https://openalex.org/W2071359790","https://openalex.org/W2073021178","https://openalex.org/W2101006499","https://openalex.org/W2106876296","https://openalex.org/W2108141991","https://openalex.org/W2114688504","https://openalex.org/W2133883957","https://openalex.org/W2144015247","https://openalex.org/W2153472959","https://openalex.org/W2154747925","https://openalex.org/W2164660906","https://openalex.org/W2168169655","https://openalex.org/W2169016078","https://openalex.org/W2211768750","https://openalex.org/W2263936419","https://openalex.org/W2320320934","https://openalex.org/W2332976074","https://openalex.org/W2344511238","https://openalex.org/W2413557253","https://openalex.org/W2519427975","https://openalex.org/W2550502448","https://openalex.org/W2563910203","https://openalex.org/W2587798615","https://openalex.org/W2593981338","https://openalex.org/W2598400219"],"related_works":["https://openalex.org/W2253930440","https://openalex.org/W2600504793","https://openalex.org/W2020809161","https://openalex.org/W1561624617","https://openalex.org/W2020099456","https://openalex.org/W7223317997","https://openalex.org/W2477963099","https://openalex.org/W2263936419","https://openalex.org/W2886275859","https://openalex.org/W2598400219"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chromosomal":[1],"instability":[2],"(CIN)":[3],"is":[4,114,142],"a":[5,30],"common":[6],"trait":[7],"of":[8,17,23,40,62,93,95,103,112,171],"cancer":[9,176],"characterised":[10],"by":[11],"the":[12,41,54,60,91,96,146,154],"continuous":[13],"gain":[14],"and":[15,48,86,125,132,158],"loss":[16],"chromosomes":[18],"during":[19],"mitosis.":[20],"Excessive":[21],"levels":[22],"CIN":[24],"can":[25],"suppress":[26],"tumour":[27],"growth,":[28],"providing":[29],"possible":[31],"therapeutic":[32],"strategy.":[33],"The":[34,73,100],"Mps1/TTK":[35],"kinase":[36],"has":[37],"been":[38],"one":[39],"prime":[42],"targets":[43],"to":[44,89],"explore":[45],"this":[46,172],"concept,":[47],"indeed":[49],"Mps1":[50,106,159],"inhibitors":[51,160],"synergise":[52],"with":[53,69,108,116,130],"spindle":[55],"poison":[56],"docetaxel":[57,70,113,131],"in":[58,64,119,145,165],"inhibiting":[59],"growth":[61],"tumours":[63,68,74],"mice.":[65],"METHODS:":[66],"mammary":[67],"and/or":[71],"Cpd-5.":[72],"were":[75],"analysed":[76],"regarding":[77],"their":[78],"histopathology,":[79],"chromosome":[80,140],"segregation":[81],"errors,":[82],"copy":[83],"number":[84],"variations":[85],"cell":[87,126,166],"death":[88],"understand":[90],"mechanism":[92],"action":[94],"drug":[97],"combination.":[98],"RESULTS:":[99],"enhanced":[101],"efficacy":[102],"combining":[104],"an":[105,117],"inhibitor":[107],"clinically":[109],"relevant":[110],"doses":[111],"associated":[115],"increase":[118],"multipolar":[120],"anaphases,":[121],"aberrant":[122],"nuclear":[123],"morphologies":[124],"death.":[127],"Tumours":[128],"treated":[129],"Cpd-5":[133],"displayed":[134],"more":[135],"genomic":[136],"deviations,":[137],"indicating":[138],"that":[139,153],"stability":[141],"affected":[143],"mostly":[144],"combinatorial":[147],"treatment.":[148],"CONCLUSIONS:":[149],"Our":[150],"study":[151],"shows":[152],"synergy":[155],"between":[156],"taxanes":[157],"depends":[161],"on":[162],"increased":[163],"errors":[164],"division,":[167],"allowing":[168],"further":[169],"optimisation":[170],"treatment":[173],"regimen":[174],"for":[175],"therapy.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-05-17T00:00:00"}
