{"id":"https://openalex.org/W2800708586","doi":"https://doi.org/10.1371/journal.ppat.1007012","title":"The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency","display_name":"The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency","publication_year":2018,"publication_date":"2018-04-23","ids":{"openalex":"https://openalex.org/W2800708586","doi":"https://doi.org/10.1371/journal.ppat.1007012","mag":"2800708586","pmid":"https://pubmed.ncbi.nlm.nih.gov/29684085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5933813"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1007012","doi":"https://doi.org/10.1371/journal.ppat.1007012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007012","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007012&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007012&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018664735","display_name":"Zichong Li","orcid":"https://orcid.org/0000-0003-0331-3208","observed_orcids":["https://orcid.org/0000-0003-0331-3208","https://orcid.org/0000-0001-7267-0415"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zichong Li","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0331-3208","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States of America","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087415274","display_name":"Uri R. Mbonye","orcid":"https://orcid.org/0000-0002-7694-0803","observed_orcids":["https://orcid.org/0000-0002-7694-0803"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uri Mbonye","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060402759","display_name":"Zeming Feng","orcid":"https://orcid.org/0000-0002-8564-896X","observed_orcids":["https://orcid.org/0000-0002-8564-896X"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeming Feng","raw_affiliation_strings":["School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China"],"raw_orcid":"https://orcid.org/0000-0002-8564-896X","affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410739","display_name":"Xiaohui Wang","orcid":"https://orcid.org/0000-0002-8683-7180","observed_orcids":["https://orcid.org/0000-0002-8683-7180"]},"institutions":[{"id":"https://openalex.org/I4210104954","display_name":"Shenzhen Center for Disease Control and Prevention","ror":"https://ror.org/01jbc0c43","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210104954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Wang","raw_affiliation_strings":["Shenzhen Center for Disease Control and Prevention, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-8683-7180","affiliations":[{"raw_affiliation_string":"Shenzhen Center for Disease Control and Prevention, Shenzhen, China","institution_ids":["https://openalex.org/I4210104954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015348295","display_name":"Xiang Gao","orcid":"https://orcid.org/0000-0002-3774-1852","observed_orcids":["https://orcid.org/0000-0002-3774-1852"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Gao","raw_affiliation_strings":["School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049581015","display_name":"Jonathan Karn","orcid":"https://orcid.org/0000-0002-2900-094X","observed_orcids":["https://orcid.org/0000-0002-2900-094X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Karn","raw_affiliation_strings":["Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038043249","display_name":"Qiang Zhou","orcid":"https://orcid.org/0000-0001-7202-3947","observed_orcids":["https://orcid.org/0000-0001-7202-3947"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qiang Zhou","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States of America","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038043249"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":3.4048,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.93034965,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"4","first_page":"e1007012","last_page":"e1007012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.9869999885559082},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.8970000147819519},{"id":"https://openalex.org/keywords/kat5","display_name":"KAT5","score":0.9070000052452087},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/histone-h4-acetylation","display_name":"histone H4 acetylation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hiv-ltr","display_name":"HIV LTR","score":0.7260000109672546},{"id":"https://openalex.org/keywords/p-tefb","display_name":"P-TEFb","score":0.871999979019165},{"id":"https://openalex.org/keywords/super-elongation-complex","display_name":"super elongation complex","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tat","display_name":"Tat","score":0.7730000019073486},{"id":"https://openalex.org/keywords/latency-reversal","display_name":"latency reversal","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/latent-hiv-reservoir","display_name":"latent HIV reservoir","score":0.6380000114440918},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.6862369775772095},{"id":"https://openalex.org/C2779634854","wikidata":"https://www.wikidata.org/wiki/Q18037206","display_name":"BRD4","level":5,"score":0.6165192127227783},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6062369346618652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5974950194358826},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5868718028068542},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.5531384944915771},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.5417320132255554},{"id":"https://openalex.org/C2777841055","wikidata":"https://www.wikidata.org/wiki/Q15314917","display_name":"P-TEFb","level":5,"score":0.5299502611160278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49595436453819275},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.469685822725296},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.4660651981830597},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4137551784515381},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.38485321402549744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3127657175064087},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2908996343612671},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12932240962982178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08508017659187317},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.07903051376342773},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074443","descriptor_name":"Lysine Acetyltransferase 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000074443","descriptor_name":"Lysine Acetyltransferase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000092468","descriptor_name":"Bromodomain Containing Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042925","descriptor_name":"Positive Transcriptional Elongation Factor B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042925","descriptor_name":"Positive Transcriptional Elongation Factor B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054322","descriptor_name":"tat Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054322","descriptor_name":"tat Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1007012","doi":"https://doi.org/10.1371/journal.ppat.1007012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007012","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007012&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4875216","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5933813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5933813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5933813","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:29684085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29684085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:32e1b521aeec49bdb77053a2d241a456","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/32e1b521aeec49bdb77053a2d241a456","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 14, Iss 4, p e1007012 (2018)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7w7511rg","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7w7511rg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS pathogens, vol 14, iss 4","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7w7511rg","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7w7511rg","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Pathogens, vol 14, iss 4","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/6173525","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_KAT5-Acetyl-Histone4-Brd4_axis_silences_HIV-1_transcription_and_promotes_viral_latency/6173525","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1007012","doi":"https://doi.org/10.1371/journal.ppat.1007012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007012","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007012&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2930824056","display_name":null,"funder_award_id":"17GYY002NF02","funder_id":"https://openalex.org/F4320326296","funder_display_name":"Xiamen Southern Oceanographic Center"},{"id":"https://openalex.org/G4780485861","display_name":"Regulation of Transcriptional Elongation by HIV-1 Tat","funder_award_id":"R01AI041757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000870022","display_name":"Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)","funder_award_id":"P30AI036219","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320326296","display_name":"Xiamen Southern Oceanographic Center","ror":"https://ror.org/05q39k474"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2800708586.pdf","grobid_xml":"https://content.openalex.org/works/W2800708586.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W952815228","https://openalex.org/W957390246","https://openalex.org/W1527634862","https://openalex.org/W1590436404","https://openalex.org/W1605366962","https://openalex.org/W1834739414","https://openalex.org/W1889176404","https://openalex.org/W1973462980","https://openalex.org/W1973694997","https://openalex.org/W1974488636","https://openalex.org/W1989804575","https://openalex.org/W1992127633","https://openalex.org/W1995910339","https://openalex.org/W1999771675","https://openalex.org/W2000759004","https://openalex.org/W2014017310","https://openalex.org/W2016326408","https://openalex.org/W2022094921","https://openalex.org/W2023243934","https://openalex.org/W2038598840","https://openalex.org/W2043422368","https://openalex.org/W2045041347","https://openalex.org/W2049874714","https://openalex.org/W2055276204","https://openalex.org/W2061005894","https://openalex.org/W2068878293","https://openalex.org/W2073229191","https://openalex.org/W2077327834","https://openalex.org/W2079713056","https://openalex.org/W2080166804","https://openalex.org/W2092067905","https://openalex.org/W2096083625","https://openalex.org/W2096673680","https://openalex.org/W2103409409","https://openalex.org/W2109042466","https://openalex.org/W2111693566","https://openalex.org/W2115630982","https://openalex.org/W2116196682","https://openalex.org/W2123647733","https://openalex.org/W2132351720","https://openalex.org/W2144697720","https://openalex.org/W2151217565","https://openalex.org/W2152505144","https://openalex.org/W2253751386","https://openalex.org/W2255452171","https://openalex.org/W2489079158","https://openalex.org/W2531411520","https://openalex.org/W2591987892","https://openalex.org/W2736205158","https://openalex.org/W2748087031"],"related_works":["https://openalex.org/W2103409409","https://openalex.org/W2596637804","https://openalex.org/W7100176902","https://openalex.org/W6989719287","https://openalex.org/W7101088449","https://openalex.org/W1991342850","https://openalex.org/W2201407177","https://openalex.org/W2064743809","https://openalex.org/W2748087031","https://openalex.org/W2131009247"],"abstract_inverted_index":{"The":[0,149],"bromodomain":[1],"protein":[2],"Brd4":[3,18,79,131],"promotes":[4],"HIV-1":[5],"latency":[6,101,119,162,183],"by":[7,13,25],"competitively":[8],"inhibiting":[9],"P-TEFb-mediated":[10],"transcription":[11,99],"induced":[12],"the":[14,22,33,41,64,82,87,124,133,136,145,175],"virus-encoded":[15],"Tat":[16,85],"protein.":[17],"is":[19,94,114,154],"recruited":[20],"to":[21,80,116,189],"HIV":[23,98,118,192],"LTR":[24,65],"interactions":[26],"with":[27,57,86],"acetyl-histones3":[28],"(AcH3)":[29],"and":[30,40,100,112,130,139,184],"AcH4.":[31],"However,":[32],"precise":[34],"modification":[35],"pattern":[36,46],"that":[37,63,93],"it":[38],"reads":[39],"writer":[42],"for":[43,96,194],"generating":[44],"this":[45],"are":[47],"unknown.":[48],"By":[49],"examining":[50],"a":[51,157,179,185],"pool":[52],"of":[53,84,147,152,182],"latently":[54],"infected":[55],"proviruses":[56],"diverse":[58],"integration":[59],"sites,":[60],"we":[61],"found":[62,115],"characteristically":[66],"has":[67],"low":[68],"AcH3":[69],"but":[70,107],"high":[71],"AcH4":[72,129],"content.":[73],"This":[74],"unusual":[75],"acetylation":[76],"profile":[77],"attracts":[78],"suppress":[81],"interaction":[83],"host":[88],"super":[89],"elongation":[90],"complex":[91],"(SEC)":[92],"essential":[95],"productive":[97],"reversal.":[102],"KAT5":[103,127,153],"(lysine":[104],"acetyltransferase":[105],"5),":[106],"not":[108],"its":[109],"paralogs":[110],"KAT7":[111],"KAT8,":[113],"promote":[117],"through":[120],"acetylating":[121],"H4":[122],"on":[123],"provirus.":[125],"Antagonizing":[126],"removes":[128],"from":[132,168],"LTR,":[134],"enhances":[135],"SEC":[137],"loading,":[138],"reverses":[140],"as":[141,143,164,166,178],"well":[142,165],"delays,":[144],"establishment":[146],"latency.":[148],"pro-latency":[150],"effect":[151],"confirmed":[155],"in":[156],"primary":[158],"CD4+":[159],"T":[160],"cell":[161],"model":[163],"cells":[167],"ART-treated":[169],"patients.":[170],"Our":[171],"data":[172],"thus":[173],"indicate":[174],"KAT5-AcH4-Brd4":[176],"axis":[177],"key":[180],"regulator":[181],"potential":[186],"therapeutic":[187],"target":[188],"reactivate":[190],"latent":[191],"reservoirs":[193],"eradication.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}