{"id":"https://openalex.org/W2800565896","doi":"https://doi.org/10.1002/pro.3432","title":"Mechanical properties of BiP protein determined by nano\u2010rheology","display_name":"Mechanical properties of BiP protein determined by nano\u2010rheology","publication_year":2018,"publication_date":"2018-04-26","ids":{"openalex":"https://openalex.org/W2800565896","doi":"https://doi.org/10.1002/pro.3432","mag":"2800565896","pmid":"https://pubmed.ncbi.nlm.nih.gov/29696702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153409"},"language":"en","primary_location":{"id":"doi:10.1002/pro.3432","doi":"https://doi.org/10.1002/pro.3432","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.3432","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3432","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3432","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053205784","display_name":"Nathalie Casanova\u2010Morales","orcid":"https://orcid.org/0000-0002-9706-0952","observed_orcids":["https://orcid.org/0000-0002-9706-0952"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Nathalie Casanova\u2010Morales","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","Nathalie Casanova-Morales and Diego Quiroga-Roger contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Nathalie Casanova-Morales and Diego Quiroga-Roger contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006240268","display_name":"Diego Quiroga\u2010Roger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Diego Quiroga\u2010Roger","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","Nathalie Casanova-Morales and Diego Quiroga-Roger contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Nathalie Casanova-Morales and Diego Quiroga-Roger contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038428015","display_name":"Hilda M. Alfaro\u2010Vald\u00e9s","orcid":"https://orcid.org/0009-0004-3101-3207","observed_orcids":["https://orcid.org/0009-0004-3101-3207"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Hilda M. Alfaro\u2010Vald\u00e9s","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087371347","display_name":"Zahra Alavi","orcid":"https://orcid.org/0000-0001-9760-174X","observed_orcids":["https://orcid.org/0000-0001-9760-174X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I35566140","display_name":"Loyola Marymount University","ror":"https://ror.org/00xhj8c72","country_code":"US","type":"education","lineage":["https://openalex.org/I35566140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zahra Alavi","raw_affiliation_strings":["Department of Physics, Loyola Marymount University, Los Angeles, California, 90045 US","Department of Physics and Astronomy, University of California - Los Angeles, Los Angeles, California, 90095 US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Loyola Marymount University, Los Angeles, California, 90045 US","institution_ids":["https://openalex.org/I35566140"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of California - Los Angeles, Los Angeles, California, 90095 US","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040704795","display_name":"Miguel I. A. Lagos\u2010Espinoza","orcid":"https://orcid.org/0009-0004-4027-2702","observed_orcids":["https://orcid.org/0009-0004-4027-2702"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Miguel I.A. Lagos\u2010Espinoza","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085646546","display_name":"Giovanni Zocchi","orcid":"https://orcid.org/0000-0001-6823-0046","observed_orcids":["https://orcid.org/0000-0001-6823-0046"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giovanni Zocchi","raw_affiliation_strings":["Department of Physics and Astronomy, University of California - Los Angeles, Los Angeles, California, 90095 US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of California - Los Angeles, Los Angeles, California, 90095 US","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014483266","display_name":"Christian A.M. Wilson","orcid":"https://orcid.org/0000-0002-6499-6957","observed_orcids":["https://orcid.org/0000-0002-6499-6957"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Christian A.M. Wilson","raw_affiliation_strings":["Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile Santiago 8380494 Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014483266","https://openalex.org/A5085646546"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I69737025"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.3174,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.49813409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"8","first_page":"1418","last_page":"1426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bip","display_name":"BiP","score":0.8920000195503235},{"id":"https://openalex.org/keywords/immunoglobulin-binding-protein","display_name":"immunoglobulin binding protein","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hsp70-chaperones","display_name":"Hsp70 chaperones","score":0.9490000009536743},{"id":"https://openalex.org/keywords/protein-mechanical-properties","display_name":"protein mechanical properties","score":0.7519999742507935},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nucleotide-binding","display_name":"nucleotide binding","score":0.7919999957084656},{"id":"https://openalex.org/keywords/atp-binding","display_name":"ATP binding","score":0.6940000057220459},{"id":"https://openalex.org/keywords/allosteric-communication","display_name":"allosteric communication","score":0.9079999923706055},{"id":"https://openalex.org/keywords/nucleotide-binding-domain","display_name":"nucleotide-binding domain","score":0.9399999976158142},{"id":"https://openalex.org/keywords/substrate-binding-domain","display_name":"substrate-binding domain","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.707738995552063},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.6848317980766296},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4020419716835022},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3910720646381378},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38446563482284546},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37886548042297363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15296947956085205},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.15072906017303467}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/pro.3432","doi":"https://doi.org/10.1002/pro.3432","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.3432","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3432","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5618838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153409","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6153409","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6153409","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:29696702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29696702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/158447","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.uchile.cl/handle/2250/158447","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein Science","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.1002/pro.3432","doi":"https://doi.org/10.1002/pro.3432","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.3432","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.3432","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1213797683","display_name":null,"funder_award_id":"DMR-1404400","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G2887387820","display_name":"Nano - Rheology of Enzymes","funder_award_id":"1404400","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4109810059","display_name":null,"funder_award_id":"Project 3160645","funder_id":"https://openalex.org/F4320324634","funder_display_name":"Fondo Nacional de Ciencia Tecnolog\u00eda e Innovaci\u00f3n"},{"id":"https://openalex.org/G7324100280","display_name":null,"funder_award_id":"Project 11130263 and 1181361 (CW), Project 3160645 (DQ)","funder_id":"https://openalex.org/F4320324634","funder_display_name":"Fondo Nacional de Ciencia Tecnolog\u00eda e Innovaci\u00f3n"},{"id":"https://openalex.org/G7626717886","display_name":null,"funder_award_id":"Project 11130263 and 1181361","funder_id":"https://openalex.org/F4320324634","funder_display_name":"Fondo Nacional de Ciencia Tecnolog\u00eda e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320323458","display_name":"Universidad de Chile","ror":"https://ror.org/047gc3g35"},{"id":"https://openalex.org/F4320324634","display_name":"Fondo Nacional de Ciencia Tecnolog\u00eda e Innovaci\u00f3n","ror":"https://ror.org/050yqvv05"},{"id":"https://openalex.org/F4320334631","display_name":"Natural Environment Research Council","ror":"https://ror.org/02b5d8509"},{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2800565896.pdf","grobid_xml":"https://content.openalex.org/works/W2800565896.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W69814808","https://openalex.org/W1520350430","https://openalex.org/W1535060282","https://openalex.org/W1969650644","https://openalex.org/W1973943659","https://openalex.org/W1978203600","https://openalex.org/W1983137299","https://openalex.org/W1990054050","https://openalex.org/W2006913591","https://openalex.org/W2010209610","https://openalex.org/W2014294043","https://openalex.org/W2019858700","https://openalex.org/W2042232940","https://openalex.org/W2042838776","https://openalex.org/W2053544172","https://openalex.org/W2076945013","https://openalex.org/W2086922403","https://openalex.org/W2101557398","https://openalex.org/W2128635872","https://openalex.org/W2131450597","https://openalex.org/W2138158290","https://openalex.org/W2143508005","https://openalex.org/W2149744037","https://openalex.org/W2162791176","https://openalex.org/W2180270062","https://openalex.org/W2240548516","https://openalex.org/W2324834733","https://openalex.org/W2338569611","https://openalex.org/W2412028122","https://openalex.org/W2540212330","https://openalex.org/W2587229664","https://openalex.org/W2741550721","https://openalex.org/W2746799961"],"related_works":["https://openalex.org/W7058313046","https://openalex.org/W7043445670","https://openalex.org/W6899031026","https://openalex.org/W4302023449","https://openalex.org/W4300862888","https://openalex.org/W3196533938","https://openalex.org/W2394447672","https://openalex.org/W2099598754","https://openalex.org/W2945973052","https://openalex.org/W1855363448"],"abstract_inverted_index":{"Abstract":[0],"Immunoglobulin":[1],"Binding":[2],"Protein":[3],"(BiP)":[4],"is":[5,62,125,136,149],"a":[6,55,119,127,163],"chaperone":[7],"and":[8,28,47,60,69,88,144,174,208],"molecular":[9,80],"motor":[10],"belonging":[11],"to":[12,64,94,100,139],"the":[13,18,33,42,48,67,76,102,109,112,140,145,155,159,191],"Hsp70":[14],"family,":[15],"involved":[16],"in":[17,32,66,75,111,131],"regulation":[19],"of":[20,30,105,158],"important":[21],"biological":[22],"processes":[23],"such":[24],"as":[25],"synthesis,":[26],"folding":[27],"translocation":[29],"proteins":[31],"Endoplasmic":[34],"Reticulum.":[35],"BiP":[36,82,106],"has":[37],"two":[38],"highly":[39],"conserved":[40],"domains:":[41],"N\u2010terminal":[43],"Nucleotide\u2010Binding":[44],"Domain":[45,51],"(NBD),":[46],"C\u2010terminal":[49],"Substrate\u2010Binding":[50],"(SBD),":[52],"connected":[53],"by":[54],"hydrophobic":[56],"linker.":[57],"ATP":[58],"binds":[59,170],"it":[61,169,196],"hydrolyzed":[63],"ADP":[65],"NBD,":[68],"BiP's":[70],"extended":[71],"polypeptide":[72],"substrates":[73],"bind":[74],"SBD.":[77],"Like":[78],"many":[79],"motors,":[81],"function":[83],"depends":[84],"on":[85],"both":[86],"structural":[87],"catalytic":[89],"properties":[90,104],"that":[91,154,186],"may":[92],"contribute":[93],"its":[95],"performance.":[96],"One":[97],"novel":[98],"approach":[99],"study":[101],"mechanical":[103],"considers":[107],"exploring":[108],"changes":[110],"viscoelastic":[113,164],"behavior":[114],"upon":[115],"ligand":[116],"binding,":[117],"using":[118],"technique":[120,124],"called":[121],"nano\u2010rheology.":[122],"This":[123],"essentially":[126],"traditional":[128],"rheology":[129],"experiment,":[130],"which":[132],"an":[133],"oscillatory":[134],"force":[135],"directly":[137],"applied":[138],"protein":[141,160],"under":[142],"study,":[143],"resulting":[146],"average":[147],"deformation":[148],"measured.":[150],"Our":[151],"results":[152],"show":[153],"folded":[156],"state":[157],"behaves":[161],"like":[162],"material,":[165],"getting":[166],"softer":[167],"when":[168,178],"nucleotides\u2010":[171],"ATP,":[172],"ADP,":[173,194],"AMP\u2010PNP\u2010,":[175],"but":[176],"stiffer":[177],"binding":[179,188],"HTFPAVL":[180],"peptide":[181,187],"substrate.":[182],"Also,":[183],"we":[184],"observed":[185],"dramatically":[189],"increases":[190],"affinity":[192],"for":[193],"decreasing":[195],"dissociation":[197],"constant":[198],"(KD)":[199],"around":[200],"1000":[201],"times,":[202],"demonstrating":[203],"allosteric":[204],"coupling":[205],"between":[206],"SBD":[207],"NBD":[209],"domains.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}