{"id":"https://openalex.org/W2799616637","doi":"https://doi.org/10.1063/1.5021183","title":"Fine-tuning of noise in gene expression with nucleosome remodeling","display_name":"Fine-tuning of noise in gene expression with nucleosome remodeling","publication_year":2018,"publication_date":"2018-05-07","ids":{"openalex":"https://openalex.org/W2799616637","doi":"https://doi.org/10.1063/1.5021183","mag":"2799616637","pmid":"https://pubmed.ncbi.nlm.nih.gov/31069303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481717"},"language":"en","primary_location":{"id":"doi:10.1063/1.5021183","doi":"https://doi.org/10.1063/1.5021183","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.5021183","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.5021183","source":{"id":"https://openalex.org/S4210206319","display_name":"APL Bioengineering","issn_l":"2473-2877","issn":["2473-2877"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320061","host_organization_name":"AIP Publishing","host_organization_lineage":["https://openalex.org/P4310320061","https://openalex.org/P4310320257"],"host_organization_lineage_names":["AIP Publishing","American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aip.scitation.org/doi/pdf/10.1063/1.5021183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041913480","display_name":"Melina R. Megaridis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melina R. Megaridis","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011019865","display_name":"Yiyang Lu","orcid":"https://orcid.org/0000-0002-9913-0416","observed_orcids":["https://orcid.org/0000-0002-9913-0416"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiyang Lu","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045744311","display_name":"Erin N. Tevonian","orcid":"https://orcid.org/0000-0001-7645-1957","observed_orcids":["https://orcid.org/0000-0001-7645-1957"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin N. Tevonian","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":"https://orcid.org/0000-0001-7645-1957","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042071828","display_name":"Kendall M. Junger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kendall M. Junger","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023527045","display_name":"Jennifer M. Moy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Moy","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036133888","display_name":"Kathrin Bohn-Wippert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathrin Bohn-Wippert","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023527494","display_name":"Roy D. Dar","orcid":"https://orcid.org/0000-0002-6006-4888","observed_orcids":["https://orcid.org/0000-0002-6006-4888"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4405271866","display_name":"Carl R. Woese Institute for Genomic Biology","ror":"https://ror.org/036j6yj81","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271866"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roy D. Dar","raw_affiliation_strings":["Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign 2 , Urbana, Illinois 61801, USA","Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign 3 , Urbana, Illinois 61801, USA","Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA"],"raw_orcid":"https://orcid.org/0000-0002-6006-4888","affiliations":[{"raw_affiliation_string":"Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign 2 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I4405271866"]},{"raw_affiliation_string":"Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign 3 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign 1 , Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023527494"],"corresponding_institution_ids":["https://openalex.org/I157725225","https://openalex.org/I4405271866"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":{"value":2200,"currency":"USD","value_usd":2200},"fwci":0.889,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.71086588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"2","first_page":"026106","last_page":"026106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/arid1a","display_name":"ARID1A","score":0.9100000262260437},{"id":"https://openalex.org/keywords/swi-snf-complex","display_name":"SWI/SNF complex","score":0.7269999980926514},{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pyrimethamine","display_name":"pyrimethamine","score":1.0},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7699999809265137},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5686892867088318},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.5443583726882935},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5390538573265076},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49669748544692993},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.48640894889831543},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.45886537432670593},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4374622702598572},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.41982564330101013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40977218747138977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38182130455970764},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33206498622894287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32217249274253845},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14194950461387634},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1063/1.5021183","doi":"https://doi.org/10.1063/1.5021183","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.5021183","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.5021183","source":{"id":"https://openalex.org/S4210206319","display_name":"APL Bioengineering","issn_l":"2473-2877","issn":["2473-2877"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320061","host_organization_name":"AIP Publishing","host_organization_lineage":["https://openalex.org/P4310320061","https://openalex.org/P4310320257"],"host_organization_lineage_names":["AIP Publishing","American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioengineering","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6481717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481717","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioeng","raw_type":"Text"},{"id":"pmid:31069303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31069303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL bioengineering","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c877191da0914d2ba1ab071a3e3082f9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c877191da0914d2ba1ab071a3e3082f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"APL Bioengineering, Vol 2, Iss 2, Pp 026106-026106-13 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1063/1.5021183","doi":"https://doi.org/10.1063/1.5021183","is_oa":true,"landing_page_url":"https://doi.org/10.1063/1.5021183","pdf_url":"https://aip.scitation.org/doi/pdf/10.1063/1.5021183","source":{"id":"https://openalex.org/S4210206319","display_name":"APL Bioengineering","issn_l":"2473-2877","issn":["2473-2877"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320061","host_organization_name":"AIP Publishing","host_organization_lineage":["https://openalex.org/P4310320061","https://openalex.org/P4310320257"],"host_organization_lineage_names":["AIP Publishing","American Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"APL Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1811142779","display_name":null,"funder_award_id":"0939511","funder_id":"https://openalex.org/F4320310422","funder_display_name":"Emergent Behaviors of Integrated Cellular Systems"},{"id":"https://openalex.org/G2432239036","display_name":null,"funder_award_id":"CBET0939511)","funder_id":"https://openalex.org/F4320310422","funder_display_name":"Emergent Behaviors of Integrated Cellular Systems"},{"id":"https://openalex.org/G270120649","display_name":null,"funder_award_id":"CBET-0939511","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"},{"id":"https://openalex.org/G4035684527","display_name":null,"funder_award_id":"0939511","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"},{"id":"https://openalex.org/G4113606792","display_name":null,"funder_award_id":"0939511","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4473449232","display_name":null,"funder_award_id":"CBET 0939511","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4608991336","display_name":"NSF Science and Technology Center: Emergent Behaviors of Integrated Cellular Systems","funder_award_id":"0939511","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G73085304","display_name":null,"funder_award_id":"0939511","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7538388732","display_name":null,"funder_award_id":"AI120746","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7996723219","display_name":"Screening for modulators of Tat positive feedback for biasing HIV latency","funder_award_id":"K22AI120746","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8543390763","display_name":null,"funder_award_id":"AI120746","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310422","display_name":"Emergent Behaviors of Integrated Cellular Systems","ror":"https://ror.org/00nxxkd60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2799616637.pdf","grobid_xml":"https://content.openalex.org/works/W2799616637.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1557709748","https://openalex.org/W1564108416","https://openalex.org/W1639755199","https://openalex.org/W1641228030","https://openalex.org/W1863332503","https://openalex.org/W1966066354","https://openalex.org/W1977316264","https://openalex.org/W1984249881","https://openalex.org/W1990310243","https://openalex.org/W1991342850","https://openalex.org/W1993009001","https://openalex.org/W1997492312","https://openalex.org/W1997519837","https://openalex.org/W1998463022","https://openalex.org/W1999777663","https://openalex.org/W2008867005","https://openalex.org/W2012548413","https://openalex.org/W2029872016","https://openalex.org/W2031319652","https://openalex.org/W2035088045","https://openalex.org/W2036349801","https://openalex.org/W2040889971","https://openalex.org/W2045953900","https://openalex.org/W2049561349","https://openalex.org/W2049653440","https://openalex.org/W2051833900","https://openalex.org/W2054350561","https://openalex.org/W2061005894","https://openalex.org/W2065609322","https://openalex.org/W2068751516","https://openalex.org/W2068978083","https://openalex.org/W2070723035","https://openalex.org/W2076445195","https://openalex.org/W2080252570","https://openalex.org/W2081859209","https://openalex.org/W2086693765","https://openalex.org/W2087004443","https://openalex.org/W2089499876","https://openalex.org/W2098258688","https://openalex.org/W2100859269","https://openalex.org/W2106578635","https://openalex.org/W2111165959","https://openalex.org/W2111167674","https://openalex.org/W2111648798","https://openalex.org/W2114870653","https://openalex.org/W2117119787","https://openalex.org/W2118623812","https://openalex.org/W2120488252","https://openalex.org/W2125937596","https://openalex.org/W2127311430","https://openalex.org/W2129375080","https://openalex.org/W2148323109","https://openalex.org/W2155418451","https://openalex.org/W2160404781","https://openalex.org/W2160803964","https://openalex.org/W2170033314","https://openalex.org/W2171228793","https://openalex.org/W2173459981","https://openalex.org/W2235108513","https://openalex.org/W2273050936","https://openalex.org/W2460529418","https://openalex.org/W2526311176","https://openalex.org/W2610834732","https://openalex.org/W2730833391","https://openalex.org/W2748087031","https://openalex.org/W2755284555","https://openalex.org/W2782697209","https://openalex.org/W2949963678","https://openalex.org/W2951941730","https://openalex.org/W4237038146"],"related_works":["https://openalex.org/W3189517893","https://openalex.org/W1975202897","https://openalex.org/W2171327609","https://openalex.org/W4225729378","https://openalex.org/W3202392980","https://openalex.org/W2730833391","https://openalex.org/W6996913820","https://openalex.org/W2170939793","https://openalex.org/W3118848880","https://openalex.org/W1991004435"],"abstract_inverted_index":{"Engineering":[0],"stochastic":[1],"fluctuations":[2],"of":[3,34,62,66,79,112,174,187,200,221,226,239],"gene":[4,201,217,227],"expression":[5,202,228],"(or":[6],"\"noise\")":[7],"is":[8,40],"integral":[9],"to":[10,29,189],"precisely":[11],"bias":[12],"cellular-fate":[13],"decisions":[14],"and":[15,21,36,57,76,83,97,150,163,204,215,223,237],"statistical":[16],"phenotypes":[17],"in":[18,81,94,109,169,185,241],"both":[19],"single-cell":[20],"multi-cellular":[22],"systems.":[23,243],"Epigenetic":[24],"regulation":[25],"has":[26],"been":[27],"shown":[28],"constitute":[30],"a":[31,64,95,126,142,181,206,231],"large":[32],"source":[33],"noise,":[35],"thus,":[37],"engineering":[38,238],"stochasticity":[39,240],"deeply":[41],"intertwined":[42],"with":[43,133,138,180,213],"epigenetics.":[44],"Here,":[45],"utilizing":[46],"chromatin":[47],"remodeling,":[48],"we":[49],"report":[50],"that":[51],"Caffeic":[52],"acid":[53],"phenethyl":[54],"ester":[55],"(CA)":[56],"Pyrimethamine":[58],"(PYR),":[59],"two":[60],"inhibitors":[61],"BAF250a,":[63],"subunit":[65],"the":[67,86,113,151,234],"Brahma-associated":[68],"factor":[69],"(BAF)":[70],"nucleosome":[71],"remodeling":[72,220],"complex,":[73],"enable":[74],"differential":[75],"tunable":[77],"control":[78,225],"noise":[80,102,139,178,203,207,229],"transcription":[82],"translation":[84],"from":[85],"human":[87],"immunodeficiency":[88],"virus":[89],"long":[90],"terminal":[91],"repeat":[92],"promoter":[93],"dose":[96],"time-dependent":[98],"manner.":[99],"CA":[100,134,162],"conserves":[101],"levels":[103,179],"while":[104,117,124,176],"increasing":[105,154],"mean":[106,144],"abundance,":[107],"resulting":[108],"direct":[110],"tuning":[111,137,199],"transcriptional":[114,121,128],"burst":[115,129,152],"size,":[116],"PYR":[118],"strictly":[119],"increases":[120],"initiation":[122],"frequency":[123],"conserving":[125,177],"constant":[127,143],"size.":[130],"Time-dependent":[131],"treatment":[132],"reveals":[135],"non-continuous":[136],"oscillating":[140],"at":[141,146],"abundance":[145,175],"early":[147],"time":[148],"points":[149],"size":[153],"for":[155,210,233],"treatments":[156],"after":[157],"5":[158],"h.":[159],"Treatments":[160],"combining":[161],"Protein":[164],"Kinase":[165],"C":[166],"agonists":[167],"result":[168],"an":[170],"even":[171],"larger":[172],"increase":[173,184],"highly":[182],"non-linear":[183],"variance":[186],"up":[188],"63\u00d7":[190],"untreated":[191],"controls.":[192],"Finally,":[193],"drug":[194],"combinations":[195],"provide":[196],"non-antagonistic":[197],"combinatorial":[198],"map":[205],"phase":[208],"space":[209],"future":[211,235],"applications":[212],"viral":[214],"synthetic":[216],"vectors.":[218],"Active":[219],"nucleosomes":[222],"BAF-mediated":[224],"expand":[230],"toolbox":[232],"design":[236],"living":[242]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2018-05-17T00:00:00"}