{"id":"https://openalex.org/W2798413648","doi":null,"title":"Siglec Interactions with Pathogens","display_name":"Siglec Interactions with Pathogens","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2798413648","mag":"2798413648"},"language":"en","primary_location":{"id":"mag:2798413648","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/978-4-431-54841-6_211.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036413821","display_name":"Ajit P Varki","orcid":"https://orcid.org/0000-0002-2206-975X","observed_orcids":["https://orcid.org/0000-0002-2206-975X"]},"institutions":[{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ajit Varki","raw_affiliation_strings":["Academia Sinica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academia Sinica","institution_ids":["https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036413821"],"corresponding_institution_ids":["https://openalex.org/I84653119"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.27002066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/siglecs","display_name":"Siglecs","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.7860000133514404},{"id":"https://openalex.org/keywords/sialoglycans","display_name":"sialoglycans","score":0.7789999842643738},{"id":"https://openalex.org/keywords/molecular-mimicry","display_name":"molecular mimicry","score":0.7799999713897705},{"id":"https://openalex.org/keywords/inhibitory-receptors","display_name":"inhibitory receptors","score":0.628000020980835},{"id":"https://openalex.org/keywords/receptor-evolution","display_name":"receptor evolution","score":0.5529999732971191},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2778017598","wikidata":"https://www.wikidata.org/wiki/Q7390325","display_name":"SIGLEC","level":3,"score":0.7831901907920837},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.606671154499054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5824137926101685},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.5652841925621033},{"id":"https://openalex.org/C2777119779","wikidata":"https://www.wikidata.org/wiki/Q963278","display_name":"Molecular mimicry","level":3,"score":0.5559021234512329},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4223233759403229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40111494064331055},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36380448937416077}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2798413648","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/978-4-431-54841-6_211.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1651368264","https://openalex.org/W1967724223","https://openalex.org/W1968858193","https://openalex.org/W1971907885","https://openalex.org/W1999481613","https://openalex.org/W2004553952","https://openalex.org/W2024507840","https://openalex.org/W2026894676","https://openalex.org/W2028439746","https://openalex.org/W2029004774","https://openalex.org/W2037311731","https://openalex.org/W2038310444","https://openalex.org/W2043626069","https://openalex.org/W2053199638","https://openalex.org/W2059837283","https://openalex.org/W2080302351","https://openalex.org/W2090027454","https://openalex.org/W2094789687","https://openalex.org/W2103063695","https://openalex.org/W2107390782","https://openalex.org/W2108462881","https://openalex.org/W2111738619","https://openalex.org/W2111986782","https://openalex.org/W2114473523","https://openalex.org/W2115969448","https://openalex.org/W2133664736","https://openalex.org/W2134530898","https://openalex.org/W2144971524","https://openalex.org/W2149076299","https://openalex.org/W2161051601","https://openalex.org/W2168470451"],"related_works":["https://openalex.org/W2161051601","https://openalex.org/W7097448034","https://openalex.org/W1809465031","https://openalex.org/W3011242662","https://openalex.org/W2110820637","https://openalex.org/W4292241412","https://openalex.org/W2037643815","https://openalex.org/W4206316205","https://openalex.org/W1971907885","https://openalex.org/W334975055"],"abstract_inverted_index":{"Sialic":[0],"acids":[1],"are":[2,36,60],"abundant":[3],"acidic":[4],"sugars":[5],"decorating":[6],"the":[7,24,103,221,224,240],"cell":[8],"surfaces":[9],"of":[10,27,33,39,50,91,109,126,138,144,223,244],"vertebrates":[11],"and":[12,31,65,72,100,140,163,242],"their":[13,179],"close":[14],"relatives,":[15],"but":[16],"rarely":[17],"found":[18],"in":[19,44,52,69,178,215,238],"other":[20],"taxa":[21],"\u2013":[22],"with":[23,111,171,182,230],"striking":[25],"exception":[26],"certain":[28],"bacterial":[29],"commensals":[30],"pathogens":[32],"vertebrates.":[34],"Siglecs":[35,58],"a":[37,48,67,236],"family":[38],"sialic":[40],"acid":[41],"recognizing":[42,75],"receptors":[43],"mammals":[45],"that":[46],"mediate":[47],"variety":[49],"functions":[51,243],"different":[53,206],"biological":[54],"processes.":[55],"The":[56],"CD33-related":[57],"(CD33rSiglecs)":[59],"prominent":[61],"on":[62],"immune":[63,105],"cells":[64],"play":[66],"role":[68,237],"distinguishing":[70],"self":[71],"non-self":[73],"by":[74,88,94,102,121,199,205],"sialoglycans":[76],"as":[77],"\u201cself-associated":[78],"molecular":[79,89],"patterns.\u201d":[80],"Some":[81],"pathogenic":[82],"microorganisms":[83],"exploit":[84],"this":[85],"self-recognition":[86],"system":[87],"mimicry":[90],"ligands":[92],"or":[93],"direct":[95],"binding,":[96],"thus":[97],"averting":[98],"detection":[99],"elimination":[101],"innate":[104],"system.":[106],"A":[107],"subset":[108],"CD33rSiglecs":[110,209],"cell-activating":[112],"properties":[113],"may":[114,196,232],"have":[115,189,212,233],"evolved":[116],"to":[117,211,220],"counter":[118],"such":[119],"exploitation":[120],"T.":[122],"Angata":[123],"(*)":[124],"Institute":[125],"Biological":[127],"Chemistry,":[128],"Academia":[129],"Sinica,":[130],"Taipei,":[131],"Taiwan":[132],"e-mail:":[133],"angata@gate.sinica.edu.tw":[134],"A.":[135],"Varki":[136],"Department":[137],"Cellular":[139],"Molecular":[141],"Medicine,":[142,164],"University":[143],"California,":[145],"San":[146],"Diego,":[147],"La":[148],"Jolla,":[149],"CA,":[150],"USA":[151],"#":[152],"Springer":[153],"Japan":[154],"2015":[155],"N.":[156],"Taniguchi":[157],"et":[158],"al.":[159],"(eds.),":[160],"Glycoscience:":[161],"Biology":[162],"DOI":[165],"10.1007/978-4-431-54841-6_211":[166],"633":[167],"pathogens.":[168,207],"In":[169],"keeping":[170],"this,":[172],"some":[173,193],"show":[174],"extreme":[175],"sequence":[176],"identity":[177],"binding":[180],"domains":[181],"respective":[183],"inhibitory":[184],"counterparts.":[185],"Human":[186],"null":[187],"polymorphisms":[188],"been":[190,213],"described":[191],"for":[192],"CD33rSiglecs,":[194],"which":[195],"be":[197],"explained":[198],"counteracting":[200],"evolutionary":[201],"selective":[202],"forces":[203],"imposed":[204],"Two":[208],"appear":[210],"inactivated":[214],"our":[216],"ancestors,":[217],"just":[218],"prior":[219],"origin":[222],"human":[225],"species.":[226],"Environmental":[227],"factors":[228],"associated":[229],"civilization":[231],"also":[234],"played":[235],"shaping":[239],"genetics":[241],"these":[245],"receptors.":[246]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-05-07T00:00:00"}
