{"id":"https://openalex.org/W279816639","doi":null,"title":"Correcting for single ascertainment by truncation for a quantitative trait.","display_name":"Correcting for single ascertainment by truncation for a quantitative trait.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W279816639","mag":"279816639","pmid":"https://pubmed.ncbi.nlm.nih.gov/3189333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1715533"},"language":"en","primary_location":{"id":"pmid:3189333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3189333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M R Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M R Young","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003810507","display_name":"Michael Boehnke","orcid":"https://orcid.org/0000-0002-6442-7754","observed_orcids":["https://orcid.org/0000-0002-6442-7754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Boehnke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023076857","display_name":"Patricia P. Moll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P P Moll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3311,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79809251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"5","first_page":"705","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-traits","display_name":"quantitative traits","score":0.5540000200271606},{"id":"https://openalex.org/keywords/parameter-constraints","display_name":"parameter constraints","score":0.6679999828338623},{"id":"https://openalex.org/keywords/robustness-to-model-misspecification","display_name":"model misspecification robustness","score":0.843999981880188},{"id":"https://openalex.org/keywords/family-based-association-study","display_name":"family-based association study","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.7460947036743164},{"id":"https://openalex.org/C106195933","wikidata":"https://www.wikidata.org/wiki/Q7847935","display_name":"Truncation (statistics)","level":2,"score":0.6518123149871826},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6442189812660217},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5322028994560242},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5224562883377075},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5099905729293823},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4602114260196686},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39784863591194153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29465797543525696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14769652485847473},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07471269369125366},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.07053312659263611},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012494","descriptor_name":"Sampling Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3189333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3189333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:279816639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3189333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1873274376","display_name":"VAX 11/750 CLUSTER","funder_award_id":"1s10rr002882-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W17404359","https://openalex.org/W46180618","https://openalex.org/W158851743","https://openalex.org/W307017435","https://openalex.org/W1499854794","https://openalex.org/W2019748387","https://openalex.org/W2041010153","https://openalex.org/W2062318434","https://openalex.org/W2115609230","https://openalex.org/W2115971910","https://openalex.org/W2117063843","https://openalex.org/W2164969234","https://openalex.org/W2290159066","https://openalex.org/W2417706951"],"related_works":["https://openalex.org/W307017435","https://openalex.org/W46180618","https://openalex.org/W1583188742","https://openalex.org/W1918099585","https://openalex.org/W1973231920","https://openalex.org/W1966775440","https://openalex.org/W1971499416","https://openalex.org/W1907121252","https://openalex.org/W4245795025","https://openalex.org/W2795342811"],"abstract_inverted_index":{"Two":[0],"methods":[1,12],"for":[2,4],"correcting":[3],"single":[5],"ascertainment":[6],"by":[7,62,76],"truncation":[8],"are":[9,13],"compared.":[10],"These":[11],"(1)":[14],"conditioning":[15,24],"on":[16,25,42,72],"the":[17,20,26,29,57,70],"phenotype":[18,31],"of":[19,39,49,51,56,85,96],"proband":[21,30],"and":[22,92],"(2)":[23],"event":[27],"that":[28,69,99],"is":[32,45,67,80,104],"greater":[33],"than":[34],"a":[35,40,89],"threshold.":[36],"The":[37,47],"use":[38],"constraint":[41,58,71],"model":[43,73],"parameters":[44,74],"considered.":[46],"lack":[48],"robustness":[50,102],"this":[52,97],"method":[53],"to":[54,82],"misspecifiction":[55],"has":[59,100],"been":[60],"demonstrated":[61],"Rao":[63,77],"et":[64,78],"al.":[65,79],"It":[66],"noted":[68],"used":[75],"equivalent":[81],"an":[83,93],"encoding":[84],"knowledge":[86],"derived":[87],"from":[88],"random":[90],"sample,":[91],"alternative":[94],"representation":[95],"information":[98],"superior":[101],"properties":[103],"proposed.":[105]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}