{"id":"https://openalex.org/W2798124151","doi":"https://doi.org/10.1016/j.biopsych.2018.02.991","title":"S100. Efficacy and Safety of Brexanolone IV Across Phase 2/3 Studies: A First-In-Class GABAA Receptor Positive Allosteric Modulator for Postpartum Depression","display_name":"S100. Efficacy and Safety of Brexanolone IV Across Phase 2/3 Studies: A First-In-Class GABAA Receptor Positive Allosteric Modulator for Postpartum Depression","publication_year":2018,"publication_date":"2018-04-09","ids":{"openalex":"https://openalex.org/W2798124151","doi":"https://doi.org/10.1016/j.biopsych.2018.02.991","mag":"2798124151"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2018.02.991","doi":"https://doi.org/10.1016/j.biopsych.2018.02.991","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2018.02.991","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000446863","display_name":"Samantha E Meltzer-Brody","orcid":"https://orcid.org/0000-0002-8509-408X","observed_orcids":["https://orcid.org/0000-0002-8509-408X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Meltzer-Brody","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001147138","display_name":"Stephen Kanes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131505","display_name":"Sage Therapeutics (United States)","ror":"https://ror.org/03t9rxt77","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131505"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Kanes","raw_affiliation_strings":["Sage Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sage Therapeutics, Inc","institution_ids":["https://openalex.org/I4210131505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059305735","display_name":"Robert A. Riesenberg","orcid":"https://orcid.org/0000-0001-9296-1076","observed_orcids":["https://orcid.org/0000-0001-9296-1076"]},"institutions":[{"id":"https://openalex.org/I4210121444","display_name":"Atlanta Center for Medical Research","ror":"https://ror.org/02gx57r28","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210121444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Riesenberg","raw_affiliation_strings":["Atlanta Center for Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Center for Medical Research","institution_ids":["https://openalex.org/I4210121444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078092878","display_name":"Cynthia Neill Epperson","orcid":"https://orcid.org/0000-0002-1010-1409","observed_orcids":["https://orcid.org/0000-0002-1010-1409"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Neill Epperson","raw_affiliation_strings":["Perelman School of Medicine at University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perelman School of Medicine at University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081287037","display_name":"Kristina M. Deligiannidis","orcid":"https://orcid.org/0000-0001-7439-2236","observed_orcids":["https://orcid.org/0000-0001-7439-2236"]},"institutions":[{"id":"https://openalex.org/I1327576362","display_name":"Feinstein Institute for Medical Research","ror":"https://ror.org/05dnene97","country_code":"US","type":"facility","lineage":["https://openalex.org/I1302444339","https://openalex.org/I1327576362"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Deligiannidis","raw_affiliation_strings":["Zucker Hillside Hospital, Feinstein Institute for Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zucker Hillside Hospital, Feinstein Institute for Medical Research","institution_ids":["https://openalex.org/I1327576362","https://openalex.org/I4210166545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000280765","display_name":"David R. Rubinow","orcid":"https://orcid.org/0000-0003-0815-2263","observed_orcids":["https://orcid.org/0000-0003-0815-2263"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rubinow","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100742271","display_name":"Haihong Li","orcid":"https://orcid.org/0000-0002-7209-3539","observed_orcids":["https://orcid.org/0000-0002-7209-3539"]},"institutions":[{"id":"https://openalex.org/I4210131505","display_name":"Sage Therapeutics (United States)","ror":"https://ror.org/03t9rxt77","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131505"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haihong Li","raw_affiliation_strings":["Sage Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sage Therapeutics, Inc","institution_ids":["https://openalex.org/I4210131505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048367095","display_name":"Christine Clemson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131505","display_name":"Sage Therapeutics (United States)","ror":"https://ror.org/03t9rxt77","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131505"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Clemson","raw_affiliation_strings":["Sage Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sage Therapeutics, Inc","institution_ids":["https://openalex.org/I4210131505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085068964","display_name":"Helen Colquhoun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131505","display_name":"Sage Therapeutics (United States)","ror":"https://ror.org/03t9rxt77","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131505"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Colquhoun","raw_affiliation_strings":["Sage Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sage Therapeutics, Inc","institution_ids":["https://openalex.org/I4210131505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"9","first_page":"S385","last_page":"S386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brexanolone","display_name":"brexanolone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/postpartum-depression","display_name":"postpartum depression","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9639999866485596},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.6669999957084656},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2780262536","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Postpartum depression","level":3,"score":0.816076397895813},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.5943859219551086},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5656413435935974},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5429224371910095},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5302842259407043},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.5286213159561157},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5041340589523315},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.48045605421066284},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47274577617645264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4153427481651306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3903008699417114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37818455696105957},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3653775453567505},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.348671555519104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3353806138038635},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32452845573425293},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.19032296538352966},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.1702153980731964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16917401552200317},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12428018450737},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.biopsych.2018.02.991","doi":"https://doi.org/10.1016/j.biopsych.2018.02.991","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2018.02.991","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2800250699","https://openalex.org/W4242628592","https://openalex.org/W2945158569","https://openalex.org/W2906323041","https://openalex.org/W2998432483","https://openalex.org/W3199138735","https://openalex.org/W3150602992","https://openalex.org/W4302314448","https://openalex.org/W3134199293","https://openalex.org/W2945025658"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-04-24T00:00:00"}
