{"id":"https://openalex.org/W2797995753","doi":"https://doi.org/10.2174/1871520618666180411110036","title":"Translational Research: A Future Strategy for Managing Squamous Cell Carcinoma of the Head and Neck?","display_name":"Translational Research: A Future Strategy for Managing Squamous Cell Carcinoma of the Head and Neck?","publication_year":2018,"publication_date":"2018-04-11","ids":{"openalex":"https://openalex.org/W2797995753","doi":"https://doi.org/10.2174/1871520618666180411110036","mag":"2797995753","pmid":"https://pubmed.ncbi.nlm.nih.gov/29637868"},"language":"en","primary_location":{"id":"doi:10.2174/1871520618666180411110036","doi":"https://doi.org/10.2174/1871520618666180411110036","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871520618666180411110036","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109185761","display_name":"Francesco Caponigro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Caponigro","raw_affiliation_strings":["Head and Neck and Soft Tissue Sarcoma Oncology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck and Soft Tissue Sarcoma Oncology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073695437","display_name":"Franco Ionna","orcid":"https://orcid.org/0000-0002-0512-274X","observed_orcids":["https://orcid.org/0000-0002-0512-274X"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Ionna","raw_affiliation_strings":["Otolaryngology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014942429","display_name":"Giuseppina Della Vittoria Scarpati","orcid":"https://orcid.org/0000-0002-2365-044X","observed_orcids":["https://orcid.org/0000-0002-2365-044X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Della Vittoria Scarpati","raw_affiliation_strings":["Medical Oncology Unit POC SS Annunziata, Taranto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit POC SS Annunziata, Taranto, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000553843","display_name":"Francesco Longo","orcid":"https://orcid.org/0000-0002-7605-2953","observed_orcids":["https://orcid.org/0000-0002-7605-2953"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Longo","raw_affiliation_strings":["Otolaryngology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087020711","display_name":"Raffaele Addeo","orcid":"https://orcid.org/0000-0001-9197-8060","observed_orcids":["https://orcid.org/0000-0001-9197-8060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Addeo","raw_affiliation_strings":["Medical Oncology Unit, San Giovanni di Dio' Hospital, A.S.L. Napoli 2 Nord, I-80027 Frattamaggiore, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, San Giovanni di Dio' Hospital, A.S.L. Napoli 2 Nord, I-80027 Frattamaggiore, Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054167828","display_name":"Roberto Manzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Manzo","raw_affiliation_strings":["Radiation Oncology Unit, Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Unit, Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019522534","display_name":"Paolo Muto","orcid":"https://orcid.org/0000-0002-7546-6441","observed_orcids":["https://orcid.org/0000-0002-7546-6441"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Muto","raw_affiliation_strings":["Radiation Oncology Unit, National Tumor Institute of Naples, Foundation G. Pascale, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology Unit, National Tumor Institute of Naples, Foundation G. Pascale, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017359826","display_name":"Salvatore Pisconti","orcid":"https://orcid.org/0000-0002-1658-523X","observed_orcids":["https://orcid.org/0000-0002-1658-523X"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Pisconti","raw_affiliation_strings":["Head and Neck and Soft Tissue Sarcoma Oncology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck and Soft Tissue Sarcoma Oncology Unit, National Tumor Institute of Naples Foundation G. Pascale, Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001145753","display_name":"L. Leopaldi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Leopaldi","raw_affiliation_strings":["Medical Oncology Unit, Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Ospedale Cardinale Ascalesi, ASL NA1, Naples, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052216253","display_name":"Francesco Perri","orcid":"https://orcid.org/0000-0001-8158-7509","observed_orcids":["https://orcid.org/0000-0001-8158-7509"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"F. Perri","raw_affiliation_strings":["Medical Oncology Unit POC SS Annunziata, Taranto, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit POC SS Annunziata, Taranto, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052216253"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6865,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81531776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"9","first_page":"1220","last_page":"1227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mutational-landscape","display_name":"mutational landscape","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.7940000295639038},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ccnd1","display_name":"CCND1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.9350000023841858},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9539999961853027},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/organ-preservation","display_name":"organ preservation","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.6597837209701538},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.628042995929718},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5797533988952637},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.501049280166626},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.4999046325683594},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41992345452308655},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.31441593170166016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28728628158569336},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2217261791229248},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2007308304309845},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12807747721672058}],"mesh":[{"descriptor_ui":"D000073869","descriptor_name":"Tobacco Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1871520618666180411110036","doi":"https://doi.org/10.2174/1871520618666180411110036","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1871520618666180411110036","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:29637868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29637868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer agents in medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313560297","https://openalex.org/W7075621385","https://openalex.org/W2170718479","https://openalex.org/W3043582485","https://openalex.org/W2158799748","https://openalex.org/W4252629413","https://openalex.org/W2058389290","https://openalex.org/W2285865191","https://openalex.org/W2922599982","https://openalex.org/W3005563222"],"abstract_inverted_index":{"BACKGROUND:":[0],"Squamous":[1],"Cell":[2],"Carcinoma":[3],"of":[4,16,43,51,103,115,131,149,161,166,171,178,222,246,291],"the":[5,14,17,49,150,154,158,169,183,212,244,247,289],"Head":[6],"and":[7,27,30,37,40,68,76,79,112,120,133,139,182,192,202,224,228,236,261,270,281],"Neck":[8],"(SCCHN)":[9],"are":[10,22,35,62,199,232,264],"neoplasms":[11],"arising":[12],"from":[13,65],"epithelium":[15],"first":[18],"aero-digestive":[19],"tract.":[20],"They":[21],"very":[23,63,200],"heterogeneous":[24,235],"both":[25,190],"clinically":[26],"biologically.":[28],"Classic":[29],"well":[31],"acknowledged":[32],"risk":[33],"factors":[34],"alcohol":[36,67,119,185,260],"tobacco":[38,45,121,229],"consumption":[39],"other":[41,184],"forms":[42],"smokeless":[44],"assumption,":[46],"although":[47],"lately":[48],"incidence":[50],"Human":[52],"Papilloma":[53],"Virus":[54,196],"(HPV)-related":[55],"SCCHN":[56,123,198,231,263,274],"is":[57],"rapidly":[58],"increasing.":[59],"HPV-related":[60,94],"tumors":[61,283],"different":[64,176,241],"their":[66,292],"tobacco-associated":[69],"counterpart,":[70],"as":[71,97],"they":[72],"show":[73,124],"strong":[74],"chemo":[75,138,201],"radio":[77,140],"sensitivity":[78],"thus":[80],"can":[81,237,275],"often":[82],"be":[83,216,238,276,285],"treated":[84],"with":[85,128,153,278],"conservative":[86],"treatment":[87],"strategies.":[88],"Moreover,":[89],"peculiar":[90],"biologic":[91],"features":[92],"characterize":[93],"tumors,":[95],"such":[96],"wild":[98,109],"type":[99,110],"TP53,":[100,265],"low":[101],"expression":[102,114],"Epidermal":[104],"Growth":[105],"Factor":[106],"Receptor":[107],"(EGFR),":[108],"CCND1":[111],"high":[113],"P16.":[116],"In":[117],"contrast,":[118],"related":[122,197,230],"opposite":[125,194],"features,":[126],"together":[127],"higher":[129],"number":[130],"chromosomal":[132],"genetic":[134,249],"abnormalities,":[135],"conferring":[136],"them":[137],"resistance.":[141],"METHODS:":[142],"We":[143],"have":[144],"performed":[145],"a":[146],"narrative":[147],"review":[148],"PubMed":[151],"database":[152],"aim":[155],"to":[156,297],"study":[157],"mutational":[159],"landscape":[160],"SCCHN.":[162],"RESULTS:":[163],"Several":[164],"lines":[165],"evidence":[167],"support":[168],"existence":[170],"at":[172],"least":[173],"two":[174],"genetically":[175],"types":[177],"SCCHN,":[179],"one":[180],"virus-related":[181],"and/or":[186],"tobacco-related,":[187],"characterized":[188,287],"by":[189,220],"clinical":[191],"biological":[193],"features.":[195],"radiosensitive,":[203],"so":[204],"suitable":[205],"for":[206,252],"organ":[207],"preserving":[208],"strategy,":[209],"which":[210],"in":[211,240,259,295],"near":[213],"future":[214],"may":[215],"induction":[217],"chemotherapy":[218,223],"followed":[219],"association":[221],"underpowered":[225],"radiotherapy.":[226],"Alcohol":[227,280],"themselves":[233],"strongly":[234],"divided":[239],"entities":[242],"on":[243,288],"basis":[245,290],"\"Driver\"":[248],"aberration,":[250],"responsible":[251],"carcinogenesis.":[253],"The":[254],"most":[255],"frequently":[256],"mutated":[257],"genes":[258],"tobacco-related":[262,282],"NOTCH1,":[266],"CCND1,":[267],"CDKN2A,":[268],"EGFR":[269],"PI3KCA.":[271],"CONCLUSIONS:":[272],"Virus-related":[273],"managed":[277],"chemo-radiotherapy.":[279],"should":[284],"further":[286],"\"Driver":[293],"Mutations\"":[294],"order":[296],"select":[298],"effective":[299],"targeted":[300],"therapies.":[301]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-04-24T00:00:00"}
