{"id":"https://openalex.org/W2797994565","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p6.236","title":"Inhaled Alprazolam, a Potential Rescue Medication, Works Rapidly in Patients with Photosensitive Epilepsy (P6.236)","display_name":"Inhaled Alprazolam, a Potential Rescue Medication, Works Rapidly in Patients with Photosensitive Epilepsy (P6.236)","publication_year":2017,"publication_date":"2017-04-18","ids":{"openalex":"https://openalex.org/W2797994565","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p6.236","mag":"2797994565"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.88.16_supplement.p6.236","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p6.236","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.88.16_supplement.p6.236","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038885649","display_name":"Jacqueline A. French","orcid":"https://orcid.org/0000-0003-2242-8027","observed_orcids":["https://orcid.org/0000-0003-2242-8027"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline French","raw_affiliation_strings":["NYU Comprehensive Epilepsy Ctr New York NY United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Comprehensive Epilepsy Ctr New York NY United States","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071565453","display_name":"Daniel J. Friedman","orcid":"https://orcid.org/0000-0003-1068-1797","observed_orcids":["https://orcid.org/0000-0003-1068-1797","https://orcid.org/0000-0002-3442-7454"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Friedman","raw_affiliation_strings":["NYU Langone Medical Center New York NY United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Medical Center New York NY United States","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012220015","display_name":"Robert T. Wechsler","orcid":"https://orcid.org/0000-0002-3146-986X","observed_orcids":["https://orcid.org/0000-0002-3146-986X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Wechsler","raw_affiliation_strings":["Consultants in Epilepsy &amp; Neurology Boise ID United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultants in Epilepsy &amp; Neurology Boise ID United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001899379","display_name":"Bree D. DiVentura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126706","display_name":"Epilepsy Study Consortium","ror":"https://ror.org/02cxejv02","country_code":"US","type":"other","lineage":["https://openalex.org/I4210126706"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bree DiVentura","raw_affiliation_strings":["The Epilepsy Study Consortium Woodbury NJ United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Epilepsy Study Consortium Woodbury NJ United States","institution_ids":["https://openalex.org/I4210126706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065010109","display_name":"Michael A. Gelfand","orcid":"https://orcid.org/0000-0002-4816-8756","observed_orcids":["https://orcid.org/0000-0002-4816-8756"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Gelfand","raw_affiliation_strings":["University of Pennsylvania Philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania Philadelphia PA United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Pollard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Pollard","raw_affiliation_strings":["Neurology, University of Pennsylvania Philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, University of Pennsylvania Philadelphia PA United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006229686","display_name":"Keith Huie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153281","display_name":"Alexza Pharmaceuticals (United States)","ror":"https://ror.org/04vnkt240","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153281"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Huie","raw_affiliation_strings":["Alexza Pharmaceuticals Inc Mountain View CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexza Pharmaceuticals Inc Mountain View CA United States","institution_ids":["https://openalex.org/I4210153281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101512131","display_name":"Blanca V\u00e1zquez","orcid":"https://orcid.org/0000-0002-1151-6681","observed_orcids":["https://orcid.org/0000-0002-1151-6681"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blanca Vazquez","raw_affiliation_strings":["Neurology/Epilepsy, NYU Medical Center New York NY United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology/Epilepsy, NYU Medical Center New York NY United States","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084922428","display_name":"Lily H. Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153281","display_name":"Alexza Pharmaceuticals (United States)","ror":"https://ror.org/04vnkt240","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153281"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Gong","raw_affiliation_strings":["Alexza Pharmaceuticals Inc Mountain View CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexza Pharmaceuticals Inc Mountain View CA United States","institution_ids":["https://openalex.org/I4210153281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076967593","display_name":"James V. Cassella","orcid":"https://orcid.org/0000-0003-3694-7100","observed_orcids":["https://orcid.org/0000-0003-3694-7100"]},"institutions":[{"id":"https://openalex.org/I4210153281","display_name":"Alexza Pharmaceuticals (United States)","ror":"https://ror.org/04vnkt240","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153281"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Cassella","raw_affiliation_strings":["Alexza Pharmaceuticals Inc Mountain View CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexza Pharmaceuticals Inc Mountain View CA United States","institution_ids":["https://openalex.org/I4210153281"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034713785","display_name":"Ed Kamemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153281","display_name":"Alexza Pharmaceuticals (United States)","ror":"https://ror.org/04vnkt240","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153281"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ed Kamemoto","raw_affiliation_strings":["Alexza Pharmaceuticals Inc Mountain View CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexza Pharmaceuticals Inc Mountain View CA United States","institution_ids":["https://openalex.org/I4210153281"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4354,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.678686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"88","issue":"16_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photosensitive-epilepsy","display_name":"photosensitive epilepsy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/reliever-medication","display_name":"rescue medication","score":0.8759999871253967},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.7480000257492065},{"id":"https://openalex.org/keywords/photosensitive-seizures","display_name":"photosensitive seizures","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2777196872","wikidata":"https://www.wikidata.org/wiki/Q319877","display_name":"Alprazolam","level":3,"score":0.9353245496749878},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6287291049957275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.523053765296936},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.41780561208724976},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.88.16_supplement.p6.236","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p6.236","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.88.16_supplement.p6.236","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2955897844","https://openalex.org/W4389449253","https://openalex.org/W4389441820","https://openalex.org/W2921487296","https://openalex.org/W4307032374","https://openalex.org/W2042668292","https://openalex.org/W2121354529","https://openalex.org/W2981640418","https://openalex.org/W4394602149","https://openalex.org/W1990308283"],"abstract_inverted_index":{"Objective:":[0],"Evaluate":[1],"ability":[2],"of":[3,17,116,138,240,266],"inhaled":[4,25,85,96,230,254],"alprazolam":[5,97,231],"to":[6,42,199],"rapidly":[7,34],"suppress":[8],"photosensitivity":[9,117,178],"in":[10,47,52,81,259,369],"a":[11,33,75,100,261,330,418,432,482,534],"double":[12],"blind":[13],"placebo-controlled":[14],"crossover":[15],"proof":[16],"concept":[18],"study.":[19],"Background:":[20],"Alprazolam":[21,28,255],"formulated":[22],"as":[23,245,329,402,417,431,465,481,519,533,550],"an":[24,403,466,520,551],"preparation":[26],"(Staccato":[27],"\u00ae":[29],")":[30],"could":[31],"represent":[32],"effective":[35],"rescue":[36],"medication":[37],"for":[38,279,338,366,381,396,411,426,459,474,514,528,542],"epilepsy":[39,68],"patients.":[40],"Time":[41],"effect":[43,185,241],"can":[44,56],"be":[45,57],"assessed":[46,149],"patients":[48,164],"with":[49,66,181,218,281,340,383,398,413,428,461,476,516,530,544],"photosensitive":[50,67],"epilepsy,":[51],"whom":[53],"epileptiform":[54,234],"activity":[55,235],"elicited":[58],"at":[59,69,109,122,143,150,211],"will.":[60],"Design/Methods:":[61],"Patients":[62],"\u2265":[63],"18":[64],"y.o":[65],"3":[70],"sites":[71],"were":[72,106,165],"tested":[73],"on":[74,196],"baseline":[76],"day,":[77],"and":[78,132,167,364,388,415,450,484,505,547],"then":[79,121],"received":[80,276,335,378,393,408,423,437,456,471,489,511,525,539],"randomized":[82],"order":[83],"either":[84],"placebo":[86],"(on":[87],"2":[88,94,123,188,237,264],"days)":[89],"or":[90,93,183,373],".5,":[91],"1":[92,111],"mg":[95],"delivered":[98],"using":[99,154],"hand-held":[101],"Staccato":[102],"device.":[103],"Study":[104,268,353,400],"days":[105],"separated":[107,207],"by":[108,187],"least":[110],"week.":[112],"Presence":[113],"(and":[114],"degree)":[115],"was":[118,141,148,203,215,242,246],"measured":[119,142],"predose,":[120],"min,":[124,126,128],"10":[125],"30":[127],"1,":[129],"2,":[130],"4":[131,200],"6":[133],"hours":[134],"post-dose.":[135],"Plasma":[136],"concentration":[137],"study":[139,227],"drug":[140],"each":[144,151],"time":[145,152],"point.":[146],"Sedation":[147,202],"point":[153],"the":[155,175,251,351,370],"100-mm":[156],"linear":[157],"visual":[158],"analogue":[159],"scale":[160],"(VAS).":[161],"Results:":[162],"Five":[163],"enrolled":[166],"completed":[168],"all":[169],"treatment":[170],"arms.":[171],"All":[172],"doses":[173,193],"decreased":[174],"mean":[176],"standardized":[177],"range":[179],"(SPR),":[180],"maximal":[182],"near-maximal":[184],"occurring":[186],"minutes":[189,265],"post":[190],"dose.":[191],"Higher":[192],"produced":[194],"effects":[195,210],"SPR":[197,209],"out":[198],"hours.":[201],"dose":[204,243],"related,":[205,244],"but":[206],"from":[208,225,440,492],"later":[212],"timepoints.":[213],"Treatment":[214],"well":[216],"tolerated":[217],"no":[219],"serious":[220],"adverse":[221],"events.":[222],"Conclusions:":[223],"Results":[224],"this":[226],"suggest":[228],"that":[229,253],"strongly":[232],"suppresses":[233],"within":[236,263],"minutes.":[238],"Duration":[239],"sedation.":[247],"This":[248],"data":[249],"supports":[250],"possibility":[252],"might":[256],"have":[257],"utility":[258],"stopping":[260],"seizure":[262],"use.":[267],"Supported":[269],"by:":[270],"Alexza":[271,359,416,447,462,495,517,531,545],"Disclosure:":[272],"Dr.":[273,332,375,390,405,420,434,453,468,486,508,522,536],"French":[274],"has":[275,334,377,392,407,422,436,455,470,488,510,524,538],"personal":[277,336,379,394,409,424,457,472,512,526,540],"compensation":[278,337,380,395,410,425,458,473,513,527,541],"activities":[280,339,382,397,412,427,460,475,515,529,543],"Acorda,":[282],"Adamas,":[283],"Alexza,":[284],"Anavex,":[285],"Biogen,":[286],"BioPharm":[287],"Solutions,":[288],"Cerecor,":[289],"Concert":[290],"Pharmaceuticals,":[291,326,348,360,446,448],"Convance,":[292],"Eisai,":[293,355,385,477],"Georgia":[294],"Regents":[295],"University,":[296],"GSK,":[297],"GW":[298,345],"Pharma,":[299,344,346,358,494],"Marinus,":[300,356,387],"MonosolRx,":[301],"Monteris,":[302],"Nestle-Health":[303],"Science,":[304],"Neurelis,":[305,497],"Novartis,":[306,499],"Ovid":[307],"Therapeutics":[308],"Inc.,":[309,322,342,350,498],"Pfizer,":[310,361,449,500],"Pfizer-Neusentis,":[311],"Pronutria,":[312],"Roivant,":[313],"Sage,":[314],"SK":[315,357,445,501],"Life":[316,502],"Sciences,":[317,503],"Sunovion,":[318,386,478],"Supernus,":[319],"Takeda,":[320],"UCB":[321,343,479],"Upsher":[323],"Smith,":[324],"Xenon":[325],"Zogenix,":[327],"Zynerba":[328,365],"consultant.":[331,419,485,535,554],"Friedman":[333],"LivaNova,":[341],"Supernus":[347],"NeuroPace,":[349],"Epilepsy":[352,399],"Consortium,":[354],"Upsher-Smith":[362,451],"Laboratories,":[363],"consulting,":[367],"participating":[368],"advisory":[371],"board,":[372],"speaking.":[374],"Wechsler":[376],"Cyberonics,":[384],"Lundbeck.":[389],"DiVentura":[391],"Consortium":[401],"employee.":[404,467,521],"Gelfand":[406],"Antares":[414],"Pollard":[421,435],"Cognizance":[429,443],"Biomarkers":[430],"part-owner.":[433],"research":[438,490],"support":[439,491],"Glaxo-Smith":[441],"Kline,":[442],"Biomarkers,":[444],"Laboratories.":[452],"Huie":[454],"Pharmaceuticals":[463,518,532,546,549],"Inc":[464],"Vazquez":[469,487],"Pharma":[480],"speaker":[483],"Acorda":[493],"Phrama,":[496],"UCB,":[504],"Marinus":[506],"Pharma.":[507],"Gong":[509],"Cassella":[523],"Kamemoto":[537],"Dance":[548],"employee":[552],"and/or":[553]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-04-24T00:00:00"}
