{"id":"https://openalex.org/W2797960489","doi":"https://doi.org/10.1371/journal.pone.0195469","title":"Memory deficiency, cerebral amyloid angiopathy, and amyloid-\u03b2 plaques in APP+PS1 double transgenic rat model of Alzheimer\u2019s disease","display_name":"Memory deficiency, cerebral amyloid angiopathy, and amyloid-\u03b2 plaques in APP+PS1 double transgenic rat model of Alzheimer\u2019s disease","publication_year":2018,"publication_date":"2018-04-11","ids":{"openalex":"https://openalex.org/W2797960489","doi":"https://doi.org/10.1371/journal.pone.0195469","mag":"2797960489","pmid":"https://pubmed.ncbi.nlm.nih.gov/29641600","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5895023"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0195469","doi":"https://doi.org/10.1371/journal.pone.0195469","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0195469","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195469&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195469&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036771511","display_name":"Diana Klakotskaia","orcid":"https://orcid.org/0000-0002-9851-5330","observed_orcids":["https://orcid.org/0000-0002-9851-5330"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Klakotskaia","raw_affiliation_strings":["Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019030645","display_name":"Cansu Agca","orcid":"https://orcid.org/0000-0001-6641-7448","observed_orcids":["https://orcid.org/0000-0001-6641-7448"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cansu Agca","raw_affiliation_strings":["Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6641-7448","affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rachel A. Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Richardson","raw_affiliation_strings":["Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111403180","display_name":"Edward G. Stopa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward G. Stopa","raw_affiliation_strings":["Department of Pathology, Rhode Island Hospital, Providence, Rhode Island, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rhode Island Hospital, Providence, Rhode Island, United States of America","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040942172","display_name":"Todd R. Schachtman","orcid":"https://orcid.org/0000-0003-2312-0323","observed_orcids":["https://orcid.org/0000-0003-2312-0323"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd R. Schachtman","raw_affiliation_strings":["Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Sciences, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012694792","display_name":"Y\u00fcksel A\u011fca","orcid":"https://orcid.org/0000-0002-9883-3291","observed_orcids":["https://orcid.org/0000-0002-9883-3291"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuksel Agca","raw_affiliation_strings":["Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012694792"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.4929,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88967252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"13","issue":"4","first_page":"e0195469","last_page":"e0195469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7250000238418579},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.8159999847412109},{"id":"https://openalex.org/keywords/learning-deficits","display_name":"learning deficits","score":0.7009999752044678},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cerebral-amyloid-angiopathy","display_name":"cerebral amyloid angiopathy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.4490000009536743},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.875},{"id":"https://openalex.org/keywords/vascular-changes","display_name":"vascular changes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/perivascular-spaces","display_name":"perivascular spaces","score":0.7689999938011169},{"id":"https://openalex.org/keywords/transgenic-rats","display_name":"transgenic rats","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.9347983598709106},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6602329015731812},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5807029604911804},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5736207962036133},{"id":"https://openalex.org/C2779703115","wikidata":"https://www.wikidata.org/wiki/Q539702","display_name":"Angiopathy","level":3,"score":0.5159853100776672},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5104912519454956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5078669190406799},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4923001527786255},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4269748032093048},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40021103620529175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25269603729248047},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.24305486679077148},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14177396893501282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06899696588516235},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016657","descriptor_name":"Cerebral Amyloid Angiopathy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055647","descriptor_name":"Rats, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0195469","doi":"https://doi.org/10.1371/journal.pone.0195469","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0195469","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195469&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4854640","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5895023","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5895023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5895023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:29641600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29641600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1ac8b47461b74df388734eaf96521b84","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1ac8b47461b74df388734eaf96521b84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 13, Iss 4, p e0195469 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/6130127","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Memory_deficiency_cerebral_amyloid_angiopathy_and_amyloid-_plaques_in_APP_PS1_double_transgenic_rat_model_of_Alzheimer_s_disease/6130127","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0195469","doi":"https://doi.org/10.1371/journal.pone.0195469","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0195469","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0195469&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000866593","display_name":"Rat Resource and Research Center","funder_award_id":"P40OD011062","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2797960489.pdf","grobid_xml":"https://content.openalex.org/works/W2797960489.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1480702808","https://openalex.org/W1556362327","https://openalex.org/W1563224172","https://openalex.org/W1594119953","https://openalex.org/W1890244436","https://openalex.org/W1966014719","https://openalex.org/W1967375871","https://openalex.org/W1967464880","https://openalex.org/W1970847895","https://openalex.org/W1973063270","https://openalex.org/W1979221664","https://openalex.org/W1985988204","https://openalex.org/W1991010898","https://openalex.org/W1991369983","https://openalex.org/W1991457465","https://openalex.org/W1996447834","https://openalex.org/W2006644005","https://openalex.org/W2040571516","https://openalex.org/W2043670258","https://openalex.org/W2051005796","https://openalex.org/W2055883416","https://openalex.org/W2073161926","https://openalex.org/W2075650045","https://openalex.org/W2076478279","https://openalex.org/W2076709120","https://openalex.org/W2082087376","https://openalex.org/W2103861118","https://openalex.org/W2117304560","https://openalex.org/W2126019582","https://openalex.org/W2128307173","https://openalex.org/W2130805835","https://openalex.org/W2141918279","https://openalex.org/W2155395206","https://openalex.org/W2166578434","https://openalex.org/W2167279371","https://openalex.org/W2207735435","https://openalex.org/W2223656268","https://openalex.org/W2397614738","https://openalex.org/W2471923151","https://openalex.org/W2605903722","https://openalex.org/W2765175830","https://openalex.org/W4211028926","https://openalex.org/W6892143429"],"related_works":["https://openalex.org/W2471923151","https://openalex.org/W3044246312","https://openalex.org/W3142984996","https://openalex.org/W137550786","https://openalex.org/W2171692422","https://openalex.org/W2348980778","https://openalex.org/W2033672570","https://openalex.org/W2390321586","https://openalex.org/W2394309361","https://openalex.org/W2041119066"],"abstract_inverted_index":{"Transgenic":[0],"rat":[1],"models":[2],"of":[3,126,129],"Alzheimer's":[4,208],"disease":[5],"were":[6,39],"used":[7],"to":[8,93,161,201],"examine":[9],"differences":[10],"in":[11,114,123,149,166,205],"memory":[12,53,91],"and":[13,27,31,52,54,59,97,109,117,151,156,169,179,186,197],"brain":[14,184],"histology.":[15],"Double":[16],"transgenic":[17,33],"female":[18],"rats":[19,34,45,61,69,80,136,173,193],"(APP+PS1)":[20],"over-expressing":[21,36],"human":[22,37],"amyloid":[23,143],"precursor":[24],"protein":[25],"(APP)":[26],"presenilin":[28],"1":[29],"(PS1)":[30],"single":[32],"(APP21)":[35],"APP":[38],"compared":[40,92],"with":[41,145,207],"wild":[42],"type":[43],"Fischer":[44],"(WT).":[46],"The":[47],"Barnes":[48],"maze":[49],"assessed":[50],"learning":[51],"showed":[55,107,138,189],"that":[56,120,190],"both":[57,94],"APP21":[58,96],"APP+PS1":[60,79,131,135,172,192],"made":[62,81],"significantly":[63,82],"more":[64,83],"errors":[65,84],"than":[66],"the":[67,71,78,95,115,124,127,130,134,162,183,191],"WT":[68,98],"during":[70],"acquisition":[72],"phase,":[73],"signifying":[74],"slower":[75],"learning.":[76],"Additionally,":[77],"following":[85],"a":[86],"retention":[87],"interval,":[88],"indicating":[89],"impaired":[90],"rats.":[99,132],"Immunohistochemistry":[100],"using":[101],"an":[102],"antibody":[103],"against":[104],"amyloid-\u03b2":[105],"(A\u03b2)":[106],"extensive":[108,146],"mostly":[110],"diffuse":[111],"A\u03b2":[112,147,163],"plaques":[113,119],"hippocampus":[116],"dense":[118],"contained":[121],"tau":[122],"cortex":[125],"brains":[128],"Furthermore,":[133],"also":[137,174],"vascular":[139,198],"changes,":[140],"including":[141],"cerebral":[142],"angiopathy":[144],"deposits":[148],"cortical":[150],"leptomeningeal":[152],"blood":[153,177],"vessel":[154],"walls":[155],"venous":[157],"collagenosis.":[158],"In":[159],"addition":[160],"accumulation":[164],"observed":[165,204],"arterial,":[167],"venous,":[168],"capillary":[170],"walls,":[171],"displayed":[175],"enlarged":[176],"vessels":[178],"perivascular":[180],"space.":[181],"Overall,":[182],"histopathology":[185],"behavioral":[187,195],"assessment":[188],"demonstrated":[194],"characteristics":[196],"changes":[199],"similar":[200],"those":[202],"commonly":[203],"patients":[206],"disease.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-04-24T00:00:00"}
