{"id":"https://openalex.org/W2797499558","doi":"https://doi.org/10.4049/jimmunol.198.supp.222.26","title":"Induced negative regulation decodes PAMP quality and quantity to generate bacteria-specific inflammatory responses","display_name":"Induced negative regulation decodes PAMP quality and quantity to generate bacteria-specific inflammatory responses","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2797499558","doi":"https://doi.org/10.4049/jimmunol.198.supp.222.26","mag":"2797499558"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.198.supp.222.26","doi":"https://doi.org/10.4049/jimmunol.198.supp.222.26","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.222.26","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053877438","display_name":"Rachel A. Gottschalk","orcid":"https://orcid.org/0000-0002-5248-8816","observed_orcids":["https://orcid.org/0000-0002-5248-8816"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A Gottschalk","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102883403","display_name":"Bhaskar Dutta","orcid":"https://orcid.org/0000-0002-4352-5419","observed_orcids":["https://orcid.org/0000-0002-4352-5419"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhaskar Dutta","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003301558","display_name":"Kathleen S Krauss","orcid":"https://orcid.org/0000-0001-9432-6623","observed_orcids":["https://orcid.org/0000-0001-9432-6623"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Krauss","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029273121","display_name":"Michael G. Dorrington","orcid":"https://orcid.org/0000-0002-2083-1229","observed_orcids":["https://orcid.org/0000-0002-2083-1229"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G Dorrington","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015292974","display_name":"Andrew J. Martins","orcid":"https://orcid.org/0000-0002-1832-1924","observed_orcids":["https://orcid.org/0000-0002-1832-1924"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J Martins","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040049345","display_name":"Stefan Uderhardt","orcid":"https://orcid.org/0000-0002-2489-2109","observed_orcids":["https://orcid.org/0000-0002-2489-2109"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Uderhardt","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030115420","display_name":"John S. Tsang","orcid":"https://orcid.org/0000-0003-3186-3047","observed_orcids":["https://orcid.org/0000-0003-3186-3047"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S Tsang","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035330277","display_name":"Parizad Torabi\u2010Parizi","orcid":"https://orcid.org/0000-0002-7446-1702","observed_orcids":["https://orcid.org/0000-0002-7446-1702"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parizad Torabi-Parizi","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041569902","display_name":"Iain D. C. Fraser","orcid":"https://orcid.org/0000-0003-2272-3907","observed_orcids":["https://orcid.org/0000-0003-2272-3907"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iain D C Fraser","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088777789","display_name":"Ronald N. Germain","orcid":"https://orcid.org/0000-0003-1495-9143","observed_orcids":["https://orcid.org/0000-0003-1495-9143"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald N Germain","raw_affiliation_strings":["NIAID, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"Supplement_1","first_page":"222.26","last_page":"222.26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.8899999856948853},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8880000114440918},{"id":"https://openalex.org/keywords/negative-regulation","display_name":"negative regulation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/ligand-concentration","display_name":"ligand concentration","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6859999895095825},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7926596403121948},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6821857690811157},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.6482338905334473},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5959670543670654},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5730478167533875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5386367440223694},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5321511626243591},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47503259778022766},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.46037325263023376},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4285806715488434},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4178629219532013},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41174665093421936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3701595962047577},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3648655116558075},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3263714909553528},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17324420809745789}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.198.supp.222.26","doi":"https://doi.org/10.4049/jimmunol.198.supp.222.26","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.198.supp.222.26","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2966249001","https://openalex.org/W2111111355","https://openalex.org/W1928620724","https://openalex.org/W4240944094","https://openalex.org/W2947932017","https://openalex.org/W4245264407","https://openalex.org/W2149675145","https://openalex.org/W2105344720","https://openalex.org/W2064962037","https://openalex.org/W2091526629"],"abstract_inverted_index":{"Abstract":[0],"Toll-like":[1],"receptors":[2,25],"(TLRs)":[3],"expressed":[4],"on":[5],"macrophages":[6,40],"are":[7,26],"ligated":[8],"in":[9,53,64,88,167],"various":[10],"combinations":[11,94],"by":[12,187],"diverse":[13],"pathogen-associated":[14],"molecular":[15],"patterns":[16],"(PAMPs),":[17],"but":[18],"how":[19],"mixtures":[20],"of":[21,45,85,90,95,98,105,111,118,142,149,181,192],"signals":[22],"through":[23],"these":[24,179],"integrated":[27],"to":[28,33,116,139,178],"mediate":[29],"distinct":[30,175],"biological":[31],"responses":[32,107,177],"different":[34],"pathogens":[35],"remains":[36],"unknown.":[37],"By":[38],"stimulating":[39],"using":[41],"a":[42,65,103,140],"wide":[43],"matrix":[44],"TLR2/TLR4":[46],"concentration":[47,82],"combinations,":[48],"we":[49,159],"identified":[50,60],"conditions":[51],"resulting":[52],"non-linear":[54,106],"responses.":[55],"Transcriptomic":[56],"and":[57,73],"RNAi":[58],"analyses":[59],"negative":[61,119,157],"regulators":[62,158],"induced":[63,121],"TLR-specific":[66],"manner":[67],"that":[68],"regulated":[69],"cytokine":[70],"production":[71,89,110],"dynamics":[72],"chemokine":[74],"milieus":[75],"across":[76],"the":[77,86,150,163,188,193],"combinatorial":[78],"matrix.":[79],"TLR4":[80,151],"ligand":[81,101,126,152],"explained":[83],"much":[84],"variation":[87],"many":[91],"chemokines.":[92],"However,":[93],"sub-maximal":[96],"amounts":[97,148],"either":[99],"single":[100],"produced":[102],"zone":[104],"with":[108],"sustained":[109,130],"select":[112],"inflammatory":[113,176],"mediators,":[114],"due":[115],"lack":[117],"regulation":[120],"only":[122],"at":[123],"higher":[124],"individual":[125],"concentrations.":[127],"A":[128],"similar":[129],"response":[131],"was":[132,185],"observed":[133],"for":[134],"Gram-positive":[135,171],"bacteria,":[136],"as":[137],"compared":[138],"panel":[141],"Gram-negative":[143,169],"species,":[144,172],"which":[145],"express":[146],"high":[147],"LPS.":[153],"The":[154],"novel":[155],"TLR4-specific":[156],"describe":[160],"thus":[161],"aid":[162],"innate":[164],"immune":[165],"system":[166],"discriminating":[168],"from":[170],"supporting":[173],"qualitatively":[174],"classes":[180],"bacteria.":[182],"This":[183],"research":[184],"supported":[186],"Intramural":[189],"Research":[190],"Program":[191],"NIH,":[194],"NIAID":[195]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2018-04-24T00:00:00"}