{"id":"https://openalex.org/W2796842840","doi":"https://doi.org/10.1016/j.celrep.2018.03.056","title":"Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism","display_name":"Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2796842840","doi":"https://doi.org/10.1016/j.celrep.2018.03.056","mag":"2796842840","pmid":"https://pubmed.ncbi.nlm.nih.gov/29641996","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5929158"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2018.03.056","doi":"https://doi.org/10.1016/j.celrep.2018.03.056","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.03.056","pdf_url":"http://www.cell.com/article/S2211124718304017/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124718304017/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079198899","display_name":"Jurian Schuijers","orcid":"https://orcid.org/0000-0003-2531-3516","observed_orcids":["https://orcid.org/0000-0003-2531-3516"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jurian Schuijers","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022314317","display_name":"John C. Manteiga","orcid":"https://orcid.org/0000-0002-0385-6176","observed_orcids":["https://orcid.org/0000-0002-0385-6176"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Colonnese Manteiga","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110974405","display_name":"Abraham S. Weintraub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Selby Weintraub","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110470190","display_name":"Daniel S. Day","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Sindt Day","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040347044","display_name":"Alicia Viridiana Zamudio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Viridiana Zamudio","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035633092","display_name":"Denes Hnisz","orcid":"https://orcid.org/0000-0002-6256-1693","observed_orcids":["https://orcid.org/0000-0002-6256-1693"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denes Hnisz","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061488860","display_name":"Tong Ihn Lee","orcid":"https://orcid.org/0000-0003-1847-0898","observed_orcids":["https://orcid.org/0000-0003-1847-0898"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Ihn Lee","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112460504","display_name":"Richard A. Young","orcid":"https://orcid.org/0000-0001-8855-8647","observed_orcids":["https://orcid.org/0000-0001-8855-8647"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Allen Young","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: young@wi.mit.edu","Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: young@wi.mit.edu","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112460504"],"corresponding_institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":7.6165,"has_fulltext":true,"cited_by_count":232,"citation_normalized_percentile":{"value":0.98559185,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"2","first_page":"349","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myc-oncogene","display_name":"MYC oncogene","score":0.9570000171661377},{"id":"https://openalex.org/keywords/super-enhancers","display_name":"super-enhancers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ctcf-binding-sites","display_name":"CTCF binding sites","score":0.9419999718666077},{"id":"https://openalex.org/keywords/transcriptional-dysregulation","display_name":"transcriptional dysregulation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/epigenome-editing","display_name":"epigenome editing","score":0.9259999990463257},{"id":"https://openalex.org/keywords/enhancer-hijacking","display_name":"enhancer hijacking","score":0.828000009059906},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9360098838806152},{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.8780843019485474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6779695153236389},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6373619437217712},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5464058518409729},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.5453483462333679},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48950254917144775},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4405045211315155},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4390675127506256},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4253289997577667},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3566678762435913},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31741905212402344}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1016/j.celrep.2018.03.056","doi":"https://doi.org/10.1016/j.celrep.2018.03.056","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.03.056","pdf_url":"http://www.cell.com/article/S2211124718304017/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:29641996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29641996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4851779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5929158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5929158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5929158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:550f4fbbf19649f2abe725687a117283","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/550f4fbbf19649f2abe725687a117283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 23, Iss 2, Pp 349-360 (2018)","raw_type":"article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/117042","doi":null,"is_oa":true,"landing_page_url":"https://orcid.org/0000-0002-0385-6176","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elsevier","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_3040667","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0003-54E0-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3012796124","doi":null,"is_oa":false,"landing_page_url":"https://dspace.mit.edu/handle/1721.1/117042","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Elsevier eBooks","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2018.03.056","doi":"https://doi.org/10.1016/j.celrep.2018.03.056","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2018.03.056","pdf_url":"http://www.cell.com/article/S2211124718304017/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3189526474","display_name":"Transcriptional regulatory networks in living cells","funder_award_id":"R01GM123511","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4774001399","display_name":null,"funder_award_id":"PF-16-146-01-DMC","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G6086781597","display_name":"Transcriptional Regulatory Networks in Living Cells","funder_award_id":"R01HG002668","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7409786955","display_name":"Pre-Doctoral Training in Biological Sciences","funder_award_id":"T32GM007287","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320314100","display_name":"Margaret and Herman Sokol Institute for Pharmaceutical Life Sciences, Montclair State University","ror":null},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2796842840.pdf","grobid_xml":"https://content.openalex.org/works/W2796842840.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1523117612","https://openalex.org/W1669374546","https://openalex.org/W1699926620","https://openalex.org/W1918416431","https://openalex.org/W1964184081","https://openalex.org/W1965057731","https://openalex.org/W1971578941","https://openalex.org/W1973062929","https://openalex.org/W1975542854","https://openalex.org/W1975777043","https://openalex.org/W1977709885","https://openalex.org/W1978902427","https://openalex.org/W1989373989","https://openalex.org/W1990320777","https://openalex.org/W1991269963","https://openalex.org/W1996060670","https://openalex.org/W1996949194","https://openalex.org/W2002395443","https://openalex.org/W2004966039","https://openalex.org/W2007553857","https://openalex.org/W2011463791","https://openalex.org/W2014624348","https://openalex.org/W2018658338","https://openalex.org/W2021080331","https://openalex.org/W2021536610","https://openalex.org/W2029722028","https://openalex.org/W2036619779","https://openalex.org/W2064537118","https://openalex.org/W2065794410","https://openalex.org/W2067067252","https://openalex.org/W2070021921","https://openalex.org/W2073829401","https://openalex.org/W2074324848","https://openalex.org/W2079407198","https://openalex.org/W2082912595","https://openalex.org/W2084620487","https://openalex.org/W2091517552","https://openalex.org/W2114866946","https://openalex.org/W2125397535","https://openalex.org/W2127988376","https://openalex.org/W2128338459","https://openalex.org/W2132530130","https://openalex.org/W2132731433","https://openalex.org/W2133821553","https://openalex.org/W2136603536","https://openalex.org/W2143599753","https://openalex.org/W2145151755","https://openalex.org/W2147449602","https://openalex.org/W2148261329","https://openalex.org/W2151765671","https://openalex.org/W2152735985","https://openalex.org/W2157214001","https://openalex.org/W2161212572","https://openalex.org/W2161577298","https://openalex.org/W2162723598","https://openalex.org/W2163605769","https://openalex.org/W2164222087","https://openalex.org/W2169710039","https://openalex.org/W2172174991","https://openalex.org/W2192926654","https://openalex.org/W2195190137","https://openalex.org/W2224894504","https://openalex.org/W2233830209","https://openalex.org/W2252575065","https://openalex.org/W2269026928","https://openalex.org/W2282817578","https://openalex.org/W2295297857","https://openalex.org/W2303393194","https://openalex.org/W2462894283","https://openalex.org/W2521981506","https://openalex.org/W2523285811","https://openalex.org/W2524507363","https://openalex.org/W2528263447","https://openalex.org/W2530292798","https://openalex.org/W2531720753","https://openalex.org/W2546024031","https://openalex.org/W2553838260","https://openalex.org/W2556041461","https://openalex.org/W2580449060","https://openalex.org/W2586373162","https://openalex.org/W2590568317","https://openalex.org/W2606007585","https://openalex.org/W2612037027","https://openalex.org/W2613597569","https://openalex.org/W2614144400","https://openalex.org/W2774733631","https://openalex.org/W6640204207","https://openalex.org/W6828444253"],"related_works":["https://openalex.org/W4210736686","https://openalex.org/W3119756236","https://openalex.org/W4393954939","https://openalex.org/W2898817714","https://openalex.org/W2321987454","https://openalex.org/W4403814146","https://openalex.org/W2613445539","https://openalex.org/W2224894504","https://openalex.org/W4392747365","https://openalex.org/W6939458016"],"abstract_inverted_index":{"Transcriptional":[0],"dysregulation":[1],"of":[2,23,64,70],"the":[3,8,28,49,65],"MYC":[4,33,50,66,82],"oncogene":[5],"is":[6,18,90,101],"among":[7],"most":[9],"frequent":[10],"events":[11],"in":[12,43,74,103,126,160],"aggressive":[13],"tumor":[14,75,134],"cells,":[15],"and":[16,45,55,85,96],"this":[17,71,97],"generally":[19,138],"accomplished":[20],"by":[21,132,156],"acquisition":[22],"a":[24,53,130,149],"super-enhancer":[25,80],"somewhere":[26],"within":[27],"2.8":[29],"Mb":[30],"TAD":[31],"where":[32],"resides.":[34],"We":[35],"find":[36],"that":[37,147],"these":[38],"diverse":[39,104,157],"cancer-specific":[40],"super-enhancers,":[41],"differing":[42],"size":[44],"location,":[46],"interact":[47],"with":[48,112,123],"gene":[51,83,152],"through":[52,109],"common":[54],"conserved":[56],"CTCF":[57,78,88],"binding":[58,89],"site":[59,73],"located":[60],"2":[61],"kb":[62],"upstream":[63],"promoter.":[67],"Genetic":[68],"perturbation":[69],"enhancer-docking":[72,98,115],"cells":[76],"reduces":[77],"binding,":[79],"interaction,":[81],"expression,":[84],"cell":[86,135,162],"proliferation.":[87],"highly":[91],"sensitive":[92],"to":[93,153],"DNA":[94],"methylation,":[95],"site,":[99],"which":[100,133],"hypomethylated":[102],"cancers,":[105,128],"can":[106,137],"be":[107,154],"inactivated":[108],"epigenetic":[110],"editing":[111],"dCas9-DNMT.":[113],"Similar":[114],"sites":[116],"occur":[117],"at":[118],"other":[119],"genes,":[120],"including":[121],"genes":[122],"prominent":[124],"roles":[125],"multiple":[127],"suggesting":[129],"mechanism":[131],"oncogenes":[136],"hijack":[139],"enhancers.":[140],"These":[141],"results":[142],"provide":[143],"insights":[144],"into":[145],"mechanisms":[146],"allow":[148],"single":[150],"target":[151],"regulated":[155],"enhancer":[158],"elements":[159],"different":[161],"types.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-04-24T00:00:00"}