{"id":"https://openalex.org/W2796721185","doi":null,"title":"Fabrication and Characterization of Collagen-Apatite Composites for Bone Tissue Engineering","display_name":"Fabrication and Characterization of Collagen-Apatite Composites for Bone Tissue Engineering","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2796721185","mag":"2796721185"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-7954","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/1695","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=7954&context=dissertations","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=7954&context=dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069206910","display_name":"Changmin Hu","orcid":"https://orcid.org/0000-0002-1472-9981","observed_orcids":["https://orcid.org/0000-0002-1472-9981"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Changmin Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1472-9981","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069206910"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ti-6al-4v","display_name":"Ti-6Al-4V","score":0.7979999780654907},{"id":"https://openalex.org/keywords/simulated-body-fluid","display_name":"simulated body fluid","score":0.7099999785423279},{"id":"https://openalex.org/keywords/gradient-porous-structure","display_name":"gradient porous structure","score":0.6990000009536743},{"id":"https://openalex.org/keywords/collagen-fibrils","display_name":"collagen fibrils","score":0.7139999866485596},{"id":"https://openalex.org/keywords/amorphous-calcium-phosphate","display_name":"amorphous calcium phosphate","score":0.796999990940094},{"id":"https://openalex.org/keywords/poly-acrylic-acid","display_name":"poly(acrylic acid)","score":0.8849999904632568},{"id":"https://openalex.org/keywords/sodium-tripolyphosphate","display_name":"sodium tripolyphosphate","score":0.9269999861717224},{"id":"https://openalex.org/keywords/silicon-incorporation","display_name":"silicon incorporation","score":0.3059999942779541},{"id":"https://openalex.org/keywords/bone-scaffolds","display_name":"bone scaffolds","score":0.7300000190734863},{"id":"https://openalex.org/keywords/non-collagenous-proteins","display_name":"non-collagenous proteins","score":0.75}],"concepts":[{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.6886886358261108},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.5893566012382507},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.568263053894043},{"id":"https://openalex.org/C2777746296","wikidata":"https://www.wikidata.org/wiki/Q178397","display_name":"Apatite","level":2,"score":0.5560302138328552},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5257421731948853},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.490774005651474},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2950862646102905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18033632636070251},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16025346517562866},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.1554568111896515},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15292766690254211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11474373936653137},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:dissertations-7954","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/1695","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=7954&context=dissertations","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-7954","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/1695","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:2796721185","doi":null,"is_oa":false,"landing_page_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=7954&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-7954","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/1695","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=7954&context=dissertations","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2796721185.pdf","grobid_xml":"https://content.openalex.org/works/W2796721185.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W119911077","https://openalex.org/W311399783","https://openalex.org/W370818192","https://openalex.org/W1828000364","https://openalex.org/W1963976818","https://openalex.org/W1964597253","https://openalex.org/W1969788257","https://openalex.org/W1971953511","https://openalex.org/W1975741112","https://openalex.org/W1976288179","https://openalex.org/W1977671514","https://openalex.org/W1978123484","https://openalex.org/W1978382520","https://openalex.org/W1988582650","https://openalex.org/W1991416066","https://openalex.org/W1992040244","https://openalex.org/W1996115570","https://openalex.org/W1997153598","https://openalex.org/W1998795859","https://openalex.org/W2002192590","https://openalex.org/W2003412769","https://openalex.org/W2006629115","https://openalex.org/W2011937071","https://openalex.org/W2020641822","https://openalex.org/W2024316702","https://openalex.org/W2030344243","https://openalex.org/W2030406313","https://openalex.org/W2031721300","https://openalex.org/W2032158797","https://openalex.org/W2033017327","https://openalex.org/W2034283431","https://openalex.org/W2035944449","https://openalex.org/W2038896412","https://openalex.org/W2041842103","https://openalex.org/W2048469956","https://openalex.org/W2053456532","https://openalex.org/W2056996061","https://openalex.org/W2058986340","https://openalex.org/W2059442046","https://openalex.org/W2060078219","https://openalex.org/W2066342146","https://openalex.org/W2069773606","https://openalex.org/W2078386735","https://openalex.org/W2080054593","https://openalex.org/W2083158310","https://openalex.org/W2083458940","https://openalex.org/W2084343882","https://openalex.org/W2093836732","https://openalex.org/W2093854253","https://openalex.org/W2094366694","https://openalex.org/W2116802863","https://openalex.org/W2127000141","https://openalex.org/W2130971715","https://openalex.org/W2131570234","https://openalex.org/W2134081246","https://openalex.org/W2136116635","https://openalex.org/W2141488316","https://openalex.org/W2316956102","https://openalex.org/W2324110626"],"related_works":["https://openalex.org/W200700552","https://openalex.org/W2030344243","https://openalex.org/W2041865280","https://openalex.org/W2790502423","https://openalex.org/W114540306","https://openalex.org/W2228040494","https://openalex.org/W2013606064","https://openalex.org/W2027232257","https://openalex.org/W2036063880","https://openalex.org/W2084343882"],"abstract_inverted_index":{"Due":[0],"to":[1,106,148,190,199,278,295,332,343,359,364,415,463,528],"the":[2,18,74,84,108,112,131,134,149,160,163,174,182,192,201,205,212,215,236,242,297,303,315,333,394,412,417,422,429,453,461,464,467,474,479,493,499,508,544],"high":[3],"demand":[4],"of":[5,22,26,29,38,111,133,162,204,214,244,267,293,300,306,311,318,335,356,378,419,425,441,457,485,502,511,548],"scaffolds":[6,16,42,439,517,552],"for":[7,254,271,531,543,561],"treating":[8],"bone":[9,24,30,255,459,532,562],"fractures":[10],"every":[11],"year,":[12],"biomimetic":[13,39,47,50,80,166,437,515,549],"coatings":[14,40,125,550],"and":[15,20,41,62,118,151,156,187,225,232,337,370,387,409,455,477,487,505,546,551],"resembling":[17,452],"composition":[19,454],"structure":[21,243,456],"natural":[23,245,458],"are":[25,471],"keen":[27],"interest":[28],"tissue":[31,256,533,563],"engineers.":[32],"In":[33],"this":[34],"research,":[35],"a":[36,67,79,91,140,165,221,264,290,375,449,519,525,537,554,558],"series":[37],"have":[43,126,340],"been":[44,127,341,541],"developed,":[45],"including":[46],"apatite":[48,69,124,188,238,495],"coatings,":[49,53],"collagen-apatite":[51,167,216,227,516],"composite":[52,168,183,193,206,217,228],"intrafibrillar":[54,58,63,250,316,433,442],"calcified":[55,64],"collagen":[56,60,65,186,247,281,307,320,382,400,426,435,444,503],"fibrils,":[57,61,436],"silicified":[59,399],"scaffolds.\\nFirst,":[66],"crack-free":[68,123],"coating":[70,137,169,184,218,229],"was":[71,88,104,170,197,261,287,322,351,372],"deposited":[72],"on":[73,173,314],"surface-treated":[75,85,175],"Ti6Al4V":[76,176],"substrate":[77,87,150],"using":[78,178],"process,":[81],"in":[82,90,431,522],"which":[83,144],"titanium":[86],"immersed":[89],"modified":[92],"simulated":[93],"body":[94],"fluid":[95],"(m-SBF).":[96],"Dual-beam":[97,195],"focused":[98],"ion":[99],"beam/scanning":[100],"electron":[101],"microscopy":[102],"(FIB/SEM)":[103],"used":[105,198,262,352,373,530],"characterize":[107,200],"cross-sectional":[109,202],"microstructures":[110,203],"ceramic":[113],"coating.":[114],"Cross-sectional":[115],"SEM":[116],"images":[117,120],"TEM":[119],"revealed":[121],"that":[122,211,226],"achieved":[128],"by":[129,241,392],"adjusting":[130],"pH":[132],"m-SBF.":[135,180],"The":[136,208,309,514],"formed":[138],"demonstrates":[139],"gradient":[141,222],"porous":[142,158,223,234],"structure,":[143,224,556],"is":[145,230,326,483],"dense":[146],"close":[147],"then":[152],"it":[153],"becomes":[154],"more":[155,157],"towards":[159],"surface":[161],"coating.\\nSecond,":[164],"also":[171,219,323],"successfully\\nformed":[172],"alloy":[177],"collagen-containing":[179],"During":[181],"formation,":[185],"co-precipitate":[189],"form":[191],"coatings.":[194,207],"FIB/SEM":[196],"result":[209],"indicates":[210],"cross-section":[213],"exhibits":[220],"thinner":[231],"less":[233],"than":[235],"pure":[237],"coating.\\nThird,":[239],"inspired":[240],"bone,":[246,336],"fibrils":[248,321,383,401,445,504],"with":[249,384,428,553],"calcification":[251],"were":[252,390,402,446],"prepared":[253,447],"engineering.":[257,564],"Poly(acrylic":[258],"acid)":[259],"(PAA)":[260],"as":[263,289,353,374,405,411],"sequestration":[265],"analog":[266,292,355,377,414],"non-collagenous":[268],"proteins":[269,358,396],"(NCPs)":[270],"stabilizing":[272],"amorphous":[273],"calcium":[274],"phosphate":[275],"(PAA-ACP)":[276],"nanoprecursors":[277,408],"infiltrate":[279],"into":[280],"fibrils.":[282,308,513],"Additionally,":[283],"sodium":[284],"tripolyphosphate":[285],"(TPP)":[286],"applied":[288],"templating":[291,376,413],"NCPs":[294],"regulate":[296],"orderly":[298],"deposition":[299,418],"minerals":[301,496],"within":[302,421,498],"gap":[304,423,500],"zone":[305,424,501],"effect":[310],"PAA":[312],"concentration":[313],"mineralization":[317],"reconstituted":[319],"investigated.\\nFourth,":[324],"silicon":[325],"an":[327,354],"essential":[328],"element":[329],"contributing":[330],"significantly":[331],"health":[334],"great":[338,526,559],"efforts":[339],"made":[342],"produce":[344,365],"silica-containing":[345],"biomaterials.":[346],"Poly":[347],"(allylamine)":[348],"hydrochloride":[349],"(PAH)":[350],"zwitterionic":[357,379,395],"stabilize":[360],"silicic":[361],"acid":[362],"(SA)":[363],"fluidic":[366,406],"silica":[367,407,420],"(PAH-SA)":[368],"nanoprecursors,":[369],"TPP":[371,410],"proteins.":[380],"Silicified":[381],"core-shell,":[385],"twisted":[386],"banded":[388],"structures":[389],"produced":[391],"controlling":[393],"analogs.":[397],"Intrafibrillar":[398],"produced\\nusing":[403],"PAH-SA":[404],"modulate":[416],"fibrils.\\nFifth,":[427],"success":[430],"reproducing":[432],"mineralized":[434,443],"collagen/apatite":[438],"consisting":[440],"via":[448],"bottom-up":[450],"approach,":[451],"from":[460],"nanoscale":[462],"macroscale.":[465],"At":[466],"macro-scale,":[468],"unidirectional":[469],"macro-pores":[470],"aligned":[472,486],"across":[473],"entire":[475],"scaffold,":[476],"at":[478,492],"micro-scale,":[480],"each":[481],"layer":[482],"comprised":[484],"well":[488],"stacked":[489],"lamella.":[490],"Finally,":[491],"nano-scale,":[494],"deposit":[497],"orient":[506],"along":[507],"long":[509],"axis":[510],"these":[512],"demonstrate":[518],"good":[520],"biocompatibility":[521],"vitro,":[523],"indicating":[524],"potential":[527,560],"be":[529],"engineering":[534],"applications.\\nIn":[535],"summary,":[536],"novel":[538],"methodology":[539],"has":[540],"developed":[542],"preparation":[545],"characterization":[547],"hierarchical":[555],"demonstrating":[557]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-04-24T00:00:00"}