{"id":"https://openalex.org/W2796201153","doi":"https://doi.org/10.1016/j.juro.2018.02.2643","title":"PD56-11 ANALYSIS OF METHYLATED DNA MARKERS FOR PREDICTION OF CANCER PROGRESSION AFTER RADICAL PROSTATECTOMY","display_name":"PD56-11 ANALYSIS OF METHYLATED DNA MARKERS FOR PREDICTION OF CANCER PROGRESSION AFTER RADICAL PROSTATECTOMY","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2796201153","doi":"https://doi.org/10.1016/j.juro.2018.02.2643","mag":"2796201153"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2018.02.2643","doi":"https://doi.org/10.1016/j.juro.2018.02.2643","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.juro.2018.02.2643","pdf_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2018.02.2643","source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2018.02.2643","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108678687","display_name":"Matthew T. Gettman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Gettman","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044820727","display_name":"Ilya Sobol","orcid":"https://orcid.org/0009-0003-6003-590X","observed_orcids":["https://orcid.org/0009-0003-6003-590X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilya Sobol","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077043597","display_name":"Brian A. Dukek","orcid":"https://orcid.org/0000-0001-7986-647X","observed_orcids":["https://orcid.org/0000-0001-7986-647X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Dukek","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109058893","display_name":"William Francis Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Taylor","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038158795","display_name":"Douglas W. Mahoney","orcid":"https://orcid.org/0000-0001-5144-0645","observed_orcids":["https://orcid.org/0000-0001-5144-0645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Mahoney","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038050880","display_name":"Tracy C. Yab","orcid":"https://orcid.org/0000-0002-9116-8428","observed_orcids":["https://orcid.org/0000-0002-9116-8428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracy Yab","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043668707","display_name":"Calise K. Berger","orcid":"https://orcid.org/0009-0006-1407-7895","observed_orcids":["https://orcid.org/0009-0006-1407-7895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Calise Berger","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082725102","display_name":"John C. Cheville","orcid":"https://orcid.org/0000-0002-8202-6268","observed_orcids":["https://orcid.org/0000-0002-8202-6268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Cheville","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110541459","display_name":"Jeffrey R. Karnes","orcid":"https://orcid.org/0000-0003-2339-5925","observed_orcids":["https://orcid.org/0000-0003-2339-5925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Karnes","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078991711","display_name":"David A. Ahlquist","orcid":"https://orcid.org/0000-0002-0652-0758","observed_orcids":["https://orcid.org/0000-0002-0652-0758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Ahlquist","raw_affiliation_strings":["Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rochester, MN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05689406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"199","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.08309999853372574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dna-methylation-markers","display_name":"DNA methylation biomarkers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cancer-recurrence-prediction","display_name":"tumor recurrence prediction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7789999842643738},{"id":"https://openalex.org/keywords/archived-tissue","display_name":"archival tissue","score":0.44600000977516174},{"id":"https://openalex.org/keywords/recurrence-risk-stratification","display_name":"recurrence risk stratification","score":0.6460000276565552},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.33500000834465027},{"id":"https://openalex.org/keywords/methylation-specific-pcr","display_name":"methylation-specific PCR","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7912538051605225},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.7783794403076172},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7045934200286865},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40581315755844116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23771679401397705}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2018.02.2643","doi":"https://doi.org/10.1016/j.juro.2018.02.2643","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.juro.2018.02.2643","pdf_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2018.02.2643","source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.juro.2018.02.2643","doi":"https://doi.org/10.1016/j.juro.2018.02.2643","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.juro.2018.02.2643","pdf_url":"https://www.auajournals.org/doi/pdf/10.1016/j.juro.2018.02.2643","source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2796201153.pdf","grobid_xml":"https://content.openalex.org/works/W2796201153.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605038001","https://openalex.org/W2044541726","https://openalex.org/W2113830858","https://openalex.org/W2013153082","https://openalex.org/W2142503898","https://openalex.org/W2115436861","https://openalex.org/W2110607976","https://openalex.org/W2563597202","https://openalex.org/W2282411245","https://openalex.org/W2027413035"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,186,292,383,399,417,433],"UrologyProstate":[4],"Cancer:":[5],"Markers":[6],"II1":[7],"Apr":[8],"2018PD56-11":[9],"ANALYSIS":[10],"OF":[11,17],"METHYLATED":[12],"DNA":[13,174,248],"MARKERS":[14],"FOR":[15],"PREDICTION":[16],"CANCER":[18],"PROGRESSION":[19],"AFTER":[20],"RADICAL":[21],"PROSTATECTOMY":[22],"Matthew":[23,44,469],"Gettman,":[24],"Ilya":[25,53,476],"Sobol,":[26],"Brian":[27,62,483],"Dukek,":[28],"William":[29,71,490],"Taylor,":[30],"Douglas":[31,80,497],"Mahoney,":[32],"Tracy":[33,89,504],"Yab,":[34],"Calise":[35,98,511],"Berger,":[36],"John":[37,107,518],"Cheville,":[38],"Jeffrey":[39,116,525],"Karnes,":[40],"and":[41,125,163,168,223,241,252,281,294,301,332,346,365,414,438],"David":[42,126,532],"Ahlquist":[43,128,533],"GettmanMatthew":[45],"Gettman":[46,470],"More":[47,56,65,74,83,92,101,110,119,129,471,478,485,492,499,506,513,520,527,534],"articles":[48,57,66,75,84,93,102,111,120,130,472,479,486,493,500,507,514,521,528,535],"by":[49,58,67,76,85,94,103,112,121,131,157,272,283,321,343,350,362,422,473,480,487,494,501,508,515,522,529,536],"this":[50,59,68,77,86,95,104,113,122,132,474,481,488,495,502,509,516,523,530,537],"author":[51,60,69,78,87,96,105,114,123,133,475,482,489,496,503,510,517,524,531,538],",":[52,61,70,79,88,97,106,115,124,353],"SobolIlya":[54],"Sobol":[55,477],"DukekBrian":[63],"Dukek":[64,484],"TaylorWilliam":[72],"Taylor":[73,491],"MahoneyDouglas":[81],"Mahoney":[82,498],"YabTracy":[90],"Yab":[91,505],"BergerCalise":[99],"Berger":[100,512],"ChevilleJohn":[108],"Cheville":[109,519],"KarnesJeffrey":[117],"Karnes":[118,526],"AhlquistDavid":[127],"View":[134],"All":[135,540],"Author":[136],"Informationhttps://doi.org/10.1016/j.juro.2018.02.2643AboutPDF":[137],"ToolsAdd":[138],"to":[139,247,258,277,287,379,430,445,448],"favoritesDownload":[140],"CitationsTrack":[141],"CitationsPermissionsReprints":[142],"ShareFacebookTwitterLinked":[143],"InEmail":[144],"INTRODUCTION":[145],"AND":[146],"OBJECTIVES":[147],"Therapeutic":[148],"decisions":[149,451],"for":[150,244,381],"prostate":[151],"cancer":[152],"(CAP)":[153],"are":[154,377],"often":[155],"guided":[156],"Gleason":[158,239,295],"grade,":[159],"which":[160],"is":[161],"subjective":[162],"lacks":[164],"precision.":[165],"In":[166],"discovery":[167],"early":[169],"validation,":[170],"we":[171],"identified":[172],"methylated":[173],"markers":[175],"(MDMs)":[176],"with":[177,199,307,335],"prognostic":[178],"association":[179],"(AUA":[180],"2017).":[181],"We":[182],"now":[183],"assess":[184],"value":[185],"novel":[187],"MDMs":[188,255,269,293,319,428,441],"in":[189,214,234],"predicting":[190],"recurrence":[191,279,385],"using":[192,237],"archival":[193],"tissue":[194],"from":[195,370],"an":[196],"independent":[197],"group":[198],">":[200,265],"12":[201],"years":[202],"follow-up":[203],"after":[204,454],"radical":[205],"prostatectomy":[206],"(RP).":[207],"METHODS":[208],"From":[209],"737":[210],"men":[211,314],"undergoing":[212],"RP":[213,309],"2004":[215],"at":[216],"our":[217],"institution,":[218],"446":[219],"were":[220,256,270,299,401,424],"randomly":[221],"selected":[222,271,320],"155":[224,313],"met":[225],"quality":[226],"criteria.":[227],"An":[228],"expert":[229],"pathologist":[230],"re-reviewed":[231],"all":[232],"specimens":[233],"blinded":[235],"fashion":[236],"updated":[238],"criteria":[240],"marked":[242],"tumors":[243],"macro-dissection":[245],"prior":[246],"extraction,":[249],"bisulfite":[250],"treatment":[251],"methylation-specific":[253],"PCR.":[254],"standardized":[257],"beta-actin.":[259],"Recurrence":[260],"was":[261,338,356],"defined":[262],"as":[263],"PSA":[264],"0.4":[266],"ng/mL.":[267],"Top":[268],"regression":[273],"partitioning":[274],"tree":[275],"models":[276],"assign":[278],"risk":[280,375],"grouped":[282],"quartiles":[284,390],"(M1":[285],"(lowest)":[286],"M4":[288,408,423],"(highest)).":[289],"Prognostic":[290],"values":[291],"grade":[296],"groups":[297,376],"(GGG)":[298],"assessed":[300],"compared":[302,378],"based":[303],"on":[304],"their":[305],"concordance":[306],"postoperative":[308],"outcomes.":[310],"RESULTS":[311],"Among":[312],"studied,":[315],"43":[316],"recurrences":[317,393],"occurred.":[318],"the":[322,407,418],"model":[323],"included":[324],"WNT3A,":[325],"AGPS7497,":[326],"FNBP1,":[327],"GSDMD,":[328],"KCNK4,":[329],"Chr1.61519554,":[330],"GALR3,":[331],"RASSF2.":[333],"Concordance":[334,355],"post-RP":[336],"outcomes":[337],"0.85":[339],"(95%":[340],"CI":[341],"0.76-0.94)":[342],"MDM":[344,371],"modeling":[345,372],"0.63":[347],"(CI":[348,358],"0.53-0.71)":[349],"GGG,":[351],"p":[352],"0.0001.":[354],"0.86":[357],"0.77":[359],"-":[360],"0.95)":[361],"combined":[363],"approaches":[364],"did":[366],"not":[367],"significantly":[368],"differ":[369],"alone.":[373],"MDM-defined":[374],"GGG":[380,425],"prediction":[382,432],"CAP":[384,434,449],"(table).":[386],"M1":[387],"&":[388,453,465],"M2":[389],"showed":[391],"no":[392],"(0/72),":[394],"yet":[395],"36":[396],"%":[397],"(26/72)":[398],"these":[400],"histologically":[402],"advanced":[403],"(GGG":[404],"2-5).":[405],"Conversely,":[406],"quartile":[409],"comprised":[410],"69%":[411],"(34/49)":[412],"recurrences,":[413],"32%":[415],"(11)":[416],"34":[419],"accurately":[420],"predicted":[421],"1.":[426],"CONCLUSIONS":[427],"appear":[429],"enhance":[431],"recurrence.":[435],"With":[436],"optimization":[437],"further":[439],"corroboration,":[440],"testing":[442],"has":[443],"potential":[444],"contribute":[446],"objectively":[447],"management":[450],"before":[452],"treatment.":[455],"\u00a9":[456],"2018FiguresReferencesRelatedDetails":[457],"Volume":[458],"199Issue":[459],"4SApril":[460],"2018Page:":[461],"e1066":[462],"Advertisement":[463,541,542],"Copyright":[464],"Permissions\u00a9":[466],"2018MetricsAuthor":[467],"Information":[468],"Expand":[539],"PDF":[543],"downloadLoading":[544],"...":[545]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2018-04-13T00:00:00"}