{"id":"https://openalex.org/W2796200035","doi":"https://doi.org/10.1101/276774","title":"Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice","display_name":"Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice","publication_year":2018,"publication_date":"2018-03-06","ids":{"openalex":"https://openalex.org/W2796200035","doi":"https://doi.org/10.1101/276774","mag":"2796200035"},"language":"en","primary_location":{"id":"doi:10.1101/276774","doi":"https://doi.org/10.1101/276774","is_oa":true,"landing_page_url":"https://doi.org/10.1101/276774","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/06/276774.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/06/276774.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091763649","display_name":"Graham J. Britton","orcid":"https://orcid.org/0000-0003-4630-1223","observed_orcids":["https://orcid.org/0000-0003-4630-1223"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graham J. Britton","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0003-4630-1223","affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037815045","display_name":"Eduardo J. Contijoch","orcid":"https://orcid.org/0000-0002-2873-6808","observed_orcids":["https://orcid.org/0000-0002-2873-6808"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo J. Contijoch","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0002-2873-6808","affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081941500","display_name":"Ilaria Mogno","orcid":"https://orcid.org/0000-0002-8180-6609","observed_orcids":["https://orcid.org/0000-0002-8180-6609"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilaria Mogno","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034950791","display_name":"Olivia H. Vennaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia H. Vennaro","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091860674","display_name":"Sean R. Llewellyn","orcid":"https://orcid.org/0000-0001-8712-5567","observed_orcids":["https://orcid.org/0000-0001-8712-5567"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean R. Llewellyn","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0001-8712-5567","affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063101011","display_name":"Ruby Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruby Ng","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112703550","display_name":"Zhihua Li","orcid":"https://orcid.org/0009-0005-2280-5293","observed_orcids":["https://orcid.org/0009-0005-2280-5293","https://orcid.org/0009-0009-5009-9524"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhihua Li","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040852112","display_name":"Arthur Mortha","orcid":"https://orcid.org/0000-0003-2673-0485","observed_orcids":["https://orcid.org/0000-0003-2673-0485"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Arthur Mortha","raw_affiliation_strings":["Department of Immunology, University of Toronto, Toronto, ON, Canada","The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0003-2673-0485","affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070354041","display_name":"Miriam M\u00e9rad","orcid":"https://orcid.org/0000-0002-4481-7827","observed_orcids":["https://orcid.org/0000-0002-4481-7827"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Merad","raw_affiliation_strings":["Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0002-4481-7827","affiliations":[{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026686512","display_name":"Anuk Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuk Das","raw_affiliation_strings":["Janssen Human Microbiome Institute, Janssen Research and Development, LLC, Spring House, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Human Microbiome Institute, Janssen Research and Development, LLC, Spring House, PA, United States","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081647956","display_name":"Dirk Gevers","orcid":"https://orcid.org/0000-0003-1998-0363","observed_orcids":["https://orcid.org/0000-0003-1998-0363"]},"institutions":[{"id":"https://openalex.org/I4405282460","display_name":"Janssen Research & Development (United States)","ror":"https://ror.org/05wae1a98","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4405282460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dirk Gevers","raw_affiliation_strings":["Janssen Human Microbiome Institute, Janssen Research and Development, LLC, Spring House, PA, United States"],"raw_orcid":"https://orcid.org/0000-0003-1998-0363","affiliations":[{"raw_affiliation_string":"Janssen Human Microbiome Institute, Janssen Research and Development, LLC, Spring House, PA, United States","institution_ids":["https://openalex.org/I4405282460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035961257","display_name":"Dermot P.B. McGovern","orcid":"https://orcid.org/0000-0001-5621-759X","observed_orcids":["https://orcid.org/0000-0001-5621-759X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4405281400","display_name":"F. Widjaja Inflammatory Bowel Disease Institute","ror":"https://ror.org/049va9195","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dermot P.B. McGovern","raw_affiliation_strings":["Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States"],"raw_orcid":"https://orcid.org/0000-0001-5621-759X","affiliations":[{"raw_affiliation_string":"Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I4405281400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091833950","display_name":"Namita Singh","orcid":"https://orcid.org/0000-0002-6782-4288","observed_orcids":["https://orcid.org/0000-0002-6782-4288","https://orcid.org/0000-0002-3967-9853"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Namita Singh","raw_affiliation_strings":["Pediatric Gastroenterology and Inflammatory Bowel Disease, Cedars-Sinai Medical Center, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Gastroenterology and Inflammatory Bowel Disease, Cedars-Sinai Medical Center, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031406053","display_name":"Jonathan G. Braun","orcid":"https://orcid.org/0000-0003-1646-2974","observed_orcids":["https://orcid.org/0000-0003-1646-2974"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Braun","raw_affiliation_strings":["UCLA David Geffen School of Medicine, Los Angeles, CA, United States"],"raw_orcid":"https://orcid.org/0000-0003-1646-2974","affiliations":[{"raw_affiliation_string":"UCLA David Geffen School of Medicine, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033603757","display_name":"Jonathan P. Jacobs","orcid":"https://orcid.org/0000-0003-4698-0254","observed_orcids":["https://orcid.org/0000-0003-4698-0254"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan P. Jacobs","raw_affiliation_strings":["Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, Los Angeles,CA, United States"],"raw_orcid":"https://orcid.org/0000-0003-4698-0254","affiliations":[{"raw_affiliation_string":"Division of Digestive Diseases, Department of Medicine, University of California Los Angeles, Los Angeles,CA, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049747447","display_name":"Jos\u00e9 C. Clemente","orcid":"https://orcid.org/0000-0002-3970-9856","observed_orcids":["https://orcid.org/0000-0002-3970-9856"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose C. Clemente","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0002-3970-9856","affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087297338","display_name":"Ari M. Grinspan","orcid":"https://orcid.org/0000-0002-0719-1538","observed_orcids":["https://orcid.org/0000-0002-0719-1538"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ari Grinspan","raw_affiliation_strings":["Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017140014","display_name":"Bruce E. Sands","orcid":"https://orcid.org/0000-0001-5762-5042","observed_orcids":["https://orcid.org/0000-0001-5762-5042"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce E. Sands","raw_affiliation_strings":["Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States"],"raw_orcid":"https://orcid.org/0000-0001-5762-5042","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015470174","display_name":"Jean\u2010Fr\u00e9d\u00e9ric Colombel","orcid":"https://orcid.org/0000-0001-6472-249X","observed_orcids":["https://orcid.org/0000-0001-6472-249X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Frederic Colombel","raw_affiliation_strings":["Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States"],"raw_orcid":"https://orcid.org/0000-0001-6472-249X","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019801327","display_name":"Marla Cindy Dubinsky","orcid":"https://orcid.org/0000-0003-4968-5795","observed_orcids":["https://orcid.org/0000-0003-4968-5795"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marla C. Dubinsky","raw_affiliation_strings":["Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States","Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":"https://orcid.org/0000-0003-4968-5795","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York,NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049350088","display_name":"Jeremiah J. Faith","orcid":"https://orcid.org/0000-0002-2691-4500","observed_orcids":["https://orcid.org/0000-0002-2691-4500"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremiah J. Faith","raw_affiliation_strings":["Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Multiscale Biology, Icahn School of Medicine at MountSinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5049350088"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":1.0},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.859000027179718},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gnotobiotic-mice","display_name":"gnotobiotic mice","score":0.8600000143051147},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.6800000071525574},{"id":"https://openalex.org/keywords/microbiota-transplantation","display_name":"microbiota transplantation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.5490000247955322},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/microbial-pathogenesis","display_name":"microbial pathogenesis","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.8085015416145325},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7178924679756165},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.6759697198867798},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6739290952682495},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6577361822128296},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6360480785369873},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6141924262046814},{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.5432965755462646},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5081384181976318},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44686949253082275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38204890489578247},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0941297709941864},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.08031508326530457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.04534837603569031}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/276774","doi":"https://doi.org/10.1101/276774","is_oa":true,"landing_page_url":"https://doi.org/10.1101/276774","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/06/276774.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/276774","doi":"https://doi.org/10.1101/276774","is_oa":true,"landing_page_url":"https://doi.org/10.1101/276774","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/06/276774.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3120193702","display_name":"The relationship between host diet, the gut microbiota, and host transcription","funder_award_id":"R01GM108505","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4610885380","display_name":null,"funder_award_id":"362048","funder_id":"https://openalex.org/F4320306301","funder_display_name":"Crohn's and Colitis Foundation of America"},{"id":"https://openalex.org/G7800188239","display_name":null,"funder_award_id":"GM108505","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2796200035.pdf","grobid_xml":"https://content.openalex.org/works/W2796200035.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1515424972","https://openalex.org/W1977181138","https://openalex.org/W1979217507","https://openalex.org/W1993399595","https://openalex.org/W2002061924","https://openalex.org/W2002477604","https://openalex.org/W2011366548","https://openalex.org/W2057460314","https://openalex.org/W2078754045","https://openalex.org/W2085284704","https://openalex.org/W2092594052","https://openalex.org/W2095158284","https://openalex.org/W2097875133","https://openalex.org/W2107369528","https://openalex.org/W2110389012","https://openalex.org/W2116231168","https://openalex.org/W2125826412","https://openalex.org/W2126657409","https://openalex.org/W2128769815","https://openalex.org/W2135375882","https://openalex.org/W2137195441","https://openalex.org/W2141125135","https://openalex.org/W2143625465","https://openalex.org/W2143889757","https://openalex.org/W2151945971","https://openalex.org/W2210563832","https://openalex.org/W2287246374","https://openalex.org/W2289494545","https://openalex.org/W2469068457","https://openalex.org/W2527987309","https://openalex.org/W2558041282","https://openalex.org/W2587506066","https://openalex.org/W2588070196","https://openalex.org/W2588969346","https://openalex.org/W2744280559","https://openalex.org/W2750838281","https://openalex.org/W2765314233","https://openalex.org/W2767008704","https://openalex.org/W2768740883","https://openalex.org/W2784224081","https://openalex.org/W2786985471","https://openalex.org/W2951276546"],"related_works":["https://openalex.org/W2910577978","https://openalex.org/W3057557785","https://openalex.org/W2802097967","https://openalex.org/W2911098902","https://openalex.org/W2950376003","https://openalex.org/W2289494545","https://openalex.org/W2088989191","https://openalex.org/W2334595438","https://openalex.org/W3168497717","https://openalex.org/W2082471133"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"examine":[2],"the":[3,54,85,100],"functional":[4,106],"contribution":[5,117],"of":[6,56,69,84,108],"Inflammatory":[7],"Bowel":[8],"Disease":[9],"(IBD)":[10],"microbes":[11,110],"to":[12,36,42,118],"immune":[13],"homeostasis":[14],"and":[15,20,32,48,60,73,89,121,128],"colitis,":[16],"we":[17],"colonized":[18,98],"unchallenged":[19,57],"colitis-susceptible":[21,65,96],"germ-free":[22],"mice":[23,59,97],"with":[24,92,99],"over":[25],"twenty":[26],"human":[27,86,102],"intestinal":[28],"microbiotas":[29,40],"from":[30],"healthy":[31,37],"IBD":[33,39,109,119],"donors.":[34],"Compared":[35],"microbiotas,":[38],"led":[41],"expanded":[43],"ROR\u03b3t":[44,50,70,74],"+":[45,51,71,75],"Th17":[46,72],"cells":[47],"reduced":[49],"Treg":[52,76],"in":[53,64,95],"gut":[55],"gnotobiotic":[58],"increased":[61],"disease":[62,87,93],"severity":[63,94],"mice.":[66],"The":[67,104],"proportions":[68],"induced":[77],"by":[78],"each":[79],"microbiota":[80],"were":[81],"highly":[82],"predictive":[83],"status":[88],"strongly":[90],"correlated":[91],"same":[101],"microbiotas.":[103],"transmittable":[105],"potential":[107,123],"suggests":[111],"a":[112,115,122],"mechanism":[113],"for":[114,125],"microbial":[116],"pathogenesis":[120],"route":[124],"its":[126],"treatment":[127],"prevention.":[129]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-04-13T00:00:00"}
