{"id":"https://openalex.org/W2796197461","doi":"https://doi.org/10.7554/elife.37462","title":"Epigenetic age-predictor for mice based on three CpG sites","display_name":"Epigenetic age-predictor for mice based on three CpG sites","publication_year":2018,"publication_date":"2018-08-24","ids":{"openalex":"https://openalex.org/W2796197461","doi":"https://doi.org/10.7554/elife.37462","mag":"2796197461","pmid":"https://pubmed.ncbi.nlm.nih.gov/30142075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6156076"},"language":"en","primary_location":{"id":"doi:10.7554/elife.37462","doi":"https://doi.org/10.7554/elife.37462","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.37462","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.37462","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102765788","display_name":"Yang Han","orcid":"https://orcid.org/0000-0001-6249-370X","observed_orcids":["https://orcid.org/0000-0001-6249-370X"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yang Han","raw_affiliation_strings":["Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087368318","display_name":"Monika Eipel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Eipel","raw_affiliation_strings":["Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021696909","display_name":"Julia Franzen","orcid":"https://orcid.org/0000-0002-2459-5841","observed_orcids":["https://orcid.org/0000-0002-2459-5841"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Franzen","raw_affiliation_strings":["Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067463217","display_name":"Vadim Sakk","orcid":"https://orcid.org/0000-0001-5797-5851","observed_orcids":["https://orcid.org/0000-0001-5797-5851"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vadim Sakk","raw_affiliation_strings":["Institute of Molecular Medicine, Ulm University","Institute of Molecular Medicine, Ulm University, Ulm, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine, Ulm University","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Ulm University, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016906516","display_name":"Bertien Dethmers-Ausema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bertien Dethmers-Ausema","raw_affiliation_strings":["Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen","Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands;","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009825521","display_name":"Laura Yndriago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100188","display_name":"Biogipuzkoa Health Research Institute","ror":"https://ror.org/01a2wsa50","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210100188"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Yndriago","raw_affiliation_strings":["Tissue Engineering Laboratory, Instituto Biodonostia","Tissue Engineering Laboratory, Instituto Biodonostia, San Sebastian, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Engineering Laboratory, Instituto Biodonostia","institution_ids":["https://openalex.org/I4210100188"]},{"raw_affiliation_string":"Tissue Engineering Laboratory, Instituto Biodonostia, San Sebastian, Spain;","institution_ids":["https://openalex.org/I4210100188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064764958","display_name":"Ander Izeta","orcid":"https://orcid.org/0000-0003-1879-7401","observed_orcids":["https://orcid.org/0000-0003-1879-7401"]},"institutions":[{"id":"https://openalex.org/I4210100188","display_name":"Biogipuzkoa Health Research Institute","ror":"https://ror.org/01a2wsa50","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210100188"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ander Izeta","raw_affiliation_strings":["Department of Biomedical Engineering, School of Engineering, Tecnun-University of Navarra","Tissue Engineering Laboratory, Instituto Biodonostia","Department of Biomedical Engineering, School of Engineering, Tecnun-University of Navarra, San Sebastian, Spain;","Tissue Engineering Laboratory, Instituto Biodonostia, San Sebastian, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Engineering, Tecnun-University of Navarra","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Tissue Engineering Laboratory, Instituto Biodonostia","institution_ids":["https://openalex.org/I4210100188"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Engineering, Tecnun-University of Navarra, San Sebastian, Spain;","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Tissue Engineering Laboratory, Instituto Biodonostia, San Sebastian, Spain;","institution_ids":["https://openalex.org/I4210100188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025350377","display_name":"Gerald de Haan","orcid":"https://orcid.org/0000-0001-9706-0138","observed_orcids":["https://orcid.org/0000-0001-9706-0138"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerald de Haan","raw_affiliation_strings":["Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen","Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands;"],"raw_orcid":"https://orcid.org/0000-0001-9706-0138","affiliations":[{"raw_affiliation_string":"Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Laboratory of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands;","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009491648","display_name":"Hartmut Geiger","orcid":"https://orcid.org/0000-0002-5794-5430","observed_orcids":["https://orcid.org/0000-0002-5794-5430","https://orcid.org/0000-0001-7314-9891"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Hartmut Geiger","raw_affiliation_strings":["Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Burnet Campus","Institute of Molecular Medicine, Ulm University","Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Burnet Campus, Cincinnati, United States","Institute of Molecular Medicine, Ulm University, Ulm, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-5794-5430","affiliations":[{"raw_affiliation_string":"Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Burnet Campus","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Ulm University","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Burnet Campus, Cincinnati, United States","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Institute of Molecular Medicine, Ulm University, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026397452","display_name":"Wolfgang Wagner","orcid":"https://orcid.org/0000-0002-1971-3217","observed_orcids":["https://orcid.org/0000-0002-1971-3217","https://orcid.org/0000-0001-9781-4630","https://orcid.org/0000-0003-1187-2990"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfgang Wagner","raw_affiliation_strings":["Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-1971-3217","affiliations":[{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering \u2013 Cell Biology, University Hospital RWTH Aachen","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany;","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute for Biomedical Engineering -Cell Biology, University Hospital RWTH Aachen, Aachen, Germany;","institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5026397452"],"corresponding_institution_ids":["https://openalex.org/I4210120689","https://openalex.org/I887968799"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":2.3104,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.89593062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-clocks","display_name":"epigenetic clocks","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cpg-sites","display_name":"CpG sites","score":0.9129999876022339},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chronological-age-estimation","display_name":"chronological age estimation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/hsf4","display_name":"HSF4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dba-2-mice","display_name":"DBA/2 mice","score":0.8489999771118164},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9869999885559082},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.7730000019073486},{"id":"https://openalex.org/keywords/life-expectancy","display_name":"life expectancy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/blood-dna","display_name":"blood DNA","score":0.4560000002384186},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8746765851974487},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.8367992639541626},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7604620456695557},{"id":"https://openalex.org/C125009961","wikidata":"https://www.wikidata.org/wiki/Q2342248","display_name":"Pyrosequencing","level":3,"score":0.7306824922561646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6187084317207336},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5191123485565186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4319849908351898},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.41514265537261963},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3800511360168457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.359258770942688},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13239508867263794}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.7554/elife.37462","doi":"https://doi.org/10.7554/elife.37462","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.37462","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/296525","doi":"https://doi.org/10.1101/296525","is_oa":true,"landing_page_url":"https://doi.org/10.1101/296525","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/04/06/296525.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5100270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6156076","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6156076","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6156076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:30142075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30142075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:publications.rwth-aachen.de:757484","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/record/757484","pdf_url":"https://publications.rwth-aachen.de/record/757484/files/757484.pdf","source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife 7, (2018). doi:10.7554/eLife.37462","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d4d5e7d2aeee448d84054cba06812065","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d4d5e7d2aeee448d84054cba06812065","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 7 (2018)","raw_type":"article"},{"id":"pmh:oai:pure.rug.nl:openaire/ba63488a-f6cb-4097-a31b-e8198b575d45","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/ba63488a-f6cb-4097-a31b-e8198b575d45","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Han, Y, Eipel, M, Franzen, J, Sakk, V, Dethmers-Ausema, B, Yndriago, L, Izeta, A, de Haan, G, Geiger, H & Wagner, W 2018, 'Epigenetic age-predictor for mice based on three CpG sites', eLife, vol. 7, 37462. https://doi.org/10.7554/eLife.37462","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/ba63488a-f6cb-4097-a31b-e8198b575d45","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/ba63488a-f6cb-4097-a31b-e8198b575d45","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, 7:37462. ELIFE SCIENCES PUBLICATIONS LTD","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.18154/rwth-conv-237545","doi":"https://doi.org/10.18154/rwth-conv-237545","is_oa":true,"landing_page_url":"https://doi.org/10.18154/rwth-conv-237545","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.7554/elife.37462","doi":"https://doi.org/10.7554/elife.37462","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.37462","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1156388270","display_name":null,"funder_award_id":"GRK\u20102254","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1854950403","display_name":null,"funder_award_id":"SFBs1074","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G309324778","display_name":null,"funder_award_id":"WA1706/8-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3841898095","display_name":null,"funder_award_id":"GRK 2254 (HEIST)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3889987697","display_name":"Verbundvorhaben: OBELICS, Epigenetik der Osteoporose, Aachen","funder_award_id":"01KU1402B","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4058417565","display_name":null,"funder_award_id":"GRK-1789","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4868772416","display_name":null,"funder_award_id":"GRK1789 (CEMMA)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5620284192","display_name":"Cdc42, hematopoietic stem cell polarity, and cell fate","funder_award_id":"R01DK104814","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5913881499","display_name":null,"funder_award_id":"SFBs 1149","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5983203204","display_name":null,"funder_award_id":"2014-A193","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G6488085881","display_name":"Blood stem cell aging and biomarker studies","funder_award_id":"R01HL134617","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6546718588","display_name":null,"funder_award_id":"1789 CEMMA","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8430501550","display_name":null,"funder_award_id":"SFBs 1275","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1548504211","https://openalex.org/W1970128784","https://openalex.org/W1974047233","https://openalex.org/W2014945558","https://openalex.org/W2080644309","https://openalex.org/W2121091193","https://openalex.org/W2136970997","https://openalex.org/W2146794662","https://openalex.org/W2159536887","https://openalex.org/W2170324063","https://openalex.org/W2291827855","https://openalex.org/W2460742292","https://openalex.org/W2585981037","https://openalex.org/W2599102161","https://openalex.org/W2599323298","https://openalex.org/W2603290806","https://openalex.org/W2605265780","https://openalex.org/W2606865793","https://openalex.org/W2624876662","https://openalex.org/W2754926974","https://openalex.org/W2767983469","https://openalex.org/W2949100461","https://openalex.org/W2952009394"],"related_works":["https://openalex.org/W3114458182","https://openalex.org/W2606865793","https://openalex.org/W4281642574","https://openalex.org/W6958668650","https://openalex.org/W7136088297","https://openalex.org/W2605265780","https://openalex.org/W7167823104","https://openalex.org/W4393442281","https://openalex.org/W4321226621","https://openalex.org/W4412441048"],"abstract_inverted_index":{"Epigenetic":[0],"clocks":[1],"for":[2],"mice":[3,52],"were":[4],"generated":[5],"based":[6],"on":[7],"deep-sequencing":[8],"analysis":[9,18],"of":[10,19,43],"the":[11,32],"methylome.":[12],"Here,":[13],"we":[14],"demonstrate":[15],"that":[16],"site-specific":[17],"DNA":[20],"methylation":[21],"levels":[22],"by":[23],"pyrosequencing":[24],"at":[25],"only":[26],"three":[27],"CG":[28],"dinucleotides":[29],"(CpGs)":[30],"in":[31,46,64,82],"genes":[33],"Prima1":[34],",":[35,37],"Hsf4":[36],"and":[38,75],"Kcns1":[39],"facilitates":[40],"precise":[41],"estimation":[42],"chronological":[44],"age":[45,81],"murine":[47],"blood":[48],"samples,":[49],"too.":[50],"DBA/2":[51],"revealed":[53],"accelerated":[54],"epigenetic":[55],"aging":[56],"as":[57],"compared":[58],"to":[59,78],"C57BL6":[60],"mice,":[61],"which":[62],"is":[63],"line":[65],"with":[66,86],"their":[67],"shorter":[68],"life-expectancy.":[69],"The":[70],"three-CpG-predictor":[71],"provides":[72],"a":[73],"simple":[74],"cost-effective":[76],"biomarker":[77],"determine":[79],"biological":[80],"large":[83],"intervention":[84],"studies":[85],"mice.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-04-13T00:00:00"}