{"id":"https://openalex.org/W2796106907","doi":"https://doi.org/10.1021/acsnano.8b00999","title":"Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation","display_name":"Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation","publication_year":2018,"publication_date":"2018-04-03","ids":{"openalex":"https://openalex.org/W2796106907","doi":"https://doi.org/10.1021/acsnano.8b00999","mag":"2796106907","pmid":"https://pubmed.ncbi.nlm.nih.gov/29613770"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.8b00999","doi":"https://doi.org/10.1021/acsnano.8b00999","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.8b00999","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2796106907"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112506185","display_name":"Piao Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210163874","display_name":"Shanghai Institute of Ceramics","ror":"https://ror.org/05etnz140","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210163874"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768020","display_name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure","ror":"https://ror.org/03yvpw311","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Piao Zhu","raw_affiliation_strings":["State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People\u2019s Republic of China","University of Chinese Academy of Sciences, Beijing 100049, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People\u2019s Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, People\u2019s Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402072","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-8206-3325","observed_orcids":["https://orcid.org/0000-0002-8206-3325","https://orcid.org/0000-0003-3696-7267"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210163874","display_name":"Shanghai Institute of Ceramics","ror":"https://ror.org/05etnz140","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210163874"]},{"id":"https://openalex.org/I4391768020","display_name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure","ror":"https://ror.org/03yvpw311","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Chen","raw_affiliation_strings":["State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-8206-3325","affiliations":[{"raw_affiliation_string":"State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People\u2019s Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108427188","display_name":"Jianlin Shi","orcid":"https://orcid.org/0000-0001-8790-195X","observed_orcids":["https://orcid.org/0000-0001-8790-195X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210163874","display_name":"Shanghai Institute of Ceramics","ror":"https://ror.org/05etnz140","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210163874"]},{"id":"https://openalex.org/I4391768020","display_name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure","ror":"https://ror.org/03yvpw311","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianlin Shi","raw_affiliation_strings":["State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-8790-195X","affiliations":[{"raw_affiliation_string":"State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People\u2019s Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100402072","https://openalex.org/A5108427188"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210163874","https://openalex.org/I4391768020"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":23.7272,"has_fulltext":false,"cited_by_count":575,"citation_normalized_percentile":{"value":0.99892955,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"12","issue":"4","first_page":"3780","last_page":"3795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonodynamic-therapy","display_name":"sonodynamic therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nanozymes","display_name":"nanozymes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6620000004768372},{"id":"https://openalex.org/keywords/manganese-oxide","display_name":"manganese oxide","score":0.7080000042915344},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rgd-peptide-targeting","display_name":"RGD peptide targeting","score":0.6830000281333923},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8790000081062317},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2778448707","wikidata":"https://www.wikidata.org/wiki/Q7562147","display_name":"Sonodynamic therapy","level":3,"score":0.9424059391021729},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6543805003166199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4952332079410553},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4908059537410736},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.43149927258491516},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4218674302101135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3577658534049988},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32557249069213867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22604051232337952},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20458388328552246},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2018909752368927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08962836861610413},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.08314275741577148}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014464","descriptor_name":"Ultrasonic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017895","descriptor_name":"Manganese Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017895","descriptor_name":"Manganese Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsnano.8b00999","doi":"https://doi.org/10.1021/acsnano.8b00999","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.8b00999","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:29613770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29613770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4776012857","display_name":"\u57fa\u4e8e\u751f\u7269\u53ef\u964d\u89e3\u4ecb\u5b54\u6709\u673a\u7845\u7684\u80bf\u7624\u58f0\u52a8\u529b\u5b66\u6cbb\u7597\u7814\u7a76","funder_award_id":"51672303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4901774129","display_name":null,"funder_award_id":"13ZR1463500","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G6165824136","display_name":null,"funder_award_id":"2015QNRC001","funder_id":"https://openalex.org/F4320311778","funder_display_name":"China Association for Science and Technology"},{"id":"https://openalex.org/G6406660527","display_name":null,"funder_award_id":"51722211","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G733776351","display_name":null,"funder_award_id":"2016YFA0203700","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320311778","display_name":"China Association for Science and Technology","ror":"https://ror.org/035vmht26"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1596848781","https://openalex.org/W1969647873","https://openalex.org/W1973042724","https://openalex.org/W1979321972","https://openalex.org/W1979533984","https://openalex.org/W1983947806","https://openalex.org/W1996921023","https://openalex.org/W2005334224","https://openalex.org/W2012154711","https://openalex.org/W2013933536","https://openalex.org/W2016066595","https://openalex.org/W2022311699","https://openalex.org/W2032525153","https://openalex.org/W2036066786","https://openalex.org/W2038636572","https://openalex.org/W2061824793","https://openalex.org/W2065402868","https://openalex.org/W2070980891","https://openalex.org/W2072441208","https://openalex.org/W2078107514","https://openalex.org/W2078487098","https://openalex.org/W2081383070","https://openalex.org/W2093258954","https://openalex.org/W2100786926","https://openalex.org/W2102073707","https://openalex.org/W2109195587","https://openalex.org/W2111722444","https://openalex.org/W2112973557","https://openalex.org/W2130486648","https://openalex.org/W2139221798","https://openalex.org/W2142051359","https://openalex.org/W2159500589","https://openalex.org/W2165176035","https://openalex.org/W2167162804","https://openalex.org/W2169941975","https://openalex.org/W2176781298","https://openalex.org/W2228092569","https://openalex.org/W2231813729","https://openalex.org/W2298818955","https://openalex.org/W2305745682","https://openalex.org/W2313798780","https://openalex.org/W2331047899","https://openalex.org/W2331772460","https://openalex.org/W2344644350","https://openalex.org/W2401893904","https://openalex.org/W2415049266","https://openalex.org/W2465658363","https://openalex.org/W2489121689","https://openalex.org/W2504396398","https://openalex.org/W2511561583","https://openalex.org/W2516755196","https://openalex.org/W2522213855","https://openalex.org/W2551124141","https://openalex.org/W2554773181","https://openalex.org/W2561740859","https://openalex.org/W2562900174","https://openalex.org/W2580488838","https://openalex.org/W2588447509","https://openalex.org/W2645970620","https://openalex.org/W2737816133","https://openalex.org/W2745249303","https://openalex.org/W2752894674","https://openalex.org/W2753630838","https://openalex.org/W2755562689","https://openalex.org/W2764028271","https://openalex.org/W2765172570","https://openalex.org/W2766519575","https://openalex.org/W2781525129","https://openalex.org/W2791785017","https://openalex.org/W4236767042","https://openalex.org/W4246947635","https://openalex.org/W4251185210"],"related_works":["https://openalex.org/W4417238018","https://openalex.org/W3150994727","https://openalex.org/W4393377114","https://openalex.org/W4291011782","https://openalex.org/W3214575292","https://openalex.org/W3188544069","https://openalex.org/W7128630123","https://openalex.org/W3160964774","https://openalex.org/W4206471084","https://openalex.org/W4415711131"],"abstract_inverted_index":{"Ultrasound":[0],"(US)-triggered":[1],"sonodynamic":[2],"therapy":[3],"(SDT)":[4],"can":[5],"solve":[6],"the":[7,19,31,39,48,56,68,87,94,102,112,126,156,182,207],"critical":[8],"issue":[9],"of":[10,14,52,70,150,158,177],"low":[11],"tissue-penetrating":[12],"depth":[13],"traditional":[15],"phototriggered":[16],"therapies,":[17],"but":[18],"SDT":[20,40,144,167],"efficacy":[21,41,145],"is":[22],"still":[23],"not":[24],"satisfactorily":[25],"high":[26,170],"in":[27,101,171],"combating":[28],"cancer":[29],"at":[30],"current":[32],"stage.":[33],"Here":[34],"we":[35],"report":[36],"on":[37,43,162],"augmenting":[38],"based":[42],"catalytic":[44,50],"nanomedicine,":[45],"which":[46,131],"takes":[47],"efficient":[49],"features":[51],"nanoenzymes":[53],"to":[54,135,190],"modulate":[55],"tumor":[57,127,160],"microenvironment":[58],"(TME).":[59],"The":[60,97,147,169],"multifunctional":[61,179],"nanosonosensitizers":[62,153,180],"have":[63,184],"been":[64,133,186],"successfully":[65],"constructed":[66],"by":[67,82],"integration":[69],"a":[71],"MnO":[72,98],"x":[73,99],"component":[74,100],"with":[75,84],"biocompatible/biodegradable":[76],"hollow":[77],"mesoporous":[78],"organosilica":[79],"nanoparticles,":[80],"followed":[81],"conjugation":[83],"protoporphyrin":[85],"(as":[86,93],"sonosensitizer)":[88],"and":[89,124,142,174,188,196,212],"cyclic":[90],"arginine-glycine-aspartic":[91],"pentapeptide":[92],"targeting":[95],"peptide).":[96],"composite":[103,152],"nanosonosensitizer":[104],"acts":[105],"as":[106],"an":[107],"inorganic":[108],"nanoenzyme":[109],"for":[110,209],"converting":[111],"tumor-overexpressed":[113],"hydrogen":[114],"peroxide":[115],"(H":[116],"2":[117,119],"O":[118],")":[120],"molecules":[121],"into":[122],"oxygen":[123,128,139],"enhancing":[125],"level":[129],"subsequently,":[130],"has":[132],"demonstrated":[134,189],"facilitate":[136],"SDT-induced":[137],"reactive":[138],"species":[140],"production":[141],"enhance":[143],"subsequently.":[146],"targeted":[148],"accumulation":[149],"these":[151,178],"efficiently":[154],"suppressed":[155],"growth":[157],"U87":[159],"xenograft":[161],"nude":[163],"mice":[164],"after":[165],"US-triggered":[166],"treatment.":[168],"vivo":[172],"biocompatibility":[173],"easy":[175],"excretion":[176],"from":[181],"body":[183],"also":[185],"evaluated":[187],"guarantee":[191],"their":[192,197],"future":[193],"clinical":[194],"translation,":[195],"TME-responsive":[198],"T":[199],"1":[200],"-weighted":[201],"magnetic":[202],"resonance":[203],"imaging":[204],"capability":[205],"provides":[206],"potential":[208],"therapeutic":[210],"guidance":[211],"monitoring":[213],"during":[214],"SDT.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":48},{"year":2024,"cited_by_count":64},{"year":2023,"cited_by_count":77},{"year":2022,"cited_by_count":92},{"year":2021,"cited_by_count":105},{"year":2020,"cited_by_count":90},{"year":2019,"cited_by_count":61},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2018-04-13T00:00:00"}