{"id":"https://openalex.org/W2795832011","doi":"https://doi.org/10.3126/jpn.v8i1.19442","title":"Diagnostic utility of trophoblastic cell surface antigen 2 immunohistochemical expression in papillary thyroid carcinoma","display_name":"Diagnostic utility of trophoblastic cell surface antigen 2 immunohistochemical expression in papillary thyroid carcinoma","publication_year":2018,"publication_date":"2018-04-03","ids":{"openalex":"https://openalex.org/W2795832011","doi":"https://doi.org/10.3126/jpn.v8i1.19442","mag":"2795832011"},"language":"en","primary_location":{"id":"doi:10.3126/jpn.v8i1.19442","doi":"https://doi.org/10.3126/jpn.v8i1.19442","is_oa":true,"landing_page_url":"https://doi.org/10.3126/jpn.v8i1.19442","pdf_url":"https://www.nepjol.info/index.php/JPN/article/download/19442/16013","source":{"id":"https://openalex.org/S2764964372","display_name":"Journal of Pathology of Nepal","issn_l":"2091-0908","issn":["2091-0908","2091-0797"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-1"],"host_organization":"https://openalex.org/P4310319254","host_organization_name":"Association of Clinical Pathologists of Nepal","host_organization_lineage":["https://openalex.org/P4310319254"],"host_organization_lineage_names":["Association of Clinical Pathologists of Nepal"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pathology of Nepal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.nepjol.info/index.php/JPN/article/download/19442/16013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002767805","display_name":"Hafez H Nesreen","orcid":"https://orcid.org/0000-0001-6608-3230","observed_orcids":["https://orcid.org/0000-0001-6608-3230"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hafez H Nesreen","raw_affiliation_strings":["National Cancer Institute, Cairo University"],"raw_orcid":"https://orcid.org/0000-0001-6608-3230","affiliations":[{"raw_affiliation_string":"National Cancer Institute, Cairo University","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076936462","display_name":"Manal Z. Shalaby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shalaby Z Manal","raw_affiliation_strings":["National Cancer Institute, Cairo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Cairo University","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113055998","display_name":"Ahmed M. Mohamed","orcid":"https://orcid.org/0009-0002-9929-5525","observed_orcids":["https://orcid.org/0009-0002-9929-5525"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed M Mohamed","raw_affiliation_strings":["National Cancer Institute, Cairo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Cairo University","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":null,"apc_paid":null,"fwci":0.5469,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66468981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":"1","first_page":"1235","last_page":"1243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trop2","display_name":"TROP2","score":0.8389999866485596},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9330000281333923},{"id":"https://openalex.org/keywords/immunohistochemical-markers","display_name":"immunohistochemical markers","score":0.7910000085830688},{"id":"https://openalex.org/keywords/follicular-thyroid-adenoma","display_name":"follicular adenoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/thyroid-cytology","display_name":"thyroid cytology","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7581921815872192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7278186678886414},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7143420577049255},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6773958206176758},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6493207216262817},{"id":"https://openalex.org/C2779022025","wikidata":"https://www.wikidata.org/wiki/Q53829","display_name":"Thyroid nodules","level":3,"score":0.5603581666946411},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5124521851539612},{"id":"https://openalex.org/C2778057883","wikidata":"https://www.wikidata.org/wiki/Q92793969","display_name":"Follicular cell","level":3,"score":0.4704500734806061},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4153691232204437},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.41068702936172485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16446444392204285}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3126/jpn.v8i1.19442","doi":"https://doi.org/10.3126/jpn.v8i1.19442","is_oa":true,"landing_page_url":"https://doi.org/10.3126/jpn.v8i1.19442","pdf_url":"https://www.nepjol.info/index.php/JPN/article/download/19442/16013","source":{"id":"https://openalex.org/S2764964372","display_name":"Journal of Pathology of Nepal","issn_l":"2091-0908","issn":["2091-0908","2091-0797"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-1"],"host_organization":"https://openalex.org/P4310319254","host_organization_name":"Association of Clinical Pathologists of Nepal","host_organization_lineage":["https://openalex.org/P4310319254"],"host_organization_lineage_names":["Association of Clinical Pathologists of Nepal"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pathology of Nepal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:78dfbd6b792546788ba26db34c8b5444","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/78dfbd6b792546788ba26db34c8b5444","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pathology of Nepal, Vol 8, Iss 1, Pp 1235-1243 (2018)","raw_type":"article"},{"id":"doi:10.60692/gm40z-9fs87","doi":"https://doi.org/10.60692/gm40z-9fs87","is_oa":true,"landing_page_url":"https://doi.org/10.60692/gm40z-9fs87","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/vb863-dn439","doi":"https://doi.org/10.60692/vb863-dn439","is_oa":true,"landing_page_url":"https://doi.org/10.60692/vb863-dn439","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3126/jpn.v8i1.19442","doi":"https://doi.org/10.3126/jpn.v8i1.19442","is_oa":true,"landing_page_url":"https://doi.org/10.3126/jpn.v8i1.19442","pdf_url":"https://www.nepjol.info/index.php/JPN/article/download/19442/16013","source":{"id":"https://openalex.org/S2764964372","display_name":"Journal of Pathology of Nepal","issn_l":"2091-0908","issn":["2091-0908","2091-0797"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-1"],"host_organization":"https://openalex.org/P4310319254","host_organization_name":"Association of Clinical Pathologists of Nepal","host_organization_lineage":["https://openalex.org/P4310319254"],"host_organization_lineage_names":["Association of Clinical Pathologists of Nepal"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pathology of Nepal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2795832011.pdf","grobid_xml":"https://content.openalex.org/works/W2795832011.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1974320281","https://openalex.org/W1990601892","https://openalex.org/W1990998243","https://openalex.org/W2000245188","https://openalex.org/W2035088817","https://openalex.org/W2095159278","https://openalex.org/W2100592376","https://openalex.org/W2102187896","https://openalex.org/W2102661246","https://openalex.org/W2134029536","https://openalex.org/W2145150141","https://openalex.org/W2158004190","https://openalex.org/W2188271125","https://openalex.org/W2202026164","https://openalex.org/W2238521829","https://openalex.org/W2313223491","https://openalex.org/W2441024320","https://openalex.org/W2467373303","https://openalex.org/W2478590544","https://openalex.org/W2523492732","https://openalex.org/W2576193143","https://openalex.org/W6889133309"],"related_works":["https://openalex.org/W3021221645","https://openalex.org/W2441024320","https://openalex.org/W4414294920","https://openalex.org/W3109084895","https://openalex.org/W2937444650","https://openalex.org/W7161576522","https://openalex.org/W2134029536","https://openalex.org/W7214712685","https://openalex.org/W3197721421","https://openalex.org/W2313223491"],"abstract_inverted_index":{"Background:":[0],"Although":[1],"nuclear":[2,31],"criteria":[3],"are":[4],"considered":[5,137],"to":[6,28,62,72,227],"be":[7],"characteristic":[8],"for":[9],"papillary":[10,20],"thyroid":[11,21,25,74,128,208],"carcinoma,":[12],"some":[13],"cases":[14],"do":[15],"raise":[16],"controversy":[17],"as":[18],"being":[19],"carcinoma":[22,26],"or":[23,133,205,216],"non-papillary":[24],"due":[27],"unclear":[29],"diagnostic":[30,67],"features.":[32],"Immunohistochemical":[33,107],"markers":[34],"can":[35],"help":[36],"in":[37,69,224,234],"identifying":[38],"PTC.":[39],"Trophoblastic":[40],"cell":[41,83,121],"surface":[42],"antigen":[43],"2":[44],"(TROP-2)":[45],"is":[46,51],"a":[47],"novel":[48],"marker":[49],"that":[50],"recently":[52],"applied":[53,112],"on":[54,79,113,214],"thyroid.":[55],"The":[56,148],"aim":[57],"of":[58,109,123,143,202],"this":[59],"study":[60,91],"was":[61,92,111,136,157,221],"evaluate":[63],"TROP-2":[64,110,146,166,193,211,219],"expression":[65],"and":[66,82,87,104,118,125,162,168,171,184,195,199,239],"utility":[68],"PTC":[70,124,144,177,225,232,249],"compared":[71,226],"other":[73,126,229],"nodules":[75],"with":[76,132],"follicular":[77,127,187],"pattern":[78],"tissue":[80],"specimens":[81,238],"block":[84],"sections.":[85],"Materials":[86],"Methods:":[88],"This":[89],"retrospective":[90],"carried":[93],"out":[94],"at":[95],"National":[96],"Cancer":[97],"Institute,":[98],"Cairo":[99],"University":[100],"between":[101,159],"January":[102,105],"2010":[103],"2015.":[106],"evaluation":[108],"archival":[114],"110":[115],"surgically":[116],"excised":[117,140],"66":[119],"cytological":[120,174,217,240],"blocks":[122],"nodules.":[129],"Membranous":[130],"staining,":[131],"without":[134],"cytoplasm,":[135],"positive.Results:":[138],"Among":[139,173],"specimens,":[141],"85.1%":[142,170],"demonstrated":[145],"staining.":[147,152],"majority":[149],"revealed":[150],"diffuse":[151],"No":[153,242],"significant":[154,244],"staining":[155,245],"difference":[156,246],"reported":[158,243],"studied":[160,230,248],"classic":[161,164],"non":[163,231],"variants.":[165],"sensitivity":[167,194],"were":[169,178,189,197],"94.4%.":[172],"materials,":[175],"all":[176,228],"positive":[179,190],"except":[180],"two":[181,186],"(false":[182,191],"negative)":[183],"only":[185],"adenomas":[188],"positive).":[192],"specificity":[196],"93.8%":[198],"94.1%.":[200],"None":[201],"nodular":[203],"hyperplasia":[204],"adjacent":[206],"normal":[207],"tissues":[209],"showed":[210],"immunoreactivity":[212],"either":[213],"histopathological":[215],"sections.Conclusion:":[218],"positivity":[220],"significantly":[222],"higher":[223],"lesion":[233],"both":[235],"surgical":[236],"pathology":[237],"materials.":[241],"among":[247],"variant.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-04-13T00:00:00"}