{"id":"https://openalex.org/W2795263753","doi":"https://doi.org/10.1093/schbul/sby014.126","title":"31. OPTIMISE-ING THE TREATMENT OF FIRST-EPISODE SCHIZOPHRENIA","display_name":"31. OPTIMISE-ING THE TREATMENT OF FIRST-EPISODE SCHIZOPHRENIA","publication_year":2018,"publication_date":"2018-03-31","ids":{"openalex":"https://openalex.org/W2795263753","doi":"https://doi.org/10.1093/schbul/sby014.126","mag":"2795263753"},"language":"en","primary_location":{"id":"doi:10.1093/schbul/sby014.126","doi":"https://doi.org/10.1093/schbul/sby014.126","is_oa":true,"landing_page_url":"https://doi.org/10.1093/schbul/sby014.126","pdf_url":"https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S49/25466309/sby014.126.pdf","source":{"id":"https://openalex.org/S117485531","display_name":"Schizophrenia Bulletin","issn_l":"0586-7614","issn":["0586-7614","1745-1701","1745-1707"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Bulletin","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S49/25466309/sby014.126.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002872855","display_name":"Celso Arango","orcid":"https://orcid.org/0000-0003-3382-4754","observed_orcids":["https://orcid.org/0000-0003-3382-4754"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Celso Arango","raw_affiliation_strings":["Hospital General Universitario Gregorio Mara\u00f1on"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General Universitario Gregorio Mara\u00f1on","institution_ids":["https://openalex.org/I2960094004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002872855"],"corresponding_institution_ids":["https://openalex.org/I2960094004"],"apc_list":{"value":4981,"currency":"USD","value_usd":4981},"apc_paid":{"value":4981,"currency":"USD","value_usd":4981},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"suppl_1","first_page":"S49","last_page":"S49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/first-episode-schizophrenia","display_name":"first-episode schizophrenia","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2778999636","wikidata":"https://www.wikidata.org/wiki/Q418785","display_name":"Amisulpride","level":4,"score":0.8965375423431396},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.720710039138794},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6184436082839966},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.5743793845176697},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5563743710517883},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5551809072494507},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5081787109375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45069390535354614},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3970538377761841}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/schbul/sby014.126","doi":"https://doi.org/10.1093/schbul/sby014.126","is_oa":true,"landing_page_url":"https://doi.org/10.1093/schbul/sby014.126","pdf_url":"https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S49/25466309/sby014.126.pdf","source":{"id":"https://openalex.org/S117485531","display_name":"Schizophrenia Bulletin","issn_l":"0586-7614","issn":["0586-7614","1745-1701","1745-1707"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Bulletin","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4824391","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5888363","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5888363","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5888363","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophr Bull","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/schbul/sby014.126","doi":"https://doi.org/10.1093/schbul/sby014.126","is_oa":true,"landing_page_url":"https://doi.org/10.1093/schbul/sby014.126","pdf_url":"https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S49/25466309/sby014.126.pdf","source":{"id":"https://openalex.org/S117485531","display_name":"Schizophrenia Bulletin","issn_l":"0586-7614","issn":["0586-7614","1745-1701","1745-1707"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2795263753.pdf","grobid_xml":"https://content.openalex.org/works/W2795263753.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2794770086","https://openalex.org/W2159545811","https://openalex.org/W2142820908","https://openalex.org/W2939285944","https://openalex.org/W7023905760","https://openalex.org/W2886339749","https://openalex.org/W2887629140","https://openalex.org/W2890881145","https://openalex.org/W3130226917","https://openalex.org/W3013918216"],"abstract_inverted_index":{"Overall":[0],"Abstract:":[1],"Even":[2],"if":[3],"there":[4],"have":[5,85,218],"been":[6,79,221],"effective":[7],"antipsychotic":[8,75,313],"treatments":[9,19,103],"for":[10,49,201,230,390,425],"more":[11,402],"than":[12,403],"fifty":[13],"years,":[14],"the":[15,45,62,138,173,199,231,242,268,299,305,323,331,342,394,418,455,487,492],"implementation":[16],"of":[17,32,124,128,149,210,225,270,304,308,325,335,345,401,423,427,451,468,486],"these":[18,144,193,496],"in":[20,61,91,130,146,184,234,263,317,327,393,431,491,494],"clinical":[21,118,395,419,503],"practice":[22],"is":[23,40,65,120,132,360],"still":[24,58],"far":[25],"from":[26,215,241],"optimal,":[27],"and":[28,109,114,126,158,167,181,197,223,322,354,379,383,397,421,445,472,474,478,504],"a":[29,147,185,235,250,264,277,280,363,370,374,398],"significant":[30],"amount":[31],"patients":[33,50,152,246,318,329,391],"with":[34,51,153,207,279,314,498],"schizophrenia":[35,53,452],"show":[36],"poor":[37],"outcomes.":[38],"It":[39,64],"unquestionable":[41],"that":[42,76,142],"antipsychotics":[43,163],"remain":[44],"first":[46,232,251,300,332,449],"treatment":[47,350],"option":[48,269],"first-episode":[52],"(FES).":[54],"However,":[55],"several":[56],"questions":[57,145,196],"demand":[59],"answer":[60],"field.":[63],"unclear":[66],"how":[67,82,110,441],"long":[68,83],"we":[69,84,94],"should":[70],"wait":[71,87],"before":[72,88],"changing":[73],"an":[74,133,170,312,484],"has":[77],"not":[78,219,255,287,319],"fully":[80],"effective,":[81],"to":[86,101,111,162,189,192,276,311,348,457],"starting":[89],"clozapine":[90,293,326],"FES,":[92],"whether":[93],"can":[95,453],"identify":[96],"who":[97],"will":[98,227],"respond":[99],"better":[100],"current":[102],"using":[104],"biological":[105],"markers":[106,447],"including":[107],"neuroimaging,":[108,179],"improve":[112,349,355],"adherence":[113],"functional":[115,356],"prognosis":[116],"after":[117,258,290,358],"remission":[119,257,289,359],"achieved.":[121],"OPTiMiSE":[122,261,296,337,385,416,435,462],"(\u2018Optimisation":[123],"Treatment":[125],"Management":[127],"Schizophrenia":[129],"Europe\u2019)":[131],"European":[134],"Consortium":[135,174],"funded":[136],"under":[137],"VII":[139],"Framework":[140],"Program":[141],"addressed":[143],"sample":[148,188,400],"nearly":[150],"500":[151],"FES":[154],"or":[155,274],"schizophreniform":[156],"psychosis":[157],"minimal":[159],"prior":[160],"exposure":[161],"recruited":[164],"across":[165],"Europe":[166],"Israel.":[168],"Within":[169],"integrative":[171],"framework,":[172],"aimed":[175],"at":[176,448],"combining":[177],"clinical,":[178],"genetic":[180,444],"biochemical":[182,446],"data":[183],"large":[186],"representative":[187],"provide":[190],"answers":[191],"clinically":[194],"relevant":[195],"prepare":[198],"field":[200],"personalised":[202],"medication":[203,381],"strategies":[204],"as":[205,249],"drugs":[206],"novel":[208,438],"mechanisms":[209],"action":[211],"become":[212],"available.":[213],"Results":[214],"this":[216,414],"study":[217],"yet":[220],"published":[222],"most":[224],"them":[226],"be":[228],"presented":[229],"time":[233],"Congress.":[236],"Based":[237,412],"on":[238,272,341,413,440,501],"previous":[239],"results":[240,489],"EUFEST":[243],"study,":[244],"all":[245,495],"received":[247],"amisulpride":[248,273],"step.":[252],"For":[253,460],"those":[254,286],"achieving":[256,288,320],"4":[259],"weeks,":[260,292],"compared":[262],"randomised":[265,366],"double-blind":[266],"fashion":[267],"staying":[271],"moving":[275],"drug":[278],"different":[281,315],"receptor-binding":[282],"profile,":[283],"olanzapine.":[284],"In":[285,433],"6":[291],"was":[294],"started.":[295],"thus":[297],"constitutes":[298],"systematic,":[301],"large-scale":[302],"testing":[303,369],"potential":[306],"benefits":[307],"early":[309],"switching":[310],"characteristics":[316],"remission,":[321],"application":[324],"non-remitting":[328],"within":[330],"10":[333],"weeks":[334],"treatment.":[336,459],"also":[338,386,436],"provides":[339],"information":[340,439],"added":[343],"value":[344],"psychosocial":[346],"interventions":[347],"adherence,":[351],"reduce":[352],"relapses":[353],"outcomes":[357],"achieved,":[361],"through":[362],"1-year":[364],"follow-up":[365],"controlled":[367],"trial":[368,396],"web-based":[371],"program":[372],"comprising":[373],"motivational":[375],"intervention":[376],"package,":[377],"psychoeducation,":[378],"electronic":[380],"alerts":[382],"updates.":[384],"collected":[387],"blood":[388],"samples":[389],"participating":[392],"systematic":[399],"200":[404],"standardised,":[405],"high-quality,":[406],"magnetic":[407],"resonance":[408],"imaging":[409],"(MRI)":[410],"images.":[411],"information,":[415],"examined":[417],"utility":[420],"cost-effectiveness":[422],"MRI":[424,442],"screening":[426],"underlying":[428],"organic":[429],"conditions":[430],"FES.":[432],"addition,":[434],"offers":[437,483],"alterations,":[443],"presentation":[450],"predict":[454],"response":[456],"subsequent":[458],"this,":[461],"used":[463],"two":[464],"broad":[465],"strategies\u2014a":[466],"combination":[467],"technology-driven":[469],"(pharmacogenetics,":[470],"proteomics,":[471],"metabolomics)":[473],"hypothesis-driven":[475],"(neuroimaging,":[476],"neurochemical,":[477],"immune-related)":[479],"markers.":[480],"This":[481],"symposium":[482],"overview":[485],"main":[488],"obtained":[490],"project":[493],"areas,":[497],"special":[499],"focus":[500],"their":[502],"research":[505],"implications.":[506]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-04-06T00:00:00"}