{"id":"https://openalex.org/W2794890152","doi":"https://doi.org/10.1093/toxsci/kfy060","title":"Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate","display_name":"Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate","publication_year":2018,"publication_date":"2018-03-18","ids":{"openalex":"https://openalex.org/W2794890152","doi":"https://doi.org/10.1093/toxsci/kfy060","mag":"2794890152","pmid":"https://pubmed.ncbi.nlm.nih.gov/29596660","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5974788"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfy060","doi":"https://doi.org/10.1093/toxsci/kfy060","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfy060","pdf_url":"https://academic.oup.com/toxsci/article-pdf/163/2/543/25092867/kfy060.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxsci/article-pdf/163/2/543/25092867/kfy060.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078078702","display_name":"Medjda Bellamri","orcid":"https://orcid.org/0000-0002-6477-967X","observed_orcids":["https://orcid.org/0000-0002-6477-967X"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Medjda Bellamri","raw_affiliation_strings":["Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101874612","display_name":"Shun Xiao","orcid":"https://orcid.org/0000-0002-1292-3705","observed_orcids":["https://orcid.org/0000-0002-1292-3705"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shun Xiao","raw_affiliation_strings":["Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building","institution_ids":["https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025580110","display_name":"Paari J Murugan","orcid":"https://orcid.org/0000-0003-4706-213X","observed_orcids":["https://orcid.org/0000-0003-4706-213X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paari Murugan","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091808340","display_name":"Christopher Weight","orcid":"https://orcid.org/0000-0001-9381-959X","observed_orcids":["https://orcid.org/0000-0001-9381-959X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J Weight","raw_affiliation_strings":["Department of Urology, University of Minnesota, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043108427","display_name":"Robert J. Turesky","orcid":"https://orcid.org/0000-0001-7355-9903","observed_orcids":["https://orcid.org/0000-0001-7355-9903"]},"institutions":[{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert J Turesky","raw_affiliation_strings":["Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building"],"raw_orcid":"https://orcid.org/0000-0001-7355-9903","affiliations":[{"raw_affiliation_string":"Masonic Cancer Center and Department of Medicinal Chemistry, Cancer and Cardiovascular Research Building","institution_ids":["https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043108427"],"corresponding_institution_ids":["https://openalex.org/I4390039358"],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":1.1434,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.72488534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"163","issue":"2","first_page":"543","last_page":"556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phip","display_name":"PhIP","score":0.9490000009536743},{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.7089999914169312},{"id":"https://openalex.org/keywords/n-hydroxylation","display_name":"N-hydroxylation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/n-acetyltransferase-2","display_name":"N-acetyltransferase 2","score":0.7509999871253967},{"id":"https://openalex.org/keywords/sulfotransferase-1a1","display_name":"sulfotransferase 1A1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.746999979019165},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mefenamic-acid","display_name":"mefenamic acid","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pentachlorophenol","display_name":"pentachlorophenol","score":0.8669999837875366},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8660986423492432},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8242752552032471},{"id":"https://openalex.org/C2777278644","wikidata":"https://www.wikidata.org/wiki/Q2758348","display_name":"Heterocyclic amine","level":3,"score":0.7069676518440247},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.7038847208023071},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5562081933021545},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5271974205970764},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4321848452091217},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.4304526746273041},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33831191062927246},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.24075055122375488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11668175458908081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10478124022483826},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06910350918769836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003296","descriptor_name":"Cooking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008460","descriptor_name":"Meat","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065767","descriptor_name":"Activation, Metabolic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/toxsci/kfy060","doi":"https://doi.org/10.1093/toxsci/kfy060","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfy060","pdf_url":"https://academic.oup.com/toxsci/article-pdf/163/2/543/25092867/kfy060.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5511630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5974788","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5974788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5974788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Sci","raw_type":"Text"},{"id":"pmid:29596660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29596660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/toxsci/kfy060","doi":"https://doi.org/10.1093/toxsci/kfy060","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfy060","pdf_url":"https://academic.oup.com/toxsci/article-pdf/163/2/543/25092867/kfy060.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1965713349","display_name":"University of Minnesota Clinical and Translational Science Institute (UMN CTSI)","funder_award_id":"UL1TR000114","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G317676174","display_name":null,"funder_award_id":"UL1TR000114","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G3260651813","display_name":"University of Minnesota Clinical and TranslationalmScience Institute (UMN CTSI)","funder_award_id":"UL1TR002494","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3995966747","display_name":null,"funder_award_id":"R01CA122320","funder_id":"https://openalex.org/F4320333173","funder_display_name":"Masonic Cancer Center, University of Minnesota"},{"id":"https://openalex.org/G5307859921","display_name":null,"funder_award_id":"077598","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6475838726","display_name":"Chemical markers of heterocyclic aromatic amines for human biomonitoring","funder_award_id":"R01CA122320","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6774997124","display_name":null,"funder_award_id":"CA-077598","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G9000895342","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA077598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333173","display_name":"Masonic Cancer Center, University of Minnesota","ror":"https://ror.org/05x083d20"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794890152.pdf","grobid_xml":"https://content.openalex.org/works/W2794890152.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W158216169","https://openalex.org/W1558196660","https://openalex.org/W1587782877","https://openalex.org/W1597660082","https://openalex.org/W1626151883","https://openalex.org/W1762202522","https://openalex.org/W1788400410","https://openalex.org/W1941284977","https://openalex.org/W1963710011","https://openalex.org/W1968243484","https://openalex.org/W1972017349","https://openalex.org/W1985370051","https://openalex.org/W1989098779","https://openalex.org/W1993650800","https://openalex.org/W2001340405","https://openalex.org/W2005338000","https://openalex.org/W2006226839","https://openalex.org/W2007805496","https://openalex.org/W2008559725","https://openalex.org/W2009366846","https://openalex.org/W2010279746","https://openalex.org/W2014352349","https://openalex.org/W2023176174","https://openalex.org/W2026519146","https://openalex.org/W2040112705","https://openalex.org/W2048039062","https://openalex.org/W2052144048","https://openalex.org/W2054125495","https://openalex.org/W2060273330","https://openalex.org/W2068499154","https://openalex.org/W2072084995","https://openalex.org/W2072828753","https://openalex.org/W2073609059","https://openalex.org/W2074512495","https://openalex.org/W2078895698","https://openalex.org/W2087498613","https://openalex.org/W2093769252","https://openalex.org/W2094019696","https://openalex.org/W2096775785","https://openalex.org/W2116891307","https://openalex.org/W2118370328","https://openalex.org/W2118579163","https://openalex.org/W2121518362","https://openalex.org/W2128635872","https://openalex.org/W2130431955","https://openalex.org/W2133443143","https://openalex.org/W2140472745","https://openalex.org/W2153718061","https://openalex.org/W2164041166","https://openalex.org/W2223049285","https://openalex.org/W2235523093","https://openalex.org/W2255287849","https://openalex.org/W2312755649","https://openalex.org/W2324080174","https://openalex.org/W2347065066","https://openalex.org/W2415326388","https://openalex.org/W2552402250","https://openalex.org/W2584155830","https://openalex.org/W2612388336","https://openalex.org/W4212858597","https://openalex.org/W6636766209","https://openalex.org/W6674676251","https://openalex.org/W6677356627","https://openalex.org/W6680448686","https://openalex.org/W6682730085"],"related_works":["https://openalex.org/W2118579163","https://openalex.org/W2027112291","https://openalex.org/W2151604732","https://openalex.org/W2118370328","https://openalex.org/W2117513632","https://openalex.org/W2126378665","https://openalex.org/W2111828865","https://openalex.org/W2413867703","https://openalex.org/W2058274153","https://openalex.org/W1748485383"],"abstract_inverted_index":{"2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine":[0],"(PhIP),":[1],"an":[2],"heterocyclic":[3],"aromatic":[4],"amine":[5],"(HAA)":[6],"formed":[7,46,129],"in":[8,26,47,66,87,103,169,203,216,227,243],"cooked":[9,48,88],"meat,":[10],"is":[11,197],"a":[12,140],"rodent":[13,244],"and":[14,39,63,75,82,93,153,158,175,192,245],"possible":[15],"human":[16,68,176,246],"prostate":[17,30,69,177,217],"carcinogen.":[18],"Recently,":[19],"we":[20],"identified":[21],"DNA":[22,76,179],"adducts":[23,34,77,128,148],"of":[24,29,35,58,134,143,156,172,181,206,213,234,241],"PhIP":[25],"the":[27,56,67,162,204,209,223,231,238],"genome":[28],"cancer":[31],"patients,":[32],"but":[33,114],"2-amino-3,":[36],"8-dimethylmidazo[4,5-f]quinoxaline":[37],"(MeIQx)":[38],"2-amino-9":[40],"H-pyrido[2,3-b]indole":[41],"(A\u03b1C),":[42],"other":[43,116,131],"prominent":[44],"HAAs":[45,59],"meats,":[49,89],"were":[50,90,100],"not":[51,94,115],"detected.":[52],"We":[53],"have":[54],"investigated":[55],"bioactivation":[57,205],"by":[60,149,166,183],"Phase":[61,107],"I":[62],"II":[64,108],"enzymes":[65],"(LNCaP)":[70],"cell":[71],"line":[72],"using":[73],"cytotoxicity":[74],"as":[78],"endpoints.":[79],"PhIP,":[80],"MeIQx,":[81],"2-amino-3-methylimidazo[4,5-f]quinoline,":[83],"another":[84],"HAA":[85],"found":[86],"poorly":[91],"bioactivated":[92],"toxic.":[95],"The":[96],"synthetic":[97],"genotoxic":[98],"N-hydroxylated-HAAs":[99],"also":[101],"assayed":[102],"LNCaP":[104,135,173,235],"cells":[105,136,174,236],"with":[106,130,137],"enzyme":[109],"inhibitors.":[110],"Notably,":[111],"2-hydroxy-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine":[112],"(HONH-PhIP),":[113],"HONH-HAAs,":[117],"induced":[118],"cytotoxicity.":[119],"Moreover,":[120],"PhIP-DNA":[121,147,163,228],"adduct":[122,164],"formation":[123],"was":[124],"20-fold":[125],"greater":[126,187],"than":[127,189],"HONH-HAAs.":[132],"Pretreatment":[133],"mefenamic":[138],"acid,":[139],"specific":[141],"inhibitor":[142],"sulfotransferase":[144],"(SULT1A1),":[145],"decreased":[146,161],"25%,":[150],"whereas":[151],"(Z)-5-(2'-hydroxybenzylidene)-2-thioxothiazolidin-4-one":[152],"pentachlorophenol,":[154],"inhibitors":[155],"SULTs":[157],"N-acetyltransferases":[159],"(NATs),":[160],"levels":[165,188,212],"75%.":[167],"NATs":[168],"cytosolic":[170],"fractions":[171],"catalyzed":[178],"binding":[180],"HONH-PhIP":[182,242],"up":[184],"to":[185,200],"100-fold":[186],"for":[190],"SULT":[191],"kinase":[193],"activities.":[194],"Recombinant":[195],"NAT2":[196,214],"catalytically":[198],"superior":[199],"recombinant":[201],"NAT1":[202,220],"HONH-PhIP;":[207],"however,":[208],"extremely":[210],"low":[211],"activity":[215],"suggest":[218],"that":[219],"may":[221],"be":[222],"major":[224],"isoform":[225],"involved":[226],"damage.":[229],"Thus,":[230],"high":[232],"susceptibility":[233],"recapitulates":[237],"DNA-damaging":[239],"effect":[240],"prostate.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-04-06T00:00:00"}