{"id":"https://openalex.org/W27946293","doi":"https://doi.org/10.1007/978-0-387-35135-3_2","title":"APP Biology, Processing and Function","display_name":"APP Biology, Processing and Function","publication_year":2007,"publication_date":"2007-02-15","ids":{"openalex":"https://openalex.org/W27946293","doi":"https://doi.org/10.1007/978-0-387-35135-3_2","mag":"27946293"},"language":"en","primary_location":{"id":"doi:10.1007/978-0-387-35135-3_2","doi":"https://doi.org/10.1007/978-0-387-35135-3_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-0-387-35135-3_2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer\u2019s Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4233332369","display_name":"Alzheimer\u2019s Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100328217","display_name":"Gopal Thinakaran","orcid":"https://orcid.org/0000-0001-5523-6780","observed_orcids":["https://orcid.org/0000-0001-5523-6780"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gopal Thinakaran","raw_affiliation_strings":["Department of Neurobiology Pharmacology and Physiology, The University of Chicago, Chicago, Illinois, 60637","The University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology Pharmacology and Physiology, The University of Chicago, Chicago, Illinois, 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084447225","display_name":"Edward H. Koo","orcid":"https://orcid.org/0000-0003-1337-8806","observed_orcids":["https://orcid.org/0000-0003-1337-8806"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward H. Koo","raw_affiliation_strings":["Department of Neurosciences, University of California San Diego, La Jolla, California, 92093","University of California,  San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California San Diego, La Jolla, California, 92093","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"University of California,  San Diego","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2797,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92326025,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"17","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9779999852180481},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.9490000009536743},{"id":"https://openalex.org/keywords/app-trafficking","display_name":"APP trafficking","score":0.8949999809265137},{"id":"https://openalex.org/keywords/aplp1","display_name":"APLP1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/aplp2","display_name":"APLP2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.722000002861023},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alzheimer-s-disease-pathogenesis","display_name":"Alzheimer's disease pathogenesis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8610000014305115},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7576718330383301},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7242481112480164},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6214044690132141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4937838017940521},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4919857680797577},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.32719388604164124},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2537544369697571},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24912169575691223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1831493377685547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08568936586380005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-0-387-35135-3_2","doi":"https://doi.org/10.1007/978-0-387-35135-3_2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-0-387-35135-3_2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer\u2019s Disease","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1483703465","https://openalex.org/W1485747833","https://openalex.org/W1491712897","https://openalex.org/W1502820594","https://openalex.org/W1564861448","https://openalex.org/W1572225000","https://openalex.org/W1762207349","https://openalex.org/W1770101373","https://openalex.org/W1867778453","https://openalex.org/W1900601199","https://openalex.org/W1933062072","https://openalex.org/W1955491145","https://openalex.org/W1963833196","https://openalex.org/W1971256323","https://openalex.org/W1971856927","https://openalex.org/W1973716796","https://openalex.org/W1975775468","https://openalex.org/W1975806945","https://openalex.org/W1982237245","https://openalex.org/W1985988204","https://openalex.org/W1988927287","https://openalex.org/W1988986946","https://openalex.org/W1994891930","https://openalex.org/W2003890494","https://openalex.org/W2008027183","https://openalex.org/W2009111659","https://openalex.org/W2018358250","https://openalex.org/W2025888688","https://openalex.org/W2029205666","https://openalex.org/W2030355018","https://openalex.org/W2030508474","https://openalex.org/W2038516967","https://openalex.org/W2038977910","https://openalex.org/W2040732053","https://openalex.org/W2041581676","https://openalex.org/W2041622179","https://openalex.org/W2042255467","https://openalex.org/W2046402345","https://openalex.org/W2048210493","https://openalex.org/W2050111346","https://openalex.org/W2051646172","https://openalex.org/W2055022577","https://openalex.org/W2056409809","https://openalex.org/W2056745213","https://openalex.org/W2057707351","https://openalex.org/W2057712792","https://openalex.org/W2057840062","https://openalex.org/W2058908104","https://openalex.org/W2062405228","https://openalex.org/W2063272219","https://openalex.org/W2063899343","https://openalex.org/W2067772115","https://openalex.org/W2070823032","https://openalex.org/W2072199290","https://openalex.org/W2074438246","https://openalex.org/W2075264721","https://openalex.org/W2079302243","https://openalex.org/W2079438371","https://openalex.org/W2082022687","https://openalex.org/W2082211142","https://openalex.org/W2082438248","https://openalex.org/W2083003238","https://openalex.org/W2090703486","https://openalex.org/W2090737341","https://openalex.org/W2091475538","https://openalex.org/W2096464090","https://openalex.org/W2108285073","https://openalex.org/W2108649886","https://openalex.org/W2113934386","https://openalex.org/W2114353725","https://openalex.org/W2130763296","https://openalex.org/W2134385751","https://openalex.org/W2139599612","https://openalex.org/W2146143136","https://openalex.org/W2149117501","https://openalex.org/W2150596288","https://openalex.org/W2160524771","https://openalex.org/W2161021536","https://openalex.org/W2164990833","https://openalex.org/W2169555689","https://openalex.org/W2170250556","https://openalex.org/W2171776741","https://openalex.org/W4319290839"],"related_works":["https://openalex.org/W2171735284","https://openalex.org/W2776024739","https://openalex.org/W2155863144","https://openalex.org/W2057672006","https://openalex.org/W4385549535","https://openalex.org/W7095993586","https://openalex.org/W2460219222","https://openalex.org/W193117575","https://openalex.org/W2035880294","https://openalex.org/W1982942777"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}