{"id":"https://openalex.org/W27941216","doi":null,"title":"Hereditary angioedema: modification of clinical manifestations with androgens.","display_name":"Hereditary angioedema: modification of clinical manifestations with androgens.","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W27941216","mag":"27941216","pmid":"https://pubmed.ncbi.nlm.nih.gov/974251"},"language":"en","primary_location":{"id":"pmid:974251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/974251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects original article series","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026374179","display_name":"Philip J. Davis","orcid":"https://orcid.org/0000-0002-6913-2058","observed_orcids":["https://orcid.org/0000-0002-6913-2058"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P J Davis","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019179538","display_name":"Faith B. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F B Davis","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015554918","display_name":"Patricia Charache","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Charache","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00231829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"6","first_page":"283","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":1.0},{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.8090000152587891},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.8840000033378601},{"id":"https://openalex.org/keywords/fluoxymesterone","display_name":"fluoxymesterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxymetholone","display_name":"oxymetholone","score":0.9810000061988831},{"id":"https://openalex.org/keywords/attack-frequency-reduction","display_name":"attack frequency reduction","score":0.5379999876022339},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5370000004768372},{"id":"https://openalex.org/keywords/long-term-corticosteroid-therapy","display_name":"long-term corticosteroid therapy","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.8787111043930054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7372732162475586},{"id":"https://openalex.org/C2777482430","wikidata":"https://www.wikidata.org/wiki/Q7168709","display_name":"Peripheral edema","level":3,"score":0.717956006526947},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.6977847218513489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5198160409927368},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.48172834515571594},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.4486163854598999},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.403522789478302},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37655460834503174},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3229900300502777},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.29897627234458923},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.06008976697921753}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005474","descriptor_name":"Fluoxymesterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010110","descriptor_name":"Oxymetholone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:974251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/974251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects original article series","raw_type":"Journal Article"},{"id":"mag:27941216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/974251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1178778297","https://openalex.org/W1547216586","https://openalex.org/W1570233039","https://openalex.org/W1965498876","https://openalex.org/W1975489439","https://openalex.org/W1982484050","https://openalex.org/W1983357763","https://openalex.org/W1987344938","https://openalex.org/W1987882040","https://openalex.org/W1990139802","https://openalex.org/W1990780034","https://openalex.org/W1997064567","https://openalex.org/W1997280214","https://openalex.org/W2001090095","https://openalex.org/W2006111363","https://openalex.org/W2011508078","https://openalex.org/W2011614525","https://openalex.org/W2015017184","https://openalex.org/W2018046176","https://openalex.org/W2027218428","https://openalex.org/W2032807860","https://openalex.org/W2033316320","https://openalex.org/W2035812542","https://openalex.org/W2038302418","https://openalex.org/W2047886043","https://openalex.org/W2058743791","https://openalex.org/W2059021156","https://openalex.org/W2069819211","https://openalex.org/W2071433447","https://openalex.org/W2074118570","https://openalex.org/W2075290880","https://openalex.org/W2076517608","https://openalex.org/W2078225148","https://openalex.org/W2080166653","https://openalex.org/W2081135727","https://openalex.org/W2092383094","https://openalex.org/W2093803225","https://openalex.org/W2097059887","https://openalex.org/W2123687712","https://openalex.org/W2127481999","https://openalex.org/W2131359209","https://openalex.org/W2132290252","https://openalex.org/W2136890362","https://openalex.org/W2140925895","https://openalex.org/W2142988890","https://openalex.org/W2143460256","https://openalex.org/W2143658065","https://openalex.org/W2163036793","https://openalex.org/W2163386417","https://openalex.org/W2256440089","https://openalex.org/W2281236496","https://openalex.org/W2335708867","https://openalex.org/W2335841220"],"related_works":["https://openalex.org/W309826541","https://openalex.org/W2411152961","https://openalex.org/W4307923203","https://openalex.org/W1972464670","https://openalex.org/W2461208210","https://openalex.org/W4233377763","https://openalex.org/W2040372651","https://openalex.org/W7095553703","https://openalex.org/W1991987876","https://openalex.org/W2111601124"],"abstract_inverted_index":{"HAE":[0],"is":[1,21],"an":[2],"autosomal":[3],"dominant":[4],"trait":[5],"of":[6,11,26,35,44,55,57],"decreased":[7,52],"levels":[8],"or":[9],"function":[10],"circulating":[12],"and":[13,29,41],"tissue":[14],"C'1":[15],"esterase":[16],"inhibitor.":[17],"The":[18],"clinical":[19],"illness":[20],"characterized":[22],"by":[23],"disabling":[24],"episodes":[25],"peripheral,":[27],"oropharyngeal":[28],"gut-wall":[30],"edema.":[31],"Long-term":[32],"fluoxymesterone":[33],"treatment":[34,43],"5":[36],"affected":[37,46],"males":[38],"(393":[39],"patient-months)":[40,49],"oxymetholone":[42],"6":[45],"females":[47],"(204":[48],"has":[50],"significantly":[51],"the":[53],"frequency":[54],"attacks":[56],"edema":[58],"without":[59],"substantive":[60],"side":[61],"effects.":[62]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}