{"id":"https://openalex.org/W2793789153","doi":"https://doi.org/10.1016/s2352-3026(18)30020-6","title":"Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial","display_name":"Ready-to-use food supplement, with or without arginine and citrulline, with daily chloroquine in Tanzanian children with sickle-cell disease: a double-blind, random order crossover trial","publication_year":2018,"publication_date":"2018-03-13","ids":{"openalex":"https://openalex.org/W2793789153","doi":"https://doi.org/10.1016/s2352-3026(18)30020-6","mag":"2793789153","pmid":"https://pubmed.ncbi.nlm.nih.gov/29548623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5871644"},"language":"en","primary_location":{"id":"doi:10.1016/s2352-3026(18)30020-6","doi":"https://doi.org/10.1016/s2352-3026(18)30020-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2352-3026(18)30020-6","pdf_url":"http://www.thelancet.com/article/S2352302618300206/pdf","source":{"id":"https://openalex.org/S2531671668","display_name":"The Lancet Haematology","issn_l":"2352-3026","issn":["2352-3026","2451-9960"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.thelancet.com/article/S2352302618300206/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008075671","display_name":"Sharon Elizabeth Cox","orcid":"https://orcid.org/0000-0002-9908-2936","observed_orcids":["https://orcid.org/0000-0002-9908-2936"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["GB","JP","TZ"],"is_corresponding":true,"raw_author_name":"Sharon E Cox","raw_affiliation_strings":["Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. Electronic address: sharon.cox@lshtm.ac.uk","Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK","Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. Electronic address: sharon.cox@lshtm.ac.uk","institution_ids":["https://openalex.org/I154840374","https://openalex.org/I4210089966","https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044335246","display_name":"Elizabeth A. Ellins","orcid":"https://orcid.org/0000-0001-5164-6416","observed_orcids":["https://orcid.org/0000-0001-5164-6416"]},"institutions":[{"id":"https://openalex.org/I39586589","display_name":"Swansea University","ror":"https://ror.org/053fq8t95","country_code":"GB","type":"education","lineage":["https://openalex.org/I39586589"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth A Ellins","raw_affiliation_strings":["Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea, UK","institution_ids":["https://openalex.org/I39586589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043860389","display_name":"Alphonce Ignace Marealle","orcid":"https://orcid.org/0000-0002-9864-5469","observed_orcids":["https://orcid.org/0000-0002-9864-5469"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Alphonce I Marealle","raw_affiliation_strings":["Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014291864","display_name":"Charles R. J. C. Newton","orcid":"https://orcid.org/0000-0002-6999-5507","observed_orcids":["https://orcid.org/0000-0002-6999-5507"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]},{"id":"https://openalex.org/I2803066836","display_name":"Warneford Hospital","ror":"https://ror.org/03we1zb10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802171185","https://openalex.org/I2803066836"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB","TZ"],"is_corresponding":false,"raw_author_name":"Charles R Newton","raw_affiliation_strings":["Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK","Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK","Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK","institution_ids":["https://openalex.org/I154840374","https://openalex.org/I2803066836","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK","institution_ids":["https://openalex.org/I2803066836","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111471489","display_name":"Deogratias Soka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Deogratias Soka","raw_affiliation_strings":["Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037005894","display_name":"Philip Galula Sasi","orcid":"https://orcid.org/0000-0002-9911-8302","observed_orcids":["https://orcid.org/0000-0002-9911-8302"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Philip Sasi","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056130529","display_name":"Gian Luca Di Tanna","orcid":"https://orcid.org/0000-0002-5470-3567","observed_orcids":["https://orcid.org/0000-0002-5470-3567"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gian Luca Di Tanna","raw_affiliation_strings":["Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK; Centre for Primary Care and Public Health, Queen Mary University of London, London, UK","Centre for Primary Care and Public Health, Queen Mary University of London, London, UK","Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK; Centre for Primary Care and Public Health, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Centre for Primary Care and Public Health, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079"]},{"raw_affiliation_string":"Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071822488","display_name":"William Johnson","orcid":"https://orcid.org/0000-0002-0347-4354","observed_orcids":["https://orcid.org/0000-0002-0347-4354"]},"institutions":[{"id":"https://openalex.org/I143804889","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365","country_code":"GB","type":"education","lineage":["https://openalex.org/I143804889"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Johnson","raw_affiliation_strings":["School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, UK","institution_ids":["https://openalex.org/I143804889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050401653","display_name":"Julie Makani","orcid":"https://orcid.org/0000-0002-4801-6250","observed_orcids":["https://orcid.org/0000-0002-4801-6250"]},"institutions":[{"id":"https://openalex.org/I154840374","display_name":"Muhimbili University of Health and Allied Sciences","ror":"https://ror.org/027pr6c67","country_code":"TZ","type":"education","lineage":["https://openalex.org/I154840374"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Julie Makani","raw_affiliation_strings":["Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"Department of Haematology, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]},{"raw_affiliation_string":"Muhimbili Wellcome Programme, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I154840374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018797559","display_name":"Andrew M. Prentice","orcid":"https://orcid.org/0000-0001-5389-451X","observed_orcids":["https://orcid.org/0000-0001-5389-451X"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]},{"id":"https://openalex.org/I4210116687","display_name":"MRC Unit the Gambia","ror":"https://ror.org/025wfj672","country_code":"GM","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210089966","https://openalex.org/I4210116687","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB","GM"],"is_corresponding":false,"raw_author_name":"Andrew M Prentice","raw_affiliation_strings":["Medical Research Council Unit The Gambia, London School of Hygiene & Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit The Gambia, London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966","https://openalex.org/I4210116687","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001317469","display_name":"Julian Halcox","orcid":"https://orcid.org/0000-0001-6926-2947","observed_orcids":["https://orcid.org/0000-0001-6926-2947"]},"institutions":[{"id":"https://openalex.org/I39586589","display_name":"Swansea University","ror":"https://ror.org/053fq8t95","country_code":"GB","type":"education","lineage":["https://openalex.org/I39586589"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julian P Halcox","raw_affiliation_strings":["Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea, UK","institution_ids":["https://openalex.org/I39586589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002772850","display_name":"Fenella Jane Kirkham","orcid":"https://orcid.org/0000-0002-2443-7958","observed_orcids":["https://orcid.org/0000-0002-2443-7958"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fenella J Kirkham","raw_affiliation_strings":["Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London, UK; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK; University Child Health, University Hospital Southampton, Southampton, UK","Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK","Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London, UK","University Child Health, University Hospital Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London, UK; Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK; University Child Health, University Hospital Southampton, Southampton, UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University Child Health, University Hospital Southampton, Southampton, UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5008075671"],"corresponding_institution_ids":["https://openalex.org/I154840374","https://openalex.org/I4210089966","https://openalex.org/I43777268"],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":{"value":5351,"currency":"EUR","value_usd":5771},"fwci":3.9998,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.94283758,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"4","first_page":"e147","last_page":"e160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10596","display_name":"Child Nutrition and Water Access","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ready-to-use-supplementary-food","display_name":"ready-to-use supplementary food","score":0.949999988079071},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.7160000205039978},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":1.0},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-energy-supplementation","display_name":"protein-energy supplementation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/malnutrition","display_name":"malnutrition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.843999981880188},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9150000214576721},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasma-arginine","display_name":"plasma arginine","score":0.7720000147819519},{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9589999914169312},{"id":"https://openalex.org/keywords/height-for-age","display_name":"height-for-age","score":0.7889999747276306},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7960000038146973},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tanzania","display_name":"Tanzania","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.750328779220581},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.711228609085083},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6358396410942078},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6071369051933289},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.5892794728279114},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4513024091720581},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.429911732673645},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4134593605995178},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4009605348110199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3858200013637543},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.3615734279155731},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.35228925943374634},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3359958529472351},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19481906294822693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13286522030830383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12400811910629272},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1224229633808136},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002956","descriptor_name":"Citrulline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013636","descriptor_name":"Tanzania","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1016/s2352-3026(18)30020-6","doi":"https://doi.org/10.1016/s2352-3026(18)30020-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2352-3026(18)30020-6","pdf_url":"http://www.thelancet.com/article/S2352302618300206/pdf","source":{"id":"https://openalex.org/S2531671668","display_name":"The Lancet Haematology","issn_l":"2352-3026","issn":["2352-3026","2451-9960"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Haematology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5871644","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5871644","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet Haematol","raw_type":"Text"},{"id":"pmid:29548623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29548623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Haematology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:419005","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1016/S2352-3026(18)30020-6>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4647062","doi":null,"is_oa":false,"landing_page_url":"https://orcid.org/0000-0002-9908-2936>","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dspace.lboro.ac.uk:2134/28159","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/28159","pdf_url":null,"source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10043675","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10043675/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Lancet Haematology , 5 (4) e147-e160. (2018)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/9621281","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Ready-to-use_food_supplement_with_or_without_arginine_and_citrulline_with_daily_chloroquine_in_Tanzanian_children_with_sickle-cell_disease_a_double-blind_random_order_crossover_trial/9621281","pdf_url":null,"source":{"id":"https://openalex.org/S4306402585","display_name":"Loughborough University Research Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:afecbb8f-92f1-4b25-924e-9a1c98b6c8ab","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:afecbb8f-92f1-4b25-924e-9a1c98b6c8ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"mag:2789023244","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/10043675/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/s2352-3026(18)30020-6","doi":"https://doi.org/10.1016/s2352-3026(18)30020-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s2352-3026(18)30020-6","pdf_url":"http://www.thelancet.com/article/S2352302618300206/pdf","source":{"id":"https://openalex.org/S2531671668","display_name":"The Lancet Haematology","issn_l":"2352-3026","issn":["2352-3026","2451-9960"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.6735000014305115,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1402059805","display_name":"Body size trajectories and cardio-metabolic resilience to obesity in three United Kingdom birth cohorts","funder_award_id":"MR/P023347/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4721147309","display_name":null,"funder_award_id":"WT-095009","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8070557304","display_name":null,"funder_award_id":"WT094780","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313322","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320276","display_name":"University of Leicester","ror":"https://ror.org/04h699437"},{"id":"https://openalex.org/F4320320341","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365"},{"id":"https://openalex.org/F4320320637","display_name":"Great Ormond Street Hospital Charity","ror":"https://ror.org/03vjq7x94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336780","display_name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","ror":"https://ror.org/033rx1153"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2793789153.pdf","grobid_xml":"https://content.openalex.org/works/W2793789153.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1192008708","https://openalex.org/W1506693633","https://openalex.org/W1849785625","https://openalex.org/W1907505545","https://openalex.org/W1974869729","https://openalex.org/W1977844791","https://openalex.org/W1999936817","https://openalex.org/W2012026140","https://openalex.org/W2030806407","https://openalex.org/W2034023936","https://openalex.org/W2037275940","https://openalex.org/W2039919755","https://openalex.org/W2043340279","https://openalex.org/W2046030426","https://openalex.org/W2049292864","https://openalex.org/W2054738348","https://openalex.org/W2068218670","https://openalex.org/W2073869392","https://openalex.org/W2082017799","https://openalex.org/W2082679209","https://openalex.org/W2083590885","https://openalex.org/W2093841568","https://openalex.org/W2099637593","https://openalex.org/W2109642048","https://openalex.org/W2113611856","https://openalex.org/W2122055594","https://openalex.org/W2125281699","https://openalex.org/W2136471728","https://openalex.org/W2136502543","https://openalex.org/W2144681723","https://openalex.org/W2150027863","https://openalex.org/W2153799024","https://openalex.org/W2157510814","https://openalex.org/W2159244719","https://openalex.org/W2166315054","https://openalex.org/W2170995347","https://openalex.org/W2227461870","https://openalex.org/W2309975949","https://openalex.org/W2336555111","https://openalex.org/W2547613834"],"related_works":["https://openalex.org/W2789023244","https://openalex.org/W2781946162","https://openalex.org/W1737282042","https://openalex.org/W2588613740","https://openalex.org/W143756522","https://openalex.org/W4321784346","https://openalex.org/W2791963889","https://openalex.org/W1547834900","https://openalex.org/W4409777297","https://openalex.org/W4224070435"],"abstract_inverted_index":{"Background":[0],"Sickle-cell":[1],"disease":[2],"increases":[3],"the":[4,34,70,78,122,230,238,265,286,359,374,380,409,416,424,489,498,511,527],"risk":[5],"of":[6,59,72,141,182,187,194,264,268,330,343,348,411,500,514],"malnutrition.":[7],"Low":[8],"arginine":[9,46,174,188,246,251,344,381,425,549,557],"and":[10,41,47,64,80,134,167,175,189,196,250,256,277,298,306,319,325,358,376,437,463,472,482,506,550,559,579,582],"nitric":[11,60],"oxide":[12],"bioavailability":[13],"are":[14,24,566],"implicated":[15],"in":[16,27,69,85,110,114,236,488,526,537,541,584],"morbidity":[17],"related":[18],"to":[19,32,132,178,214,247,252,316,322,345,355,366,382,396,407,426,555,568,575],"sickle-cell":[20,88,544,587],"disease.":[21,89,545,588],"Simple":[22],"interventions":[23,271],"required,":[25],"especially":[26],"low-income":[28],"settings.":[29],"We":[30,91,117],"aimed":[31],"test":[33],"hypotheses":[35],"that:":[36],"(1)":[37],"supplementary":[38,74],"arginine,":[39,245],"citrulline,":[40],"daily":[42,201],"chloroquine":[43,156,162,202,206],"increase":[44],"bioavailable":[45],"flow-mediated":[48],"dilatation":[49],"(FMD;":[50],"maximal":[51],"diameter":[52],"change;":[53],"FMD":[54,258,361,443],"max":[55,259,362,444],"%),":[56],"a":[57,93,224],"measure":[58],"oxide-dependent":[61],"endothelial":[62,562],"function;":[63],"(2)":[65],"protein":[66],"energy":[67],"supplementation":[68],"form":[71],"ready-to-use":[73],"food":[75],"(RUSF)":[76],"improves":[77],"height-for-age":[79,274,473],"body-mass":[81,278,466],"index-for-age":[82,279,467],"Z":[83,275,280,468,474],"-scores":[84],"children":[86,120,152,199,311,315,321,327,333,542],"with":[87,99,150,173,197,294,299,392,415,450,480,543,586],"Methods":[90],"performed":[92],"double-blind,":[94],"random":[95],"order":[96],"crossover":[97],"trial":[98,291],"two":[100,239],"4-month":[101,107],"intervention":[102,413,461],"periods":[103],"(each":[104],"followed":[105],"by":[106,389],"washout":[108,225,422,483,512,529],"periods)":[109],"Muhimbili":[111,123],"National":[112],"Hospital":[113],"Dar-es-Salaam,":[115],"Tanzania.":[116],"enrolled":[118],"119":[119,326],"from":[121],"Sickle":[124],"Cohort":[125],"who":[126,524],"were":[127,146,211,227,242,272,283,312,328,493,504,518],"aged":[128],"8\u201312":[129],"years,":[130],"naive":[131],"hydroxyurea,":[133],"had":[135],"documented":[136],"HbSS":[137],"phenotype.":[138],"Two":[139],"formulations":[140,241],"RUSF":[142,240,270,532,553],"(providing":[143],"500":[144,534],"kcal/day)":[145],"tested:":[147],"basic":[148],"(RUSF-b),":[149],"which":[151,170,198,501,515],"also":[153],"received":[154,200],"weekly":[155],"(150":[157],"mg":[158,161,205],"or":[159,219,420],"225":[160],"base,":[163],"dependent":[164],"on":[165,285],"bodyweight);":[166],"vascular":[168],"(RUSF-v),":[169],"was":[171,386,446],"fortified":[172],"citrulline":[176,551],"(designed":[177],"achieve":[179],"mean":[180,243,257,273,360],"intakes":[181],"0\u00b72":[183],"g/kg":[184,191],"per":[185,192,208],"day":[186,193],"0\u00b71":[190],"citrulline),":[195],"(maximum":[203],"3":[204],"base/kg":[207],"day).":[209],"Children":[210],"randomly":[212],"allocated":[213],"receive":[215],"either":[216,460],"RUSF-b":[217,323,375,393,438,456],"first":[218,221,318],"RUSF-v":[220,317,377,390,433,451],"and,":[222],"after":[223,448],"period,":[226],"then":[228],"given":[229],"other":[231],"treatment.":[232],"The":[233,261,341],"primary":[234,262],"outcomes":[235,263,578],"comparing":[237],"plasma":[244],"ornithine":[248,346],"ratio,":[249,255],"asymmetric":[253,383,427],"dimethylarginine":[254,384,428],"%.":[260],"combined":[266],"effect":[267,410],"both":[269,432],"-score":[276,469,475],"-score.":[281],"Analyses":[282],"done":[284],"eligible":[287],"intention-to-treat":[288],"population.":[289],"This":[290],"is":[292],"registered":[293],"ClinicalTrials.gov,":[295],"number":[296],"NCT01718054;":[297],"ISRCTN74331412.":[300],"Findings":[301],"Between":[302],"Aug":[303],"9,":[304],"2012,":[305],"Feb":[307],"26,":[308],"2014,":[309],"145":[310],"randomised":[313],"(71":[314],"74":[320],"first)":[324],"treated,":[329],"whom":[331],"114":[332],"yielded":[334],"complete":[335],"data":[336],"for":[337],"all":[338],"reported":[339],"endpoints.":[340],"ratio":[342,385,429],"(mean":[347],"individual":[349],"differences":[350],"\u22128\u00b767%,":[351],"95%":[352],"CI":[353],"\u221219\u00b755":[354],"2\u00b720;":[356],"p=0\u00b712)":[357],"%":[363,445],"(1\u00b700,":[364],"\u22120\u00b747":[365],"2\u00b747;":[367],"p=0\u00b718)":[368],"did":[369],"not":[370,455],"significantly":[371,387],"differ":[372],"between":[373],"treatments.":[378],"However,":[379,442,546],"increased":[388,430,478],"compared":[391,414,479],"(56\u00b726%,":[394],"31\u00b713":[395],"81\u00b738;":[397],"p<0\u00b70001).":[398,441],"In":[399,485],"planned":[400],"analyses":[401],"that":[402],"used":[403],"mixed":[404],"effects":[405,573],"models":[406],"estimate":[408],"each":[412],"participants":[417,487],"at":[418],"baseline":[419,481],"during":[421,497,510],"periods,":[423,513],"following":[431],"treatment":[434,439,449],"(86%;":[435],"p<0\u00b70001)":[436,453],"(40%;":[440],"higher":[447],"(0\u00b792;":[452],"but":[454],"(0\u00b739;":[457],"p=0\u00b722).":[458],"Following":[459],"(RUSF-b":[462],"RUSF-v,":[464],"pooled)":[465],"(0\u00b7091;":[470],"p=0\u00b7001)":[471],"(0\u00b7013;":[476],"p=0\u00b7081)":[477],"timepoints.":[484],"83":[486],"treated":[490],"population,":[491],"there":[492],"71":[494],"adverse":[495,508],"events":[496,509],"intervention,":[499],"21":[502],"(30%)":[503],"serious,":[505],"81":[507],"26":[516],"(32%)":[517],"serious":[519],"(p=0\u00b731),":[520],"including":[521],"one":[522],"patient":[523],"died":[525],"second":[528],"period.":[530],"Interpretation":[531],"providing":[533],"kcal/day":[535],"results":[536],"small":[538],"weight":[539],"gains":[540],"even":[547],"without":[548],"fortification,":[552],"seems":[554],"ameliorate":[556],"dysregulation":[558],"might":[560],"improve":[561],"function.":[563],"Long-term":[564],"studies":[565],"required":[567],"assess":[569],"whether":[570],"these":[571],"physiological":[572],"translate":[574],"improved":[576],"clinical":[577],"better":[580],"growth":[581],"development":[583],"patients":[585],"Funding":[589],"Wellcome":[590],"Trust.":[591]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}