{"id":"https://openalex.org/W2793663847","doi":null,"title":"Microglia and astrocytoma cells express alkylindole-sensitive receptors","display_name":"Microglia and astrocytoma cells express alkylindole-sensitive receptors","publication_year":2014,"publication_date":"2014-10-13","ids":{"openalex":"https://openalex.org/W2793663847","mag":"2793663847"},"language":"en","primary_location":{"id":"pmh:oai:digital.lib.washington.edu:1773/26072","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/26072","pdf_url":"https://digital.lib.washington.edu:443/researchworks/bitstream/1773/26072/1/Fung_washington_0250E_13200.pdf","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digital.lib.washington.edu:443/researchworks/bitstream/1773/26072/1/Fung_washington_0250E_13200.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009307107","display_name":"Susan Fung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susan Fung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009307107"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/st11","display_name":"ST11","score":0.9929999709129333},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/microglial-migration","display_name":"microglial migration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5389999747276306},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8038395643234253},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.6581688523292542},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5896385908126831},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5126366019248962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35303232073783875},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.25512266159057617},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25225234031677246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22264516353607178},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.13961458206176758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10055544972419739}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digital.lib.washington.edu:1773/26072","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/26072","pdf_url":"https://digital.lib.washington.edu:443/researchworks/bitstream/1773/26072/1/Fung_washington_0250E_13200.pdf","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:digital.lib.washington.edu:1773/26582","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1773/26582","pdf_url":null,"source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2793663847","doi":null,"is_oa":false,"landing_page_url":"https://digital.lib.washington.edu:443/researchworks/handle/1773/26582","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.lib.washington.edu:1773/26072","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/26072","pdf_url":"https://digital.lib.washington.edu:443/researchworks/bitstream/1773/26072/1/Fung_washington_0250E_13200.pdf","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2793663847.pdf","grobid_xml":"https://content.openalex.org/works/W2793663847.grobid-xml"},"referenced_works_count":161,"referenced_works":["https://openalex.org/W7389608","https://openalex.org/W1495651595","https://openalex.org/W1524310794","https://openalex.org/W1528808852","https://openalex.org/W1528827595","https://openalex.org/W1543575007","https://openalex.org/W1559459501","https://openalex.org/W1596721271","https://openalex.org/W1600542667","https://openalex.org/W1607901775","https://openalex.org/W1629776612","https://openalex.org/W1819429514","https://openalex.org/W1844263281","https://openalex.org/W1849819493","https://openalex.org/W1883661543","https://openalex.org/W1893117746","https://openalex.org/W1912636290","https://openalex.org/W1928931031","https://openalex.org/W1931308193","https://openalex.org/W1938950485","https://openalex.org/W1940834207","https://openalex.org/W1940894649","https://openalex.org/W1966146877","https://openalex.org/W1967908989","https://openalex.org/W1968911801","https://openalex.org/W1968930767","https://openalex.org/W1969150916","https://openalex.org/W1972222177","https://openalex.org/W1972296893","https://openalex.org/W1972700706","https://openalex.org/W1974578380","https://openalex.org/W1975025283","https://openalex.org/W1976768202","https://openalex.org/W1981955070","https://openalex.org/W1982426576","https://openalex.org/W1984286105","https://openalex.org/W1987073744","https://openalex.org/W1987726287","https://openalex.org/W1989073099","https://openalex.org/W1989230986","https://openalex.org/W1989958716","https://openalex.org/W1990909879","https://openalex.org/W1993039760","https://openalex.org/W1993463179","https://openalex.org/W1997436944","https://openalex.org/W2001544973","https://openalex.org/W2002669868","https://openalex.org/W2003674452","https://openalex.org/W2003770019","https://openalex.org/W2004468399","https://openalex.org/W2007868976","https://openalex.org/W2007988355","https://openalex.org/W2008134464","https://openalex.org/W2010129998","https://openalex.org/W2013115730","https://openalex.org/W2014067369","https://openalex.org/W2015187778","https://openalex.org/W2015943785","https://openalex.org/W2016260328","https://openalex.org/W2016964866","https://openalex.org/W2018607339","https://openalex.org/W2018779108","https://openalex.org/W2020452031","https://openalex.org/W2024653583","https://openalex.org/W2024957425","https://openalex.org/W2025183726","https://openalex.org/W2026951529","https://openalex.org/W2028248924","https://openalex.org/W2031671233","https://openalex.org/W2034053511","https://openalex.org/W2035898098","https://openalex.org/W2044609482","https://openalex.org/W2046136399","https://openalex.org/W2047275239","https://openalex.org/W2050827038","https://openalex.org/W2051064552","https://openalex.org/W2054472394","https://openalex.org/W2054961000","https://openalex.org/W2056188558","https://openalex.org/W2057976080","https://openalex.org/W2059977407","https://openalex.org/W2062292065","https://openalex.org/W2062710441","https://openalex.org/W2063013021","https://openalex.org/W2063155826","https://openalex.org/W2065210647","https://openalex.org/W2065542456","https://openalex.org/W2066139135","https://openalex.org/W2067267561","https://openalex.org/W2067960394","https://openalex.org/W2071384116","https://openalex.org/W2071428987","https://openalex.org/W2074629565","https://openalex.org/W2075894678","https://openalex.org/W2075944492","https://openalex.org/W2077344563","https://openalex.org/W2078746080","https://openalex.org/W2081205319","https://openalex.org/W2082433795","https://openalex.org/W2082755707","https://openalex.org/W2084859122","https://openalex.org/W2088308416","https://openalex.org/W2088776629","https://openalex.org/W2092535327","https://openalex.org/W2093173626","https://openalex.org/W2094660330","https://openalex.org/W2095368989","https://openalex.org/W2095900053","https://openalex.org/W2097472214","https://openalex.org/W2099878623","https://openalex.org/W2101045106","https://openalex.org/W2101225932","https://openalex.org/W2101898118","https://openalex.org/W2102688677","https://openalex.org/W2103247095","https://openalex.org/W2103617764","https://openalex.org/W2109759840","https://openalex.org/W2109969209","https://openalex.org/W2111449390","https://openalex.org/W2112755850","https://openalex.org/W2113377685","https://openalex.org/W2116194397","https://openalex.org/W2118044926","https://openalex.org/W2118574612","https://openalex.org/W2120964417","https://openalex.org/W2122828560","https://openalex.org/W2123700490","https://openalex.org/W2124248227","https://openalex.org/W2125493895","https://openalex.org/W2126302487","https://openalex.org/W2131332792","https://openalex.org/W2131686384","https://openalex.org/W2134197723","https://openalex.org/W2134307340","https://openalex.org/W2134737903","https://openalex.org/W2135314437","https://openalex.org/W2137382688","https://openalex.org/W2138357748","https://openalex.org/W2138684513","https://openalex.org/W2138800281","https://openalex.org/W2139870433","https://openalex.org/W2143312146","https://openalex.org/W2144283038","https://openalex.org/W2145159189","https://openalex.org/W2148898943","https://openalex.org/W2148977460","https://openalex.org/W2149685020","https://openalex.org/W2150206249","https://openalex.org/W2155473143","https://openalex.org/W2161289668","https://openalex.org/W2163136069","https://openalex.org/W2163845213","https://openalex.org/W2165138487","https://openalex.org/W2167414381","https://openalex.org/W2167675954","https://openalex.org/W2168094733","https://openalex.org/W2169052846","https://openalex.org/W2169768722","https://openalex.org/W2201960130","https://openalex.org/W2266635801","https://openalex.org/W2316420687"],"related_works":["https://openalex.org/W2145163338","https://openalex.org/W7025284079","https://openalex.org/W2582926135","https://openalex.org/W2415707524","https://openalex.org/W2404231242","https://openalex.org/W6990497166","https://openalex.org/W2256364531","https://openalex.org/W2625208797","https://openalex.org/W1933488366","https://openalex.org/W2156262841"],"abstract_inverted_index":{"Two":[0],"cannabinoid":[1,18,86],"(CB)":[2],"receptors,":[3],"CB1":[4,46],"and":[5,19,47,50,56,64,68,79,93,132,192],"CB2,":[6],"have":[7],"been":[8],"identified":[9,33],"at":[10],"the":[11,114],"molecular":[12],"level.":[13],"Evidence":[14],"suggests":[15],"that":[16,62,100,105,165,197,222],"other":[17],"cannabinboid-like":[20],"receptors":[21,34,49,102,199],"remain":[22],"to":[23,36,107,184,209,239],"be":[24,205],"identified.":[25],"Using":[26],"newly":[27],"developed":[28],"compounds,":[29],"our":[30],"lab":[31],"has":[32],"sensitive":[35],"alkylindoles":[37],"(AI)":[38],"which":[39],"exhibit":[40],"a":[41,124],"distinct":[42],"pharmacological":[43],"profile":[44],"from":[45],"CB2":[48],"are":[51,103],"expressed":[52,200],"by":[53,151,201],"both":[54,130],"microglia":[55,81,116,134,228],"astrocytomas.":[57],"Radioligand":[58],"binding":[59,73],"data":[60],"show":[61,221],"WIN-2,":[63],"novel":[65],"analogues,":[66],"ST-11":[67,92,217],"ST-48,":[69],"compete":[70],"for":[71],"[3H]WIN-2":[72],"in":[74,82,120,123,219],"DBT":[75,175],"mouse":[76],"astrocytoma":[77],"cells":[78,112,203],"primary":[80],"culture,":[83],"while":[84,227],"classic":[85],"ligands":[87],"did":[88,139,146,160,188],"not.":[89],"In":[90,182,213],"microglia,":[91,185],"ST-48":[94],"increase":[95,240],"intracellular":[96],"cAMP":[97],"levels,":[98],"suggesting":[99,196],"AI":[101,127,158,171,186,235],"GPCRs":[104],"couple":[106],"Gs.":[108],"As":[109],"resident":[110],"immune":[111],"of":[113,216,234,242],"CNS,":[115],"play":[117],"many":[118],"roles":[119],"maintaining":[121],"homeostasis":[122],"healthy":[125],"brain.":[126],"analogues":[128,159,172,187,236],"inhibit":[129,147],"basal":[131,193],"ATP-stimulated":[133],"cell":[135,142,148,176,190,194],"migration.":[136],"The":[137],"compounds":[138],"not":[140,161],"affect":[141],"viability,":[143],"yet":[144],"they":[145],"proliferation":[149],"stimulated":[150],"macrophage":[152],"colony":[153],"stimulating":[154],"factor":[155],"(M-CSF).":[156],"Interestingly,":[157],"modulate":[162],"effector":[163],"proteins":[164],"characterize":[166],"M1":[167],"or":[168],"M2":[169],"phenotypes.":[170],"also":[173],"inhibited":[174],"migration,":[177],"though":[178],"with":[179],"lower":[180],"efficacy.":[181],"contrast":[183],"reduce":[189,210],"viability":[191],"proliferation,":[195],"AI-sensitive":[198],"cancer":[202],"may":[204],"an":[206],"effective":[207],"target":[208],"tumor":[211,223],"growth.":[212],"vivo":[214],"study":[215,233],"formulated":[218],"liposomes":[220],"volume":[224],"was":[225,230],"reduced":[226],"reactivity":[229],"increased.":[231],"Further":[232],"is":[237],"needed":[238],"understanding":[241],"this":[243],"phenomenon.":[244]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-03-29T00:00:00"}
