{"id":"https://openalex.org/W2793469780","doi":"https://doi.org/10.1016/j.bbrc.2018.01.152","title":"Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis","display_name":"Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2793469780","doi":"https://doi.org/10.1016/j.bbrc.2018.01.152","mag":"2793469780","pmid":"https://pubmed.ncbi.nlm.nih.gov/29395080"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2018.01.152","doi":"https://doi.org/10.1016/j.bbrc.2018.01.152","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2018.01.152","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083335294","display_name":"Akilandeswari Gopalan","orcid":"https://orcid.org/0009-0001-8092-6289","observed_orcids":["https://orcid.org/0009-0001-8092-6289"]},"institutions":[{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akilandeswari Gopalan","raw_affiliation_strings":["Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India","institution_ids":["https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009392128","display_name":"Raghu Bhagavat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raghu Bhagavat","raw_affiliation_strings":["Department of Biochemistry, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085789773","display_name":"Nagasuma R Chandra","orcid":"https://orcid.org/0000-0002-9939-8439","observed_orcids":["https://orcid.org/0000-0002-9939-8439"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nagasuma Chandra","raw_affiliation_strings":["Department of Biochemistry, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008931559","display_name":"Savithri S. Handanahal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Savithri Handanahal Subbarao","raw_affiliation_strings":["Department of Biochemistry, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111992672","display_name":"Alamelu Raja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Alamelu Raja","raw_affiliation_strings":["Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India","institution_ids":["https://openalex.org/I4210140595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016945086","display_name":"Ramalingam Bethunaickan","orcid":"https://orcid.org/0000-0003-4595-5233","observed_orcids":["https://orcid.org/0000-0003-4595-5233"]},"institutions":[{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ramalingam Bethunaickan","raw_affiliation_strings":["Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India. Electronic address: ramalingam.b@nirt.res.in","Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India"],"raw_orcid":"https://orcid.org/0000-0003-4595-5233","affiliations":[{"raw_affiliation_string":"Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India. Electronic address: ramalingam.b@nirt.res.in","institution_ids":["https://openalex.org/I4210140595"]},{"raw_affiliation_string":"Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India","institution_ids":["https://openalex.org/I4210140595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016945086"],"corresponding_institution_ids":["https://openalex.org/I4210140595"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.5668,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.65136198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"496","issue":"3","first_page":"799","last_page":"805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.11580000072717667,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tetr","display_name":"TetR","score":0.878000020980835},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.7609999775886536},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.8880000114440918},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.3230000138282776},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.6895104050636292},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.657390832901001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6072219610214233},{"id":"https://openalex.org/C2777274385","wikidata":"https://www.wikidata.org/wiki/Q24778590","display_name":"TetR","level":5,"score":0.5364587306976318},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.48842301964759827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4861895442008972},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3487207293510437},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3447878658771515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22736310958862305},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.22202777862548828},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12533152103424072},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013753","descriptor_name":"Tetracycline Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbrc.2018.01.152","doi":"https://doi.org/10.1016/j.bbrc.2018.01.152","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2018.01.152","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:29395080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29395080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.iisc.ac.in:59393","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/59393/1/Che_3-7_2120_2018.pdf","pdf_url":"http://eprints.iisc.ac.in/59393/1/Che_3-7_2120_2018.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.nirt.res.in:1580","doi":null,"is_oa":false,"landing_page_url":"http://eprints.nirt.res.in/1580/1/201805.pdf","pdf_url":"http://eprints.nirt.res.in/1580/1/201805.pdf","source":{"id":"https://openalex.org/S4377196491","display_name":"NIRT Institutional Scholarship Repository (National Institute of Research in Tuberculosis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140595","host_organization_name":"National Institute of Research in Tuberculosis","host_organization_lineage":["https://openalex.org/I4210140595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3554945402","display_name":null,"funder_award_id":"DST/INSPIRE Fellowship/2012/86","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1565773306","https://openalex.org/W1795451287","https://openalex.org/W1930402573","https://openalex.org/W1969585273","https://openalex.org/W1973626320","https://openalex.org/W1980595924","https://openalex.org/W1986081726","https://openalex.org/W1988051578","https://openalex.org/W2009393298","https://openalex.org/W2040094585","https://openalex.org/W2049723770","https://openalex.org/W2051984679","https://openalex.org/W2052018677","https://openalex.org/W2064428882","https://openalex.org/W2077996022","https://openalex.org/W2095214972","https://openalex.org/W2101213002","https://openalex.org/W2109471619","https://openalex.org/W2121277457","https://openalex.org/W2129445206","https://openalex.org/W2130479394","https://openalex.org/W2131590438","https://openalex.org/W2132022155","https://openalex.org/W2155920295","https://openalex.org/W2164527823","https://openalex.org/W2731177663","https://openalex.org/W2758249239","https://openalex.org/W3009705041","https://openalex.org/W4211206272","https://openalex.org/W4237342534"],"related_works":["https://openalex.org/W3124238566","https://openalex.org/W4390744805","https://openalex.org/W2885319161","https://openalex.org/W2945976668","https://openalex.org/W2011322868","https://openalex.org/W7166570305","https://openalex.org/W3159194716","https://openalex.org/W2804531865","https://openalex.org/W7100051895","https://openalex.org/W6958297841"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-03-29T00:00:00"}