{"id":"https://openalex.org/W2793423697","doi":"https://doi.org/10.1002/cmdc.201700752","title":"Helenalin Analogues Targeting NF\u2010\u03baB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles","display_name":"Helenalin Analogues Targeting NF\u2010\u03baB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles","publication_year":2018,"publication_date":"2018-01-19","ids":{"openalex":"https://openalex.org/W2793423697","doi":"https://doi.org/10.1002/cmdc.201700752","mag":"2793423697","pmid":"https://pubmed.ncbi.nlm.nih.gov/29349898","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5894512"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201700752","doi":"https://doi.org/10.1002/cmdc.201700752","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201700752","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5894512","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016244640","display_name":"John C. Widen","orcid":"https://orcid.org/0000-0002-8973-1509","observed_orcids":["https://orcid.org/0000-0002-8973-1509"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Widen","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060437000","display_name":"Aaron Kempema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron M. Kempema","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017269781","display_name":"Jordan W. Baur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan W. Baur","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086716584","display_name":"Hannah M. Skopec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah M. Skopec","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041345350","display_name":"Jacob T. Edwards","orcid":"https://orcid.org/0000-0002-7585-2844","observed_orcids":["https://orcid.org/0000-0002-7585-2844"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob T. Edwards","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054073192","display_name":"Tenley J. Brown","orcid":"https://orcid.org/0000-0002-6784-8255","observed_orcids":["https://orcid.org/0000-0002-6784-8255"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tenley J. Brown","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024316652","display_name":"Dennis A. Brown","orcid":"https://orcid.org/0000-0002-7503-3750","observed_orcids":["https://orcid.org/0000-0002-7503-3750"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis A. Brown","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039646541","display_name":"Frederick A. Meece","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick A. Meece","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009655060","display_name":"Daniel A. Harki","orcid":"https://orcid.org/0000-0001-5950-931X","observed_orcids":["https://orcid.org/0000-0001-5950-931X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel A. Harki","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA"],"raw_orcid":"https://orcid.org/0000-0001-5950-931X","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Minnesota, 2231 6th Street S.E., Minneapolis, MN, 55455 USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009655060"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.9665,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.67291905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"4","first_page":"303","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pseudoguaianolides","display_name":"pseudoguaianolides","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alpha-methylene-gamma-butyrolactone","display_name":"\u03b1-methylene-\u03b3-butyrolactones","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cyclopentenones","display_name":"cyclopentenones","score":0.9670000076293945},{"id":"https://openalex.org/keywords/michael-acceptors","display_name":"Michael acceptors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thiol-reactivity","display_name":"thiol reactivity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/electrophiles","display_name":"electrophiles","score":0.6919999718666077},{"id":"https://openalex.org/keywords/covalent-inhibitors","display_name":"covalent inhibitors","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cysteine-modification","display_name":"cysteine modification","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.7360000014305115},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cellular-potency","display_name":"cellular potency","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.7495847940444946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7153948545455933},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5953625440597534},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.5762115716934204},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5501216650009155},{"id":"https://openalex.org/C2777454769","wikidata":"https://www.wikidata.org/wiki/Q11172462","display_name":"Methylene","level":2,"score":0.5361272096633911},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.4324228763580322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31599462032318115},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19565486907958984},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.13580244779586792},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045789","descriptor_name":"Sesquiterpenes, Guaiane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cmdc.201700752","doi":"https://doi.org/10.1002/cmdc.201700752","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201700752","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:29349898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29349898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5364476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5894512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5894512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5894512","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5364476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5894512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3055558025","display_name":null,"funder_award_id":"S10-RR-024618","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3384598828","display_name":"LTQ Orbitrap XL Mass Spectrometer","funder_award_id":"1s10rr024618-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5302978274","display_name":"CHEMOPROTEOMICS PROFILING OF PARTHENOLIDE IN HUMAN GLIOBLASTOMA","funder_award_id":"R21CA194661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6128537790","display_name":null,"funder_award_id":"2010.01","funder_id":"https://openalex.org/F4320333077","funder_display_name":"Academic Health Center, University of Minnesota"},{"id":"https://openalex.org/G9000895342","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA077598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306536","display_name":"V Foundation for Cancer Research","ror":"https://ror.org/00kbbk236"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332819","display_name":"College of Pharmacy, University of Minnesota","ror":null},{"id":"https://openalex.org/F4320333077","display_name":"Academic Health Center, University of Minnesota","ror":"https://ror.org/017zqws13"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337586","display_name":"Hyundai Hope On Wheels","ror":"https://ror.org/01f6q3121"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W20888715","https://openalex.org/W1504155896","https://openalex.org/W1581923494","https://openalex.org/W1921253197","https://openalex.org/W1964862845","https://openalex.org/W1971225062","https://openalex.org/W1980480652","https://openalex.org/W2000252737","https://openalex.org/W2010993054","https://openalex.org/W2013736151","https://openalex.org/W2018514966","https://openalex.org/W2024964682","https://openalex.org/W2027704988","https://openalex.org/W2030297745","https://openalex.org/W2042943489","https://openalex.org/W2043765788","https://openalex.org/W2048785097","https://openalex.org/W2051014544","https://openalex.org/W2060871791","https://openalex.org/W2068854551","https://openalex.org/W2069562068","https://openalex.org/W2072968205","https://openalex.org/W2073679908","https://openalex.org/W2078585784","https://openalex.org/W2084183850","https://openalex.org/W2094863064","https://openalex.org/W2098962649","https://openalex.org/W2103518432","https://openalex.org/W2108370829","https://openalex.org/W2126685647","https://openalex.org/W2143945519","https://openalex.org/W2317971631","https://openalex.org/W2319379232","https://openalex.org/W2510208057","https://openalex.org/W2518692338","https://openalex.org/W2557257112","https://openalex.org/W2564708666","https://openalex.org/W2623565822","https://openalex.org/W4243375675","https://openalex.org/W4253973392","https://openalex.org/W7096172262"],"related_works":["https://openalex.org/W2412874600","https://openalex.org/W2546961906","https://openalex.org/W1964862845","https://openalex.org/W2047686620","https://openalex.org/W4376454441","https://openalex.org/W2547734997","https://openalex.org/W2104530151","https://openalex.org/W98953347","https://openalex.org/W4200376373","https://openalex.org/W2340349715"],"abstract_inverted_index":{"Helenalin":[0,20],"is":[1],"a":[2,29,32,67,86],"pseudoguaianolide":[3],"natural":[4],"product":[5],"that":[6,25,41],"targets":[7],"Cys38":[8],"within":[9],"the":[10,43,55,59,89,95,100,104,110,116,128,134],"DNA":[11],"binding":[12],"domain":[13],"of":[14,46,58,70,76,82,88,99,109,118,137],"NF-\u03baB":[15,63,106,135],"transcription":[16],"factor":[17],"p65":[18],"(RelA).":[19],"contains":[21],"two":[22,37],"Michael":[23,60,120],"acceptors":[24,61],"covalently":[26],"modify":[27],"cysteines:":[28],"\u03b1-methylene-\u03b3-butyrolactone":[30,129],"and":[31,48,78],"cyclopentenone.":[33],"We":[34],"recently":[35],"reported":[36],"simplified":[38,139],"helenalin":[39,47,140],"analogues":[40,72,90,111],"mimic":[42],"biological":[44,123],"activity":[45],"contain":[49],"both":[50],"electrophilic":[51],"moieties.":[52],"To":[53],"determine":[54,94],"individual":[56],"contributions":[57,117],"toward":[62],"inhibition,":[64],"we":[65],"synthesized":[66],"small":[68],"library":[69],"helenalin-based":[71],"containing":[73],"various":[74],"combinations":[75],"\u03b1-methylene-\u03b3-butyrolactones":[77],"cyclopentenones.":[79],"The":[80],"kinetics":[81],"thiol":[83,97],"addition":[84],"to":[85,93,114,122,133],"subset":[87],"was":[91],"measured":[92],"relative":[96],"reactivities":[98],"embedded":[101],"electrophiles.":[102],"Additionally,":[103],"cellular":[105],"inhibitory":[107],"activities":[108],"were":[112],"determined":[113],"elucidate":[115],"each":[119],"acceptor":[121],"potency.":[124],"Our":[125],"studies":[126],"suggest":[127],"contributes":[130],"most":[131],"significantly":[132],"inhibition":[136],"our":[138],"analogues.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}
