{"id":"https://openalex.org/W2793374792","doi":"https://doi.org/10.1101/249094","title":"A hypermorphic Nfkbid allele represents an Idd7 locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8 + T-cells in NOD mice","display_name":"A hypermorphic Nfkbid allele represents an Idd7 locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8 + T-cells in NOD mice","publication_year":2018,"publication_date":"2018-01-22","ids":{"openalex":"https://openalex.org/W2793374792","doi":"https://doi.org/10.1101/249094","mag":"2793374792"},"language":"en","primary_location":{"id":"doi:10.1101/249094","doi":"https://doi.org/10.1101/249094","is_oa":true,"landing_page_url":"https://doi.org/10.1101/249094","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/26/249094.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/26/249094.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017680831","display_name":"Maximiliano F Presa","orcid":"https://orcid.org/0000-0002-0160-6528","observed_orcids":["https://orcid.org/0000-0002-0160-6528"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maximiliano Presa","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073737674","display_name":"Jeremy J. Racine","orcid":"https://orcid.org/0000-0001-5514-3074","observed_orcids":["https://orcid.org/0000-0001-5514-3074"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy J. Racine","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058797260","display_name":"Jennifer R. Dwyer","orcid":"https://orcid.org/0000-0002-5893-6026","observed_orcids":["https://orcid.org/0000-0002-5893-6026"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer R. Dwyer","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084410485","display_name":"Deanna J. Lamont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanna J. Lamont","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083680144","display_name":"Jeremy J. Ratiu","orcid":"https://orcid.org/0000-0001-9234-7674","observed_orcids":["https://orcid.org/0000-0001-9234-7674"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy J. Ratiu","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013782882","display_name":"Vishal Sarsani","orcid":"https://orcid.org/0000-0002-9272-3438","observed_orcids":["https://orcid.org/0000-0002-9272-3438"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishal Kumar Sarsani","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102830191","display_name":"Yi\u2010Guang Chen","orcid":"https://orcid.org/0000-0001-9616-8841","observed_orcids":["https://orcid.org/0000-0001-9616-8841","https://orcid.org/0000-0002-1741-9719"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Guang Chen","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031428652","display_name":"Aron M. Geurts","orcid":"https://orcid.org/0000-0002-4347-2505","observed_orcids":["https://orcid.org/0000-0002-4347-2505"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aron Geurts","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wisconsin USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wisconsin USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042556806","display_name":"Ingo Schmitz","orcid":"https://orcid.org/0000-0002-5360-0419","observed_orcids":["https://orcid.org/0000-0002-5360-0419"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo Schmitz","raw_affiliation_strings":["Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg Germany","Systems-Oriented Immunology and Inflammation Research Group, Helmholtz Centre for Infection Research, Braunschweig Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Magdeburg Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"Systems-Oriented Immunology and Inflammation Research Group, Helmholtz Centre for Infection Research, Braunschweig Germany","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019180679","display_name":"Timothy M. Stearns","orcid":"https://orcid.org/0000-0002-5533-6076","observed_orcids":["https://orcid.org/0000-0002-5533-6076"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Stearns","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061477322","display_name":"Jennifer Allocco","orcid":"https://orcid.org/0000-0002-1498-0543","observed_orcids":["https://orcid.org/0000-0002-1498-0543"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Allocco","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112454089","display_name":"Harold D. Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold D. Chapman","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073755118","display_name":"DAVID V. SERREZE","orcid":"https://orcid.org/0000-0001-7614-5925","observed_orcids":["https://orcid.org/0000-0001-7614-5925"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David V. Serreze","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, Maine USA"],"raw_orcid":"https://orcid.org/0000-0001-7614-5925","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, Maine USA","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073755118"],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/thymic-negative-selection","display_name":"thymic negative selection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/autoreactive-t-cells","display_name":"autoreactive T cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.7059999704360962},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/regulatory-b-cells","display_name":"regulatory B cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/diabetogenic-t-cells","display_name":"diabetogenic T cells","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7871606349945068},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7145276665687561},{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.6522625684738159},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.6040468215942383},{"id":"https://openalex.org/C2778830056","wikidata":"https://www.wikidata.org/wiki/Q606766","display_name":"Central tolerance","level":4,"score":0.5875932574272156},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5467017292976379},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5040634870529175},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4497987926006317},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.4367808699607849},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4308057725429535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40275245904922485},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3446842432022095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3368939161300659},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30009138584136963},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2945884168148041},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2842407822608948},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0706658661365509},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/249094","doi":"https://doi.org/10.1101/249094","is_oa":true,"landing_page_url":"https://doi.org/10.1101/249094","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/26/249094.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/249094","doi":"https://doi.org/10.1101/249094","is_oa":true,"landing_page_url":"https://doi.org/10.1101/249094","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/03/26/249094.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7300000190734863}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2793374792.pdf","grobid_xml":"https://content.openalex.org/works/W2793374792.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1508404210","https://openalex.org/W1514230952","https://openalex.org/W1521451515","https://openalex.org/W1562291393","https://openalex.org/W1606653742","https://openalex.org/W1647467702","https://openalex.org/W1665834499","https://openalex.org/W1847495702","https://openalex.org/W1886270478","https://openalex.org/W1944789479","https://openalex.org/W1964367916","https://openalex.org/W1987528256","https://openalex.org/W1997112242","https://openalex.org/W2008403890","https://openalex.org/W2012158167","https://openalex.org/W2018353201","https://openalex.org/W2027959125","https://openalex.org/W2041061869","https://openalex.org/W2062573090","https://openalex.org/W2066449582","https://openalex.org/W2066592806","https://openalex.org/W2067005267","https://openalex.org/W2068138585","https://openalex.org/W2069109607","https://openalex.org/W2071100300","https://openalex.org/W2100032086","https://openalex.org/W2100742549","https://openalex.org/W2102542457","https://openalex.org/W2105381419","https://openalex.org/W2106523909","https://openalex.org/W2110458118","https://openalex.org/W2111211062","https://openalex.org/W2116008998","https://openalex.org/W2119097397","https://openalex.org/W2122726748","https://openalex.org/W2123367066","https://openalex.org/W2130362630","https://openalex.org/W2145720279","https://openalex.org/W2152784340","https://openalex.org/W2164712805","https://openalex.org/W2168936111","https://openalex.org/W2169633465","https://openalex.org/W2225235073","https://openalex.org/W2287906200","https://openalex.org/W2326383168","https://openalex.org/W2328202118","https://openalex.org/W2464717012","https://openalex.org/W2497477392","https://openalex.org/W2611469017"],"related_works":["https://openalex.org/W2410457253","https://openalex.org/W2076513055","https://openalex.org/W2100599721","https://openalex.org/W2126232873","https://openalex.org/W11189207","https://openalex.org/W1763016828","https://openalex.org/W2120091065","https://openalex.org/W2056965678","https://openalex.org/W2076559131","https://openalex.org/W2114632269"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"both":[2],"NOD":[3,38,109,146,167,225],"mice":[4,39,110,168,226],"and":[5,131,178,237],"humans,":[6],"the":[7,42,77,83,99,102,113,196],"development":[8],"of":[9,101,118,127,155,163,174,188,198,201,211,217],"type":[10],"1":[11],"diabetes":[12],"(T1D)":[13],"is":[14,143],"dependent":[15],"in":[16,37,166,170,224,230],"part":[17,231],"on":[18,86],"autoreactive":[19,175],"CD8":[20,63,120,157,180,203,213],"+":[21,64,121,158,181,204,214],"T-cells":[22],"recognizing":[23],"pancreatic":[24],"\u00df-cell":[25],"peptides":[26],"presented":[27],"by":[28,53,108,232],"often":[29],"quite":[30],"common":[31,43,103],"MHC":[32],"class":[33,49,104],"I":[34,50,105],"variants.":[35],"Studies":[36],"previously":[40,91],"revealed":[41],"H2-K":[44],"d":[45],"and/or":[46],"H2-D":[47],"b":[48],"molecules":[51,106],"expressed":[52,107],"this":[54],"strain":[55],"acquire":[56],"an":[57,95,124,138,145,191],"aberrant":[58],"ability":[59],"to":[60,82,93,98,111,151,195],"mediate":[61,112],"pathogenic":[62,212],"T-cell":[65],"responses":[66],"through":[67],"interactions":[68],"with":[69],"T1D":[70,222],"susceptibility":[71],"(":[72],"Idd":[73],")":[74],"genes":[75],"outside":[76],"MHC.":[78],"A":[79],"gene(s)":[80],"mapping":[81],"Idd7":[84,147,192],"locus":[85],"proximal":[87],"Chromosome":[88],"7":[89],"was":[90],"shown":[92],"be":[94],"important":[96],"contributor":[97],"failure":[100],"normal":[114],"thymic":[115,128,153,209],"negative":[116,129,172],"selection":[117,130,173],"diabetogenic":[119,156,176,202],"T-cells.":[122,159,182,205],"Using":[123],"inducible":[125],"model":[126],"mRNA":[132],"transcript":[133],"analyses":[134],"we":[135],"initially":[136],"identified":[137],"elevated":[139],"Nfkbid":[140,164,189,218],"expression":[141,165,219],"variant":[142],"likely":[144,227],"region":[148],"gene":[149,193],"contributing":[150,194],"impaired":[152],"deletion":[154,200,210],"CRISPR/Cas9-mediated":[160],"genetic":[161],"attenuation":[162],"resulted":[169],"improved":[171],"AI4":[177],"NY8.3":[179],"These":[183],"results":[184],"indicated":[185],"allelic":[186],"variants":[187],"represent":[190],"efficiency":[197],"intrathymic":[199],"However,":[206],"while":[207],"enhancing":[208],"T-cells,":[215],"ablation":[216],"surprisingly":[220],"accelerated":[221],"onset":[223],"at":[228],"least":[229],"numerically":[233],"decreasing":[234],"regulatory":[235],"T-":[236],"B-lymphocytes":[238],"(Tregs/Bregs),":[239],"thereby":[240],"reducing":[241],"their":[242],"peripheral":[243],"immunosuppressive":[244],"effects.":[245]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
