{"id":"https://openalex.org/W2793072","doi":null,"title":"Complement- and IgG-mediated phagocytosis in human macrophages in calcium dependent and involves synoptotagmin IV","display_name":"Complement- and IgG-mediated phagocytosis in human macrophages in calcium dependent and involves synoptotagmin IV","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2793072","mag":"2793072"},"language":"en","primary_location":{"id":"mag:2793072","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:561235","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056756085","display_name":"Maria Lindmark","orcid":"https://orcid.org/0000-0003-2214-6249","observed_orcids":["https://orcid.org/0000-0003-2214-6249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Lindmark","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2214-6249","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Carin Johansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carin Johansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073263620","display_name":"Giampietro Schiavo","orcid":"https://orcid.org/0000-0002-4319-8745","observed_orcids":["https://orcid.org/0000-0002-4319-8745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giampietro Schiavo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4319-8745","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053810386","display_name":"Birgitta J. Rasmusson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birgitta Rasmusson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056470540","display_name":"Olle I. Stendahl","orcid":"https://orcid.org/0000-0001-8404-9909","observed_orcids":["https://orcid.org/0000-0001-8404-9909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olle Stendahl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8404-9909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00030672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.843999981880188},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9850000143051147},{"id":"https://openalex.org/keywords/complement-receptor-3","display_name":"complement receptor 3","score":0.9200000166893005},{"id":"https://openalex.org/keywords/synaptotagmin-iv","display_name":"synaptotagmin IV","score":0.8709999918937683},{"id":"https://openalex.org/keywords/synaptotagmin-ii","display_name":"synaptotagmin II","score":0.9959999918937683},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8870000243186951},{"id":"https://openalex.org/keywords/phagosome","display_name":"phagosome","score":0.5289999842643738},{"id":"https://openalex.org/keywords/phagolysosome-maturation","display_name":"phagolysosome maturation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lipophosphoglycan","display_name":"lipophosphoglycan","score":0.8650000095367432},{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.5879999995231628},{"id":"https://openalex.org/keywords/complement-receptor-1","display_name":"complement receptor 1","score":0.4269999861717224},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.6610000133514404},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/phagocytic-receptors","display_name":"phagocytic receptors","score":0.5609999895095825},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C161478664","wikidata":"https://www.wikidata.org/wiki/Q901955","display_name":"Phagosome","level":3,"score":0.8948763012886047},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.8891937732696533},{"id":"https://openalex.org/C144382850","wikidata":"https://www.wikidata.org/wiki/Q3377952","display_name":"Phagolysosome","level":4,"score":0.7770453691482544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6278594136238098},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.584485650062561},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4654536843299866},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4541241526603699},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4307126998901367},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.42687493562698364},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.42571669816970825},{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.41192683577537537},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3417697846889496},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3192109167575836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2978958189487457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26706868410110474},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22896364331245422}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2793072","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:561235","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063808802","https://openalex.org/W1985866176","https://openalex.org/W567770927","https://openalex.org/W412280120","https://openalex.org/W2990898628","https://openalex.org/W2053934144","https://openalex.org/W322995407","https://openalex.org/W107348889","https://openalex.org/W7099398966","https://openalex.org/W2080496656"],"abstract_inverted_index":{"Professional":[0],"phagocytes":[1,353],"such":[2],"as":[3,357,371],"neutrophil":[4],"granulocytes":[5],"and":[6,28,52,61,64,119,198,218,231,243,278,286,317,340,354,363,365],"macrophages":[7,62],"are":[8,29,130,135,349],"an":[9,187],"esential":[10],"part":[11],"of":[12,23,34,43,113,128,157,176,190,263,310,314,320,333],"the":[13,20,35,41,57,81,83,103,111,126,145,174,196,203,209,228,234,245,251,256,261,296],"innate":[14],"immune":[15],"system.":[16],"The":[17],"neutrophils":[18,154,217,323],"form":[19,98],"first":[21,146],"line":[22],"defence":[24],"against":[25],"invading":[26],"microorganisms":[27,66],"important":[30],"for":[31],"rapid":[32],"killing":[33],"intruders.":[36],"Macrophages":[37],"arrive":[38],"later":[39],"at":[40],"site":[42],"infection,":[44],"kill":[45,65],"micoorganisms,":[46],"degrade":[47],"dead":[48],"cells,":[49],"present":[50,215,350],"antigens":[51],"secrete":[53],"substances":[54],"that":[55,90,183,208,284,301,331,347,366],"orchestrate":[56],"inflammatory":[58],"response.":[59],"Neutrophils":[60],"ingest":[63],"in":[67,87,101,152,216,221,236,266,292,322,344,351,360,382],"a":[68,88,99,158,237,372],"process":[69],"called":[70],"phagocytosis,":[71],"where":[72],"calcium":[73,290,358],"signalling":[74,151],"has":[75],"shown":[76],"to":[77,97,137,173,233,244,273,374],"be":[78,342,369],"involved.":[79],"Inside":[80],"cell":[82],"microorganism":[84],"is":[85,105,108,214,219],"enclosed":[86],"phagosome,":[89],"sequentially":[91],"fuses":[92],"with":[93,141,250],"various":[94],"intracellular":[95,150,188,345],"vesicles":[96],"phagolysosome":[100,315],"which":[102,171,192],"intruder":[104],"killed.":[106],"Killing":[107],"achieved":[109],"through":[110],"actions":[112],"lytic":[114],"enzymes,":[115],"nitrogen":[116],"oxide":[117],"(NO)":[118],"reactive":[120],"oxygen":[121],"metabolites":[122],"(ROM).":[123],"Studies":[124],"on":[125,195,199,227],"regulation":[127],"phagocytosis":[129,242,339],"essential":[131],"since":[132],"many":[133],"pathogens":[134],"able":[136],"survive":[138],"by":[139],"interfering":[140],"this":[142],"process.":[143],"In":[144,202,255,295],"study":[147],"we":[148,167,206,259,299],"investigated":[149],"human":[153,267],"following":[155],"engagement":[156],"phagocytic":[159],"receptor,":[160],"complement":[161],"receptor":[162],"3":[163],"(CR3).":[164],"For":[165],"this,":[166],"used":[168,370],"antibody-coated":[169],"PANSORBINS\u00ae":[170],"bound":[172],"s-chain":[175],"CR3":[177],"without":[178],"inducing":[179],"phagocytosis.":[180,222,280,326],"We":[181,281],"found":[182,226,283],"these":[184,293],"particles":[185],"elicited":[186],"production":[189,319],"ROM":[191,321,334],"was":[193,225,289],"dependent":[194,291],"cytoskeleton":[197],"phospholipase":[200],"D.":[201],"second":[204],"study,":[205,258,298],"showed":[207],"putative":[210],"calcium-sensor":[211],"synaptotagmin":[212,264],"II":[213,224],"involved":[220,343],"Synaptotagmin":[223,269],"specific":[229],"granules":[230],"translocated":[232,271],"phagosome":[235],"calcium-dependent":[238],"manner":[239],"during":[240,276,324,337],"eR-mediated":[241,325,338],"plasma":[246],"membrane":[247],"after":[248],"stimulation":[249],"formylated":[252],"peptide,":[253],"N-formyl-methionyl-leucyl-phenylalanine.":[254],"third":[257],"demonstrate":[260],"presence":[262],"IV":[265,270],"macrophages.":[268],"transiendy":[272],"macrophage":[274],"phagosomes":[275],"eR-":[277,285],"Fc\u03b3R-mediated":[279],"also":[282],"FcyR-mediated":[287],"uptake":[288],"cells.":[294],"fourth":[297],"show":[300,330],"lipophosphoglycan":[302],"(LPG)":[303],"from":[304],"Leishmania":[305],"donovani":[306],"induced":[307],"elevated":[308],"levels":[309],"periphagosomal":[311],"F-actin,":[312],"inhibition":[313],"maturation":[316,362,381],"diminished":[318],"Together,":[327],"our":[328],"data":[329],"generation":[332],"occurs":[335],"early":[336],"could":[341,355],"signalling,":[346],"synaptotagmins":[348],"professional":[352],"act":[356],"sensors":[359],"phagosomal":[361,380],"secretion,":[364],"LPG":[367],"can":[368,378],"tool":[373],"investigate":[375],"how":[376],"actin":[377],"regulate":[379],"neutrophils.":[383]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
