{"id":"https://openalex.org/W2793007164","doi":"https://doi.org/10.1097/cco.0000000000000445","title":"The emerging role of immunotherapy in advanced urothelial cancers","display_name":"The emerging role of immunotherapy in advanced urothelial cancers","publication_year":2018,"publication_date":"2018-03-16","ids":{"openalex":"https://openalex.org/W2793007164","doi":"https://doi.org/10.1097/cco.0000000000000445","mag":"2793007164","pmid":"https://pubmed.ncbi.nlm.nih.gov/29553950"},"language":"en","primary_location":{"id":"doi:10.1097/cco.0000000000000445","doi":"https://doi.org/10.1097/cco.0000000000000445","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cco.0000000000000445","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054650087","display_name":"William Tabayoyong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Tabayoyong","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Department of Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Department of Urology","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069915515","display_name":"Jianjun Gao","orcid":"https://orcid.org/0000-0001-6138-4472","observed_orcids":["https://orcid.org/0000-0001-6138-4472"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianjun Gao","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069915515"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.3215,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.27331434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"3","first_page":"172","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.48730000853538513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metastatic-bladder-cancer","display_name":"metastatic bladder cancer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":1.0},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fda-approval","display_name":"FDA approval","score":0.6690000295639038},{"id":"https://openalex.org/keywords/first-line-and-second-line-treatment","display_name":"first-line and second-line treatment","score":0.7250000238418579},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.865586519241333},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7024204134941101},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.6511261463165283},{"id":"https://openalex.org/C2911057145","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Metastatic Urothelial Carcinoma","level":5,"score":0.597054123878479},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5952696800231934},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5599838495254517},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5410946011543274},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5211791396141052},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49331942200660706},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.49154481291770935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4722309112548828},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4399099349975586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3722950220108032},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3636460304260254},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32675713300704956},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2573903203010559},{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.17404064536094666},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11261287331581116}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/cco.0000000000000445","doi":"https://doi.org/10.1097/cco.0000000000000445","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cco.0000000000000445","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},{"id":"pmid:29553950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29553950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W142771617","https://openalex.org/W1538902372","https://openalex.org/W1858135205","https://openalex.org/W1966023125","https://openalex.org/W1971208896","https://openalex.org/W1972882573","https://openalex.org/W1974722941","https://openalex.org/W1981463252","https://openalex.org/W1983093014","https://openalex.org/W1985401118","https://openalex.org/W1993289360","https://openalex.org/W2016983859","https://openalex.org/W2029175700","https://openalex.org/W2056535502","https://openalex.org/W2060070314","https://openalex.org/W2073571081","https://openalex.org/W2081447339","https://openalex.org/W2092977595","https://openalex.org/W2098028863","https://openalex.org/W2098853737","https://openalex.org/W2101562875","https://openalex.org/W2102116016","https://openalex.org/W2118471749","https://openalex.org/W2131577873","https://openalex.org/W2145871366","https://openalex.org/W2148562299","https://openalex.org/W2154610258","https://openalex.org/W2155464214","https://openalex.org/W2162130153","https://openalex.org/W2162889226","https://openalex.org/W2289712604","https://openalex.org/W2465860350","https://openalex.org/W2522313999","https://openalex.org/W2528473944","https://openalex.org/W2530516001","https://openalex.org/W2559804019","https://openalex.org/W2570159314","https://openalex.org/W2582671354","https://openalex.org/W2587048937","https://openalex.org/W2588916311","https://openalex.org/W2604441970","https://openalex.org/W2744743363","https://openalex.org/W2745624257","https://openalex.org/W2760661635","https://openalex.org/W2771737095","https://openalex.org/W2781525129","https://openalex.org/W4211115520","https://openalex.org/W4298025629"],"related_works":["https://openalex.org/W2785486713","https://openalex.org/W2807693780","https://openalex.org/W4390273304","https://openalex.org/W2612383893","https://openalex.org/W2952201050","https://openalex.org/W2624571669","https://openalex.org/W2917042146","https://openalex.org/W2793892124","https://openalex.org/W4292756596","https://openalex.org/W2771637939"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Recent":[3,145],"Food":[4],"and":[5,61,75,94,114,141,178],"Drug":[6],"Administration":[7],"(FDA)":[8],"approval":[9,52],"of":[10,19,35,53,86,91,104,121],"five":[11],"new":[12],"immune":[13,87,118,126,131,158],"checkpoint":[14,127,159],"inhibitors":[15,128],"for":[16,29,181],"the":[17,24,33,45,56,107,117,122,130,176],"treatment":[18,27,163],"metastatic":[20,152,182],"urothelial":[21,153],"cancer":[22,98,137],"represents":[23],"first":[25,177],"major":[26],"breakthrough":[28],"this":[30],"disease":[31],"since":[32],"introduction":[34],"combination":[36],"chemotherapy":[37],"over":[38],"30":[39],"years":[40],"ago.":[41],"This":[42],"review":[43],"examines":[44],"recent":[46],"clinical":[47,146],"trials":[48,147],"leading":[49],"to":[50,111,134,157],"FDA":[51],"these":[54],"agents,":[55],"current":[57],"challenges":[58],"facing":[59],"immunotherapy":[60],"areas":[62],"that":[63,149],"require":[64],"further":[65],"research.":[66],"RECENT":[67],"FINDINGS:":[68],"The":[69],"programmed":[70,78],"death":[71,79],"1":[72],"receptor":[73],"(PD-1)":[74],"its":[76],"ligand":[77],"ligand-1":[80],"(PD-L1)":[81],"are":[82,155,165],"important":[83],"negative":[84],"regulators":[85],"activity,":[88],"preventing":[89],"destruction":[90,115],"normal":[92,108],"tissues":[93],"autoimmunity.":[95],"Aggressive":[96],"bladder":[97,136],"cells":[99],"express":[100],"aberrantly":[101],"high":[102],"levels":[103],"PD-L1,":[105],"hijacking":[106],"immune-regulatory":[109],"pathway":[110],"evade":[112],"detection":[113],"by":[116],"system.":[119],"Blockade":[120],"PD-1/PD-L1":[123],"axis":[124],"with":[125,138,151],"augments":[129],"system's":[132],"ability":[133],"eradicate":[135],"impressive":[139],"safety":[140],"tolerability":[142],"profiles.":[143],"SUMMARY:":[144],"demonstrate":[148],"patients":[150],"carcinoma":[154],"responsive":[156],"inhibitor":[160],"therapy.":[161],"Optimal":[162],"regimens":[164],"still":[166],"under":[167],"development,":[168],"but":[169],"activity":[170],"has":[171],"been":[172],"demonstrated":[173],"in":[174],"both":[175],"second-line":[179],"setting":[180],"disease.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-03-29T00:00:00"}