{"id":"https://openalex.org/W2792761069","doi":"https://doi.org/10.1097/01.qai.0000479639.95171.a0","title":"B-104 HIV cure research","display_name":"B-104 HIV cure research","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2792761069","doi":"https://doi.org/10.1097/01.qai.0000479639.95171.a0","mag":"2792761069"},"language":"en","primary_location":{"id":"doi:10.1097/01.qai.0000479639.95171.a0","doi":"https://doi.org/10.1097/01.qai.0000479639.95171.a0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000479639.95171.a0","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008716404","display_name":"David M. Margolis","orcid":"https://orcid.org/0000-0001-5714-0002","observed_orcids":["https://orcid.org/0000-0001-5714-0002"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Margolis","raw_affiliation_strings":["UNC Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008716404"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"Supplement 1","first_page":"41","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-cure","display_name":"HIV cure","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.7009999752044678},{"id":"https://openalex.org/keywords/viral-reservoir","display_name":"viral reservoir","score":0.753000020980835},{"id":"https://openalex.org/keywords/hiv-latency","display_name":"HIV latency","score":0.5080000162124634},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/hiv-specific-immune-response","display_name":"HIV-specific immune response","score":0.7910000085830688},{"id":"https://openalex.org/keywords/integrated-provirus","display_name":"integrated provirus","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.9014742374420166},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.7650272250175476},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6072165369987488},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.5933759808540344},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5792244672775269},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5779359936714172},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.57133948802948},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.48091956973075867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4473412334918976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42971447110176086},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.4288628101348877},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.3473282754421234},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.282798171043396},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.27372264862060547},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.18509066104888916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07537007331848145},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.qai.0000479639.95171.a0","doi":"https://doi.org/10.1097/01.qai.0000479639.95171.a0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.qai.0000479639.95171.a0","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4299402328","https://openalex.org/W2013554131","https://openalex.org/W2522575686","https://openalex.org/W2736822140","https://openalex.org/W4205621222","https://openalex.org/W3008968097","https://openalex.org/W2154912932","https://openalex.org/W2528299189","https://openalex.org/W2316371451","https://openalex.org/W2203560898"],"abstract_inverted_index":{"Effective":[0],"antiretroviral":[1],"therapy":[2,163],"(ART)":[3],"blunts":[4],"viremia,":[5],"enabling":[6],"HIV-1-infected":[7],"individuals":[8],"to":[9,23,53,76,103,116,123,135,160],"control":[10],"infection":[11,19,38],"and":[12,43,100,120,129,156],"live":[13],"long,":[14],"productive":[15],"lives.":[16],"However,":[17],"HIV-1":[18],"remains":[20],"incurable":[21],"owing":[22],"the":[24,46,50,61,72,87,91,101,105,125,137,143,154],"persistence":[25],"of":[26,64,74,89,108,145],"infected":[27,110,147],"cells":[28],"harboring":[29],"integrated":[30],"provirus":[31],"within":[32],"host":[33],"cellular":[34],"DNA.":[35],"This":[36],"latent":[37],"is":[39],"unaffected":[40],"by":[41,60],"ART":[42],"hidden":[44],"from":[45],"immune":[47,127],"system.":[48],"In":[49],"renewed":[51],"efforts":[52,80,113,134,158],"eradicate":[54],"persistent":[55],"infection,":[56],"spurred":[57],"in":[58,95,130],"part":[59],"remarkable":[62],"case":[63],"Timothy":[65],"Brown,":[66],"initial":[67],"studies":[68],"have":[69,114],"focused":[70],"on":[71],"development":[73],"therapies":[75],"disrupt":[77],"latency.":[78],"These":[79],"unmasked":[81],"residual":[82],"viral":[83,93],"genomes":[84],"but":[85],"highlighted":[86],"challenge":[88],"impacting":[90],"diverse":[92],"reservoir":[94],"a":[96,131],"clinically":[97],"safe":[98],"manner,":[99],"need":[102],"enable":[104],"speedy":[106],"clearance":[107],"latently":[109],"cells.":[111,148],"New":[112],"begun":[115],"use":[117],"both":[118],"old":[119],"new":[121],"strategies":[122],"enhance":[124],"HIV-1-specific":[126],"response,":[128],"few":[132],"cases":[133],"bring":[136],"kick":[138],"against":[139],"latency":[140],"together":[141],"with":[142],"kill":[144],"persistently":[146],"Although":[149],"very":[150],"substantial":[151],"challenges":[152],"remain,":[153],"broad":[155],"inventive":[157],"launched":[159],"develop":[161],"eradication":[162],"inspire":[164],"hope.":[165]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2018-03-29T00:00:00"}