{"id":"https://openalex.org/W2792653744","doi":"https://doi.org/10.3390/diseases6010022","title":"Lipid Target in Very High-Risk Cardiovascular Patients: Lesson from PCSK9 Monoclonal Antibodies","display_name":"Lipid Target in Very High-Risk Cardiovascular Patients: Lesson from PCSK9 Monoclonal Antibodies","publication_year":2018,"publication_date":"2018-03-17","ids":{"openalex":"https://openalex.org/W2792653744","doi":"https://doi.org/10.3390/diseases6010022","mag":"2792653744","pmid":"https://pubmed.ncbi.nlm.nih.gov/29562587","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5871968"},"language":"en","primary_location":{"id":"doi:10.3390/diseases6010022","doi":"https://doi.org/10.3390/diseases6010022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diseases6010022","pdf_url":"https://www.mdpi.com/2079-9721/6/1/22/pdf?version=1525344281","source":{"id":"https://openalex.org/S2736521255","display_name":"Diseases","issn_l":"2079-9721","issn":["2079-9721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-9721/6/1/22/pdf?version=1525344281","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086494578","display_name":"Giovanni Ciccarelli","orcid":"https://orcid.org/0000-0001-6919-899X","observed_orcids":["https://orcid.org/0000-0001-6919-899X"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Ciccarelli","raw_affiliation_strings":["Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025311323","display_name":"Saverio D\u2019Elia","orcid":"https://orcid.org/0000-0001-5415-1953","observed_orcids":["https://orcid.org/0000-0001-5415-1953"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Saverio D\u2019Elia","raw_affiliation_strings":["Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089294085","display_name":"Michele De Paulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele De Paulis","raw_affiliation_strings":["Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034394063","display_name":"Paolo Golino","orcid":"https://orcid.org/0000-0002-3590-6983","observed_orcids":["https://orcid.org/0000-0002-3590-6983"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Golino","raw_affiliation_strings":["Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3590-6983","affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070014524","display_name":"Giovanni Cimmino","orcid":"https://orcid.org/0000-0002-3802-7052","observed_orcids":["https://orcid.org/0000-0002-3802-7052"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanni Cimmino","raw_affiliation_strings":["Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3802-7052","affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoracic and Respiratory Sciences, Section of Cardiology, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070014524"],"corresponding_institution_ids":["https://openalex.org/I197809005"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2172},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2172},"fwci":0.4284,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.43456948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.5649999976158142},{"id":"https://openalex.org/keywords/ldl-metabolism","display_name":"LDL metabolism","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ldl-cholesterol-targets","display_name":"LDL cholesterol targets","score":0.5509999990463257},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/statin-intolerance","display_name":"statin intolerance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.9560658931732178},{"id":"https://openalex.org/C2778849439","wikidata":"https://www.wikidata.org/wiki/Q6397985","display_name":"Kexin","level":5,"score":0.7088378667831421},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.6608368158340454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5740224123001099},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5736361742019653},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.48572713136672974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45700040459632874},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.45078009366989136},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.4438892602920532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3461647629737854},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34093379974365234},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2916211485862732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1862119436264038}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/diseases6010022","doi":"https://doi.org/10.3390/diseases6010022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diseases6010022","pdf_url":"https://www.mdpi.com/2079-9721/6/1/22/pdf?version=1525344281","source":{"id":"https://openalex.org/S2736521255","display_name":"Diseases","issn_l":"2079-9721","issn":["2079-9721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"journal-article"},{"id":"pmid:29562587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29562587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5871968","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5871968/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9a444c9749694149b9db65009a56eb9a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9a444c9749694149b9db65009a56eb9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diseases, Vol 6, Iss 1, p 22 (2018)","raw_type":"article"},{"id":"pmh:oai:iris.unicampania.it:11591/402362","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/402362","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/diseases6010022","doi":"https://doi.org/10.3390/diseases6010022","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diseases6010022","pdf_url":"https://www.mdpi.com/2079-9721/6/1/22/pdf?version=1525344281","source":{"id":"https://openalex.org/S2736521255","display_name":"Diseases","issn_l":"2079-9721","issn":["2079-9721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2792653744.pdf","grobid_xml":"https://content.openalex.org/works/W2792653744.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W188711227","https://openalex.org/W1143709456","https://openalex.org/W1430649507","https://openalex.org/W1502524639","https://openalex.org/W1516521057","https://openalex.org/W1520609538","https://openalex.org/W1966307362","https://openalex.org/W1966936568","https://openalex.org/W1969615558","https://openalex.org/W1969627037","https://openalex.org/W1978765794","https://openalex.org/W1979489668","https://openalex.org/W1985554823","https://openalex.org/W1992463182","https://openalex.org/W1994137263","https://openalex.org/W2001328643","https://openalex.org/W2011175975","https://openalex.org/W2019071303","https://openalex.org/W2023735564","https://openalex.org/W2024930123","https://openalex.org/W2025403744","https://openalex.org/W2037398388","https://openalex.org/W2039417191","https://openalex.org/W2040612932","https://openalex.org/W2044880495","https://openalex.org/W2052237041","https://openalex.org/W2054851194","https://openalex.org/W2054982668","https://openalex.org/W2056256068","https://openalex.org/W2059094096","https://openalex.org/W2064994023","https://openalex.org/W2067539811","https://openalex.org/W2069616685","https://openalex.org/W2070826050","https://openalex.org/W2073940384","https://openalex.org/W2081915217","https://openalex.org/W2084024458","https://openalex.org/W2085975467","https://openalex.org/W2088623825","https://openalex.org/W2092101695","https://openalex.org/W2092991344","https://openalex.org/W2094629035","https://openalex.org/W2095059215","https://openalex.org/W2097510503","https://openalex.org/W2103606790","https://openalex.org/W2107295258","https://openalex.org/W2110522622","https://openalex.org/W2111099202","https://openalex.org/W2115169717","https://openalex.org/W2119475560","https://openalex.org/W2120986848","https://openalex.org/W2125958550","https://openalex.org/W2128460332","https://openalex.org/W2134159541","https://openalex.org/W2142527465","https://openalex.org/W2147602249","https://openalex.org/W2150387584","https://openalex.org/W2152789823","https://openalex.org/W2153808905","https://openalex.org/W2155598961","https://openalex.org/W2157442811","https://openalex.org/W2160637851","https://openalex.org/W2161942248","https://openalex.org/W2163148865","https://openalex.org/W2175943040","https://openalex.org/W2295628337","https://openalex.org/W2300129093","https://openalex.org/W2322095705","https://openalex.org/W2328529137","https://openalex.org/W2330843213","https://openalex.org/W2332087646","https://openalex.org/W2335533912","https://openalex.org/W2341665659","https://openalex.org/W2369654042","https://openalex.org/W2402599050","https://openalex.org/W2415553152","https://openalex.org/W2477666361","https://openalex.org/W2495887823","https://openalex.org/W2509676484","https://openalex.org/W2534514123","https://openalex.org/W2549845247","https://openalex.org/W2554832534","https://openalex.org/W2557654447","https://openalex.org/W2560899778","https://openalex.org/W2563852152","https://openalex.org/W2581503010","https://openalex.org/W2583862987","https://openalex.org/W2593823350","https://openalex.org/W2595169180","https://openalex.org/W2596179513","https://openalex.org/W2596236174","https://openalex.org/W2596676407","https://openalex.org/W2600576046","https://openalex.org/W2604547305","https://openalex.org/W2610389201","https://openalex.org/W2731199601","https://openalex.org/W2733425720","https://openalex.org/W2746224452","https://openalex.org/W2747847803","https://openalex.org/W2748800769","https://openalex.org/W2754562397","https://openalex.org/W2761079932","https://openalex.org/W2766232664","https://openalex.org/W2768219381","https://openalex.org/W2768588165","https://openalex.org/W2790059086","https://openalex.org/W2792727944","https://openalex.org/W3021842026","https://openalex.org/W4236673002","https://openalex.org/W4238580056","https://openalex.org/W4246764494","https://openalex.org/W6642702895"],"related_works":["https://openalex.org/W2549845247","https://openalex.org/W2252288490","https://openalex.org/W2794679925","https://openalex.org/W2743198652","https://openalex.org/W2193234196","https://openalex.org/W2765203099","https://openalex.org/W2027932918","https://openalex.org/W2945864434","https://openalex.org/W2911352043","https://openalex.org/W635875665"],"abstract_inverted_index":{"The":[0,21],"role":[1,179],"of":[2,39,50,110,119,131,142,165,180],"low-density":[3],"lipoproteins":[4],"(LDLs)":[5],"as":[6],"a":[7,66,128,230],"major":[8,70,111,234],"risk":[9,121],"factor":[10],"for":[11,24],"cardiovascular":[12,54,71,112,235],"disease":[13],"has":[14,94,173,187,223],"been":[15,95,224],"demonstrated":[16,225],"by":[17],"several":[18],"epidemiological":[19],"studies.":[20],"molecular":[22,167],"basis":[23],"LDLs":[25],"in":[26,65,69,102,115,127,170,220,229,233],"atherosclerotic":[27],"plaque":[28],"formation":[29],"and":[30,43,123,176],"progression":[31],"is":[32,137,191],"not":[33],"completely":[34],"unraveled":[35],"yet.":[36],"Pharmacological":[37],"modulation":[38],"plasma":[40,61,87,103,156,216],"LDL-C":[41,62,88,104,157,217],"concentrations":[42,63],"randomized":[44],"clinical":[45,91],"trials":[46],"addressing":[47],"the":[48,79,98,100,106,108,133,160,166,177,197],"impact":[49],"lipid-lowering":[51],"interventions":[52],"on":[53,201],"outcome":[55],"have":[56,77],"clearly":[57],"shown":[58,96],"that":[59,97],"reducing":[60],"results":[64],"significant":[67,231],"decrease":[68,215],"events.":[72,125,236],"For":[73],"many":[74],"years,":[75],"statins":[76],"represented":[78],"most":[80],"powerful":[81],"pharmacological":[82],"agents":[83],"available":[84],"to":[85,139,195,214,226],"lower":[86,107],"concentrations.":[89,158],"In":[90,159],"trials,":[92],"it":[93],"greater":[99],"reduction":[101,232],"concentrations,":[105,218],"rate":[109],"events,":[113],"especially":[114],"high-risk":[116],"patients,":[117,132],"because":[118,141],"multiple":[120],"factors":[122],"recurrent":[124],"However,":[126],"substantial":[129],"number":[130],"recommended":[134],"LDL":[135,171,198],"target":[136],"difficult":[138],"achieve":[140],"different":[143],"factors:":[144],"genetic":[145],"background":[146],"(familial":[147],"hypercholesterolemia),":[148],"side":[149],"effects":[150],"(statin":[151],"intolerance),":[152],"or":[153],"high":[154],"baseline":[155],"last":[161],"decade,":[162],"our":[163],"understanding":[164],"mechanisms":[168],"involved":[169],"metabolism":[172],"progressed":[174],"significantly":[175],"key":[178],"proprotein":[181],"convertase":[182],"subtilisin/kexin":[183],"type":[184],"9":[185],"(PCSK9)":[186],"emerged.":[188],"This":[189],"protein":[190],"an":[192,209],"enzyme":[193],"able":[194],"bind":[196],"receptors":[199],"(LDL-R)":[200],"hepatocytes,":[202],"favoring":[203],"their":[204],"degradation.":[205],"Blocking":[206],"PCSK9":[207],"represents":[208],"intriguing":[210],"new":[211],"therapeutic":[212],"approach":[213],"which":[219],"recent":[221],"studies":[222],"also":[227],"result":[228]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-03-29T00:00:00"}