{"id":"https://openalex.org/W2792272002","doi":"https://doi.org/10.1055/a-0583-7570","title":"Per-rectal endoscopic myotomy (PREM) for pediatric Hirschsprung\u2019s disease","display_name":"Per-rectal endoscopic myotomy (PREM) for pediatric Hirschsprung\u2019s disease","publication_year":2018,"publication_date":"2018-03-22","ids":{"openalex":"https://openalex.org/W2792272002","doi":"https://doi.org/10.1055/a-0583-7570","mag":"2792272002","pmid":"https://pubmed.ncbi.nlm.nih.gov/29566397"},"language":"en","primary_location":{"id":"doi:10.1055/a-0583-7570","doi":"https://doi.org/10.1055/a-0583-7570","is_oa":true,"landing_page_url":"https://doi.org/10.1055/a-0583-7570","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0583-7570.pdf","source":{"id":"https://openalex.org/S195182175","display_name":"Endoscopy","issn_l":"0013-726X","issn":["0013-726X","1438-8812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endoscopy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0583-7570.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064441978","display_name":"Amol Bapaye","orcid":"https://orcid.org/0000-0001-7632-814X","observed_orcids":["https://orcid.org/0000-0001-7632-814X"]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Amol Bapaye","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035337309","display_name":"Tarun Bharadwaj","orcid":"https://orcid.org/0000-0002-7015-8597","observed_orcids":["https://orcid.org/0000-0002-7015-8597"]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tarun Bharadwaj","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023965590","display_name":"Mahesh Rangrao Mahadik","orcid":"https://orcid.org/0000-0003-0058-6016","observed_orcids":["https://orcid.org/0000-0003-0058-6016"]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahesh Mahadik","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108623356","display_name":"Sandeep Ware","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Ware","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009108308","display_name":"Pankaj Nemade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pankaj Nemade","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000697333","display_name":"Rajendra Pujari","orcid":"https://orcid.org/0000-0003-2201-8140","observed_orcids":["https://orcid.org/0000-0003-2201-8140"]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajendra Pujari","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090431612","display_name":"Jay Bapaye","orcid":"https://orcid.org/0000-0002-4118-8770","observed_orcids":["https://orcid.org/0000-0002-4118-8770"]},"institutions":[{"id":"https://openalex.org/I4210116893","display_name":"Deenanath Mangeshkar Hospital and Research Center","ror":"https://ror.org/02fv7x872","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210116893"]},{"id":"https://openalex.org/I4210157510","display_name":"Smt. Kashibai Navale Medical College and General hospital","ror":"https://ror.org/05kqjh845","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210157510"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jay Bapaye","raw_affiliation_strings":["Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","Smt. Kashibai Navale Medical College, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shivanand Desai Center for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Center, Pune, India","institution_ids":["https://openalex.org/I4210116893"]},{"raw_affiliation_string":"Smt. Kashibai Navale Medical College, Pune, India","institution_ids":["https://openalex.org/I4210157510"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064441978"],"corresponding_institution_ids":["https://openalex.org/I4210116893"],"apc_list":null,"apc_paid":null,"fwci":2.5703,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.88158191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"50","issue":"06","first_page":"644","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12150","display_name":"Intestinal Malrotation and Obstruction Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hirschsprung-disease","display_name":"Hirschsprung disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6430000066757202},{"id":"https://openalex.org/keywords/refractory-constipation","display_name":"refractory constipation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/megacolon","display_name":"megacolon","score":0.8169999718666077},{"id":"https://openalex.org/keywords/rectoanal-inhibitory-reflex","display_name":"rectoanal inhibitory reflex","score":0.796999990940094},{"id":"https://openalex.org/keywords/endoscopic-myotomy","display_name":"endoscopic myotomy","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9690155982971191},{"id":"https://openalex.org/C2776928572","wikidata":"https://www.wikidata.org/wiki/Q1956720","display_name":"Myotomy","level":4,"score":0.7997190952301025},{"id":"https://openalex.org/C2779089422","wikidata":"https://www.wikidata.org/wiki/Q1343645","display_name":"Hirschsprung's disease","level":3,"score":0.7495078444480896},{"id":"https://openalex.org/C2779222388","wikidata":"https://www.wikidata.org/wiki/Q1754226","display_name":"Megacolon","level":2,"score":0.4961865544319153},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3861766457557678},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3545657694339752},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2157127559185028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19443023204803467},{"id":"https://openalex.org/C2779958274","wikidata":"https://www.wikidata.org/wiki/Q661015","display_name":"Achalasia","level":3,"score":0.17078560590744019},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.07588881254196167}],"mesh":[{"descriptor_ui":"D000074433","descriptor_name":"Myotomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006627","descriptor_name":"Hirschsprung Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/a-0583-7570","doi":"https://doi.org/10.1055/a-0583-7570","is_oa":true,"landing_page_url":"https://doi.org/10.1055/a-0583-7570","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0583-7570.pdf","source":{"id":"https://openalex.org/S195182175","display_name":"Endoscopy","issn_l":"0013-726X","issn":["0013-726X","1438-8812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endoscopy","raw_type":"journal-article"},{"id":"pmid:29566397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29566397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endoscopy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1055/a-0583-7570","doi":"https://doi.org/10.1055/a-0583-7570","is_oa":true,"landing_page_url":"https://doi.org/10.1055/a-0583-7570","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-0583-7570.pdf","source":{"id":"https://openalex.org/S195182175","display_name":"Endoscopy","issn_l":"0013-726X","issn":["0013-726X","1438-8812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endoscopy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2792272002.pdf","grobid_xml":"https://content.openalex.org/works/W2792272002.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W197135370","https://openalex.org/W2074764741","https://openalex.org/W2428131260","https://openalex.org/W2466194317","https://openalex.org/W4246957167"],"related_works":["https://openalex.org/W2795270504","https://openalex.org/W4220707834","https://openalex.org/W3213397176","https://openalex.org/W7163660359","https://openalex.org/W3034113727","https://openalex.org/W3110715433","https://openalex.org/W3024258403","https://openalex.org/W2428131260","https://openalex.org/W4400068039","https://openalex.org/W4224215439"],"abstract_inverted_index":{"Per-rectal":[0],"endoscopic":[1,54,82,241],"myotomy":[2,55,83],"(PREM)":[3,56],"for":[4,57,181,239],"pediatric":[5,99],"Hirschsprung's":[6,59,102,134],"diseaseHirschsprung's":[7],"disease":[8,60,135],"is":[9,65,237],"a":[10,98,123,140,224],"congenital":[11],"disorder":[12],"characterized":[13],"by":[14,80,118],"the":[15,22,26,68,91,111,184,199,211,228,244,248],"absence":[16,229],"of":[17,25,29,63,95,133,202,230],"intrinsic":[18],"ganglion":[19,155,231],"cells":[20,156],"in":[21,74,97,194,243],"myenteric":[23],"plexuses":[24],"hindgut.The":[27],"majority":[28],"patients":[30],"present":[31],"during":[32],"infancy":[33],"or":[34,40,76,85],"childhood":[35],"with":[36,101,149,221,247],"constipation,":[37],"intestinal":[38],"obstruction,":[39],"megacolon":[41],"[1].Standard":[42],"treatment":[43],"includes":[44],"single-or":[45],"multi-stage":[46],"pull-through":[47],"surgery":[48],"[2].We":[49],"have":[50],"previously":[51],"reported":[52],"per-rectal":[53,240],"adult":[58],"[3].The":[61],"rationale":[62],"this":[64],"to":[66],"disrupt":[67],"spastic":[69,124,141],"bowel":[70],"segments,":[71],"like":[72],"those":[73],"achalasia":[75],"pylorospasm":[77],"are":[78],"disrupted":[79],"peroral":[81],"(POEM)":[84],"pyloromyotomy":[86],"(G-POEM)":[87],"[4,5].This":[88],"report":[89],"describes":[90],"technique":[92],"and":[93,126,145,227],"outcome":[94],"PREM":[96,182],"patient":[100,236],"disease.An":[103],"8-year-old":[104,196],"boy":[105,197],"had":[106,107],"refractory":[108],"constipation":[109],"since":[110],"neonatal":[112],"period":[113],"that":[114],"was":[115,187],"partially":[116],"relieved":[117],"high-dose":[119],"laxatives.Barium":[120],"enema":[121,193],"demonstrated":[122,154,169],"rectum":[125,144,212],"dilated":[127,146],"sigmoid":[128,147],"colon,":[129],"which":[130],"were":[131,162],"classical":[132],"(\u25b6":[136,165],"Fig.":[137,166,190,206,233],"1).Colonoscopy":[138],"showed":[139],"non-distensible":[142],"empty":[143],"colon":[148],"stool":[150],"residue.Deep":[151],"mucosal":[152],"biopsies":[153],"at":[157,213],"8":[158,214],"cm":[159,215],"but":[160],"these":[161],"absent":[163,170],"distally":[164],"2).":[167],"Manometry":[168],"rectoanal":[171],"inhibitory":[172],"reflex":[173],"(RAIR).Given":[174],"our":[175],"previous":[176],"experience,":[177],"we":[178],"obtained":[179],"consent":[180],"from":[183,210],"patient's":[185],"parents.PREM":[186],"performed":[188],"\u25b6":[189],"1":[191],"Barium":[192],"an":[195],"showing":[198,223],"characteristic":[200],"signs":[201],"Hirsch-":[203],"sprung's":[204],"disease.\u25b6":[205],"2":[207],"Biopsy":[208],"taken":[209],"(magnification":[216],"\u00d7":[217],"40),":[218],"stained":[219],"immunohistochemically":[220],"S100,":[222],"nerve":[225],"bundle":[226],"cells.\u25b6":[232],"3":[234],"The":[235],"positioned":[238],"myotomy,":[242],"prone":[245],"position":[246],"buttocks":[249],"strapped":[250],"laterally.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-03-29T00:00:00"}