{"id":"https://openalex.org/W2792242565","doi":"https://doi.org/10.1080/10826068.2018.1425710","title":"Immunotherapy approach with recombinant survivin adjuvanted with alum and MIP suppresses tumor growth in murine model of breast cancer","display_name":"Immunotherapy approach with recombinant survivin adjuvanted with alum and MIP suppresses tumor growth in murine model of breast cancer","publication_year":2018,"publication_date":"2018-01-22","ids":{"openalex":"https://openalex.org/W2792242565","doi":"https://doi.org/10.1080/10826068.2018.1425710","mag":"2792242565","pmid":"https://pubmed.ncbi.nlm.nih.gov/29355462"},"language":"en","primary_location":{"id":"doi:10.1080/10826068.2018.1425710","doi":"https://doi.org/10.1080/10826068.2018.1425710","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826068.2018.1425710","pdf_url":null,"source":{"id":"https://openalex.org/S113958752","display_name":"Preparative Biochemistry & Biotechnology","issn_l":"1082-6068","issn":["1082-6068","1532-2297"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preparative Biochemistry & Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100998823","display_name":"Himani Garg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himani Garg","raw_affiliation_strings":["Amity Institute of Virology and Immunology, Amity University, Uttar Pradesh, Noida, India","Talwar Research Foundation, Neb Sarai, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Virology and Immunology, Amity University, Uttar Pradesh, Noida, India","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"Talwar Research Foundation, Neb Sarai, New Delhi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102942522","display_name":"Jagdish Chandra Gupta","orcid":"https://orcid.org/0000-0002-9456-0097","observed_orcids":["https://orcid.org/0000-0002-9456-0097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jagdish C. Gupta","raw_affiliation_strings":["Talwar Research Foundation, Neb Sarai, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Talwar Research Foundation, Neb Sarai, New Delhi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019452347","display_name":"Gursaran P. Talwar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. P. Talwar","raw_affiliation_strings":["Talwar Research Foundation, Neb Sarai, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Talwar Research Foundation, Neb Sarai, New Delhi, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073728973","display_name":"Shweta Dubey","orcid":"https://orcid.org/0000-0002-0457-9692","observed_orcids":["https://orcid.org/0000-0002-0457-9692","https://orcid.org/0009-0000-5496-8963"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shweta Dubey","raw_affiliation_strings":["Amity Institute of Virology and Immunology, Amity University, Uttar Pradesh, Noida, India"],"raw_orcid":"https://orcid.org/0000-0002-0457-9692","affiliations":[{"raw_affiliation_string":"Amity Institute of Virology and Immunology, Amity University, Uttar Pradesh, Noida, India","institution_ids":["https://openalex.org/I191972202"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073728973"],"corresponding_institution_ids":["https://openalex.org/I191972202"],"apc_list":null,"apc_paid":null,"fwci":0.5239,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58544875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"48","issue":"3","first_page":"264","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/recombinant-protein-vaccine","display_name":"recombinant protein vaccine","score":0.7950000166893005},{"id":"https://openalex.org/keywords/aluminium-adjuvants","display_name":"alum adjuvant","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mycobacterium-indicus-pranii","display_name":"Mycobacterium indicus pranii","score":0.9950000047683716},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.753000020980835},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.8446178436279297},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7387701272964478},{"id":"https://openalex.org/C2780924562","wikidata":"https://www.wikidata.org/wiki/Q190527","display_name":"Alum","level":2,"score":0.6907318830490112},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6149997711181641},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5640729069709778},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5589339137077332},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5487353801727295},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5309543013572693},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5233466029167175},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5140932202339172},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.4616900682449341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4591673016548157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4538425803184509},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4445885419845581},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4353322386741638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32702112197875977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14997676014900208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12199407815933228},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000534","descriptor_name":"Alum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/10826068.2018.1425710","doi":"https://doi.org/10.1080/10826068.2018.1425710","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826068.2018.1425710","pdf_url":null,"source":{"id":"https://openalex.org/S113958752","display_name":"Preparative Biochemistry & Biotechnology","issn_l":"1082-6068","issn":["1082-6068","1532-2297"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preparative Biochemistry & Biotechnology","raw_type":"journal-article"},{"id":"pmid:29355462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29355462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Preparative biochemistry & biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7594586519","display_name":null,"funder_award_id":"SR/FT/LS-75/2012","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1530089119","https://openalex.org/W1551407310","https://openalex.org/W1697826352","https://openalex.org/W1964266353","https://openalex.org/W1976457595","https://openalex.org/W1989838539","https://openalex.org/W1990017773","https://openalex.org/W1990954596","https://openalex.org/W2011076638","https://openalex.org/W2047392100","https://openalex.org/W2050435702","https://openalex.org/W2055790994","https://openalex.org/W2056371902","https://openalex.org/W2061662618","https://openalex.org/W2064580048","https://openalex.org/W2092448563","https://openalex.org/W2096615903","https://openalex.org/W2108886474","https://openalex.org/W2113573520","https://openalex.org/W2120183880","https://openalex.org/W2148888494","https://openalex.org/W2151960859","https://openalex.org/W2157976581","https://openalex.org/W2165437317","https://openalex.org/W2323956652","https://openalex.org/W2406126047","https://openalex.org/W2462022051","https://openalex.org/W4254279810"],"related_works":["https://openalex.org/W2905928689","https://openalex.org/W2339804629","https://openalex.org/W4287878165","https://openalex.org/W2090287101","https://openalex.org/W4324149149","https://openalex.org/W2944451779","https://openalex.org/W4385874209","https://openalex.org/W1964266353","https://openalex.org/W2022938862","https://openalex.org/W2060076339"],"abstract_inverted_index":{"Survivin":[0],"has":[1],"received":[2],"attention":[3],"as":[4,102],"a":[5,145],"potential":[6,26],"target":[7],"for":[8,86,165,170],"cancer":[9,56,160],"immunotherapy":[10,147],"because":[11],"of":[12,27,29,46,88,130,167],"its":[13],"crucial":[14],"role":[15],"in":[16,51,125,155],"oncogenesis.":[17],"We":[18],"undertook":[19],"this":[20],"study":[21],"to":[22],"evaluate":[23],"the":[24,47,140],"immunotherapeutic":[25],"combination":[28,48,117,129,146],"recombinant":[30,131,150],"survivin":[31,59,75,132],"along":[32],"with":[33,79,96,111,128],"adjuvant":[34,116],"alum":[35,80],"and":[36,69,81,83,115,120,136,153,162],"immune":[37],"modulator":[38],"Mycobacterium":[39],"indicus":[40],"pranii":[41],"(MIP).":[42],"In":[43],"vivo":[44],"efficacy":[45],"was":[49,61,77,84,118],"studied":[50],"an":[52],"invasive":[53],"murine":[54,158],"breast":[55,159],"model.":[57],"Recombinant":[58],"protein":[60,76],"purified":[62],"from":[63],"Escherichia":[64],"coli":[65],"based":[66],"expression":[67],"system":[68],"characterized":[70],"by":[71],"western":[72],"blotting.":[73],"Purified":[74],"combined":[78],"MIP":[82,154],"used":[85],"immunization":[87],"Balb/c":[89,104],"mice.":[90],"Antigen-primed":[91],"animals":[92],"were":[93],"then":[94],"challenged":[95],"syngeneic":[97],"mammary":[98],"tumor":[99,108,123],"cells":[100],"known":[101],"4T-1.":[103],"mice":[105,126],"spontaneously":[106],"develop":[107],"when":[109],"inoculated":[110],"4T-1":[112],"cells.":[113],"Antigen":[114],"immunogenic":[119],"significantly":[121],"suppressed":[122],"growth":[124],"immunized":[127],"(10":[133],"\u00b5g),":[134],"alum,":[135,152],"MIP.":[137],"This":[138],"is":[139],"first":[141],"report":[142],"that":[143],"describes":[144],"approach":[148],"using":[149],"survivin,":[151],"highly":[156],"metastatic":[157],"model":[161],"holds":[163],"promise":[164],"development":[166],"new":[168],"biotherapeutics":[169],"cancer.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}