{"id":"https://openalex.org/W2792145403","doi":"https://doi.org/10.3389/fimmu.2018.00526","title":"High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells","display_name":"High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells","publication_year":2018,"publication_date":"2018-03-14","ids":{"openalex":"https://openalex.org/W2792145403","doi":"https://doi.org/10.3389/fimmu.2018.00526","mag":"2792145403","pmid":"https://pubmed.ncbi.nlm.nih.gov/29593748","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5861144"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2018.00526","doi":"https://doi.org/10.3389/fimmu.2018.00526","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.00526","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00526/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00526/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066547819","display_name":"Rob J.W. Arts","orcid":"https://orcid.org/0000-0002-6649-7190","observed_orcids":["https://orcid.org/0000-0002-6649-7190"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob J. W. Arts","raw_affiliation_strings":["Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113694163","display_name":"Po-Kai Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Kai Huang","raw_affiliation_strings":["College of Life Science, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu City, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042752501","display_name":"De Yang","orcid":"https://orcid.org/0000-0001-6705-8504","observed_orcids":["https://orcid.org/0000-0001-6705-8504"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"De Yang","raw_affiliation_strings":["Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institue at Frederick, Frederick, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institue at Frederick, Frederick, MD, United States","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036752858","display_name":"Leo A. B. Joosten","orcid":"https://orcid.org/0000-0001-6166-9830","observed_orcids":["https://orcid.org/0000-0001-6166-9830"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leo A. B. Joosten","raw_affiliation_strings":["Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008373339","display_name":"Jos W. M. van der Meer","orcid":"https://orcid.org/0000-0001-5120-3690","observed_orcids":["https://orcid.org/0000-0001-5120-3690"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos W. M. van der Meer","raw_affiliation_strings":["Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joost J. Oppenheim","raw_affiliation_strings":["Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institue at Frederick, Frederick, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institue at Frederick, Frederick, MD, United States","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027955775","display_name":"Mihai Gheorghe Netea","orcid":"https://orcid.org/0000-0003-2421-6052","observed_orcids":["https://orcid.org/0000-0003-2421-6052"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I28109999","display_name":"University of Medicine and Pharmacy of Craiova","ror":"https://ror.org/031d5vw30","country_code":"RO","type":"education","lineage":["https://openalex.org/I28109999"]}],"countries":["NL","RO"],"is_corresponding":false,"raw_author_name":"Mihai G. Netea","raw_affiliation_strings":["Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands","Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania","institution_ids":["https://openalex.org/I28109999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022374661","display_name":"Shih\u2010Chin Cheng","orcid":"https://orcid.org/0000-0003-1251-8774","observed_orcids":["https://orcid.org/0000-0003-1251-8774"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Chin Cheng","raw_affiliation_strings":["College of Life Science, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu City, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022374661"],"corresponding_institution_ids":["https://openalex.org/I25846049"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.3953,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78917723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"526","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgn1","display_name":"HMGN1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7149999737739563},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/innate-immune-tolerance","display_name":"innate immune tolerance","score":0.9120000004768372},{"id":"https://openalex.org/keywords/alarmins","display_name":"alarmins","score":0.824999988079071},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.8600000143051147},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7979999780654907},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.7549999952316284},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/histone-deacetylation","display_name":"histone deacetylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/lipopolysaccharide-tolerance","display_name":"lipopolysaccharide tolerance","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7148603796958923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5248684287071228},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5162041783332825},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4972536861896515},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4124099910259247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32552874088287354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31977739930152893},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27685871720314026},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2678145170211792}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024241","descriptor_name":"HMGN1 Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.3389/fimmu.2018.00526","doi":"https://doi.org/10.3389/fimmu.2018.00526","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.00526","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00526/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5861144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5861144","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:29593748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29593748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ad0f6edde30f47c6808b2f025226051c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ad0f6edde30f47c6808b2f025226051c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 9 (2018)","raw_type":"article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/190010","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/190010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/190010","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/190010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/190780","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/190780","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 9","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2018.00526","doi":"https://doi.org/10.3389/fimmu.2018.00526","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2018.00526","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00526/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7920715977","display_name":null,"funder_award_id":"105-2320-B-007-007 and 106-2628-B-007-002-MY4","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2792145403.pdf","grobid_xml":"https://content.openalex.org/works/W2792145403.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W168035116","https://openalex.org/W1773515121","https://openalex.org/W1964986858","https://openalex.org/W1978371085","https://openalex.org/W1980673092","https://openalex.org/W1992082488","https://openalex.org/W1993792235","https://openalex.org/W2002294822","https://openalex.org/W2011897320","https://openalex.org/W2012885541","https://openalex.org/W2018653121","https://openalex.org/W2020942709","https://openalex.org/W2024357272","https://openalex.org/W2041308303","https://openalex.org/W2051932976","https://openalex.org/W2067031028","https://openalex.org/W2076143571","https://openalex.org/W2079112084","https://openalex.org/W2081249048","https://openalex.org/W2084806080","https://openalex.org/W2089532303","https://openalex.org/W2106087378","https://openalex.org/W2106765180","https://openalex.org/W2112540182","https://openalex.org/W2118166844","https://openalex.org/W2128337342","https://openalex.org/W2129751113","https://openalex.org/W2134146607","https://openalex.org/W2136497284","https://openalex.org/W2140403277","https://openalex.org/W2141029513","https://openalex.org/W2152568820","https://openalex.org/W2280032391"],"related_works":["https://openalex.org/W2129751113","https://openalex.org/W2885710337","https://openalex.org/W2068425699","https://openalex.org/W7096538317","https://openalex.org/W8712975","https://openalex.org/W2285912532","https://openalex.org/W7015746486","https://openalex.org/W1981037268","https://openalex.org/W2099410504","https://openalex.org/W2794117904"],"abstract_inverted_index":{"HMGN1":[0,18,32,85,102],"(High-mobility":[1],"group":[2],"Nucleosome-binding":[3],"protein":[4,11],"1)":[5],"functions":[6],"as":[7,20,133],"a":[8,49,63,125],"non-histone":[9],"chromatin-binding":[10],"in":[12,48,98,128],"the":[13,42,68,71],"cell":[14],"nucleus.":[15],"However,":[16],"extracellular":[17],"acts":[19],"an":[21,104],"endogenous":[22,105],"danger-associated":[23],"inflammatory":[24,130],"mediator":[25],"(also":[26],"called":[27],"alarmin).":[28],"We":[29],"demonstrated":[30],"that":[31,108],"not":[33],"only":[34],"directly":[35],"stimulated":[36],"cytokine":[37,115],"production,":[38],"but":[39],"also":[40,89],"had":[41],"capacity":[43],"to":[44,54,94],"induce":[45,110],"immune":[46],"tolerance":[47,59,97],"TLR4":[50,106],"dependent":[51],"pathway,":[52],"similar":[53,93],"lipopolysaccharide":[55],"(LPS)-induced":[56],"tolerance.":[57],"HMGN1-induced":[58],"was":[60],"accompanied":[61],"by":[62,136],"metabolic":[64],"shift":[65],"associated":[66],"with":[67],"inhibition":[69],"of":[70,73,87,114],"induction":[72],"Warburg":[74],"effect":[75],"(aerobic":[76],"glycolysis)":[77],"and":[78,117,120],"histone":[79],"deacetylation":[80],"via":[81],"Sirtuin-1.":[82],"In":[83,100],"addition,":[84],"pre-challenge":[86],"mice":[88],"downregulated":[90],"TNF":[91],"production":[92,116],"LPS":[95],"induced":[96,135],"vivo.":[99],"conclusion,":[101],"is":[103],"ligand":[107],"can":[109],"both":[111],"acute":[112],"stimulation":[113],"long-term":[118],"tolerance,":[119],"thus":[121],"it":[122],"might":[123],"play":[124],"modulatory":[126],"role":[127],"sterile":[129],"processes":[131],"such":[132],"those":[134],"infection,":[137],"trauma":[138],"or":[139],"ischemia.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-03-29T00:00:00"}