{"id":"https://openalex.org/W2791928484","doi":"https://doi.org/10.1200/jco.2018.36.6_suppl.45","title":"Low testosterone at first PSA failure and assessment of the risk of death in men with unfavorable-risk prostate cancer treated on prospective clinical trials.","display_name":"Low testosterone at first PSA failure and assessment of the risk of death in men with unfavorable-risk prostate cancer treated on prospective clinical trials.","publication_year":2018,"publication_date":"2018-02-20","ids":{"openalex":"https://openalex.org/W2791928484","doi":"https://doi.org/10.1200/jco.2018.36.6_suppl.45","mag":"2791928484"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.6_suppl.45","doi":"https://doi.org/10.1200/jco.2018.36.6_suppl.45","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.6_suppl.45","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057173854","display_name":"Katelyn M. Atkins","orcid":"https://orcid.org/0000-0002-3165-4803","observed_orcids":["https://orcid.org/0000-0002-3165-4803"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Mae Atkins","raw_affiliation_strings":["Harvard Medical School Radiation Oncology Program/ Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School Radiation Oncology Program/ Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100678189","display_name":"Ming\u2010Hui Chen","orcid":"https://orcid.org/0000-0003-1935-2447","observed_orcids":["https://orcid.org/0000-0003-1935-2447"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Hui Chen","raw_affiliation_strings":["University of Connecticut, Storrs, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT;","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048740236","display_name":"Jing Wu","orcid":"https://orcid.org/0000-0001-7808-6981","observed_orcids":["https://orcid.org/0000-0001-7808-6981","https://orcid.org/0000-0003-3615-4581"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wu","raw_affiliation_strings":["University of Rhode Island, Kingston, RI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island, Kingston, RI;","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020110978","display_name":"Andrew A. Renshaw","orcid":"https://orcid.org/0000-0002-1318-4238","observed_orcids":["https://orcid.org/0000-0002-1318-4238"]},"institutions":[{"id":"https://openalex.org/I1292848113","display_name":"Baptist Hospital of Miami","ror":"https://ror.org/000pfrh90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1292848113","https://openalex.org/I4210097785"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew A. Renshaw","raw_affiliation_strings":["Baptist Hospital and Miami Cancer Institute, Miami, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baptist Hospital and Miami Cancer Institute, Miami, FL;","institution_ids":["https://openalex.org/I1292848113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070767858","display_name":"Marian J. Loffredo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian Loffredo","raw_affiliation_strings":["Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056766924","display_name":"Philip W. Kantoff","orcid":"https://orcid.org/0000-0001-7275-0597","observed_orcids":["https://orcid.org/0000-0001-7275-0597"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip W. Kantoff","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007578304","display_name":"Eric Jay Small","orcid":"https://orcid.org/0000-0003-3191-6268","observed_orcids":["https://orcid.org/0000-0003-3191-6268"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Jay Small","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072365761","display_name":"Anthony Victor D'Amico","orcid":"https://orcid.org/0000-0002-4084-9944","observed_orcids":["https://orcid.org/0000-0002-4084-9944"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Victor D'Amico","raw_affiliation_strings":["Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute/ Brigham and Women's Hospital, Boston, MA;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"6_suppl","first_page":"45","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone-deficiency","display_name":"androgen deficiency","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6539999842643738},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/prostate-cancer-specific-mortality","display_name":"prostate cancer-specific mortality","score":0.8080000281333923},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9480000138282776},{"id":"https://openalex.org/keywords/other-cause-mortality","display_name":"other-cause mortality","score":0.7289999723434448},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.7480000257492065},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/salvage-androgen-deprivation-therapy","display_name":"salvage androgen deprivation therapy","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9406657218933105},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8306592106819153},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6679229736328125},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6396713852882385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5493438243865967},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5330126881599426},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5260988473892212},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5145465731620789},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.508730947971344},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.504130482673645},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49662667512893677},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4239104986190796},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.42314374446868896},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4126071333885193},{"id":"https://openalex.org/C2778559712","wikidata":"https://www.wikidata.org/wiki/Q4759442","display_name":"Androgen suppression","level":4,"score":0.41005682945251465},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.16339969635009766},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.13378232717514038}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.6_suppl.45","doi":"https://doi.org/10.1200/jco.2018.36.6_suppl.45","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.6_suppl.45","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2777544969","https://openalex.org/W3140986940","https://openalex.org/W4412821502","https://openalex.org/W7162189318","https://openalex.org/W2579042675","https://openalex.org/W4407634137","https://openalex.org/W4379336186","https://openalex.org/W4405084952","https://openalex.org/W2123111830","https://openalex.org/W1603080623"],"abstract_inverted_index":{"45":[0],"Background:":[1],"Low":[2,223],"testosterone":[3,72,92,158,217,224,273],"at":[4,27,74,93,159,218,225,274],"prostate":[5,58,102,119,141,250,259],"cancer":[6,59,120,142,251,260],"diagnosis":[7],"has":[8,42],"been":[9,44],"associated":[10,97],"with":[11,56,64,98,154,192,213,247,256,267,271],"a":[12,125,193,230,281],"worse":[13],"prognosis.":[14,233],"Whether":[15],"this":[16],"is":[17,241],"true":[18],"and":[19,34,46,66,79,81,105,117,182,252],"how":[20],"to":[21,36,52,86,243,263],"define":[22],"the":[23,37,99,167,278],"best":[24],"treatment":[25],"approach":[26],"first":[28,132,219,226],"PSA":[29,75,94,133,160,220,227,275],"failure":[30,76,95,228,276],"following":[31,131],"definitive":[32],"therapy":[33,69],"prior":[35],"documentation":[38],"of":[39,101,128,144,169,199,280],"metastatic":[40,249],"disease":[41],"not":[43],"elucidated":[45],"was":[47,96,209],"studied.":[48],"Methods:":[49],"Between":[50],"1995":[51],"2001,":[53],"58":[54],"men":[55,136,153,212,246,255,270],"unfavorable-risk":[57],"treated":[60],"on":[61],"clinical":[62],"trials":[63],"radiation":[65],"androgen":[67],"deprivation":[68],"(ADT)":[70],"had":[71],"levels":[73],"available.":[77],"Cox":[78],"Fine":[80],"Gray":[82],"regressions":[83],"were":[84],"performed":[85],"ascertain":[87],"whether":[88],"low":[89,155,214,272],"versus":[90,148,156,215],"normal":[91,157,216],"risk":[100,168,198],"cancer-specific,":[103],"other-cause":[104],"all-cause":[106],"mortality":[107],"(PCSM,":[108],"OCM,":[109],"ACM)":[110],"adjusting":[111],"for":[112],"age,":[113],"salvage":[114],"ADT":[115,244,268],"use":[116,266],"known":[118],"prognostic":[121],"factors.":[122],"Results:":[123],"After":[124],"median":[126],"follow-up":[127],"6.68":[129],"years":[130],"failure,":[134,161],"31":[135],"(53.4%)":[137],"died;":[138],"10":[139],"from":[140],"(32.3%),":[143],"which":[145],"8/11":[146],"(72.7%)":[147],"2/47":[149],"(4.3%)":[150],"occurred":[151],"in":[152,166,211,245,254,269,277],"respectively.":[162],"A":[163],"significant":[164],"increase":[165],"ACM":[170],"(adjusted":[171],"hazard":[172],"ratio,":[173],"AHR":[174],"[2.54,":[175],"95%":[176,186,203],"CI":[177,187,204],"1.04-6.21];":[178],"P":[179,189,206],"=":[180,190,207],"0.04)":[181],"PCSM":[183],"(AHR":[184,201],"[13.71,":[185],"2.4-78.16];":[188],"0.003),":[191],"reciprocal":[194],"trend":[195],"toward":[196],"decreased":[197],"OCM":[200],"[0.18,":[202],"0.02-1.55];":[205],"0.12)":[208],"observed":[210],"failure.":[221],"Conclusions:":[222],"confers":[229],"very":[231],"poor":[232],"Given":[234],"prolonged":[235],"survival":[236],"when":[237],"abiraterone":[238],"or":[239],"docetaxel":[240],"added":[242],"castrate-sensitive":[248],"possibly":[253],"localized":[257],"high-risk":[258],"provides":[261],"rationale":[262],"support":[264],"their":[265],"setting":[279],"phase":[282],"II":[283],"trial.":[284]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2018-03-29T00:00:00"}
