{"id":"https://openalex.org/W2791908216","doi":"https://doi.org/10.1177/1078155217752079","title":"Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect","display_name":"Aplastic anemia secondary to propylthiouracil: A rare and life-threatening adverse effect","publication_year":2018,"publication_date":"2018-01-22","ids":{"openalex":"https://openalex.org/W2791908216","doi":"https://doi.org/10.1177/1078155217752079","mag":"2791908216","pmid":"https://pubmed.ncbi.nlm.nih.gov/29357782"},"language":"en","primary_location":{"id":"doi:10.1177/1078155217752079","doi":"https://doi.org/10.1177/1078155217752079","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1078155217752079","pdf_url":null,"source":{"id":"https://openalex.org/S66425452","display_name":"Journal of Oncology Pharmacy Practice","issn_l":"1078-1552","issn":["1078-1552","1477-092X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Pharmacy Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076513555","display_name":"Hira Ghazal Shaikh","orcid":"https://orcid.org/0000-0001-5604-4166","observed_orcids":["https://orcid.org/0000-0001-5604-4166"]},"institutions":[{"id":"https://openalex.org/I1310421338","display_name":"Allegheny Health Network","ror":"https://ror.org/0101kry21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hira Shaikh","raw_affiliation_strings":["Allegheny Health Network, Pittsburgh, USA"],"raw_orcid":"https://orcid.org/0000-0001-5604-4166","affiliations":[{"raw_affiliation_string":"Allegheny Health Network, Pittsburgh, USA","institution_ids":["https://openalex.org/I1310421338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108625478","display_name":"Amir Shahzad Kamran","orcid":"https://orcid.org/0009-0000-9210-2191","observed_orcids":["https://orcid.org/0009-0000-9210-2191"]},"institutions":[{"id":"https://openalex.org/I1310421338","display_name":"Allegheny Health Network","ror":"https://ror.org/0101kry21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir Kamran","raw_affiliation_strings":["Allegheny Health Network, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allegheny Health Network, Pittsburgh, USA","institution_ids":["https://openalex.org/I1310421338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112534134","display_name":"Soorih Shaikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310421338","display_name":"Allegheny Health Network","ror":"https://ror.org/0101kry21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soorih Shaikh","raw_affiliation_strings":["Allegheny Health Network, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allegheny Health Network, Pittsburgh, USA","institution_ids":["https://openalex.org/I1310421338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044628707","display_name":"Prerna Mewawalla","orcid":"https://orcid.org/0009-0008-7464-6898","observed_orcids":["https://orcid.org/0009-0008-7464-6898"]},"institutions":[{"id":"https://openalex.org/I1310421338","display_name":"Allegheny Health Network","ror":"https://ror.org/0101kry21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310421338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prerna Mewawalla","raw_affiliation_strings":["Allegheny Health Network, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allegheny Health Network, Pittsburgh, USA","institution_ids":["https://openalex.org/I1310421338"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076513555"],"corresponding_institution_ids":["https://openalex.org/I1310421338"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.3651,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60546077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"25","issue":"3","first_page":"715","last_page":"718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.12370000034570694,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.12120000272989273,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.9900000095367432},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/drug-induced-bone-marrow-toxicity","display_name":"drug-induced bone marrow toxicity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7379999756813049},{"id":"https://openalex.org/keywords/pancytopenia","display_name":"pancytopenia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.7009999752044678},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.765999972820282},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9443138241767883},{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.880493700504303},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.7161084413528442},{"id":"https://openalex.org/C2779382419","wikidata":"https://www.wikidata.org/wiki/Q1757427","display_name":"Pancytopenia","level":3,"score":0.5161924958229065},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.4838818311691284},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44767889380455017},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4123348593711853},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3844338357448578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34614038467407227},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.29355260729789734},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.2352289855480194}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011441","descriptor_name":"Propylthiouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/1078155217752079","doi":"https://doi.org/10.1177/1078155217752079","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1078155217752079","pdf_url":null,"source":{"id":"https://openalex.org/S66425452","display_name":"Journal of Oncology Pharmacy Practice","issn_l":"1078-1552","issn":["1078-1552","1477-092X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Pharmacy Practice","raw_type":"journal-article"},{"id":"pmid:29357782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29357782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W32335384","https://openalex.org/W1964935809","https://openalex.org/W1971293030","https://openalex.org/W1971678782","https://openalex.org/W1972779461","https://openalex.org/W1995352994","https://openalex.org/W2009942530","https://openalex.org/W2021630792","https://openalex.org/W2026587609","https://openalex.org/W2028456559","https://openalex.org/W2030122788","https://openalex.org/W2046625708","https://openalex.org/W2049309893","https://openalex.org/W2052285621","https://openalex.org/W2059891370","https://openalex.org/W2086264703","https://openalex.org/W2133201734","https://openalex.org/W2141299388","https://openalex.org/W2142975818","https://openalex.org/W2159939738","https://openalex.org/W2560876009","https://openalex.org/W2778362492","https://openalex.org/W3148251129","https://openalex.org/W4229847517","https://openalex.org/W4243225672","https://openalex.org/W4246483858","https://openalex.org/W4256537759"],"related_works":["https://openalex.org/W3108391892","https://openalex.org/W4318357124","https://openalex.org/W4229847517","https://openalex.org/W2903487220","https://openalex.org/W2066215680","https://openalex.org/W2414157379","https://openalex.org/W2288408238","https://openalex.org/W3039175976","https://openalex.org/W1497815047","https://openalex.org/W2046625708"],"abstract_inverted_index":{"BACKGROUND:":[0],"Propylthiouracil":[1],"has":[2,139],"been":[3,140],"in":[4,40,54],"use":[5],"for":[6,12,164],"more":[7],"than":[8],"half":[9],"a":[10,47,114],"century":[11],"the":[13,38,55,58,70,93,153,156,165,188,200,207],"treatment":[14,205],"of":[15,49,57,69,120,148,161,206],"hyperthyroidism.":[16],"While":[17],"it":[18],"is":[19,30,155],"largely":[20],"known":[21],"to":[22,42,91,107,133,152,169,187,198],"cause":[23],"agranulocytosis,":[24],"its":[25],"association":[26],"with":[27,64,102,204],"aplastic":[28,44,111],"anemia":[29,45,112,138],"rarely":[31],"heard":[32],"of.":[33],"Our":[34],"case":[35],"will":[36],"be":[37,196],"third":[39],"literature":[41],"suggest":[43],"as":[46,110,143,181],"manifestation":[48],"propylthiouracil,":[50],"which":[51,105],"unfortunately":[52],"culminated":[53],"death":[56],"patient.":[59],"CASE:":[60],"A":[61],"67-year-old":[62],"female,":[63],"recently":[65],"diagnosed":[66],"metastatic":[67],"adenocarcinoma":[68],"lung,":[71],"developed":[72,83,126],"hyperthyroidism":[73],"after":[74,97],"being":[75],"started":[76,88],"on":[77,89,113],"Nivolumab":[78],"and":[79,122,129,159,202],"Iplimumab.":[80],"After":[81],"she":[82,86,99,125],"atrial":[84],"fibrillation,":[85],"was":[87,100],"propylthiouracil":[90,121],"control":[92],"thyroid":[94],"activity.":[95],"Soon":[96],"that,":[98],"admitted":[101],"severe":[103],"neutropenia,":[104],"progressed":[106],"pancytopenia":[108],"confirmed":[109],"bone":[115],"marrow":[116],"biopsy.":[117],"Despite":[118],"discontinuation":[119],"aggressive":[123],"treatment,":[124],"septic":[127],"shock":[128],"multi-organ":[130],"failure,":[131],"leading":[132],"her":[134],"death.":[135],"CONCLUSION:":[136],"Aplastic":[137],"sparingly":[141],"reported":[142],"an":[144,175],"extremely":[145,176],"rare":[146],"complication":[147,166],"propylthiouracil.":[149,170,212],"Further":[150],"adding":[151],"ambiguity":[154],"unknown":[157],"etiology":[158],"lack":[160],"specific":[162],"therapy":[163],"when":[167,209],"attributed":[168],"The":[171],"disease":[172,208],"can":[173],"carry":[174],"poor":[177],"prognosis":[178],"if":[179],"untreated,":[180],"proven":[182],"by":[183,211],"our":[184],"case.":[185],"Due":[186],"same":[189],"reasons,":[190],"we":[191],"recommend":[192],"that":[193],"further":[194],"investigations":[195],"done":[197],"elucidate":[199],"pathogenesis":[201],"assist":[203],"caused":[210]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}