{"id":"https://openalex.org/W2791744441","doi":"https://doi.org/10.1007/s11912-018-0654-5","title":"Immunotherapy for Head and Neck Squamous Cell Carcinoma","display_name":"Immunotherapy for Head and Neck Squamous Cell Carcinoma","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2791744441","doi":"https://doi.org/10.1007/s11912-018-0654-5","mag":"2791744441","pmid":"https://pubmed.ncbi.nlm.nih.gov/29502288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835060"},"language":"en","primary_location":{"id":"doi:10.1007/s11912-018-0654-5","doi":"https://doi.org/10.1007/s11912-018-0654-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11912-018-0654-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs11912-018-0654-5.pdf","source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs11912-018-0654-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057924190","display_name":"Jessica M. Moskovitz","orcid":"https://orcid.org/0000-0003-2360-6411","observed_orcids":["https://orcid.org/0000-0003-2360-6411"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Moskovitz","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065065876","display_name":"Jennifer D. Moy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Moy","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086074491","display_name":"Robert Louis Ferris","orcid":"https://orcid.org/0000-0001-6605-2071","observed_orcids":["https://orcid.org/0000-0001-6605-2071"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L. Ferris","raw_affiliation_strings":["Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. ferrrl@upmc.edu","Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. ferrrl@upmc.edu","Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA. ferrrl@upmc.edu","University of Pittsburgh Eye and Ear Institute, 200 North Lothrop Street, Suite 500, Pittsburgh, PA, 15213, USA. ferrrl@upmc.edu","Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. ferrrl@upmc.edu","institution_ids":["https://openalex.org/I4210128526"]},{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. ferrrl@upmc.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA. ferrrl@upmc.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh Eye and Ear Institute, 200 North Lothrop Street, Suite 500, Pittsburgh, PA, 15213, USA. ferrrl@upmc.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086074491"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":2.0953,"has_fulltext":true,"cited_by_count":162,"citation_normalized_percentile":{"value":0.90416354,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"20","issue":"2","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9290000200271606},{"id":"https://openalex.org/keywords/treatment-resistance-mechanisms","display_name":"treatment resistance mechanisms","score":0.7239999771118164},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5490000247955322},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9220560789108276},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7769465446472168},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6732233762741089},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6710345149040222},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5766951441764832},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.57071852684021},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.55316561460495},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5524731874465942},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5178933143615723},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.4534076750278473},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.451585590839386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3586961030960083}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11912-018-0654-5","doi":"https://doi.org/10.1007/s11912-018-0654-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11912-018-0654-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs11912-018-0654-5.pdf","source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5835060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5835060","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Oncol Rep","raw_type":"Text"},{"id":"pmid:29502288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29502288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11912-018-0654-5","doi":"https://doi.org/10.1007/s11912-018-0654-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11912-018-0654-5","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs11912-018-0654-5.pdf","source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2791744441.pdf","grobid_xml":"https://content.openalex.org/works/W2791744441.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W605097856","https://openalex.org/W1512225597","https://openalex.org/W1518048883","https://openalex.org/W1518563847","https://openalex.org/W1541404499","https://openalex.org/W1571418278","https://openalex.org/W1576919975","https://openalex.org/W1834998094","https://openalex.org/W1913970044","https://openalex.org/W1914776013","https://openalex.org/W1951108084","https://openalex.org/W1963665993","https://openalex.org/W1965180311","https://openalex.org/W1971030977","https://openalex.org/W1971180916","https://openalex.org/W1972146805","https://openalex.org/W1972168906","https://openalex.org/W1973091654","https://openalex.org/W1975262935","https://openalex.org/W1978758070","https://openalex.org/W1978868813","https://openalex.org/W1980802790","https://openalex.org/W1982981861","https://openalex.org/W1983007530","https://openalex.org/W1983906625","https://openalex.org/W1985804036","https://openalex.org/W1987723373","https://openalex.org/W1987862069","https://openalex.org/W1990791836","https://openalex.org/W1992416250","https://openalex.org/W1992676863","https://openalex.org/W1996123836","https://openalex.org/W1996445525","https://openalex.org/W1998181914","https://openalex.org/W1999468766","https://openalex.org/W2000463365","https://openalex.org/W2001118140","https://openalex.org/W2001224424","https://openalex.org/W2001428172","https://openalex.org/W2001816519","https://openalex.org/W2004271732","https://openalex.org/W2005204942","https://openalex.org/W2010121426","https://openalex.org/W2010706029","https://openalex.org/W2013492504","https://openalex.org/W2016732129","https://openalex.org/W2016940606","https://openalex.org/W2016983859","https://openalex.org/W2017577544","https://openalex.org/W2021472146","https://openalex.org/W2022208959","https://openalex.org/W2023427658","https://openalex.org/W2025421597","https://openalex.org/W2026318599","https://openalex.org/W2030612376","https://openalex.org/W2031200496","https://openalex.org/W2031851764","https://openalex.org/W2032352705","https://openalex.org/W2034751554","https://openalex.org/W2035576607","https://openalex.org/W2037898720","https://openalex.org/W2038723984","https://openalex.org/W2039395562","https://openalex.org/W2041056400","https://openalex.org/W2041127810","https://openalex.org/W2042699075","https://openalex.org/W2043043829","https://openalex.org/W2050785743","https://openalex.org/W2052195653","https://openalex.org/W2052727153","https://openalex.org/W2053353274","https://openalex.org/W2055186346","https://openalex.org/W2056944587","https://openalex.org/W2057965214","https://openalex.org/W2059588067","https://openalex.org/W2060332172","https://openalex.org/W2060672294","https://openalex.org/W2062257317","https://openalex.org/W2063721051","https://openalex.org/W2065819686","https://openalex.org/W2066671159","https://openalex.org/W2067224845","https://openalex.org/W2071732845","https://openalex.org/W2076197602","https://openalex.org/W2081414148","https://openalex.org/W2082081599","https://openalex.org/W2083262432","https://openalex.org/W2084728135","https://openalex.org/W2088202198","https://openalex.org/W2088571368","https://openalex.org/W2089296782","https://openalex.org/W2090806526","https://openalex.org/W2091135133","https://openalex.org/W2091206905","https://openalex.org/W2091312795","https://openalex.org/W2092190749","https://openalex.org/W2093424661","https://openalex.org/W2094217947","https://openalex.org/W2094955298","https://openalex.org/W2096825083","https://openalex.org/W2096866753","https://openalex.org/W2097545995","https://openalex.org/W2097617059","https://openalex.org/W2097995306","https://openalex.org/W2099674544","https://openalex.org/W2100928937","https://openalex.org/W2101027485","https://openalex.org/W2101041628","https://openalex.org/W2102939102","https://openalex.org/W2104810134","https://openalex.org/W2105499507","https://openalex.org/W2105595995","https://openalex.org/W2107783310","https://openalex.org/W2107830051","https://openalex.org/W2108789863","https://openalex.org/W2109949307","https://openalex.org/W2110718030","https://openalex.org/W2111161262","https://openalex.org/W2112256663","https://openalex.org/W2112561613","https://openalex.org/W2112845420","https://openalex.org/W2112887207","https://openalex.org/W2112927491","https://openalex.org/W2115316834","https://openalex.org/W2115674896","https://openalex.org/W2116226279","https://openalex.org/W2117692326","https://openalex.org/W2121291860","https://openalex.org/W2123363005","https://openalex.org/W2128035403","https://openalex.org/W2137289789","https://openalex.org/W2137797191","https://openalex.org/W2138357033","https://openalex.org/W2139340015","https://openalex.org/W2140231263","https://openalex.org/W2141208318","https://openalex.org/W2141267339","https://openalex.org/W2141274038","https://openalex.org/W2143163879","https://openalex.org/W2145453174","https://openalex.org/W2146906100","https://openalex.org/W2147653557","https://openalex.org/W2148707387","https://openalex.org/W2148834247","https://openalex.org/W2149252678","https://openalex.org/W2150108811","https://openalex.org/W2153101406","https://openalex.org/W2153398168","https://openalex.org/W2154152644","https://openalex.org/W2155374321","https://openalex.org/W2155384808","https://openalex.org/W2155909750","https://openalex.org/W2159365184","https://openalex.org/W2160202883","https://openalex.org/W2163196794","https://openalex.org/W2163426702","https://openalex.org/W2163814058","https://openalex.org/W2167685509","https://openalex.org/W2168478794","https://openalex.org/W2168662093","https://openalex.org/W2169779496","https://openalex.org/W2169992085","https://openalex.org/W2170137783","https://openalex.org/W2182583959","https://openalex.org/W2274310825","https://openalex.org/W2280581576","https://openalex.org/W2297728992","https://openalex.org/W2340636398","https://openalex.org/W2346380472","https://openalex.org/W2401063966","https://openalex.org/W2401455386","https://openalex.org/W2418262374","https://openalex.org/W2464062738","https://openalex.org/W2474401389","https://openalex.org/W2498463209","https://openalex.org/W2522313999","https://openalex.org/W2523194272","https://openalex.org/W2527129822","https://openalex.org/W2529484692","https://openalex.org/W2535326629","https://openalex.org/W2537963082","https://openalex.org/W2557336488","https://openalex.org/W2558219863","https://openalex.org/W2560367415","https://openalex.org/W2572174216","https://openalex.org/W2593611879","https://openalex.org/W2599396226","https://openalex.org/W2606964316","https://openalex.org/W3173586783"],"related_works":["https://openalex.org/W2894737021","https://openalex.org/W4414529082","https://openalex.org/W7127383955","https://openalex.org/W7222319667","https://openalex.org/W2890431112","https://openalex.org/W4409328570","https://openalex.org/W2790502904","https://openalex.org/W2982474543","https://openalex.org/W2721554966","https://openalex.org/W3007231374"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Discussion":[3],"of":[4,73,112,146,155,165],"current":[5,29],"strategies":[6],"targeting":[7,44],"the":[8,28,59,71,107,139,153,170],"immune":[9,45],"system":[10],"related":[11],"to":[12,91,126,130,137,172],"solid":[13],"tumors":[14],"with":[15,31,117,144],"emphasis":[16],"on":[17],"head":[18],"and":[19,33,64,70,85,133,162],"neck":[20],"squamous":[21],"cell":[22,66],"carcinoma":[23],"(HNSCC).This":[24],"review":[25],"will":[26,168,177],"outline":[27],"challenges":[30],"immunotherapy":[32],"future":[34],"goals":[35],"for":[36,62,76,115],"treatment":[37,142],"using":[38],"these":[39,74,77,166],"agents.":[40],"RECENT":[41],"FINDINGS:":[42],"Agents":[43],"checkpoint":[46,93],"receptors":[47],"(IR)":[48],"such":[49],"as":[50,109],"program":[51],"death":[52],"1":[53],"(PD1)":[54],"have":[55],"been":[56],"used":[57],"in":[58,152],"clinical":[60],"realm":[61],"melanoma":[63],"non-small":[65],"lung":[67],"cancer":[68],"(NSCLC),":[69],"use":[72],"agents":[75],"malignancies":[78],"has":[79,149],"provided":[80],"crucial":[81],"information":[82],"about":[83],"how":[84],"why":[86],"patients":[87,116,175],"respond":[88],"or":[89],"not":[90,160],"inhibitory":[92],"receptor":[94],"blockade":[95],"therapy":[96],"(ICR).":[97],"The":[98],"anti":[99],"PD1":[100],"agent,":[101],"nivolumab,":[102],"was":[103],"recently":[104],"approved":[105],"by":[106],"FDA":[108],"a":[110],"standard":[111],"care":[113],"regimen":[114,143],"platinum":[118],"refractory":[119],"recurrent/metastatic":[120],"(R/M)":[121],"HNSCC.":[122],"Molecular":[123],"pathways":[124],"leading":[125],"resistance":[127,158],"are":[128],"starting":[129],"be":[131],"identified,":[132],"work":[134],"is":[135,159],"underway":[136],"understand":[138],"most":[140],"optimal":[141],"incorporation":[145],"immunotherapy.":[147],"ICR":[148],"renewed":[150],"interest":[151],"immunology":[154],"cancer,":[156],"but":[157],"uncommon,":[161],"thus":[163],"understanding":[164],"mechanisms":[167],"allow":[169],"clinician":[171],"appropriately":[173],"select":[174],"that":[176],"benefit":[178],"from":[179],"this":[180],"therapy.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}