{"id":"https://openalex.org/W2791367071","doi":"https://doi.org/10.3390/pathogens7020033","title":"Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei","display_name":"Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei","publication_year":2018,"publication_date":"2018-03-22","ids":{"openalex":"https://openalex.org/W2791367071","doi":"https://doi.org/10.3390/pathogens7020033","mag":"2791367071","pmid":"https://pubmed.ncbi.nlm.nih.gov/29565282","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6027259"},"language":"en","primary_location":{"id":"doi:10.3390/pathogens7020033","doi":"https://doi.org/10.3390/pathogens7020033","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens7020033","pdf_url":"https://www.mdpi.com/2076-0817/7/2/33/pdf?version=1525344701","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-0817/7/2/33/pdf?version=1525344701","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102028019","display_name":"Srinivasan Ramakrishnan","orcid":"https://orcid.org/0000-0001-8370-0528","observed_orcids":["https://orcid.org/0000-0001-8370-0528"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivasan Ramakrishnan","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054188956","display_name":"Beejan Asady","orcid":"https://orcid.org/0000-0002-7503-418X","observed_orcids":["https://orcid.org/0000-0002-7503-418X"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beejan Asady","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roberto Docampo","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA","Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":"https://orcid.org/0000-0003-4229-8784","affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000842323"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":2.9255,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.90667675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"2","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-contact-sites","display_name":"membrane contact sites","score":0.8619999885559082},{"id":"https://openalex.org/keywords/acidocalcisomes","display_name":"acidocalcisomes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9919999837875366},{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.6010000109672546},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bioenergetics","display_name":"bioenergetics","score":0.8140000104904175},{"id":"https://openalex.org/keywords/trypanosome-parasites","display_name":"trypanosome parasites","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7893937230110168},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.7348177433013916},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.7052716612815857},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5777866840362549},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5652399063110352},{"id":"https://openalex.org/C88020867","wikidata":"https://www.wikidata.org/wiki/Q6815123","display_name":"Membrane contact site","level":5,"score":0.5549830198287964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5377827286720276},{"id":"https://openalex.org/C2779549974","wikidata":"https://www.wikidata.org/wiki/Q541987","display_name":"Trypanosoma","level":2,"score":0.4523206949234009},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3300606906414032},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.27978450059890747},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25121748447418213},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.1720525324344635},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.054008543491363525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pathogens7020033","doi":"https://doi.org/10.3390/pathogens7020033","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens7020033","pdf_url":"https://www.mdpi.com/2076-0817/7/2/33/pdf?version=1525344701","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4996126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6027259","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6027259","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6027259","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"Text"},{"id":"pmid:29565282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29565282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7f10b8c0cc20453f8d377cb93facde27","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7f10b8c0cc20453f8d377cb93facde27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pathogens, Vol 7, Iss 2, p 33 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pathogens7020033","doi":"https://doi.org/10.3390/pathogens7020033","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens7020033","pdf_url":"https://www.mdpi.com/2076-0817/7/2/33/pdf?version=1525344701","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5316311330","display_name":null,"funder_award_id":"AI-108222","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7457663146","display_name":"The roles of polyphosphate and acidocalcisomes in Trypanosoma brucei","funder_award_id":"R01AI077538","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7567005682","display_name":"Calcium signaling in Trypanosoma brucei","funder_award_id":"R01AI108222","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320310010","display_name":"University of Georgia","ror":"https://ror.org/00te3t702"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2791367071.pdf","grobid_xml":"https://content.openalex.org/works/W2791367071.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1940716720","https://openalex.org/W1963791094","https://openalex.org/W1967763539","https://openalex.org/W1974939251","https://openalex.org/W1983772092","https://openalex.org/W1986213783","https://openalex.org/W1986855328","https://openalex.org/W1996035662","https://openalex.org/W1997266228","https://openalex.org/W1997527771","https://openalex.org/W1998035894","https://openalex.org/W2015536770","https://openalex.org/W2029727594","https://openalex.org/W2029980942","https://openalex.org/W2036145275","https://openalex.org/W2037121210","https://openalex.org/W2046353863","https://openalex.org/W2057833233","https://openalex.org/W2066029883","https://openalex.org/W2067841051","https://openalex.org/W2075400125","https://openalex.org/W2094449064","https://openalex.org/W2096579721","https://openalex.org/W2097979902","https://openalex.org/W2105769353","https://openalex.org/W2114228694","https://openalex.org/W2115021528","https://openalex.org/W2115929745","https://openalex.org/W2125219081","https://openalex.org/W2133815054","https://openalex.org/W2135633020","https://openalex.org/W2148483715","https://openalex.org/W2150055532","https://openalex.org/W2157236463","https://openalex.org/W2163484619","https://openalex.org/W2170638980","https://openalex.org/W2182369134","https://openalex.org/W2288568691","https://openalex.org/W2542183658","https://openalex.org/W2552607372","https://openalex.org/W2560338825","https://openalex.org/W2580573179","https://openalex.org/W2614044637","https://openalex.org/W2744973006","https://openalex.org/W2766127467","https://openalex.org/W4255760236"],"related_works":["https://openalex.org/W1997266228","https://openalex.org/W1998035894","https://openalex.org/W1508527953","https://openalex.org/W2808333527","https://openalex.org/W3013273675","https://openalex.org/W4212851483","https://openalex.org/W2057833233","https://openalex.org/W2947871760","https://openalex.org/W3119897429","https://openalex.org/W3082191187"],"abstract_inverted_index":{"Membrane":[0],"contact":[1,25,43,53,101,126],"sites":[2,26,44,54,102,127],"are":[3],"regions":[4],"of":[5,20,24,41,58,116,124,138],"close":[6,114],"apposition":[7],"between":[8,105],"two":[9],"organelles,":[10],"typically":[11],"less":[12],"than":[13],"30":[14],"nanometers":[15],"apart,":[16],"that":[17,103],"facilitate":[18,55],"transfer":[19],"biomolecules.":[21],"The":[22],"presence":[23,40],"has":[27],"been":[28],"demonstrated":[29],"in":[30,45,71,82,140],"yeast,":[31],"plants,":[32],"and":[33,95,107],"mammalian":[34,49],"cells.":[35],"Here,":[36],"we":[37,88,110],"investigated":[38],"the":[39,62,69,113,136],"such":[42],"Trypanosoma":[46],"brucei.":[47],"In":[48,85],"cells,":[50],"endoplasmic":[51],"reticulum-mitochondria":[52],"mitochondrial":[56],"uptake":[57],"Ca2+":[59,80,139],"released":[60],"by":[61],"ER-located":[63],"inositol":[64],"1,4,5-trisphosphate":[65],"receptor":[66],"(InsP3R).":[67],"However,":[68],"InsP3R":[70],"trypanosomes":[72],"localizes":[73],"to":[74,98],"acidocalcisomes,":[75],"which":[76],"serve":[77],"as":[78],"major":[79],"stores":[81],"these":[83,117,125],"parasites.":[84],"this":[86],"work,":[87],"have":[89,111],"used":[90],"super-resolution":[91],"structured":[92],"illumination":[93],"microscopy":[94,97],"electron":[96],"identify":[99],"membrane":[100],"exist":[104],"acidocalcisomes":[106],"mitochondria.":[108],"Furthermore,":[109],"confirmed":[112],"association":[115],"organelles":[118],"using":[119],"proximity":[120],"ligation":[121],"assays.":[122],"Characterization":[123],"may":[128],"be":[129],"a":[130],"necessary":[131],"starting":[132],"point":[133],"towards":[134],"unraveling":[135],"role":[137],"regulating":[141],"trypanosome":[142],"bioenergetics.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2018-03-29T00:00:00"}
