{"id":"https://openalex.org/W2791103809","doi":"https://doi.org/10.1074/jbc.ra118.001785","title":"Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA","display_name":"Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA","publication_year":2018,"publication_date":"2018-03-22","ids":{"openalex":"https://openalex.org/W2791103809","doi":"https://doi.org/10.1074/jbc.ra118.001785","mag":"2791103809","pmid":"https://pubmed.ncbi.nlm.nih.gov/29567833","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5949999"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.ra118.001785","doi":"https://doi.org/10.1074/jbc.ra118.001785","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.001785","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.ra118.001785","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100349852","display_name":"Ke Liu","orcid":"https://orcid.org/0000-0002-4683-9325","observed_orcids":["https://orcid.org/0000-0002-4683-9325"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ke Liu","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]},{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047305204","display_name":"Chao Xu","orcid":"https://orcid.org/0000-0003-0444-7080","observed_orcids":["https://orcid.org/0000-0003-0444-7080"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chao Xu","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]},{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115600784","display_name":"Ming Lei","orcid":"https://orcid.org/0000-0001-5558-1285","observed_orcids":["https://orcid.org/0000-0001-5558-1285"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ming Lei","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]},{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074099037","display_name":"Ally W. H. Yang","orcid":"https://orcid.org/0000-0002-8678-0946","observed_orcids":["https://orcid.org/0000-0002-8678-0946"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ally Yang","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011736665","display_name":"P. Loppnau","orcid":"https://orcid.org/0009-0004-0002-355X","observed_orcids":["https://orcid.org/0009-0004-0002-355X"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter Loppnau","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071531544","display_name":"Timothy R. Hughes","orcid":"https://orcid.org/0000-0002-8721-4719","observed_orcids":["https://orcid.org/0000-0002-8721-4719"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4405287053","display_name":"Donnelly Centre for Cellular and Biomolecular Research","ror":"https://ror.org/0400kyd42","country_code":"CA","type":"facility","lineage":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Timothy R. Hughes","raw_affiliation_strings":["Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4405287053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017127830","display_name":"Jinrong Min","orcid":"https://orcid.org/0000-0001-5210-3130","observed_orcids":["https://orcid.org/0000-0001-5210-3130"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2803004491","display_name":"Structural Genomics Consortium","ror":"https://ror.org/04jzps455","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2803004491"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jinrong Min","raw_affiliation_strings":["Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: jr.min@utoronto.ca","Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: jr.min@utoronto.ca","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]},{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017127830"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2803004491"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.6536,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.91643069,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"293","issue":"19","first_page":"7344","last_page":"7354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyl-cpg-binding-domain","display_name":"methyl-CpG binding domain","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dna-binding-selectivity","display_name":"DNA binding selectivity","score":0.6489999890327454},{"id":"https://openalex.org/keywords/matrix-attachment-regions","display_name":"matrix attachment regions","score":0.597000002861023},{"id":"https://openalex.org/keywords/scaffold-attachment-regions","display_name":"scaffold attachment regions","score":0.9810000061988831},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6286696791648865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45734429359436035},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37553492188453674},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37038618326187134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36701834201812744},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3525524139404297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3513956069946289},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34782999753952026},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3374329209327698}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.ra118.001785","doi":"https://doi.org/10.1074/jbc.ra118.001785","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.001785","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5488705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5949999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5949999","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5949999","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:29567833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29567833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.ra118.001785","doi":"https://doi.org/10.1074/jbc.ra118.001785","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.001785","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1485802007","display_name":null,"funder_award_id":"OGI-055","funder_id":"https://openalex.org/F4320319905","funder_display_name":"Ontario Genomics Institute"},{"id":"https://openalex.org/G3913106684","display_name":null,"funder_award_id":"ACB12002","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4356617607","display_name":null,"funder_award_id":"AGM-12006","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6612317865","display_name":"Open access research to promote drug discovery.","funder_award_id":"092809/Z/10/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319905","display_name":"Ontario Genomics Institute","ror":"https://ror.org/00c68jz96"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1506411903","https://openalex.org/W1559742681","https://openalex.org/W1659768997","https://openalex.org/W1857890191","https://openalex.org/W1964545612","https://openalex.org/W1965598953","https://openalex.org/W1965991279","https://openalex.org/W1973952385","https://openalex.org/W1975325714","https://openalex.org/W1975572122","https://openalex.org/W1975791071","https://openalex.org/W1978867062","https://openalex.org/W1998517881","https://openalex.org/W2010984732","https://openalex.org/W2012531419","https://openalex.org/W2013282937","https://openalex.org/W2014817033","https://openalex.org/W2017647714","https://openalex.org/W2021958912","https://openalex.org/W2030513330","https://openalex.org/W2035016973","https://openalex.org/W2037316977","https://openalex.org/W2040875973","https://openalex.org/W2044987317","https://openalex.org/W2046069528","https://openalex.org/W2046801755","https://openalex.org/W2046829847","https://openalex.org/W2049888367","https://openalex.org/W2059099579","https://openalex.org/W2061224013","https://openalex.org/W2064779454","https://openalex.org/W2080972330","https://openalex.org/W2085889911","https://openalex.org/W2097778167","https://openalex.org/W2104151407","https://openalex.org/W2110808180","https://openalex.org/W2113972309","https://openalex.org/W2114150529","https://openalex.org/W2118455767","https://openalex.org/W2119507369","https://openalex.org/W2124026197","https://openalex.org/W2130222411","https://openalex.org/W2144049324","https://openalex.org/W2148760132","https://openalex.org/W2152145111","https://openalex.org/W2153900602","https://openalex.org/W2154197653","https://openalex.org/W2154714625","https://openalex.org/W2157415768","https://openalex.org/W2159211495","https://openalex.org/W2159324718","https://openalex.org/W2163341755","https://openalex.org/W2166000509","https://openalex.org/W2166288018","https://openalex.org/W2167388443","https://openalex.org/W2170356111","https://openalex.org/W2613119278","https://openalex.org/W2625488274","https://openalex.org/W2777103725","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W2964676038","https://openalex.org/W2097778167","https://openalex.org/W2608190121","https://openalex.org/W6987372672","https://openalex.org/W2015353463","https://openalex.org/W7098825130","https://openalex.org/W2118813986","https://openalex.org/W1999263344","https://openalex.org/W7099917307","https://openalex.org/W2322858711"],"abstract_inverted_index":{"Cytosine":[0],"methylation":[1],"is":[2,66,158],"a":[3,130,173],"well-characterized":[4],"epigenetic":[5],"mark":[6],"and":[7,12,21,81,91,102,124,197,223],"occurs":[8],"at":[9],"both":[10,122,195],"CG":[11,19],"non-CG":[13],"sites":[14,215,220],"in":[15,44,52,79,181,206,236],"DNA.":[16],"Both":[17],"methylated":[18,123],"(mCG)-":[20],"mCH":[22],"(H":[23],"=":[24],"A,":[25],"C,":[26],"or":[27,147,213],"T)-containing":[28],"DNAs,":[29,32,128],"especially":[30],"mCAC-containing":[31],"are":[33],"recognized":[34],"by":[35,151],"methyl-CpG\u2013binding":[36,56],"protein":[37],"2":[38],"(MeCP2)":[39],"to":[40,61,121,145,194,208],"regulate":[41],"gene":[42,237],"expression":[43],"neuron":[45],"development.":[46],"However,":[47],"the":[48,53,72,76,97,109,113,133,141,153,167,230],"molecular":[49],"mechanism":[50],"involved":[51],"binding":[54,87,192],"of":[55,59,75,100,108,164,176,233],"domain":[57],"(MBD)":[58],"MeCP2":[60,80,101,189,222],"these":[62],"different":[63],"DNA":[64,150],"motifs":[65],"unclear.":[67],"Here,":[68],"we":[69],"systematically":[70],"characterized":[71],"DNA-binding":[73,219],"selectivities":[74],"MBD":[77,98,118,142],"domains":[78,99,119,143],"MBD1\u20134":[82,103],"with":[83,129,160,172],"isothermal":[84],"titration":[85],"calorimetry\u2013based":[86],"assays,":[88],"mutagenesis":[89],"studies,":[90],"X-ray":[92],"crystallography.":[93],"We":[94,137],"found":[95,139],"that":[96,140,178,205],"bind":[104,144],"mCG-containing":[105],"DNAs":[106],"independently":[107],"sequence":[110,135,175],"identity":[111],"outside":[112],"mCG":[114,209],"dinucleotide.":[115],"Moreover,":[116],"some":[117],"bound":[120],"unmethylated":[125,211],"CA":[126,149,212],"dinucleotide\u2013containing":[127],"preference":[131],"for":[132,221],"CAC":[134],"motif.":[136],"also":[138,186,216],"mCA":[146],"nonmethylated":[148],"recognizing":[152],"complementary":[154],"TG":[155,214],"dinucleotide,":[156],"which":[157],"consistent":[159],"an":[161],"overlooked":[162],"ligand":[163],"MeCP2,":[165],"i.e.":[166],"matrix/scaffold":[168],"attachment":[169],"regions":[170],"(MARs/SARs)":[171],"consensus":[174],"5\u2032-GGTGT-3\u2032":[177],"was":[179],"identified":[180],"early":[182],"1990s.":[183],"Our":[184],"results":[185,203],"explain":[187],"why":[188],"exhibits":[190],"similar":[191],"affinity":[193],"mCA-":[196],"hmCA-containing":[198],"dsDNAs.":[199],"In":[200],"summary,":[201],"our":[202],"suggest":[204],"addition":[207],"sites,":[210],"serve":[217],"as":[218],"other":[224],"MBD-containing":[225,234],"proteins.":[226],"This":[227],"discovery":[228],"expands":[229],"genome-wide":[231],"activity":[232],"proteins":[235],"regulation.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}
