{"id":"https://openalex.org/W2791069126","doi":"https://doi.org/10.1016/j.tranon.2018.02.015","title":"Inhibition of pMAPK14 Overcomes Resistance to Sorafenib in Hepatoma Cells with Hepatitis B Virus","display_name":"Inhibition of pMAPK14 Overcomes Resistance to Sorafenib in Hepatoma Cells with Hepatitis B Virus","publication_year":2018,"publication_date":"2018-03-07","ids":{"openalex":"https://openalex.org/W2791069126","doi":"https://doi.org/10.1016/j.tranon.2018.02.015","mag":"2791069126","pmid":"https://pubmed.ncbi.nlm.nih.gov/29524828","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5884218"},"language":"en","primary_location":{"id":"doi:10.1016/j.tranon.2018.02.015","doi":"https://doi.org/10.1016/j.tranon.2018.02.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2018.02.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523317304321/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2791069126"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1936523317304321/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082485854","display_name":"Dvora Witt-Kehati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dvora Witt-Kehati","raw_affiliation_strings":["Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043650841","display_name":"Alexandra Fridkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexandra Fridkin","raw_affiliation_strings":["Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033915405","display_name":"Maya Bitton Alaluf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maya Bitton Alaluf","raw_affiliation_strings":["Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062212324","display_name":"Romy R. Zemel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Romy Zemel","raw_affiliation_strings":["Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074737362","display_name":"Amir Shlomai","orcid":"https://orcid.org/0000-0001-7437-9381","observed_orcids":["https://orcid.org/0000-0001-7437-9381"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Amir Shlomai","raw_affiliation_strings":["Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel; The Liver Institute, Beilinson Hospital Rabin Medical Center, Petah-Tikva, Israel. Electronic address: amirsh9@clalit.org.il","Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","The Liver Institute, Beilinson Hospital Rabin Medical Center, Petah-Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel; The Liver Institute, Beilinson Hospital Rabin Medical Center, Petah-Tikva, Israel. Electronic address: amirsh9@clalit.org.il","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Department of Medicine D, Beilinson hospital Rabin Medical Center, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The Liver Institute, Beilinson Hospital Rabin Medical Center, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074737362"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.2758,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.88019913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"511","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.12189999967813492,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib-resistance","display_name":"sorafenib resistance","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mapk14","display_name":"MAPK14","score":0.8360000252723694},{"id":"https://openalex.org/keywords/raf-mek-erk-pathway","display_name":"Raf/MEK/ERK pathway","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hbx-protein","display_name":"HBx protein","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.7419999837875366},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9920246005058289},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8844485878944397},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.7512849569320679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.660771369934082},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5528560876846313},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5398726463317871},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5265788435935974},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.522503674030304},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5081655979156494},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4814662039279938},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4666203260421753},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3772014379501343},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3338380455970764},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3278403878211975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15461617708206177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.tranon.2018.02.015","doi":"https://doi.org/10.1016/j.tranon.2018.02.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2018.02.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523317304321/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4795985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5884218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29524828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29524828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5884218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5884218/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4fb2b474ab3347928c9dea1da2f5bc1f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4fb2b474ab3347928c9dea1da2f5bc1f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Oncology, Vol 11, Iss 2, Pp 511-517 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.tranon.2018.02.015","doi":"https://doi.org/10.1016/j.tranon.2018.02.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2018.02.015","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523317304321/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2791069126.pdf","grobid_xml":"https://content.openalex.org/works/W2791069126.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1542425243","https://openalex.org/W1690185597","https://openalex.org/W1749960448","https://openalex.org/W1971837077","https://openalex.org/W1989647054","https://openalex.org/W1998697663","https://openalex.org/W2005383067","https://openalex.org/W2010338556","https://openalex.org/W2019218097","https://openalex.org/W2024450952","https://openalex.org/W2032592312","https://openalex.org/W2034992482","https://openalex.org/W2044951291","https://openalex.org/W2047743944","https://openalex.org/W2061345986","https://openalex.org/W2070396671","https://openalex.org/W2088629624","https://openalex.org/W2092888413","https://openalex.org/W2112135110","https://openalex.org/W2128227067","https://openalex.org/W2128871289","https://openalex.org/W2129866880","https://openalex.org/W2149848093","https://openalex.org/W2163403599","https://openalex.org/W2286872394","https://openalex.org/W3139763557","https://openalex.org/W4245403358"],"related_works":["https://openalex.org/W2019218097","https://openalex.org/W1867820366","https://openalex.org/W4411749461","https://openalex.org/W4328024834","https://openalex.org/W2805705724","https://openalex.org/W2789473795","https://openalex.org/W2523310041","https://openalex.org/W4319601030","https://openalex.org/W3088813400","https://openalex.org/W3103690456"],"abstract_inverted_index":{"Hepatitis":[0],"B":[1],"virus":[2],"(HBV)":[3],"targets":[4,50],"the":[5,29,33,48,55,59,63,118,122,159,171],"liver":[6,13],"and":[7,67,164],"is":[8,21,45,96,102,139],"a":[9,129],"major":[10,49],"driver":[11],"for":[12],"cancer.":[14],"Clinical":[15],"data":[16],"suggest":[17],"that":[18,43,75,132,179],"HBV":[19,66,80,94,100,148,180],"infection":[20],"associated":[22,103],"with":[23,28,78,104,147,189,196],"reduced":[24],"response":[25,69],"to":[26,70,84,90,136,168,184],"treatment":[27],"multi-kinase":[30],"inhibitor":[31],"sorafenib,":[32,52],"first":[34],"available":[35],"molecularly":[36],"targeted":[37],"anti-hepatocellular":[38],"carcinoma":[39],"(HCC)":[40],"drug.":[41],"Given":[42],"Raf":[44],"one":[46],"of":[47,51,58,65,107,121,158,162,173],"we":[53,73],"investigated":[54],"activation":[56],"state":[57],"Raf-Mek-Erk":[60],"pathway":[61],"in":[62,68,92,141,145,156,170,194],"presence":[64,172],"sorafenib.":[71,185],"Here":[72],"show":[74],"hepatoma":[76,143],"cells":[77,91,144],"replicating":[79],"are":[81],"less":[82],"susceptible":[83],"sorafenib":[85,114,137,163,169,190],"inhibitory":[86],"effect":[87],"as":[88],"compared":[89],"which":[93],"expression":[95],"suppressed.":[97],"However,":[98],"although":[99],"replication":[101],"increased":[105],"level":[106],"pErk,":[108],"its":[109],"blockade":[110],"only":[111],"modestly":[112],"augments":[113],"effect.":[115],"In":[116],"contrast,":[117],"phosphorylated":[119],"form":[120],"pro-oncogenic":[123],"Mitogen-Activated":[124],"Protein":[125],"Kinase":[126],"14":[127],"(pMAPK14),":[128],"protein":[130,150],"kinase":[131],"was":[133],"recently":[134],"linked":[135],"resistance,":[138],"induced":[140],"sorafenib-treated":[142],"association":[146],"X":[149],"expression.":[151],"Knocking":[152],"down":[153],"pMAPK14":[154,187],"results":[155],"augmentation":[157],"therapeutic":[160],"efficacy":[161],"largely":[165],"alleviates":[166],"resistance":[167,183],"HBV.":[174],"Thus,":[175],"this":[176],"study":[177],"suggests":[178],"promotes":[181],"HCC":[182],"Combining":[186],"inhibitors":[188],"may":[191],"be":[192],"beneficial":[193],"patients":[195],"HBV-associated":[197],"HCC.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-03-29T00:00:00"}