{"id":"https://openalex.org/W2790950135","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p117","title":"Abstract P117: Hydralazine Prevents the Rupture of Experimental Cerebral Aneurysms in Hypertensive Rats","display_name":"Abstract P117: Hydralazine Prevents the Rupture of Experimental Cerebral Aneurysms in Hypertensive Rats","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2790950135","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p117","mag":"2790950135"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.70.suppl_1.p117","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p117","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.70.suppl_1.p117","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101443048","display_name":"Takeshi Miyamoto","orcid":"https://orcid.org/0000-0001-9136-1829","observed_orcids":["https://orcid.org/0000-0001-9136-1829"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Miyamoto","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Takeshi Miyamoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Takeshi Miyamoto","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978383","display_name":"Keiko T. Kitazato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko T Kitazato","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Keiko T Kitazato"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Keiko T Kitazato","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038924268","display_name":"Yoshiteru Tada","orcid":"https://orcid.org/0000-0001-7637-1033","observed_orcids":["https://orcid.org/0000-0001-7637-1033"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiteru Tada","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Yoshiteru Tada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Yoshiteru Tada","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenji Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Shimada","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Kenji Shimada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Kenji Shimada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019546205","display_name":"Kenji Yagi","orcid":"https://orcid.org/0000-0001-9392-5827","observed_orcids":["https://orcid.org/0000-0001-9392-5827"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Yagi","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Kenji Yagi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Kenji Yagi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089115116","display_name":"Masaaki Korai","orcid":"https://orcid.org/0000-0002-5326-3467","observed_orcids":["https://orcid.org/0000-0002-5326-3467"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Korai","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Masaaki Korai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Masaaki Korai","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064458383","display_name":"Hidetsugu Maekawa","orcid":"https://orcid.org/0000-0002-5633-4582","observed_orcids":["https://orcid.org/0000-0002-5633-4582"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetsugu Maekawa","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Hidetsugu Maekawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Hidetsugu Maekawa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044970442","display_name":"Tadashi Yamaguchi","orcid":"https://orcid.org/0000-0001-5761-4888","observed_orcids":["https://orcid.org/0000-0001-5761-4888"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Yamaguchi","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Tadashi Yamaguchi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Tadashi Yamaguchi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019738100","display_name":"Yasuhisa Kanematsu","orcid":"https://orcid.org/0000-0001-8107-5597","observed_orcids":["https://orcid.org/0000-0001-8107-5597"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhisa Kanematsu","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Yasuhisa Kanematsu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Yasuhisa Kanematsu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020200536","display_name":"Junichiro Satomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichiro Satomi","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Junichiro Satomi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Junichiro Satomi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014880968","display_name":"Tomoki N Hashimoto","orcid":"https://orcid.org/0000-0002-6046-9148","observed_orcids":["https://orcid.org/0000-0002-6046-9148"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoki Hashimoto","raw_affiliation_strings":["Univ of California, San Francisco, San Francisco, CA","Tomoki Hashimoto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Tomoki Hashimoto","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108383120","display_name":"Shinji Nagahiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Nagahiro","raw_affiliation_strings":["Tokushima Univ Graduate Sch, Tokushima, Japan","Shinji Nagahiro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Univ Graduate Sch, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"Shinji Nagahiro","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydralazine","display_name":"hydralazine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intracranial-aneurysm-rupture","display_name":"intracranial aneurysm rupture","score":0.9419999718666077},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9129999876022339},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/renal-hypertension","display_name":"renal hypertension","score":0.7149999737739563},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hemodynamic-stress","display_name":"hemodynamic stress","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2780521442","wikidata":"https://www.wikidata.org/wiki/Q419987","display_name":"Hydralazine","level":3,"score":0.9458914399147034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8957943916320801},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.5903378129005432},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5891430974006653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49351203441619873},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.48593869805336},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.4803803563117981},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4546698331832886},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4041856527328491},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3653388023376465},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33617740869522095}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.70.suppl_1.p117","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p117","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.70.suppl_1.p117","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164577650","https://openalex.org/W2765091081","https://openalex.org/W4207071761","https://openalex.org/W2268126089","https://openalex.org/W2141696510","https://openalex.org/W4414659632","https://openalex.org/W1499343543","https://openalex.org/W2795457495","https://openalex.org/W2145037064","https://openalex.org/W4281973696"],"abstract_inverted_index":{"Introduction:":[0],"Subarachnoid":[1],"hemorrhage":[2],"(SAH)":[3],"is":[4,21],"a":[5,12,22],"catastrophic":[6],"event":[7],"with":[8,102],"high":[9],"morbidity":[10],"and":[11,63,84,126,155,175,191,239,270],"poor":[13],"prognosis.":[14],"While":[15,216],"epidemiological":[16],"studies":[17],"showed":[18,234],"that":[19,45,254],"hypertension":[20],"risk":[23],"factor":[24],"for":[25],"aneurysmal":[26],"rupture,":[27],"it":[28,225],"remains":[29],"unclear":[30],"whether":[31,58],"lowering":[32,46,255],"the":[33,38,43,47,50,61,110,121,140,157,182,221,235,242,256,260,266,273],"blood":[34],"pressure":[35],"(BP)":[36],"prevents":[37,49],"rupture":[39,51,64,201,261],"of":[40,52,65,123,184,223,237,246,262,268],"aneurysms.":[41,129,199],"Under":[42],"hypothesis":[44],"BP":[48,142],"experimental":[53],"cerebral":[54,198,243,263,274],"aneurysms,":[55,224],"we":[56,78],"investigated":[57],"hydralazine":[59,103,217],"reduces":[60],"incidence":[62],"aneurysms":[66,264],"in":[67,120,139,161,205,241,272],"our":[68],"rat":[69],"model.":[70],"Methods:":[71],"In":[72,181],"10-week-old":[73],"female":[74],"Sprague-Dawley":[75],"rats":[76,195,213],"(n=34)":[77],"elicited":[79],"estrogen":[80],"deficiency,":[81],"renal":[82],"hypertension,":[83],"hemodynamic":[85],"stress.":[86],"Two":[87],"weeks":[88],"later,":[89],"they":[90],"were":[91],"divided":[92],"into":[93],"2":[94,107,132,166,189,212],"groups;":[95],"group":[96,106,148,162,165,188,193,206,211,247],"1":[97,163,194,207,248],"(n=17)":[98,108],"was":[99,109,159,203],"treated":[100],"perorally":[101],"(100":[104],"mg/kg/day),":[105],"vehicle":[111],"control.":[112],"We":[113],"recorded":[114],"their":[115,227],"death":[116],"or":[117],"abnormal":[118],"behavior":[119],"course":[122,183],"90":[124,185],"days":[125],"inspected":[127],"ruptured":[128],"Results:":[130],"At":[131],"weeks,":[133],"both":[134],"groups":[135],"manifested":[136],"an":[137],"increase":[138],"systolic":[141],"(SBP)":[143],"(group":[144],"1,":[145],"205":[146],"mmHg;":[147],"2,":[149],"207":[150],"mmHg).":[151],"After":[152],"30-,":[153],"60-,":[154],"90-days,":[156],"SBP":[158,257],"lower":[160,204],"than":[164,210],"(150":[167],"vs":[168,172,177],"210":[169],"mmHg,":[170,174,179],"163":[171],"211":[173],"173":[176],"210,":[178],"respectively).":[180],"days,":[186],"9":[187],"(53%)":[190],"8":[192],"(47%)":[196],"developed":[197],"The":[200],"rate":[202],"(3/8,":[208],"38%)":[209],"(9/9:":[214],"100%).":[215],"did":[218],"not":[219],"prevent":[220,259],"development":[222],"prevented":[226],"rupture.":[228],"qRT-PCR":[229],"performed":[230],"on":[231],"day":[232],"35":[233],"down-regulation":[236,267],"MCP-1":[238,269],"MMP-9":[240,271],"vascular":[244,275],"wall":[245],"rats.":[249],"Conclusion:":[250],"Our":[251],"findings":[252],"suggest":[253],"may":[258],"via":[265],"wall.":[276]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}