{"id":"https://openalex.org/W2790420596","doi":"https://doi.org/10.1515/cclm-2017-0988","title":"Clinically relevant discrepancies between different rheumatoid factor assays","display_name":"Clinically relevant discrepancies between different rheumatoid factor assays","publication_year":2018,"publication_date":"2018-02-10","ids":{"openalex":"https://openalex.org/W2790420596","doi":"https://doi.org/10.1515/cclm-2017-0988","mag":"2790420596","pmid":"https://pubmed.ncbi.nlm.nih.gov/29427550"},"language":"en","primary_location":{"id":"doi:10.1515/cclm-2017-0988","doi":"https://doi.org/10.1515/cclm-2017-0988","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cclm-2017-0988","pdf_url":"http://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-10/cclm-2017-0988/cclm-2017-0988.xml","source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-10/cclm-2017-0988/cclm-2017-0988.xml","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064989159","display_name":"Willem J.J. Falkenburg","orcid":"https://orcid.org/0000-0002-6739-8581","observed_orcids":["https://orcid.org/0000-0002-6739-8581"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I4210091224","display_name":"Reade","ror":"https://ror.org/00bp9f906","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210091224"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Willem J.J. Falkenburg","raw_affiliation_strings":["Amsterdam Rheumatology and Immunology Center , Reade, Amsterdam , The Netherlands","Department of Immunopathology, Sanquin Research , Amsterdam , The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6739-8581","affiliations":[{"raw_affiliation_string":"Amsterdam Rheumatology and Immunology Center , Reade, Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4210091224"]},{"raw_affiliation_string":"Department of Immunopathology, Sanquin Research , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065395363","display_name":"Helen J. von Richthofen","orcid":"https://orcid.org/0000-0002-2062-5986","observed_orcids":["https://orcid.org/0000-0002-2062-5986"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Helen J. von Richthofen","raw_affiliation_strings":["Department of Immunopathology, Sanquin Research , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Sanquin Research , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025108696","display_name":"Jana Koers","orcid":"https://orcid.org/0000-0002-1451-9642","observed_orcids":["https://orcid.org/0000-0002-1451-9642"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jana Koers","raw_affiliation_strings":["Department of Immunopathology, Sanquin Research , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Sanquin Research , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069762574","display_name":"Cas W. Weykamp","orcid":"https://orcid.org/0000-0002-2603-9128","observed_orcids":["https://orcid.org/0000-0002-2603-9128"]},"institutions":[{"id":"https://openalex.org/I4210122377","display_name":"Streekziekenhuis Koningin Beatrix","ror":"https://ror.org/02vn5as77","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210122377"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cas Weykamp","raw_affiliation_strings":["Queen Beatrix Hospital , Winterswijk , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Beatrix Hospital , Winterswijk , The Netherlands","institution_ids":["https://openalex.org/I4210122377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005955733","display_name":"Marco W.J. Schreurs","orcid":"https://orcid.org/0000-0003-4198-183X","observed_orcids":["https://orcid.org/0000-0003-4198-183X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marco W.J. Schreurs","raw_affiliation_strings":["Department of Immunology, Laboratory Medical Immunology , Erasmus MC University Medical Center Rotterdam , Rotterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Laboratory Medical Immunology , Erasmus MC University Medical Center Rotterdam , Rotterdam , The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085963496","display_name":"Liesbeth E. Bakker\u2010Jonges","orcid":"https://orcid.org/0000-0002-8205-8278","observed_orcids":["https://orcid.org/0000-0002-8205-8278"]},"institutions":[{"id":"https://openalex.org/I4210099110","display_name":"Reinier de Graaf Hospital","ror":"https://ror.org/00wkhef66","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210099110"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Liesbeth E. Bakker-Jonges","raw_affiliation_strings":["Medical Laboratories , Department of Immunology, Reinier de Graaf Groep , Delft , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratories , Department of Immunology, Reinier de Graaf Groep , Delft , The Netherlands","institution_ids":["https://openalex.org/I4210099110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039471453","display_name":"Inez-Anne Haagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105568","display_name":"OLVG","ror":"https://ror.org/01d02sf11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210105568"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Inez-Anne Haagen","raw_affiliation_strings":["Department of Hematology and Clinical Chemistry Laboratories, Onze Lieve Vrouwe Gasthuis , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Clinical Chemistry Laboratories, Onze Lieve Vrouwe Gasthuis , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4210105568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075695885","display_name":"Willem Frederik Lems","orcid":"https://orcid.org/0000-0002-6885-3953","observed_orcids":["https://orcid.org/0000-0002-6885-3953"]},"institutions":[{"id":"https://openalex.org/I4210091224","display_name":"Reade","ror":"https://ror.org/00bp9f906","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210091224"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Willem F. Lems","raw_affiliation_strings":["Amsterdam Rheumatology and Immunology Center , Reade, Amsterdam , The Netherlands","Amsterdam Rheumatology and Immunology Center , VU University Medical Center , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Rheumatology and Immunology Center , Reade, Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4210091224"]},{"raw_affiliation_string":"Amsterdam Rheumatology and Immunology Center , VU University Medical Center , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110447951","display_name":"D\u00f6rte Hamann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D\u00f6rte Hamann","raw_affiliation_strings":["Department of Immunopathology and Blood Coagulation, Sanquin Diagnostic Services , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology and Blood Coagulation, Sanquin Diagnostic Services , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090739507","display_name":"Dirkjan van Schaardenburg","orcid":"https://orcid.org/0000-0003-4006-3762","observed_orcids":["https://orcid.org/0000-0003-4006-3762"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210091224","display_name":"Reade","ror":"https://ror.org/00bp9f906","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210091224"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dirkjan van Schaardenburg","raw_affiliation_strings":["Amsterdam Rheumatology and Immunology Center , Reade, Amsterdam , The Netherlands","Amsterdam Rheumatology and Immunology Center, Academic Medical Center , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam Rheumatology and Immunology Center , Reade, Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I4210091224"]},{"raw_affiliation_string":"Amsterdam Rheumatology and Immunology Center, Academic Medical Center , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050087953","display_name":"Theo Rispens","orcid":"https://orcid.org/0000-0001-9600-1312","observed_orcids":["https://orcid.org/0000-0001-9600-1312"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Theo Rispens","raw_affiliation_strings":["Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3020210244","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5050087953","https://openalex.org/A5064989159"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3020210244","https://openalex.org/I4210091224","https://openalex.org/I887064364"],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":{"value":2400,"currency":"EUR","value_usd":2712},"fwci":2.6067,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88219164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"56","issue":"10","first_page":"1749","last_page":"1758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/assay-discrepancy","display_name":"assay discrepancy","score":0.828000009059906},{"id":"https://openalex.org/keywords/target-antigens","display_name":"target antigens","score":0.4790000021457672},{"id":"https://openalex.org/keywords/human-igg","display_name":"human IgG","score":0.9229999780654907},{"id":"https://openalex.org/keywords/rabbit-igg","display_name":"rabbit IgG","score":1.0},{"id":"https://openalex.org/keywords/anti-citrullinated-protein-antibodies","display_name":"anti-citrullinated protein antibodies","score":0.8809999823570251},{"id":"https://openalex.org/keywords/joint-pain","display_name":"joint pain","score":0.746999979019165},{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.921999990940094},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.7991794943809509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7502800226211548},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6168015003204346},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6157103776931763},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5759632587432861},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42467597126960754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4237663149833679},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.41132238507270813},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32853513956069946},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2515884339809418},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018771","descriptor_name":"Arthralgia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1515/cclm-2017-0988","doi":"https://doi.org/10.1515/cclm-2017-0988","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cclm-2017-0988","pdf_url":"http://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-10/cclm-2017-0988/cclm-2017-0988.xml","source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","raw_type":"journal-article"},{"id":"pmid:29427550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29427550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry and laboratory medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.eur.nl:openaire/b1654fa6-512c-4282-9e46-b89ed12fc36a","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/b1654fa6-512c-4282-9e46-b89ed12fc36a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Falkenburg, W J J, von Richthofen, H J, Koers, J, Weykamp, C, Schreurs, M W J, Bakker-Jonges, L E, Haagen, I-A, Lems, W F, Hamann, D, van Schaardenburg, D & Rispens, T 2018, 'Clinically relevant discrepancies between different rheumatoid factor assays', Clinical Chemistry and Laboratory Medicine, vol. 56, no. 10, pp. 1749-1758. https://doi.org/10.1515/cclm-2017-0988","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/e21347f7-7d72-4362-8270-2b77f38f93fe","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/clinically-relevant-discrepancies-between-different-rheumatoid-factor-assays(e21347f7-7d72-4362-8270-2b77f38f93fe).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical chemistry and laboratory medicine, 56(10), 1749 - 1758. Walter de Gruyter GmbH","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/b1654fa6-512c-4282-9e46-b89ed12fc36a","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/b1654fa6-512c-4282-9e46-b89ed12fc36a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Chemistry and Laboratory Medicine, 56(10), 1749 - 1758. De Gruyter","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:104790","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/104790","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/85e1338a-960a-4a3a-b5e9-95f5135bded3","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/85e1338a-960a-4a3a-b5e9-95f5135bded3","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Falkenburg, W J J, von Richthofen, H J, Koers, J, Weykamp, C, Schreurs, M W J, Bakker-Jonges, L E, Haagen, I-A, Lems, W F, Hamann, D, van Schaardenburg, D & Rispens, T 2018, 'Clinically relevant discrepancies between different rheumatoid factor assays', Clinical chemistry and laboratory medicine, vol. 56, no. 10, pp. 1749-1758. https://doi.org/10.1515/cclm-2017-0988","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repub.eur.nl:104790","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/104790","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/2aff99f8-27fe-42d8-a163-aa911131c0ae","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/2aff99f8-27fe-42d8-a163-aa911131c0ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Chemistry and Laboratory Medicine, 56(10), 1749 - 1758. Walter de Gruyter GmbH","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1515/cclm-2017-0988","doi":"https://doi.org/10.1515/cclm-2017-0988","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cclm-2017-0988","pdf_url":"http://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-10/cclm-2017-0988/cclm-2017-0988.xml","source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G375995949","display_name":null,"funder_award_id":"436001001","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790420596.pdf","grobid_xml":"https://content.openalex.org/works/W2790420596.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W40613454","https://openalex.org/W199411197","https://openalex.org/W1581070829","https://openalex.org/W1746384354","https://openalex.org/W1969154794","https://openalex.org/W1976411430","https://openalex.org/W1989356572","https://openalex.org/W2000728769","https://openalex.org/W2001733286","https://openalex.org/W2010125625","https://openalex.org/W2012130146","https://openalex.org/W2024988150","https://openalex.org/W2026146116","https://openalex.org/W2032679326","https://openalex.org/W2036916905","https://openalex.org/W2040710272","https://openalex.org/W2041729262","https://openalex.org/W2045450362","https://openalex.org/W2055371669","https://openalex.org/W2056361967","https://openalex.org/W2065419533","https://openalex.org/W2072033974","https://openalex.org/W2077592888","https://openalex.org/W2089597165","https://openalex.org/W2092013550","https://openalex.org/W2101143483","https://openalex.org/W2104669609","https://openalex.org/W2110604741","https://openalex.org/W2112157366","https://openalex.org/W2120399809","https://openalex.org/W2128952811","https://openalex.org/W2139679747","https://openalex.org/W2141521401","https://openalex.org/W2152348310","https://openalex.org/W2152676410","https://openalex.org/W2191929286","https://openalex.org/W2254127261","https://openalex.org/W2316767234","https://openalex.org/W2398726495","https://openalex.org/W2411832526","https://openalex.org/W2735846911","https://openalex.org/W2742819701","https://openalex.org/W4248541645","https://openalex.org/W4256286029"],"related_works":["https://openalex.org/W2808503889","https://openalex.org/W4362693967","https://openalex.org/W2139679747","https://openalex.org/W3033951641","https://openalex.org/W2062983795","https://openalex.org/W3159043317","https://openalex.org/W2114439436","https://openalex.org/W199411197","https://openalex.org/W4221068995","https://openalex.org/W2784454730"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Accurate":[2],"measurements":[3,54],"of":[4,74,151,196,217,232],"rheumatoid":[5,15],"factors":[6],"(RFs),":[7],"autoantibodies":[8],"binding":[9,182],"IgG,":[10],"are":[11,27,257],"important":[12,45,245],"for":[13,19,247],"diagnosing":[14],"arthritis":[16],"(RA)":[17],"and":[18,34,50,97,156,185,224,241,253],"predicting":[20],"disease":[21,254],"course.":[22],"Worldwide,":[23],"various":[24],"RF":[25,48,53,58,64,90,106,118,132,152,167,203,218,233,239,260],"assays":[26,59,70,136,219],"being":[28],"used":[29],"that":[30,159,220],"differ":[31,221],"in":[32,47,62,94,109,126,134,169,222,238],"technique":[33,223],"target":[35,76,141,225],"antigens.":[36],"We":[37],"studied":[38],"whether":[39],"assay":[40,130],"choice":[41],"leads":[42,235],"to":[43,173,183,236],"clinically":[44],"discrepancies":[46,102,237],"status":[49,240],"level.":[51],"Methods:":[52],"using":[55,137],"four":[56,111],"commercial":[57,112],"were":[60,103,131,175,211],"compared":[61],"32":[63],"+":[65,133,163],"samples.":[66],"Using":[67],"enzyme-linked":[68],"immunosorbent":[69],"(ELISAs),":[71],"the":[72,75,110,124,127,140,229],"influence":[73],"antigen":[77],"source":[78],"\u2013":[79,87],"human":[80],"IgG":[81,85],"(hIgG)":[82],"versus":[83],"rabbit":[84],"(rIgG)":[86],"on":[88,259],"measured":[89,108],"levels":[91,107,119,210],"was":[92],"investigated":[93],"arthralgia":[95,164],"patients":[96],"RA":[98,199,251],"patients.":[99],"Results:":[100],"Substantial":[101],"found":[104],"between":[105],"assays.":[113],"Six":[114],"samples":[115],"(19%)":[116],"with":[117,144,206,228],"below":[120],"or":[121,187],"slightly":[122],"above":[123],"cutoff":[125],"rIgG-based":[128,170],"Phadia":[129],"three":[135],"hIgG":[138,155,184,188],"as":[139],"antigen,":[142,226],"some":[143],"very":[145],"high":[146],"levels.":[147,242],"Direct":[148],"ELISA":[149],"comparisons":[150],"reactivity":[153],"against":[154,178],"rIgG":[157,186],"estimated":[158],"among":[160],"173":[161],"ACPA":[162],"patients,":[165,200],"originally":[166],"negative":[168],"assays,":[171],"up":[172],"10%":[174],"single":[176],"positive":[177],"hIgG.":[179],"Monoclonal":[180],"RFs":[181],"only":[189],"supported":[190],"these":[191],"findings.":[192],"In":[193],"a":[194],"cohort":[195],"69":[197],"early":[198],"virtually":[201],"all":[202],"responses":[204],"reacted":[205],"both":[207],"targets,":[208],"although":[209],"still":[212],"variable.":[213],"Conclusions:":[214],"The":[215],"use":[216],"together":[227],"different":[230],"specificities":[231],"responses,":[234],"This":[243],"has":[244],"consequences":[246],"patient":[248],"care":[249],"if":[250],"diagnosis":[252],"progression":[255],"assessments":[256],"based":[258],"test":[261],"results.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}