{"id":"https://openalex.org/W2790400829","doi":"https://doi.org/10.1038/s41523-018-0058-6","title":"Biomarkers of aging associated with past treatments in breast cancer survivors: when therapy-induced pathways turn out to be potential therapeutic targets","display_name":"Biomarkers of aging associated with past treatments in breast cancer survivors: when therapy-induced pathways turn out to be potential therapeutic targets","publication_year":2018,"publication_date":"2018-02-28","ids":{"openalex":"https://openalex.org/W2790400829","doi":"https://doi.org/10.1038/s41523-018-0058-6","mag":"2790400829","pmid":"https://pubmed.ncbi.nlm.nih.gov/29532007","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840380"},"language":"en","primary_location":{"id":"doi:10.1038/s41523-018-0058-6","doi":"https://doi.org/10.1038/s41523-018-0058-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41523-018-0058-6","pdf_url":"https://www.nature.com/articles/s41523-018-0058-6.pdf","source":{"id":"https://openalex.org/S4210207747","display_name":"npj Breast Cancer","issn_l":"2374-4677","issn":["2374-4677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Breast Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41523-018-0058-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047367574","display_name":"Wafaa Jabbour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wafaa Jabbour","raw_affiliation_strings":["Mansourieh Laboratory, Mansourieh, Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mansourieh Laboratory, Mansourieh, Lebanon","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039534008","display_name":"Didier Wion","orcid":"https://orcid.org/0000-0001-7144-6470","observed_orcids":["https://orcid.org/0000-0001-7144-6470"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4400008982","display_name":"Brain Tech Laboratory","ror":"https://ror.org/01027m165","country_code":"FR","type":"education","lineage":["https://openalex.org/I154526488","https://openalex.org/I4400008982","https://openalex.org/I4405258737","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Didier Wion","raw_affiliation_strings":["2INSERM U1205, BrainTech Lab, Universit\u00e9 Grenoble Alpes, Domaine de la Merci, 38700 La Tronche, France","INSERM U1205, BrainTech Lab, Universit\u00e9 Grenoble Alpes, Domaine de la Merci, 38700, La Tronche, France"],"raw_orcid":"https://orcid.org/0000-0001-7144-6470","affiliations":[{"raw_affiliation_string":"2INSERM U1205, BrainTech Lab, Universit\u00e9 Grenoble Alpes, Domaine de la Merci, 38700 La Tronche, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4400008982","https://openalex.org/I899635006"]},{"raw_affiliation_string":"INSERM U1205, BrainTech Lab, Universit\u00e9 Grenoble Alpes, Domaine de la Merci, 38700, La Tronche, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4400008982","https://openalex.org/I899635006"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039534008"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4400008982","https://openalex.org/I899635006"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0755,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.3358512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"4","issue":"1","first_page":"4","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging-biomarkers","display_name":"aging biomarkers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/breast-cancer-survivors","display_name":"breast cancer survivors","score":0.996999979019165},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7509999871253967},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6610000133514404},{"id":"https://openalex.org/keywords/late-effects-of-cancer-therapy","display_name":"late effects of cancer treatment","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7403520345687866},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5490232110023499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5079494118690491},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.449465811252594},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3900440037250519},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3607650101184845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29376208782196045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24220985174179077}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s41523-018-0058-6","doi":"https://doi.org/10.1038/s41523-018-0058-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41523-018-0058-6","pdf_url":"https://www.nature.com/articles/s41523-018-0058-6.pdf","source":{"id":"https://openalex.org/S4210207747","display_name":"npj Breast Cancer","issn_l":"2374-4677","issn":["2374-4677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Breast Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4753361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5840380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29532007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29532007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ breast cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5840380","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5840380/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Breast Cancer","raw_type":"Text"},{"id":"pmh:oai:HAL:inserm-02276143v1","doi":null,"is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-02276143","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Breast Cancer, 2018, 4 (1), ⟨10.1038/s41523-018-0058-6⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d64c508f45c845a1b2632b84248435c6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d64c508f45c845a1b2632b84248435c6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Breast Cancer, Vol 4, Iss 1, Pp 1-2 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41523-018-0058-6","doi":"https://doi.org/10.1038/s41523-018-0058-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41523-018-0058-6","pdf_url":"https://www.nature.com/articles/s41523-018-0058-6.pdf","source":{"id":"https://openalex.org/S4210207747","display_name":"npj Breast Cancer","issn_l":"2374-4677","issn":["2374-4677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Breast Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790400829.pdf","grobid_xml":"https://content.openalex.org/works/W2790400829.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2041353769","https://openalex.org/W2091542516","https://openalex.org/W2119523599","https://openalex.org/W2120587170","https://openalex.org/W2198808464","https://openalex.org/W2337885453","https://openalex.org/W2529740710","https://openalex.org/W2771932310","https://openalex.org/W2774166447","https://openalex.org/W2781217878"],"related_works":["https://openalex.org/W2774166447","https://openalex.org/W4403176649","https://openalex.org/W3197929512","https://openalex.org/W4393084606","https://openalex.org/W4250067957","https://openalex.org/W3129930642","https://openalex.org/W4224935295","https://openalex.org/W7212129388","https://openalex.org/W4410808246","https://openalex.org/W7142990974"],"abstract_inverted_index":{"In":[0],"a":[1,46],"recent":[2],"paper":[3],"in":[4,15,30,36],"NPJ":[5],"Breast":[6],"Cancer":[7],",":[8],"Scuric":[9],"et":[10],"al.":[11],"1":[12],"found":[13],"that":[14],"breast":[16],"cancer":[17],"patients,":[18],"chemotherapy":[19],"and":[20,35],"radiation":[21],"exposure":[22],"were":[23,51,56],"associated":[24],"with":[25],"some":[26],"biomarkers":[27],"of":[28,44,48,63],"aging":[29],"white":[31],"blood":[32,38],"cell":[33],"(WBC)":[34],"peripheral":[37],"mononuclear":[39],"cells":[40],"(PBMCs).":[41],"Elevated":[42],"levels":[43],"sTNF-RII,":[45],"biomarker":[47],"pro-inflammatory":[49],"activation,":[50],"also":[52],"detected.":[53],"These":[54],"results":[55],"obtained":[57],"3\u20136":[58],"years":[59],"after":[60],"the":[61],"completion":[62],"primary":[64],"treatments.":[65]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-03-29T00:00:00"}