{"id":"https://openalex.org/W2790337233","doi":"https://doi.org/10.1016/j.ydbio.2018.03.012","title":"The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis","display_name":"The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis","publication_year":2018,"publication_date":"2018-03-22","ids":{"openalex":"https://openalex.org/W2790337233","doi":"https://doi.org/10.1016/j.ydbio.2018.03.012","mag":"2790337233","pmid":"https://pubmed.ncbi.nlm.nih.gov/29577883","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5916339"},"language":"en","primary_location":{"id":"doi:10.1016/j.ydbio.2018.03.012","doi":"https://doi.org/10.1016/j.ydbio.2018.03.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2018.03.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160618300162/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0012160618300162/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029328962","display_name":"Lindsay E. Parrie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lindsay E. Parrie","raw_affiliation_strings":["Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States. Electronic address: lparrie@colostate.edu","Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States. Electronic address: lparrie@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079484591","display_name":"Jenna A.E. Crowell","orcid":"https://orcid.org/0009-0009-9515-1023","observed_orcids":["https://orcid.org/0009-0009-9515-1023"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna A.E. Crowell","raw_affiliation_strings":["Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014827285","display_name":"Glenn C. Telling","orcid":"https://orcid.org/0000-0002-6294-1805","observed_orcids":["https://orcid.org/0000-0002-6294-1805"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glenn C. Telling","raw_affiliation_strings":["Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States. Electronic address: glenn.telling@colostate.edu","Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States. Electronic address: glenn.telling@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089783447","display_name":"Richard A. Bessen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Bessen","raw_affiliation_strings":["Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, United States","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014827285","https://openalex.org/A5029328962"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.9238,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67809171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"438","issue":"1","first_page":"23","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-prion-protein","display_name":"cellular prion protein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/olfactory-receptor-neurons","display_name":"olfactory sensory neurons","score":0.9959999918937683},{"id":"https://openalex.org/keywords/axon-targeting","display_name":"axon targeting","score":0.8299999833106995},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.902999997138977},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/axon-migration","display_name":"axon migration","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.955673098564148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8580245971679688},{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.6746190786361694},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6596458554267883},{"id":"https://openalex.org/C154988683","wikidata":"https://www.wikidata.org/wiki/Q7086506","display_name":"Olfactory ensheathing glia","level":4,"score":0.6309351921081543},{"id":"https://openalex.org/C2780187430","wikidata":"https://www.wikidata.org/wiki/Q3052544","display_name":"Olfactory epithelium","level":3,"score":0.5960448980331421},{"id":"https://openalex.org/C2779404012","wikidata":"https://www.wikidata.org/wiki/Q24726721","display_name":"Olfactory marker protein","level":4,"score":0.5820394158363342},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5789122581481934},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5287299156188965},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5276792645454407},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49895524978637695},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.49186277389526367},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.45534878969192505},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4497168958187103},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.41719380021095276},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.18509122729301453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07713747024536133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.058810412883758545}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018621","descriptor_name":"PrPC Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018621","descriptor_name":"PrPC Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ydbio.2018.03.012","doi":"https://doi.org/10.1016/j.ydbio.2018.03.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2018.03.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160618300162/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},{"id":"pmid:29577883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29577883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5510396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5916339","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5916339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5916339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.ydbio.2018.03.012","doi":"https://doi.org/10.1016/j.ydbio.2018.03.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2018.03.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160618300162/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6683867227","display_name":"Fyn activation in prion disease","funder_award_id":"R21NS096662","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000904054","display_name":"Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases","funder_award_id":"P01AI077774","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309627","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333551","display_name":"College of Veterinary Medicine and Biomedical Sciences, Texas A and M University","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790337233.pdf","grobid_xml":"https://content.openalex.org/works/W2790337233.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1501063259","https://openalex.org/W1542222934","https://openalex.org/W1580359002","https://openalex.org/W1636573694","https://openalex.org/W1678001779","https://openalex.org/W1795727608","https://openalex.org/W1964552609","https://openalex.org/W1964962082","https://openalex.org/W1969758868","https://openalex.org/W1973268967","https://openalex.org/W1975781078","https://openalex.org/W1977654917","https://openalex.org/W1990952979","https://openalex.org/W1991004216","https://openalex.org/W1992380356","https://openalex.org/W1993222068","https://openalex.org/W2001534443","https://openalex.org/W2009728876","https://openalex.org/W2011445998","https://openalex.org/W2012449484","https://openalex.org/W2017501471","https://openalex.org/W2029730520","https://openalex.org/W2069186336","https://openalex.org/W2075309338","https://openalex.org/W2076425777","https://openalex.org/W2076642826","https://openalex.org/W2077587504","https://openalex.org/W2079141558","https://openalex.org/W2080225301","https://openalex.org/W2089340953","https://openalex.org/W2093987055","https://openalex.org/W2094660895","https://openalex.org/W2095001137","https://openalex.org/W2105136114","https://openalex.org/W2110913851","https://openalex.org/W2117032037","https://openalex.org/W2126552458","https://openalex.org/W2138712855","https://openalex.org/W2139286715","https://openalex.org/W2147592113","https://openalex.org/W2148128487","https://openalex.org/W2152059298","https://openalex.org/W2154598437","https://openalex.org/W2156344024","https://openalex.org/W2164620775","https://openalex.org/W2167871684","https://openalex.org/W2296927341","https://openalex.org/W2412620019","https://openalex.org/W2611707378","https://openalex.org/W2752378286","https://openalex.org/W4235821864"],"related_works":["https://openalex.org/W3000299502","https://openalex.org/W1969758868","https://openalex.org/W2110913851","https://openalex.org/W2803414753","https://openalex.org/W2040930547","https://openalex.org/W2010473698","https://openalex.org/W7120682959","https://openalex.org/W2292991685","https://openalex.org/W2045591775","https://openalex.org/W2064303517"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-03-29T00:00:00"}