{"id":"https://openalex.org/W2790282353","doi":"https://doi.org/10.3892/ijmm.2018.3550","title":"Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells","display_name":"Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells","publication_year":2018,"publication_date":"2018-03-07","ids":{"openalex":"https://openalex.org/W2790282353","doi":"https://doi.org/10.3892/ijmm.2018.3550","mag":"2790282353","pmid":"https://pubmed.ncbi.nlm.nih.gov/29532858"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.2018.3550","doi":"https://doi.org/10.3892/ijmm.2018.3550","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2018.3550","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2018.3550/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/ijmm.2018.3550/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101831723","display_name":"Bingxin Zhang","orcid":"https://orcid.org/0000-0003-2617-0588","observed_orcids":["https://orcid.org/0000-0003-2617-0588","https://orcid.org/0009-0007-8948-2067","https://orcid.org/0009-0005-1546-8532","https://orcid.org/0009-0005-6344-2257","https://orcid.org/0009-0008-0323-8715"]},"institutions":[{"id":"https://openalex.org/I4210130148","display_name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/02fsmcz03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130148"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingxin Zhang","raw_affiliation_strings":["Department of Dermatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China","institution_ids":["https://openalex.org/I4210130148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069090484","display_name":"Zishen Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114130","display_name":"People's Hospital of Cangzhou","ror":"https://ror.org/027hqk105","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114130"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zishen Zhao","raw_affiliation_strings":["Department of Dermatology, Cangzhou City People's Hospital, Cangzhou, Hebei 061000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Cangzhou City People's Hospital, Cangzhou, Hebei 061000, P.R. China","institution_ids":["https://openalex.org/I4210114130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100544421","display_name":"Xiaoyin Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyin Meng","raw_affiliation_strings":["Department of Gynaecology and Obstetrics, Tianjin Hospital, Tianjin 300211, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Tianjin Hospital, Tianjin 300211, P.R. China","institution_ids":["https://openalex.org/I4210142182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101983787","display_name":"Hongguang Chen","orcid":"https://orcid.org/0000-0002-4435-4391","observed_orcids":["https://orcid.org/0000-0002-4435-4391"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongguang Chen","raw_affiliation_strings":["Department of Anesthesiology, Tianjin Institute of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China","institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100526273","display_name":"Guojun Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114130","display_name":"People's Hospital of Cangzhou","ror":"https://ror.org/027hqk105","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114130"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojun Fu","raw_affiliation_strings":["Department of Dermatology, Cangzhou City People's Hospital, Cangzhou, Hebei 061000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Cangzhou City People's Hospital, Cangzhou, Hebei 061000, P.R. China","institution_ids":["https://openalex.org/I4210114130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029647632","display_name":"Keliang Xie","orcid":"https://orcid.org/0000-0003-0919-9768","observed_orcids":["https://orcid.org/0000-0003-0919-9768","https://orcid.org/0000-0001-6362-6084"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keliang Xie","raw_affiliation_strings":["Department of Anesthesiology, Tianjin Institute of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Tianjin Institute of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China","institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0743,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.93888871,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"41","issue":"6","first_page":"3653","last_page":"3661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.9789999723434448},{"id":"https://openalex.org/keywords/uv-b-radiation","display_name":"UV-B radiation","score":0.781000018119812},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8199999928474426},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/skin-damage","display_name":"skin damage","score":0.7310000061988831},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.9701703786849976},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7777477502822876},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7458795309066772},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7162408828735352},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6702941060066223},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.581326961517334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5671850442886353},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5591040849685669},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.44760483503341675},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3460730314254761},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33856281638145447},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3316625952720642},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3043862581253052},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2990812063217163},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.2666109800338745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26633864641189575},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08879327774047852},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07207334041595459}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.2018.3550","doi":"https://doi.org/10.3892/ijmm.2018.3550","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2018.3550","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2018.3550/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:29532858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29532858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijmm.2018.3550","doi":"https://doi.org/10.3892/ijmm.2018.3550","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2018.3550","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2018.3550/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7559382252","display_name":null,"funder_award_id":"81601667","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790282353.pdf","grobid_xml":"https://content.openalex.org/works/W2790282353.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W21287426","https://openalex.org/W80532691","https://openalex.org/W1048755173","https://openalex.org/W1160464115","https://openalex.org/W1488294447","https://openalex.org/W1944998666","https://openalex.org/W1964859071","https://openalex.org/W1969843775","https://openalex.org/W1971665258","https://openalex.org/W1979189029","https://openalex.org/W1984055188","https://openalex.org/W1991463695","https://openalex.org/W1992850195","https://openalex.org/W2018610367","https://openalex.org/W2029947074","https://openalex.org/W2034392492","https://openalex.org/W2038478235","https://openalex.org/W2039523157","https://openalex.org/W2042442020","https://openalex.org/W2054988846","https://openalex.org/W2064653247","https://openalex.org/W2067077836","https://openalex.org/W2067297015","https://openalex.org/W2078690146","https://openalex.org/W2080454544","https://openalex.org/W2081373083","https://openalex.org/W2088324108","https://openalex.org/W2093743573","https://openalex.org/W2094461058","https://openalex.org/W2127967819","https://openalex.org/W2130378684","https://openalex.org/W2131889240","https://openalex.org/W2165848437","https://openalex.org/W2167366746","https://openalex.org/W2169145907","https://openalex.org/W2169657429","https://openalex.org/W2172213810","https://openalex.org/W2176121808","https://openalex.org/W2346853333","https://openalex.org/W2352174999","https://openalex.org/W2431112453","https://openalex.org/W2461787228","https://openalex.org/W2510013939","https://openalex.org/W2512980923","https://openalex.org/W2528040020","https://openalex.org/W2528557481","https://openalex.org/W2534535431","https://openalex.org/W2536233390","https://openalex.org/W2570892670","https://openalex.org/W2586807519","https://openalex.org/W2616756095","https://openalex.org/W2730832359","https://openalex.org/W3030068520","https://openalex.org/W3032676742"],"related_works":["https://openalex.org/W1591526813","https://openalex.org/W2976335823","https://openalex.org/W3032676742","https://openalex.org/W2151848842","https://openalex.org/W2619546258","https://openalex.org/W1996701526","https://openalex.org/W1989480777","https://openalex.org/W4417503209","https://openalex.org/W2089302797","https://openalex.org/W2915244548"],"abstract_inverted_index":{"Chronic":[0],"ultraviolet":[1],"(UV)":[2],"exposure-induced":[3],"oxidative":[4,35,88,207],"stress":[5,208],"is":[6,23],"associated":[7],"with":[8],"the":[9,15,41,44,72,82,97,108,134,153,159,171,191,214],"pathogenesis":[10],"of":[11,43,59,85,110,137,152,161,175,193],"skin":[12],"damage.":[13],"However,":[14],"nuclear":[16],"factor":[17,19,26],"erythroid\u20112\u2011related":[18],"2":[20],"(Nrf2)":[21],"pathway":[22],"a":[24,54],"critical":[25],"in":[27,57,182],"protecting":[28],"cells":[29,104,203],"against":[30,87],"UVB\u2011induced":[31,102,196],"injury":[32,90],"through":[33,213],"inhibiting":[34,210],"stress.":[36],"Furthermore,":[37],"Nrf2":[38,140,178],"activation":[39,212],"requires":[40],"involvement":[42],"phosphoinositide-3":[45],"kinase":[46,48],"(PI3K)/protein":[47],"B":[49],"(AKT)":[50],"pathway,":[51],"which":[52],"has":[53],"major":[55],"role":[56],"survival":[58],"various":[60],"cell":[61,122],"types.":[62],"Molecular":[63],"hydrogen":[64,86,157,194,200],"exerts":[65],"protective":[66,83],"effects":[67,84,192],"on":[68,195],"UV\u2011induced":[69],"injury,":[70],"but":[71],"underlying":[73],"mechanisms":[74],"have":[75],"remained":[76],"elusive.":[77],"The":[78],"present":[79],"study":[80],"assessed":[81],"stress\u2011induced":[89],"caused":[91],"by":[92,126,209],"UVB":[93,172,205],"irradiation":[94],"and":[95,120,124,128,141,167,169,179],"investigated":[96,146],"molecular":[98],"mechanisms.":[99],"In":[100],"vitro,":[101],"HaCaT":[103,183,197],"were":[105,145],"collected":[106],"for":[107],"detection":[109],"reactive":[111,162],"oxygen":[112,163],"species,":[113,164],"8\u2011iso\u2011prostaglandin":[114,165],"F2\u03b1,":[115],"malondialdehyde":[116],"via":[117],"fluorescence":[118],"spectrometry":[119],"ELISA;":[121],"activity":[123],"cytotoxicity":[125],"MTT":[127],"lactate":[129],"dehydrogenase":[130],"assays,":[131],"respectively.":[132],"Additionally,":[133],"expression":[135,174],"level":[136],"PI3K,":[138,176],"Akt,":[139,177],"heme":[142,180],"oxygenase\u20111":[143,181],"(HO\u20111)":[144],"using":[147],"western":[148],"blot,":[149],"etc.":[150],"All":[151],"results":[154],"indicated":[155],"that":[156],"decreased":[158],"levels":[160],"F2\u03b1":[166],"malondialdehyde,":[168],"promoted":[170],"exposure\u2011induced":[173],"cells.":[184,198],"Of":[185],"note,":[186],"PI3K":[187],"inhibition":[188],"partially":[189],"reversed":[190],"Therefore,":[199],"effectively":[201],"protects":[202],"from":[204],"radiation\u2011induced":[206],"Nrf2/HO\u20111":[211],"PI3K/Akt":[215],"signaling":[216],"pathway.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-03-29T00:00:00"}