{"id":"https://openalex.org/W2790180451","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.280","title":"Germline BRCA1/2, PALB2, and ATM mutations in 3,030 patients with pancreatic adenocarcinoma: Survival analysis of carriers and noncarriers.","display_name":"Germline BRCA1/2, PALB2, and ATM mutations in 3,030 patients with pancreatic adenocarcinoma: Survival analysis of carriers and noncarriers.","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2790180451","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.280","mag":"2790180451"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.4_suppl.280","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.280","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.280","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077416215","display_name":"Pashtoon Murtaza Kasi","orcid":"https://orcid.org/0000-0002-5169-7085","observed_orcids":["https://orcid.org/0000-0002-5169-7085"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pashtoon Murtaza Kasi","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL;","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016908886","display_name":"Fergus J. Couch","orcid":"https://orcid.org/0000-0001-9417-9985","observed_orcids":["https://orcid.org/0000-0001-9417-9985"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fergus Couch","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037364927","display_name":"William R. Bamlet","orcid":"https://orcid.org/0000-0003-2903-1284","observed_orcids":["https://orcid.org/0000-0003-2903-1284"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R Bamlet","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003869193","display_name":"Chunling Hu","orcid":"https://orcid.org/0000-0002-6814-4639","observed_orcids":["https://orcid.org/0000-0002-6814-4639"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunling Hu","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085507659","display_name":"Steven N. Hart","orcid":"https://orcid.org/0000-0001-7714-2734","observed_orcids":["https://orcid.org/0000-0001-7714-2734"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Hart","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033145217","display_name":"Eric C. Polley","orcid":"https://orcid.org/0000-0002-5152-8740","observed_orcids":["https://orcid.org/0000-0002-5152-8740"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Polley","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048782070","display_name":"Gloria M. Petersen","orcid":"https://orcid.org/0000-0003-3424-7039","observed_orcids":["https://orcid.org/0000-0003-3424-7039"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria M. Petersen","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006194799","display_name":"Robert R. McWilliams","orcid":"https://orcid.org/0000-0002-8199-5040","observed_orcids":["https://orcid.org/0000-0002-8199-5040"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. McWilliams","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"4_suppl","first_page":"280","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.28780001401901245,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.9480000138282776},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.996999979019165},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/palb2","display_name":"PALB2","score":1.0},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.984000027179718},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8550000190734863},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.8410000205039978},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.6320000290870667},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.4729999899864197},{"id":"https://openalex.org/keywords/treatment-era-comparison","display_name":"treatment era comparison","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2778144015","wikidata":"https://www.wikidata.org/wiki/Q18046302","display_name":"PALB2","level":5,"score":0.8348079919815063},{"id":"https://openalex.org/C2777148230","wikidata":"https://www.wikidata.org/wiki/Q17144959","display_name":"FOLFIRINOX","level":5,"score":0.7457847595214844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7355588674545288},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6096771359443665},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5856356024742126},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5671485066413879},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5292567610740662},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.5255060195922852},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5073429942131042},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5009734630584717},{"id":"https://openalex.org/C2776071976","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"CHEK2","level":5,"score":0.48683327436447144},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.47559627890586853},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.46512719988822937},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4359566271305084},{"id":"https://openalex.org/C2909462720","wikidata":"https://www.wikidata.org/wiki/Q421651","display_name":"BRCA2 Protein","level":5,"score":0.41648465394973755},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4102490544319153},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39694929122924805},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.395962119102478},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3175852298736572},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29184240102767944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19248732924461365},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.15709277987480164},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.11564844846725464},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.06890547275543213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.4_suppl.280","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.280","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.280","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2802135837","https://openalex.org/W2781674630","https://openalex.org/W4210375721","https://openalex.org/W2783420726","https://openalex.org/W2890803263","https://openalex.org/W2586745916","https://openalex.org/W3091797030","https://openalex.org/W2805031648","https://openalex.org/W4205911326","https://openalex.org/W4283767839"],"abstract_inverted_index":{"280":[0],"Background:":[1],"Patients":[2],"with":[3,108,190,213,238,275,280],"pancreatic":[4],"adenocarcinoma":[5],"(PDAC)":[6],"can":[7],"have":[8,176],"mutations":[9,29,117,178,214,240,267,282],"in":[10,78,179,211,241,270],"breast":[11],"cancer":[12],"associated":[13],"genes":[14],"(":[15],"BRCA1/2)":[16],"and":[17,50,55,64,109,124,143,154,161,265,298],"other":[18],"homologous":[19],"recombination":[20],"(HR)":[21,129],"pathway":[22],"genes.":[23,185],"The":[24],"therapeutic":[25],"significance":[26],"of":[27,43,52,84,105,169,188,273,295,300],"these":[28,239,281],"for":[30,138,311],"PDAC":[31,46,68,106,199,296,312],"patients":[32,47,69,107,172,189,212,237,274,279,297],"is":[33],"not":[34,225],"yet":[35],"established.":[36],"We":[37,59],"performed":[38,119],"a":[39],"comprehensive":[40],"survival":[41,202],"analysis":[42,104,194],"3,030":[44],"unselected":[45],"comparing":[48],"non-carriers":[49,250],"carriers":[51],"BRCA1/2,":[53,263],"PALB2,":[54,113,182,264],"ATM":[56,115,184,266],"mutations.":[57],"Methods:":[58],"analyzed":[60,90],"germline":[61,116,262],"DNA":[62,87],"samples":[63,88],"outcomes":[65,247],"from":[66,71],"confirmed":[67],"recruited":[70],"1999-2014":[72],"into":[73],"the":[74,121,242],"Mayo":[75],"Clinic":[76],"SPORE":[77],"Pancreatic":[79],"Cancer":[80],"registry.":[81],"A":[82,145,167],"total":[83,168],"3,046":[85],"genomic":[86],"were":[89,98,130,157,173,268],"by":[91,100,233],"next":[92],"generation":[93],"sequencing.":[94,102],"All":[95],"pathogenic":[96],"variants":[97],"validated":[99],"Sanger":[101],"Survival":[103],"without":[110,219],"BRCA1,":[111,180],"BRCA2,":[112,181],"or":[114,183],"was":[118,149,195,203,224],"using":[120,132],"Kaplan-Meier":[122],"method":[123],"log-rank":[125],"tests.":[126],"Hazard":[127],"ratios":[128],"calculated":[131],"Cox":[133],"proportional":[134],"hazard":[135],"modeling":[136],"adjusted":[137],"co-variates":[139],"including":[140],"age,":[141],"sex,":[142],"stage.":[144],"p-value":[146],"<":[147],"0.05":[148],"considered":[150],"statistically":[151,226],"significant.":[152],"Pre-":[153],"post-FOLFIRINOX":[155,243],"eras":[156],"defined":[158],"as":[159,215],"before":[160],"after":[162],"June":[163],"1,":[164],"2011.":[165],"Results:":[166],"139":[170],"(4.6%)":[171],"noted":[174],"to":[175,197,217,288,290],"deleterious":[177],"After":[186],"exclusion":[187],"missing":[191],"data,":[192],"final":[193],"restricted":[196],"2,452":[198],"patients.":[200,313],"Overall":[201],"slightly":[204],"better":[205,246],"(14.2":[206],"months":[207],"versus":[208],"11.3":[209],"months)":[210],"compared":[216],"those":[218],"mutations,":[220],"although":[221],"this":[222,303],"finding":[223],"significant":[227],"(p":[228],"=":[229,258],"0.07).":[230],"When":[231],"stratified":[232],"FOLFIRINOX":[234],"era,":[235],"40":[236],"era":[244,278],"had":[245,283],"than":[248],"668":[249],"(adjusted":[251],"HR":[252],"0.62;":[253],"95%":[254],"CI":[255],"0.43-0.89;":[256],"p":[257],"0.0062).":[259],"Conclusions:":[260],"Deleterious":[261],"seen":[269],"approximately":[271],"5%":[272],"PDAC.":[276],"Post-FOLFIRINOX":[277],"improved":[284],"outcomes,":[285],"possibly":[286],"secondary":[287],"exposure":[289],"DNA-damaging":[291],"chemotherapies.":[292],"Germline":[293],"screening":[294],"development":[299],"trials":[301],"incorporating":[302],"information":[304],"(e.g.,":[305],"PARP":[306],"inhibitors)":[307],"has":[308],"potential":[309],"value":[310]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2018-03-29T00:00:00"}