{"id":"https://openalex.org/W2790132064","doi":"https://doi.org/10.1152/ajplung.00405.2017","title":"Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice","display_name":"Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice","publication_year":2018,"publication_date":"2018-03-15","ids":{"openalex":"https://openalex.org/W2790132064","doi":"https://doi.org/10.1152/ajplung.00405.2017","mag":"2790132064","pmid":"https://pubmed.ncbi.nlm.nih.gov/29543040","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6087899"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00405.2017","doi":"https://doi.org/10.1152/ajplung.00405.2017","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00405.2017","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6087899","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011392113","display_name":"Jeffrey E. Gotts","orcid":"https://orcid.org/0000-0002-6269-8753","observed_orcids":["https://orcid.org/0000-0002-6269-8753"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey E. Gotts","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020320154","display_name":"Lauren F. Chun","orcid":"https://orcid.org/0000-0001-6358-2827","observed_orcids":["https://orcid.org/0000-0001-6358-2827"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Chun","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064708000","display_name":"Jason Anthony Abbott","orcid":"https://orcid.org/0000-0002-4406-3121","observed_orcids":["https://orcid.org/0000-0002-4406-3121"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Abbott","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104668570","display_name":"Xiaohui Fang","orcid":"https://orcid.org/0000-0003-2731-5021","observed_orcids":["https://orcid.org/0000-0003-2731-5021"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohui Fang","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070754174","display_name":"Naoki Takasaka","orcid":"https://orcid.org/0000-0002-3016-233X","observed_orcids":["https://orcid.org/0000-0002-3016-233X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoki Takasaka","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041863997","display_name":"Stephen L. Nishimura","orcid":"https://orcid.org/0000-0003-2312-4113","observed_orcids":["https://orcid.org/0000-0003-2312-4113"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Nishimura","raw_affiliation_strings":["Department of Pathology, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086579894","display_name":"Matthew L. Springer","orcid":"https://orcid.org/0000-0002-6689-8234","observed_orcids":["https://orcid.org/0000-0002-6689-8234"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Springer","raw_affiliation_strings":["Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008874542","display_name":"Suzaynn F. Schick","orcid":"https://orcid.org/0000-0001-7101-3077","observed_orcids":["https://orcid.org/0000-0001-7101-3077"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzaynn F. Schick","raw_affiliation_strings":["Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062212651","display_name":"Carolyn S. Calfee","orcid":"https://orcid.org/0000-0001-9208-6865","observed_orcids":["https://orcid.org/0000-0001-9208-6865"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn S. Calfee","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011392113"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":2.5988,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89890583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"315","issue":"1","first_page":"L25","last_page":"L40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke-exposure","display_name":"cigarette smoke exposure","score":0.9240000247955322},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9599999785423279},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9490000009536743},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bacterial-pneumonia","display_name":"bacterial pneumonia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pneumococcal-pneumonia","display_name":"pneumococcal pneumonia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/immune-cell-recruitment","display_name":"immune cell recruitment","score":0.7139999866485596},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.8500000238418579},{"id":"https://openalex.org/keywords/surfactant-protein-d","display_name":"surfactant protein D","score":0.953000009059906},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":1.0},{"id":"https://openalex.org/keywords/lung-epithelial-injury","display_name":"lung epithelial injury","score":0.8889999985694885},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tobacco-products","display_name":"tobacco products","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.7347564101219177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.720164954662323},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.712339460849762},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.686154842376709},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6354668140411377},{"id":"https://openalex.org/C2779892413","wikidata":"https://www.wikidata.org/wiki/Q7205992","display_name":"Pneumococcal pneumonia","level":4,"score":0.6200888156890869},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5509188175201416},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.5168293118476868},{"id":"https://openalex.org/C2776345407","wikidata":"https://www.wikidata.org/wiki/Q3776920","display_name":"Bacterial pneumonia","level":3,"score":0.48900139331817627},{"id":"https://openalex.org/C9418649","wikidata":"https://www.wikidata.org/wiki/Q5275407","display_name":"Diffuse alveolar damage","level":4,"score":0.47902244329452515},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4582563638687134},{"id":"https://openalex.org/C2776088486","wikidata":"https://www.wikidata.org/wiki/Q7205996","display_name":"Pneumolysin","level":4,"score":0.41643229126930237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20708784461021423},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15790089964866638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13987794518470764},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011018","descriptor_name":"Pneumonia, Pneumococcal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011018","descriptor_name":"Pneumonia, Pneumococcal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011018","descriptor_name":"Pneumonia, Pneumococcal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014028","descriptor_name":"Tobacco Smoke Pollution","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018410","descriptor_name":"Pneumonia, Bacterial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1152/ajplung.00405.2017","doi":"https://doi.org/10.1152/ajplung.00405.2017","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00405.2017","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6087899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6087899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},{"id":"pmid:29543040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29543040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt26t407hc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/26t407hc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology, vol 315, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt26t407hc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/26t407hc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Physiology - Lung Cellular and Molecular Physiology, vol 315, iss 1","raw_type":"article"},{"id":"pmh:qt26t407hc","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/26t407hc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gotts, JE; Chun, LF; Abbott, J; Fang, X; Takasaki, N; Nishimura, SL; \u00c2\u00a0et al.(2018). Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.. American journal of physiology. Lung cellular and molecular physiology. doi: 10.1152/ajplung.00405.2017. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/26t407hc","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6087899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6087899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6043160594","display_name":"Improved Models to Inform Tobacco Product Regulation","funder_award_id":"P50CA180890","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W121198607","https://openalex.org/W207268442","https://openalex.org/W1532091886","https://openalex.org/W1723532226","https://openalex.org/W1785914948","https://openalex.org/W1816622697","https://openalex.org/W1825962579","https://openalex.org/W1845797841","https://openalex.org/W1894360771","https://openalex.org/W1925319210","https://openalex.org/W1964906546","https://openalex.org/W1965737875","https://openalex.org/W1967429254","https://openalex.org/W1972099358","https://openalex.org/W1973774591","https://openalex.org/W1973896986","https://openalex.org/W1980701046","https://openalex.org/W1986454360","https://openalex.org/W1987719335","https://openalex.org/W1995682707","https://openalex.org/W1998901595","https://openalex.org/W2001998219","https://openalex.org/W2014084227","https://openalex.org/W2019549413","https://openalex.org/W2024224130","https://openalex.org/W2027614636","https://openalex.org/W2029268245","https://openalex.org/W2029335692","https://openalex.org/W2034061664","https://openalex.org/W2036327819","https://openalex.org/W2036396154","https://openalex.org/W2036568786","https://openalex.org/W2050218130","https://openalex.org/W2053851172","https://openalex.org/W2058975819","https://openalex.org/W2061628196","https://openalex.org/W2062082499","https://openalex.org/W2064775635","https://openalex.org/W2065468254","https://openalex.org/W2065480048","https://openalex.org/W2066741376","https://openalex.org/W2067401298","https://openalex.org/W2067629091","https://openalex.org/W2068854215","https://openalex.org/W2073264366","https://openalex.org/W2077726738","https://openalex.org/W2087942502","https://openalex.org/W2092658097","https://openalex.org/W2093852073","https://openalex.org/W2095054225","https://openalex.org/W2097240008","https://openalex.org/W2098744085","https://openalex.org/W2105130485","https://openalex.org/W2107231652","https://openalex.org/W2111603601","https://openalex.org/W2114698211","https://openalex.org/W2115802113","https://openalex.org/W2115907155","https://openalex.org/W2117983612","https://openalex.org/W2120192399","https://openalex.org/W2122868587","https://openalex.org/W2123077733","https://openalex.org/W2124881192","https://openalex.org/W2126475210","https://openalex.org/W2129958874","https://openalex.org/W2132040583","https://openalex.org/W2133090072","https://openalex.org/W2138824466","https://openalex.org/W2139698802","https://openalex.org/W2144222001","https://openalex.org/W2144304154","https://openalex.org/W2145710202","https://openalex.org/W2146323311","https://openalex.org/W2153156760","https://openalex.org/W2157344181","https://openalex.org/W2159547586","https://openalex.org/W2162205004","https://openalex.org/W2163240112","https://openalex.org/W2168895700","https://openalex.org/W2169126410","https://openalex.org/W2170822548","https://openalex.org/W2256141364","https://openalex.org/W2288620069","https://openalex.org/W2292713941","https://openalex.org/W2396212074","https://openalex.org/W2555467097","https://openalex.org/W2593595133","https://openalex.org/W2611615951","https://openalex.org/W2614896227","https://openalex.org/W2618861551","https://openalex.org/W2620241325","https://openalex.org/W2766731651","https://openalex.org/W3020992950","https://openalex.org/W4294658238"],"related_works":["https://openalex.org/W4410271849","https://openalex.org/W2593595133","https://openalex.org/W3127011454","https://openalex.org/W4302275694","https://openalex.org/W2950722085","https://openalex.org/W2029335692","https://openalex.org/W2123282532","https://openalex.org/W1949434953","https://openalex.org/W2084477527","https://openalex.org/W7065044659"],"abstract_inverted_index":{"Evidence":[0],"is":[1,21,32],"accumulating":[2],"that":[3,187,205],"exposure":[4,93,190],"to":[5,71,136,197,215],"cigarette":[6],"smoke":[7],"(CS)":[8],"increases":[9],"the":[10,22,33,125,140,192,198,213],"risk":[11],"of":[12,26,36,43,74,89,122,154,194,223,229,244],"developing":[13],"acute":[14,188,230],"respiratory":[15],"distress":[16],"syndrome":[17],"(ARDS).":[18],"Streptococcus":[19],"pneumoniae":[20],"most":[23],"common":[24],"cause":[25,35],"bacterial":[27,60,201,234],"pneumonia,":[28,61,202],"which":[29],"in":[30,116,226,233],"turn":[31],"leading":[34],"ARDS.":[37],"Chronic":[38],"smokers":[39],"have":[40],"increased":[41,152],"rates":[42],"pneumococcal":[44,50,106],"colonization":[45],"and":[46,62,145,157,160,173,181],"develop":[47],"more":[48,149,177,216],"severe":[49,178,217],"pneumonia":[51,235],"than":[52,113],"nonsmokers;":[53],"yet":[54],"mechanistic":[55],"connections":[56],"between":[57],"CS":[58,78,92,189],"exposure,":[59],"ARDS":[63],"pathogenesis":[64],"remain":[65],"relatively":[66],"unexplored.":[67],"We":[68],"exposed":[69],"mice":[70,109,129,147,165,214],"3":[72],"wk":[73],"moderate":[75],"whole":[76],"body":[77],"or":[79,100,246],"air,":[80],"followed":[81],"by":[82],"intranasal":[83],"inoculation":[84],"with":[85,118,132,176],"an":[86,203],"invasive":[87],"serotype":[88],"S.":[90],"pneumoniae.":[91],"alone":[94],"caused":[95],"no":[96],"detectable":[97],"lung":[98,179,199,219,231],"injury":[99,232],"bronchoalveolar":[101],"lavage":[102],"(BAL)":[103],"inflammation.":[104],"During":[105],"infection,":[107],"CS-exposed":[108,146,163],"had":[110,148,167],"greater":[111],"survival":[112,141],"air-exposed":[114],"mice,":[115],"association":[117],"reduced":[119],"systemic":[120],"spread":[121],"bacteria":[123],"from":[124],"lungs.":[126],"However,":[127],"when":[128],"were":[130],"treated":[131],"antibiotics":[133],"after":[134],"infection":[135],"improve":[137],"clinical":[138,238],"relevance,":[139,239],"benefit":[142,209],"was":[143],"lost,":[144],"pulmonary":[150],"edema,":[151],"numbers":[153],"BAL":[155],"monocytes,":[156],"elevated":[158],"monocyte":[159],"lymphocyte":[161],"chemokines.":[162],"antibiotic-treated":[164],"also":[166],"higher":[168],"serum":[169],"surfactant":[170],"protein":[171],"D":[172],"angiopoietin-2,":[174],"consistent":[175],"epithelial":[180],"endothelial":[182],"injury.":[183,220],"The":[184,221],"results":[185],"indicate":[186],"enhances":[191],"recruitment":[193],"immune":[195],"cells":[196],"during":[200],"effect":[204],"may":[206,236],"provide":[207],"microbiological":[208],"but":[210],"simultaneously":[211],"exposes":[212],"inflammatory":[218],"inclusion":[222],"antibiotic":[224],"treatment":[225],"preclinical":[227],"studies":[228,243],"enhance":[237],"particularly":[240],"for":[241],"future":[242],"current":[245],"emerging":[247],"tobacco":[248],"products.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2018-03-29T00:00:00"}
