{"id":"https://openalex.org/W2789933865","doi":"https://doi.org/10.1111/ene.13622","title":"Low cytomegalovirus seroprevalence in early multiple sclerosis: a case for the \u2018hygiene hypothesis\u2019?","display_name":"Low cytomegalovirus seroprevalence in early multiple sclerosis: a case for the \u2018hygiene hypothesis\u2019?","publication_year":2018,"publication_date":"2018-03-12","ids":{"openalex":"https://openalex.org/W2789933865","doi":"https://doi.org/10.1111/ene.13622","mag":"2789933865","pmid":"https://pubmed.ncbi.nlm.nih.gov/29528545"},"language":"en","primary_location":{"id":"doi:10.1111/ene.13622","doi":"https://doi.org/10.1111/ene.13622","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ene.13622","pdf_url":null,"source":{"id":"https://openalex.org/S162635963","display_name":"European Journal of Neurology","issn_l":"1351-5101","issn":["1351-5101","1468-1331"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080299482","display_name":"Elisenda Alari\u2010Pahissa","orcid":"https://orcid.org/0000-0001-7424-5383","observed_orcids":["https://orcid.org/0000-0001-7424-5383"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Alari\u2010Pahissa","raw_affiliation_strings":["Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086472240","display_name":"Ant\u00eda Moreira","orcid":"https://orcid.org/0000-0002-6395-5184","observed_orcids":["https://orcid.org/0000-0002-6395-5184"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Moreira","raw_affiliation_strings":["Neurology Department Universitat Aut\u00f2noma de Barcelona Hospital del Mar Medical Research Institute (IMIM) Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department Universitat Aut\u00f2noma de Barcelona Hospital del Mar Medical Research Institute (IMIM) Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055579985","display_name":"Ana Zabalza","orcid":"https://orcid.org/0000-0003-3860-5251","observed_orcids":["https://orcid.org/0000-0003-3860-5251"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Zabalza","raw_affiliation_strings":["Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029175418","display_name":"Roberto \u00c1lvarez\u2010Lafuente","orcid":"https://orcid.org/0000-0002-3132-1486","observed_orcids":["https://orcid.org/0000-0002-3132-1486"]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210097846","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/014v12a39","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210097846"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Alvarez\u2010Lafuente","raw_affiliation_strings":["Neurology Service Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico de San Carlos Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico de San Carlos Madrid","institution_ids":["https://openalex.org/I2961216182","https://openalex.org/I4210097846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057282973","display_name":"Elvira Munteis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Munteis","raw_affiliation_strings":["Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Vera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Vera","raw_affiliation_strings":["Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Arroyo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109886","display_name":"Hospital Universitario Quir\u00f3nsalud Madrid","ror":"https://ror.org/018q88z15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210109886"]},{"id":"https://openalex.org/I4405267828","display_name":"IDCQ Hospitales y Sanidad, S.L.U.","ror":"https://ror.org/04k611z44","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4405267828"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Arroyo","raw_affiliation_strings":["Neurology Service Hospital Universitario Quir\u00f3nsaluld Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service Hospital Universitario Quir\u00f3nsaluld Madrid","institution_ids":["https://openalex.org/I4210109886","https://openalex.org/I4405267828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113700106","display_name":"J. C. Alvarez\u2010Cerme\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. C. Alvarez\u2010Cerme\u00f1o","raw_affiliation_strings":["Neurology Department, Ramon y Cajal University Hospital, Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Ramon y Cajal University Hospital, Madrid","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083509914","display_name":"Luisa Mar\u00eda Villar","orcid":"https://orcid.org/0000-0002-9067-3668","observed_orcids":["https://orcid.org/0000-0002-9067-3668"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L. M. Villar","raw_affiliation_strings":["Immunology Department Hospital Universitario Ram\u00f3n y Cajal Madrid"],"raw_orcid":"https://orcid.org/0000-0002-9067-3668","affiliations":[{"raw_affiliation_string":"Immunology Department Hospital Universitario Ram\u00f3n y Cajal Madrid","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044514864","display_name":"Miguel L\u00f3pez\u2010Botet","orcid":"https://orcid.org/0000-0003-4882-065X","observed_orcids":["https://orcid.org/0000-0003-4882-065X"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. L\u00f3pez\u2010Botet","raw_affiliation_strings":["Immunology Unit, University Pompeu Fabra, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Unit, University Pompeu Fabra, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"last","author":{"id":null,"display_name":"J. E. Mart\u00ednez\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-6765-5587","observed_orcids":["https://orcid.org/0000-0001-6765-5587"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J. E. Mart\u00ednez\u2010Rodr\u00edguez","raw_affiliation_strings":["Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona"],"raw_orcid":"https://orcid.org/0000-0001-6765-5587","affiliations":[{"raw_affiliation_string":"Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":2.3002,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.87759243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"7","first_page":"925","last_page":"933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.14069999754428864,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.8040000200271606},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/seroprevalence","display_name":"seroprevalence","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hygiene-hypothesis","display_name":"hygiene hypothesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.921999990940094},{"id":"https://openalex.org/keywords/human-herpesvirus-6","display_name":"human herpesvirus 6","score":0.9160000085830688},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.6679999828338623},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5770000219345093},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nkg2c","display_name":"NKG2C","score":0.9409999847412109},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/disability","display_name":"disability","score":0.5820000171661377},{"id":"https://openalex.org/keywords/viral-infection-and-autoimmunity","display_name":"viral infection and autoimmunity","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7232013940811157},{"id":"https://openalex.org/C2776535787","wikidata":"https://www.wikidata.org/wiki/Q1084257","display_name":"Serostatus","level":4,"score":0.7009585499763489},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.619085431098938},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.602771520614624},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5914465188980103},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4727678596973419},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.45444780588150024},{"id":"https://openalex.org/C2778494684","wikidata":"https://www.wikidata.org/wiki/Q3511357","display_name":"Seroprevalence","level":4,"score":0.45155489444732666},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3520747423171997},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3490574061870575},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33208805322647095},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.31880444288253784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2832053005695343},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2752065658569336},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.202065110206604},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.1189424991607666}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016036","descriptor_name":"Seroepidemiologic Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061148","descriptor_name":"Hygiene Hypothesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/ene.13622","doi":"https://doi.org/10.1111/ene.13622","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ene.13622","pdf_url":null,"source":{"id":"https://openalex.org/S162635963","display_name":"European Journal of Neurology","issn_l":"1351-5101","issn":["1351-5101","1468-1331"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:29528545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29528545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:recercat.cat:2072/335507","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10230/35714","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositori.upf.edu:10230/35714","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10230/35714","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1933832107","display_name":null,"funder_award_id":"FIS/PI14/00177","funder_id":"https://openalex.org/F4320321595","funder_display_name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras"},{"id":"https://openalex.org/G3072953133","display_name":null,"funder_award_id":"SAF 2013\u201049063\u2010C2\u20101\u2010R","funder_id":"https://openalex.org/F4320321595","funder_display_name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras"},{"id":"https://openalex.org/G5735704306","display_name":null,"funder_award_id":"FIS/PI17/00254","funder_id":"https://openalex.org/F4320321595","funder_display_name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras"},{"id":"https://openalex.org/G7064191448","display_name":null,"funder_award_id":"RD16/0015/0011","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320321595","display_name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","ror":"https://ror.org/0348bpk17"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320324660","display_name":"Red Espa\u00f1ola de Esclerosis M\u00faltiple","ror":"https://ror.org/00dgcm453"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1601440281","https://openalex.org/W1928377279","https://openalex.org/W1965351429","https://openalex.org/W1984168657","https://openalex.org/W1993358435","https://openalex.org/W2006197871","https://openalex.org/W2015904469","https://openalex.org/W2019329212","https://openalex.org/W2035323717","https://openalex.org/W2040809972","https://openalex.org/W2061593724","https://openalex.org/W2068367301","https://openalex.org/W2074215315","https://openalex.org/W2107053474","https://openalex.org/W2137879329","https://openalex.org/W2139113477","https://openalex.org/W2140407525","https://openalex.org/W2145647613","https://openalex.org/W2171373682","https://openalex.org/W2177223454","https://openalex.org/W2184898873","https://openalex.org/W2293314724","https://openalex.org/W2598318906","https://openalex.org/W2626763528","https://openalex.org/W2710695880","https://openalex.org/W6967205033"],"related_works":["https://openalex.org/W3169599583","https://openalex.org/W2140407525","https://openalex.org/W4308432023","https://openalex.org/W4402385124","https://openalex.org/W7115812069","https://openalex.org/W4389445710","https://openalex.org/W4416276929","https://openalex.org/W2988256220","https://openalex.org/W2185195218","https://openalex.org/W7221033186"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Cytomegalovirus":[3,123],"(CMV)":[4],"infection":[5],"has":[6,23],"recently":[7],"been":[8],"associated":[9,141,173],"with":[10,50,55,57,67,86,142,157,174,186,217],"a":[11,24,175],"lower":[12,129,176],"multiple":[13],"sclerosis":[14],"(MS)":[15],"susceptibility,":[16],"although":[17],"it":[18,22],"remains":[19],"controversial":[20],"whether":[21,43],"protective":[25],"role":[26],"or":[27,134],"is":[28],"merely":[29],"an":[30,190],"epiphenomenon":[31],"related":[32,229],"to":[33,41,106,225,230],"westernization":[34],"and":[35,71,97,110,117,168,236],"early-life":[36],"viral":[37],"infections.":[38],"We":[39],"aimed":[40],"evaluate":[42],"CMV":[44,211,226],"serostatus":[45],"may":[46],"differ":[47],"in":[48,125,131,178,193,204,215],"patients":[49,56,85,156,185,216],"early":[51,126,179,187,218,247],"MS":[52,68,87,127,133,158,180,188,222],"as":[53,113,115],"compared":[54],"non-early":[58,132],"MS,":[59,89],"analyzing":[60],"the":[61,231,250],"putative":[62],"association":[63],"of":[64,83,162,221,233,241,249],"this":[65],"virus":[66,109],"clinical":[69],"course":[70],"humoral":[72,104,207],"immune":[73,244],"responses":[74,105,245],"against":[75],"other":[76],"herpesviruses.":[77],"METHODS:":[78],"Multicentric":[79],"analysis":[80],"was":[81,128,213],"undertaken":[82],"310":[84],"(early":[88],"disease":[90,143],"duration":[91,144],"\u22645":[92],"years,":[93],"n":[94],"=":[95,100],"127)":[96],"controls":[98,135],"(n":[99],"155),":[101],"evaluating":[102],"specific":[103],"CMV,":[107],"Epstein-Barr":[108,242],"human":[111],"herpesvirus-6,":[112],"well":[114],"T-cell":[116,235],"natural":[118],"killer":[119],"(NK)-cell":[120],"immunophenotypes.":[121],"RESULTS:":[122],"seroprevalence":[124,212],"than":[130],"(P":[136,181,197],"<":[137,153,182,198],"0.01),":[138,199],"being":[139],"independently":[140],"(odds":[145],"ratio,":[146],"1.04;":[147],"95%":[148],"confidence":[149],"interval,":[150],"1.01-1.08,":[151],"P":[152],"0.05).":[154,183],"CMV+":[155,184],"displayed":[159],"increased":[160],"proportions":[161],"differentiated":[163,234],"T-cells":[164],"(CD27-CD28-,":[165],"CD57+,":[166],"LILRB1+)":[167],"NKG2C+":[169],"NK-cells,":[170],"which":[171],"were":[172],"disability":[177],"had":[189],"age-related":[191],"decline":[192],"serum":[194],"anti-EBNA-1":[195],"antibodies":[196],"but":[200],"no":[201],"CMV-related":[202],"differences":[203],"anti-human":[205],"herpesvirus-6":[206],"responses.":[208],"CONCLUSIONS:":[209],"Low":[210],"observed":[214],"MS.":[219],"Modification":[220],"risk":[223],"attributed":[224],"might":[227],"be":[228],"induction":[232],"NK-cell":[237],"subsets":[238],"and/or":[239],"modulation":[240],"virus-specific":[243],"at":[246],"stages":[248],"disease.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-03-29T00:00:00"}