{"id":"https://openalex.org/W2789923947","doi":"https://doi.org/10.1016/j.cellimm.2018.02.009","title":"Characterization of CD4+ T cell-mediated cytotoxicity in patients with multiple myeloma","display_name":"Characterization of CD4+ T cell-mediated cytotoxicity in patients with multiple myeloma","publication_year":2018,"publication_date":"2018-02-12","ids":{"openalex":"https://openalex.org/W2789923947","doi":"https://doi.org/10.1016/j.cellimm.2018.02.009","mag":"2789923947","pmid":"https://pubmed.ncbi.nlm.nih.gov/29454645"},"language":"en","primary_location":{"id":"doi:10.1016/j.cellimm.2018.02.009","doi":"https://doi.org/10.1016/j.cellimm.2018.02.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cellimm.2018.02.009","pdf_url":null,"source":{"id":"https://openalex.org/S193466101","display_name":"Cellular Immunology","issn_l":"0008-8749","issn":["0008-8749","1090-2163"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaole Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160222","display_name":"Liaocheng People's Hospital","ror":"https://ror.org/052vn2478","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaole Zhang","raw_affiliation_strings":["Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China","institution_ids":["https://openalex.org/I4210160222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102755454","display_name":"Lei Gao","orcid":"https://orcid.org/0000-0003-2336-976X","observed_orcids":["https://orcid.org/0000-0003-2336-976X"]},"institutions":[{"id":"https://openalex.org/I4210160222","display_name":"Liaocheng People's Hospital","ror":"https://ror.org/052vn2478","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Gao","raw_affiliation_strings":["Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China","institution_ids":["https://openalex.org/I4210160222"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Meng","raw_affiliation_strings":["Liaocheng Blood Center, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaocheng Blood Center, Liaocheng, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034505830","display_name":"Chunting Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278720","display_name":"Liaocheng Vocational and Technical College","ror":"https://ror.org/00et7st63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278720"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunting Han","raw_affiliation_strings":["Liaocheng Vocational and Technical College, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaocheng Vocational and Technical College, Liaocheng, Shandong Province, China","institution_ids":["https://openalex.org/I4405278720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429902","display_name":"Qiang Li","orcid":"https://orcid.org/0000-0001-8317-4978","observed_orcids":["https://orcid.org/0000-0001-8317-4978"]},"institutions":[{"id":"https://openalex.org/I4210160222","display_name":"Liaocheng People's Hospital","ror":"https://ror.org/052vn2478","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Li","raw_affiliation_strings":["Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China","institution_ids":["https://openalex.org/I4210160222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012157476","display_name":"Zhenjun Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160222","display_name":"Liaocheng People's Hospital","ror":"https://ror.org/052vn2478","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenjun Feng","raw_affiliation_strings":["Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China","institution_ids":["https://openalex.org/I4210160222"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100333401","display_name":"Lei Chen","orcid":"https://orcid.org/0000-0001-6188-5453","observed_orcids":["https://orcid.org/0000-0001-6188-5453"]},"institutions":[{"id":"https://openalex.org/I4210160222","display_name":"Liaocheng People's Hospital","ror":"https://ror.org/052vn2478","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Chen","raw_affiliation_strings":["Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China. Electronic address: leichen01_lc@sina.com","Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China. Electronic address: leichen01_lc@sina.com","institution_ids":["https://openalex.org/I4210160222"]},{"raw_affiliation_string":"Department of Hematology, Liaocheng People's Hospital, Liaocheng, Shandong Province, China","institution_ids":["https://openalex.org/I4210160222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100333401"],"corresponding_institution_ids":["https://openalex.org/I4210160222"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.0952,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76976849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"327","issue":null,"first_page":"62","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/cytotoxic-cd4-t-cells","display_name":"cytotoxic CD4+ T cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/gzma","display_name":"granzyme A","score":0.7149999737739563},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":1.0},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.6460000276565552},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/t-cell-senescence","display_name":"T cell senescence","score":0.6610000133514404},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.9406980276107788},{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.6515612006187439},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.6404261589050293},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.6080950498580933},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5955729484558105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.554409921169281},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5438989996910095},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.5167045593261719},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.48658883571624756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46982359886169434},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.42554765939712524},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4160260558128357},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38796114921569824},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29932236671447754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22963273525238037},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16294506192207336},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.14271456003189087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08844631910324097},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053804","descriptor_name":"Granzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cellimm.2018.02.009","doi":"https://doi.org/10.1016/j.cellimm.2018.02.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cellimm.2018.02.009","pdf_url":null,"source":{"id":"https://openalex.org/S193466101","display_name":"Cellular Immunology","issn_l":"0008-8749","issn":["0008-8749","1090-2163"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Immunology","raw_type":"journal-article"},{"id":"pmid:29454645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29454645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1961195323","https://openalex.org/W1964923494","https://openalex.org/W1981291019","https://openalex.org/W2039361986","https://openalex.org/W2044471691","https://openalex.org/W2050558251","https://openalex.org/W2056320810","https://openalex.org/W2067155443","https://openalex.org/W2096005550","https://openalex.org/W2120474651","https://openalex.org/W2122081259","https://openalex.org/W2133459531","https://openalex.org/W2135905952","https://openalex.org/W2152014155","https://openalex.org/W2233038984","https://openalex.org/W2302088846","https://openalex.org/W2307715703","https://openalex.org/W2327011634","https://openalex.org/W2339229309","https://openalex.org/W2400276917","https://openalex.org/W2536457304","https://openalex.org/W2548238752","https://openalex.org/W2548692573"],"related_works":["https://openalex.org/W4408593130","https://openalex.org/W4405045254","https://openalex.org/W4416447519","https://openalex.org/W3169865581","https://openalex.org/W4387357207","https://openalex.org/W4416446680","https://openalex.org/W2548238752","https://openalex.org/W2022501656","https://openalex.org/W4378713835","https://openalex.org/W4386170624"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-03-29T00:00:00"}
